Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMID 11112352)

Published in Genomics on December 01, 2000

Authors

M K Farmer1, M J Robbins, A D Medhurst, D A Campbell, K Ellington, M Duckworth, A M Brown, D N Middlemiss, G W Price, M N Pangalos

Author Affiliations

1: Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW, United Kingdom.

Articles citing this

Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflugers Arch (2003) 2.45

The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron (2011) 2.02

The solute carrier 6 family of transporters. Br J Pharmacol (2012) 1.14

The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2). Biochem J (2006) 1.08

Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors. Brain Res (2007) 0.90

Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. Mol Cell Biol (2004) 0.89

Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport. J Biol Chem (2009) 0.86

Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system. BMC Neurosci (2013) 0.83

Genome-wide time-to-event analysis on smoking progression stages in a family-based study. Brain Behav (2016) 0.81

SLC6 family transporter SNF-10 is required for protease-mediated activation of sperm motility in C. elegans. Dev Biol (2014) 0.80

B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain. PLoS One (2013) 0.80

Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes. PLoS One (2013) 0.80

Functional coding variants in SLC6A15, a possible risk gene for major depression. PLoS One (2013) 0.77

SNF-10 connects male-derived signals to the onset of sperm motility in C. elegans. Worm (2015) 0.75

Articles by these authors

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology (1986) 5.83

Randomised controlled trial of nasal ventilation in acute ventilatory failure due to chronic obstructive airways disease. Lancet (1993) 5.43

The calcium current of Helix neuron. J Gen Physiol (1978) 5.18

Spermine and spermidine as gating molecules for inward rectifier K+ channels. Science (1994) 4.82

Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation (1995) 4.48

A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI. Mem Inst Oswaldo Cruz (2009) 4.27

A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. Nature (1989) 3.99

HEREDITARY DEGENERATION OF THE RAT RETINA. Br J Ophthalmol (1938) 3.65

In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis. Infect Immun (1995) 3.56

Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: results from the National Surgical Adjuvant Breast and Bowel Project B-16. J Clin Oncol (1990) 3.48

The future of general practice in Newcastle upon Tyne. Lancet (1986) 3.47

Properties of internally perfused, voltage-clamped, isolated nerve cell bodies. J Gen Physiol (1978) 3.44

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest (1990) 3.39

(-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature (1980) 3.33

Receptor-effector coupling by G proteins. Biochim Biophys Acta (1990) 3.31

Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7. Proc Natl Acad Sci U S A (1984) 3.25

Calcium current-dependent and voltage-dependent inactivation of calcium channels in Helix aspersa. J Physiol (1981) 3.23

Discrimination of human macrophages and dendritic cells by means of monoclonal antibodies. Scand J Immunol (1986) 3.11

Exchange of conduction pathways between two related K+ channels. Science (1991) 3.09

Admission after mild head injury: benefits and costs. Br Med J (Clin Res Ed) (1982) 2.99

Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. J Cell Biol (1993) 2.95

Cardiac Na currents and the inactivating, reopening, and waiting properties of single cardiac Na channels. J Gen Physiol (1985) 2.93

Two months of doxorubicin-cyclophosphamide with and without interval reinduction therapy compared with 6 months of cyclophosphamide, methotrexate, and fluorouracil in positive-node breast cancer patients with tamoxifen-nonresponsive tumors: results from the National Surgical Adjuvant Breast and Bowel Project B-15. J Clin Oncol (1990) 2.91

Gating of inwardly rectifying K+ channels localized to a single negatively charged residue. Nature (1994) 2.91

DNA markers define two major phylogenetic lineages of Trypanosoma cruzi. Mol Biochem Parasitol (1996) 2.90

Variations of serum-calcium in the rabbit. Biochem J (1932) 2.87

A physical and genetic map of the IncN plasmid R46. Plasmid (1981) 2.86

Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes. Nature (1984) 2.85

Sodium current in single rat heart muscle cells. J Physiol (1981) 2.83

Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ (1997) 2.74

BINOCULAR VISION IN MINERS. Br J Ophthalmol (1948) 2.73

A G protein directly regulates mammalian cardiac calcium channels. Science (1987) 2.58

Interprofessional collaboration in primary health care. J R Coll Gen Pract (1987) 2.56

Evidence for high-energy extraterrestrial neutrinos at the IceCube detector. Science (2013) 2.56

Heterologous regulation of the cardiac Ca2+ channel alpha 1 subunit by skeletal muscle beta and gamma subunits. Implications for the structure of cardiac L-type Ca2+ channels. J Biol Chem (1991) 2.55

Note on the nitrogen content of certain proteins. Biochem J (1932) 2.54

Direct activation of mammalian atrial muscarinic potassium channels by GTP regulatory protein Gk. Science (1987) 2.50

Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels. J Pharmacol Exp Ther (2000) 2.47

HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine. Circulation (1996) 2.46

8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur J Pharmacol (1983) 2.45

Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies). Aliment Pharmacol Ther (1998) 2.45

Early outward current in rat single ventricular cells. Circ Res (1984) 2.41

Risk factors for acute wheezing in infants and children: viruses, passive smoke, and IgE antibodies to inhalant allergens. Pediatrics (1993) 2.41

Inactivation determined by a single site in K+ pores. Pflugers Arch (1993) 2.37

A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line. Cell (1986) 2.32

Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circ Res (1996) 2.29

Alteration and restoration of K+ channel function by deletions at the N- and C-termini. Neuron (1990) 2.26

