Cellular magnesium homeostasis.

Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating. Cell (2016) 1.48

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity. Sci Rep (2011) 1.18

Regulation and function of TRPM7 in human endothelial cells: TRPM7 as a potential novel regulator of endothelial function. PLoS One (2013) 1.00

The efficacy of magnesium sulfate loading on microalbuminuria following SIRS: One step forward in dosing. Daru (2012) 0.96

X-ray structures of magnesium and manganese complexes with the N-terminal domain of calmodulin: insights into the mechanism and specificity of metal ion binding to an EF-hand. Biochemistry (2012) 0.93

MLKL forms cation channels. Cell Res (2016) 0.92

Mg2+-dependent interactions of ATP with the cystathionine-β-synthase (CBS) domains of a magnesium transporter. J Biol Chem (2014) 0.90

Loss of MAGT1 abrogates the Mg2+ flux required for T cell signaling and leads to a novel human primary immunodeficiency. Magnes Res (2011) 0.87

Membrane protein CNNM4-dependent Mg2+ efflux suppresses tumor progression. J Clin Invest (2014) 0.87

Molecular mechanism of Mg2+-dependent gating in CorA. Nat Commun (2014) 0.86

The SLC41 family of MgtE-like magnesium transporters. Mol Aspects Med (2013) 0.85

A repulsion mechanism explains magnesium permeation and selectivity in CorA. Proc Natl Acad Sci U S A (2014) 0.84

A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA. Virus Res (2012) 0.83

Magnesium impacts myosin V motor activity by altering key conformational changes in the mechanochemical cycle. Biochemistry (2013) 0.82

TRPM channels and magnesium in early embryonic development. Int J Dev Biol (2015) 0.80

Cell membrane-anchored biosensors for real-time monitoring of the cellular microenvironment. J Am Chem Soc (2014) 0.78

Magnesium modulates actin binding and ADP release in myosin motors. J Biol Chem (2014) 0.77

SLC41A1, a Na(+)/Mg(2+) exchanger, is downregulated during exercise. Biomed Rep (2014) 0.77

The elementome of calcium-based urinary stones and its role in urolithiasis. Nat Rev Urol (2015) 0.77

Magnesium-permeable TRPM6 polymorphisms in patients with meningomyelocele. Springerplus (2016) 0.76

Formation of ternary complexes with MgATP: effects on the detection of Mg2+ in biological samples by bidentate fluorescent sensors. Inorg Chem (2014) 0.75

A fully integrated new paradigm for lithium's mode of action - lithium utilizes latent cellular fail-safe mechanisms. Neuropsychiatr Dis Treat (2017) 0.75

Characterization of Drosophila CMP-sialic acid synthetase activity reveals unusual enzymatic properties. Biochem J (2016) 0.75

In Utero and Lactational Exposure Study in Rats to Identify Replacements for Di(2-ethylhexyl) Phthalate. Sci Rep (2017) 0.75

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife (2016) 0.75

Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells. Stem Cell Res Ther (2017) 0.75

Mibefradil represents a new class of benzimidazole TRPM7 channel agonists. Pflugers Arch (2015) 0.75

Increase of Compact Bone Thickness in Rat Tibia after Implanting MgO into the Bone Marrow Cavity. J Funct Biomater (2014) 0.75

Proton Pump Inhibitor Use and Magnesium Concentrations in Hemodialysis Patients: A Cross-Sectional Study. PLoS One (2015) 0.75

Mitochondrial Mg(2+) homeostasis decides cellular energy metabolism and vulnerability to stress. Sci Rep (2016) 0.75

A Critical Role of TRPM7 As an Ion Channel Protein in Mediating the Mineralization of the Craniofacial Hard Tissues. Front Physiol (2016) 0.75

Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans. PLoS Genet (2016) 0.75

Solute carrier 41A3 encodes for a mitochondrial Mg(2+) efflux system. Sci Rep (2016) 0.75

Elemental Content of Calcium Oxalate Stones from a Canine Model of Urinary Stone Disease. PLoS One (2015) 0.75

Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function. Biophys J (2016) 0.75

Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution. Nat Methods (2017) 0.75

ATP-dependent modulation of MgtE in Mg(2+) homeostasis. Nat Commun (2017) 0.75

The Involvement of Mg(2+) in Regulation of Cellular and Mitochondrial Functions. Oxid Med Cell Longev (2017) 0.75

TRPM7 senses oxidative stress to release Zn(2+) from unique intracellular vesicles. Proc Natl Acad Sci U S A (2017) 0.75

Serum magnesium and risk of new onset heart failure in men: the Kuopio Ischemic Heart Disease Study. Eur J Epidemiol (2016) 0.75