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix. EMBO J (1990) 2.25

Kinetoplastid mitochondria contain functional tRNAs which are encoded in nuclear DNA and also contain small minicircle and maxicircle transcripts of unknown function. Nucleic Acids Res (1989) 2.22

Sodium current in single heart muscle cells. Nature (1979) 2.19

Patch and whole cell calcium currents recorded simultaneously in snail neurons. J Gen Physiol (1984) 2.17

Molecular determinants of dofetilide block of HERG K+ channels. Circ Res (1998) 2.13

Prognosis in the irritable bowel syndrome: a 5-year prospective study. Lancet (1987) 2.13

A comparison of calcium currents in rat and guinea pig single ventricular cells. Circ Res (1984) 2.12

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. Pain (2000) 2.11

Comparison of histidine-tryptophan-ketoglutarate and University of Wisconsin preservation in renal transplantation. Am J Transplant (2007) 2.10

Increased chloride conductance as the proximate cause of hydrogen ion concentration effects in Aplysia neurons. J Gen Physiol (1970) 2.09

Normalization of current kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel. Nature (1991) 2.09

GAP domains responsible for ras p21-dependent inhibition of muscarinic atrial K+ channel currents. Science (1992) 2.09

Anterior interosseus nerve injury following tension band wiring of the olecranon. Injury (2005) 2.08

GABAA and GABAB receptor site distribution in the rat central nervous system. Neuroscience (1987) 2.07

The agonist effect of dihydropyridines on Ca channels. Nature (1984) 2.07

Mitotic chromosome loss in a disomic haploid of Saccharomyces cerevisiae. Genetics (1975) 2.06

Single nucleotide polymorphisms as tools in human genetics. Hum Mol Genet (2000) 2.05

Induction of calcium currents by the expression of the alpha 1-subunit of the dihydropyridine receptor from skeletal muscle. Nature (1989) 2.04

Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors. Circulation (1994) 2.02

Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current. Circ Res (1993) 2.02

Immunosuppressive activity of a subline of the mouse EL-4 lymphoma. Evidence for minute virus of mice causing the inhibition. J Exp Med (1976) 2.01

Osteoarthritis of the thumb carpometacarpal joint: correlation of ultrasound appearances to disability and treatment response. Clin Radiol (2012) 2.00

Similarity of unitary Ca2+ currents in three different species. Nature (1982) 2.00

Scanning calorimetric study of the thermal unfolding of catabolite activator protein from Escherichia coli in the absence and presence of cyclic mononucleotides. Biochemistry (1988) 2.00

An unusually compact ribosomal DNA repeat in the protozoan Giardia lamblia. Nucleic Acids Res (1987) 2.00

Primary autosomal recessive microcephaly (MCPH1) maps to chromosome 8p22-pter. Am J Hum Genet (1998) 2.00

First observation of PeV-energy neutrinos with IceCube. Phys Rev Lett (2013) 2.00

Parkinson's disease: prospects for improved drug therapy. Trends Pharmacol Sci (1997) 2.00

Light response of a giant Aplysia neuron. J Gen Physiol (1973) 1.96

A description of activation and conduction in calcium channels based on tail and turn-on current measurements in the snail. J Physiol (1983) 1.93

K+ pore structure revealed by reporter cysteines at inner and outer surfaces. Neuron (1995) 1.91

Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. Brain Res Mol Brain Res (2001) 1.90

Leucine auxotrophy restricts growth of Mycobacterium bovis BCG in macrophages. Infect Immun (1996) 1.89

Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab. Oncogene (2010) 1.88

Wnt-1 regulation of connexin43 in cardiac myocytes. J Clin Invest (2000) 1.87

Specification of pore properties by the carboxyl terminus of inwardly rectifying K+ channels. Science (1994) 1.85

Nucleotide sequence and expression in vitro of cDNA derived from mRNA of int-1, a provirally activated mouse mammary oncogene. Mol Cell Biol (1985) 1.85

Relapsing experimental allergic encephalomyelitis in the SJL/J mouse. Lab Invest (1981) 1.84

Unified account of the variable effects of carbon dioxide on nerve cells. Science (1970) 1.84

C-terminus determinants for Mg2+ and polyamine block of the inward rectifier K+ channel IRK1. EMBO J (1995) 1.84

Discovery of very-high-energy gamma-rays from the Galactic Centre ridge. Nature (2006) 1.81

The alpha subunit of the GTP binding protein Gk opens atrial potassium channels. Science (1987) 1.79

Coupling of ATP-sensitive K+ channels to A1 receptors by G proteins in rat ventricular myocytes. Am J Physiol (1990) 1.79

The units of calcium conduction in Helix neurones. Nature (1978) 1.78

Interaction between calcium ions and surface charge as it relates to calcium currents. J Membr Biol (1983) 1.76

Nonmodal gating of cardiac calcium channels as revealed by dihydropyridines. J Gen Physiol (1989) 1.76

A 5-hydroxytryptamine receptor in human atrium. Br J Pharmacol (1990) 1.76

SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology (1997) 1.76

The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol Cell Biol (1992) 1.75

Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias. J Cardiovasc Electrophysiol (2000) 1.74

KChAP as a chaperone for specific K(+) channels. Am J Physiol Cell Physiol (2000) 1.73