Nuclear Magnetic Resonance Study of RNA Structures at the 3'-End of the Hepatitis C Virus Genome. Biochemistry (2017) 0.75

Kinetic Analyses of Single-Strand Break Repair by Human DNA Ligase III Isoforms Reveals Biochemical Differences from DNA Ligase I. J Biol Chem (2017) 0.75

The role of magnesium sulfate in the intensive care unit. EXCLI J (2017) 0.75

Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med (2004) 30.26

Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature (1993) 7.89

Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol Rev (1999) 6.30

Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science (1999) 6.04

Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiol Rev (1990) 5.94

LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability. Nature (2001) 5.52

A key role for TRPM7 channels in anoxic neuronal death. Cell (2003) 4.46

TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science (2001) 4.33

Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell (2003) 4.15

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet (2002) 3.90

The TRPM7 channel is inactivated by PIP(2) hydrolysis. Nat Cell Biol (2002) 3.63

Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels. J Gen Physiol (2002) 3.39

TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem (2003) 3.15

Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends Genet (2004) 2.88

TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. J Gen Physiol (2003) 2.86

Prader-Willi syndrome: current understanding of cause and diagnosis. Am J Med Genet (1990) 2.77

Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet (2002) 2.63

Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science (2008) 2.59

Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7. J Gen Physiol (2006) 2.56

Mechanism of magnesium activation of calcium-activated potassium channels. Nature (2002) 2.50

TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes. Cell Cycle (2010) 2.29

TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J (2006) 2.20

Regulation of cellular magnesium. Front Biosci (2000) 2.19

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci (2006) 2.19

Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia. Proc Natl Acad Sci U S A (2004) 2.17

Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol Cell (2001) 2.12

Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria. J Biol Chem (1986) 2.04

Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia. J Clin Invest (2007) 1.91

Regulation of cell magnesium. Arch Biochem Biophys (1992) 1.90

Annexin 1: more than an anti-phospholipase protein. Inflamm Res (2004) 1.90

Paracellin-1 and the modulation of ion selectivity of tight junctions. J Cell Sci (2005) 1.90

Beta-adrenergic receptors and their regulation. Am J Respir Crit Care Med (1995) 1.85

Physiological role of mitochondrial Ca2+ transport. J Bioenerg Biomembr (1994) 1.77

The claudins. Genome Biol (2009) 1.76

Technique for in situ measurement of calcium in intracellular inositol 1,4,5-trisphosphate-sensitive stores using the fluorescent indicator mag-fura-2. Proc Natl Acad Sci U S A (1993) 1.75

Molecular determinants of Mg2+ and Ca2+ permeability and pH sensitivity in TRPM6 and TRPM7. J Biol Chem (2007) 1.75

TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain. J Biol Chem (2006) 1.75

Parallel stimulation of glucose and Mg(2+) accumulation by insulin in rat hearts and cardiac ventricular myocytes. Circ Res (2000) 1.73

The bacterial magnesium transporter CorA can functionally substitute for its putative homologue Mrs2p in the yeast inner mitochondrial membrane. J Biol Chem (1999) 1.70

Magnesium transport across cell membranes. J Membr Biol (1984) 1.68

Phosphorylation of annexin I by TRPM7 channel-kinase. J Biol Chem (2004) 1.63

Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium. Proc Natl Acad Sci U S A (2009) 1.60

Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. Proc Natl Acad Sci U S A (2009) 1.60

Potentiation of TRPM7 inward currents by protons. J Gen Physiol (2005) 1.60

Electron probe X-ray microanalysis of post-tetanic Ca2+ and Mg2+ movements across the sarcoplasmic reticulum in situ. J Biol Chem (1985) 1.58

Magnesium as a regulatory cation: criteria and evaluation. Magnesium (1987) 1.56

Modulation of cardiac ion channels by magnesium. Annu Rev Physiol (1991) 1.56

Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria. EMBO J (2003) 1.56

Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys (2006) 1.55

NIPA1 gene mutations cause autosomal dominant hereditary spastic paraplegia (SPG6). Am J Hum Genet (2003) 1.54

Cloning and characterization of a novel Mg(2+)/H(+) exchanger. EMBO J (1999) 1.53

Elongation factor-2 kinase and its newly discovered relatives. FEBS Lett (2002) 1.52

Rapid mobilization of cellular Ca2+ in bovine parathyroid cells evoked by extracellular divalent cations. Evidence for a cell surface calcium receptor. J Biol Chem (1987) 1.52

Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. Biochemistry (2005) 1.51

Magnesium gating of the inwardly rectifying K+ channel. Annu Rev Physiol (1991) 1.51

The channel kinases TRPM6 and TRPM7 are functionally nonredundant. J Biol Chem (2005) 1.50

A novel claudin 16 mutation associated with childhood hypercalciuria abolishes binding to ZO-1 and results in lysosomal mistargeting. Am J Hum Genet (2003) 1.47

Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes. Science (1988) 1.46

Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proc Natl Acad Sci U S A (2004) 1.46

SLC41A2 encodes a plasma-membrane Mg2+ transporter. Biochem J (2007) 1.45

Regulation of magnesium homeostasis and transport in mammalian cells. Arch Biochem Biophys (2006) 1.45

Structure, properties and regulation of magnesium transport proteins. Biometals (2002) 1.44

Molecular identification of ancient and modern mammalian magnesium transporters. Am J Physiol Cell Physiol (2009) 1.43

The CorA magnesium transporter gene family. Microb Comp Genomics (1998) 1.42

Cloning and characterization of MgtE, a putative new class of Mg2+ transporter from Bacillus firmus OF4. J Bacteriol (1995) 1.41

SLC41A1 is a novel mammalian Mg2+ carrier. J Biol Chem (2008) 1.37

TRPM7 channels in hippocampal neurons detect levels of extracellular divalent cations. Proc Natl Acad Sci U S A (2007) 1.37

NIPA1(SPG6), the basis for autosomal dominant form of hereditary spastic paraplegia, encodes a functional Mg2+ transporter. J Biol Chem (2006) 1.34

Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter. Physiol Genomics (2005) 1.33

Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16. J Clin Invest (2006) 1.33

The magnesium dependence of sodium-pump-mediated sodium-potassium and sodium-sodium exchange in intact human red cells. J Physiol (1981) 1.32

TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. J Mol Biol (2008) 1.32

Molecular cloning and characterization of a novel gene family of four ancient conserved domain proteins (ACDP). Gene (2003) 1.31

Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties. BMC Genomics (2005) 1.30

Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters. Physiol Genomics (2005) 1.30

Magnesium transport in prokaryotes. J Biol Inorg Chem (1999) 1.29

Hormonal control of Mg2+ transport in the heart. Nature (1990) 1.26

The nuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo. J Biol Chem (1992) 1.26

The human solute carrier SLC41A1 belongs to a novel eukaryotic subfamily with homology to prokaryotic MgtE Mg2+ transporters. Biochem Biophys Res Commun (2003) 1.26

The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Genomics (2001) 1.25

Functional characterization of the mouse [corrected] solute carrier, SLC41A2. Biochem Biophys Res Commun (2005) 1.25

The epithelial Mg2+ channel transient receptor potential melastatin 6 is regulated by dietary Mg2+ content and estrogens. J Am Soc Nephrol (2006) 1.23

Activation of TRPM7 channels by phospholipase C-coupled receptor agonists. J Biol Chem (2006) 1.21

TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes. Cell Metab (2008) 1.21

Massive autophosphorylation of the Ser/Thr-rich domain controls protein kinase activity of TRPM6 and TRPM7. PLoS One (2008) 1.19

TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Proc Natl Acad Sci U S A (2008) 1.17

The alpha-kinase family: an exceptional branch on the protein kinase tree. Cell Mol Life Sci (2009) 1.16

Molecular determinants of magnesium homeostasis: insights from human disease. J Am Soc Nephrol (2008) 1.15

ATP and PIP2 dependence of the magnesium-inhibited, TRPM7-like cation channel in cardiac myocytes. Am J Physiol Cell Physiol (2006) 1.15

An Na+-stimulated Mg2+-transport system in human red blood cells. Biochim Biophys Acta (1986) 1.14

The biochemistry of diabetes. Biochem J (1988) 1.14

Vascular smooth muscle cell differentiation to an osteogenic phenotype involves TRPM7 modulation by magnesium. Hypertension (2010) 1.14

Hormonal regulation of Mg2+ transport and homeostasis in eukaryotic cells. Biometals (2002) 1.13

Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation. J Biol Chem (2003) 1.13

Chemistry and biochemistry of magnesium. Mol Aspects Med (2003) 1.12

EGF increases TRPM6 activity and surface expression. J Am Soc Nephrol (2008) 1.11

Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions. J Cell Sci (2006) 1.11

Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch (2005) 1.11

Regulation of intracellular magnesium by Mg2+ efflux. Biochem Biophys Res Commun (1984) 1.10

Enzymatic properties of a novel phorbol ester receptor/protein kinase, nPKC. J Biochem (1989) 1.09

Magnesium homeostasis and alcohol consumption. Magnes Res (2008) 0.86