Characterization of the transporterB0AT3 (Slc6a17) in the rodent central nervous system.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 3689596)

Published in BMC Neurosci on May 14, 2013

Authors

Maria G A Hägglund1, Sofie V Hellsten, Sonchita Bagchi, Anna Ljungdahl, Victor C O Nilsson, Sonja Winnergren, Olga Stephansson, Juris Rumaks, Simons Svirskis, Vija Klusa, Helgi B Schiöth, Robert Fredriksson

Author Affiliations

1: Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.

Articles cited by this

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol (2002) 82.19

Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02

Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci Lett (2003) 18.34

Central nervous system control of food intake. Nature (2000) 15.85

Direct observation of individual endogenous protein complexes in situ by proximity ligation. Nat Methods (2006) 12.63

NeuN, a neuronal specific nuclear protein in vertebrates. Development (1992) 10.82

Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature (1987) 8.89

Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell (1985) 6.06

Protein detection using proximity-dependent DNA ligation assays. Nat Biotechnol (2002) 6.05

Gastrointestinal regulation of food intake. J Clin Invest (2007) 4.47

Identification and characterization of the vesicular GABA transporter. Nature (1997) 4.26

Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science (2000) 3.68

Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science (1988) 3.54

The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. J Neurosci (1998) 2.76

The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons. J Neurosci (2001) 2.68

Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem (1991) 2.66

Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6. Pflugers Arch (2003) 2.45

Cytokine detection by antibody-based proximity ligation. Proc Natl Acad Sci U S A (2004) 2.29

Light and electron microscopic studies of the distribution of microtubule-associated protein 2 in rat brain: a difference between dendritic and axonal cytoskeletons. J Comp Neurol (1984) 2.21

In situ detection of phosphorylated platelet-derived growth factor receptor beta using a generalized proximity ligation method. Mol Cell Proteomics (2007) 2.10

The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron (2011) 2.02

A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Prim Care Companion J Clin Psychiatry (2004) 1.94

The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav (2002) 1.89

Immunocytochemical localization of candidates for vesicular glutamate transporters in the rat cerebral cortex. J Comp Neurol (2001) 1.71

The glycine site of the NMDA receptor--five years on. Trends Pharmacol Sci (1993) 1.54

Food-associated cues alter forebrain functional connectivity as assessed with immediate early gene and proenkephalin expression. BMC Biol (2007) 1.31

The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids. Pflugers Arch (2003) 1.27

Brain circuits regulating energy homeostasis. Regul Pept (2008) 1.24

Evidence for glutamate, in addition to acetylcholine and GABA, neurotransmitter synthesis in basal forebrain neurons projecting to the entorhinal cortex. Neuroscience (2001) 1.24

Short-term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus. Eur J Neurosci (2005) 1.24

Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. J Biol Chem (2002) 1.22

Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle. Biochim Biophys Acta (2000) 1.20

Excitatory and inhibitory connections show selectivity in the neocortex. J Physiol (2004) 1.18

Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem (2011) 1.15

The SLC6A14 gene shows evidence of association with obesity. J Clin Invest (2003) 1.15

Molecular cloning and primary structure of human glial fibrillary acidic protein. Proc Natl Acad Sci U S A (1989) 1.14

Enhanced anxiety, depressive-like behaviour and impaired recognition memory in mice with reduced expression of the vesicular glutamate transporter 1 (VGLUT1). Eur J Neurosci (2007) 1.12

The repertoire of solute carriers of family 6: identification of new human and rodent genes. Biochem Biophys Res Commun (2005) 1.09

Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain. Biochem Biophys Res Commun (2005) 1.08

The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2). Biochem J (2006) 1.08

The SLC6 orphans are forming a family of amino acid transporters. Neurochem Int (2006) 1.07

Changes of immunocytochemical localization of vesicular glutamate transporters in the rat visual system after the retinofugal denervation. J Comp Neurol (2003) 1.06

Brain circuits regulating energy homeostasis. Neuroscientist (2004) 1.04

Increased mRNA levels of tyrosine hydroxylase and dopamine transporter in the VTA of male rats after chronic food restriction. Eur J Neurosci (2006) 1.04

Immunohistochemical characterization of an anti-epithelial monoclonal antibody (mAB lu-5). Virchows Arch A Pathol Anat Histopathol (1985) 1.02

Protein, amino acids and the control of food intake. Br J Nutr (2004) 0.99

Selective cortical VGLUT1 increase as a marker for antidepressant activity. Neuropharmacology (2005) 0.98

Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family. Genomics (2000) 0.97

Polymorphisms in the amino acid transporter solute carrier family 6 (neurotransmitter transporter) member 14 gene contribute to polygenic obesity in French Caucasians. Diabetes (2004) 0.97

Evidence for increased expression of the vesicular glutamate transporter, VGLUT1, by a course of antidepressant treatment. J Neurochem (2005) 0.97

Influence of fluoxetine on the ability of bupropion to modulate extracellular dopamine and norepinephrine concentrations in three mesocorticolimbic areas of rats. Neuropharmacology (2002) 0.97

The orphan transporter Rxt1/NTT4 (SLC6A17) functions as a synaptic vesicle amino acid transporter selective for proline, glycine, leucine, and alanine. Mol Pharmacol (2008) 0.96

The evolutionary history and tissue mapping of GPR123: specific CNS expression pattern predominantly in thalamic nuclei and regions containing large pyramidal cells. J Neurochem (2006) 0.94

Distribution and morphological characterization of phosphate-activated glutaminase-immunoreactive neurons in cat visual cortex. Brain Res (2003) 0.90

Unexpected localization of the Na+/Cl--dependent-like orphan transporter, Rxt1, on synaptic vesicles in the rat central nervous system. Eur J Neurosci (1999) 0.89

A rat brain cDNA encoding the neurotransmitter transporter with an unusual structure. FEBS Lett (1993) 0.87

Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport. J Biol Chem (2009) 0.86

Ghrelin, appetite regulation, and food reward: interaction with chronic stress. Int J Pept (2011) 0.86

Neurotransmitter transporter family cDNAs in a rat midbrain library: 'orphan transporters' suggest sizable structural variations. Brain Res Mol Brain Res (1992) 0.85

Characterization of an atypical member of the Na+/Cl(-)-dependent transporter family: chromosomal localization and distribution in GABAergic and glutamatergic neurons in the rat brain. J Neurochem (1994) 0.83

The two orphan Na+/Cl(-)-dependent transporters Rxt1 and V-7-3-2 have an overlapping expression pattern in the rat central nervous system. Receptors Channels (1996) 0.82

Threonine deprivation rapidly activates the system A amino acid transporter in primary cultures of rat neurons from the essential amino acid sensor in the anterior piriform cortex. J Nutr (2003) 0.80

Immunolabeling of the Na+/Cl(-)-dependent "orphan" transporter Rxt1 in the rat central nervous system. J Neurosci Res (1995) 0.79

Distribution and sites of synthesis of NTT4, an orphan member of the Na+/Cl(-)-dependent neurotransmitter transporter family, in the rat CNS. Eur J Neurosci (1996) 0.79

Immunocytochemical evidence of vesicular localization of the orphan transporter RXT1 in the rat spinal cord. Neuroscience (1999) 0.79

Isolation and molecular characterization of the porcine SLC6A14 gene excludes it as a candidate gene for fat deposition and growth. J Appl Genet (2010) 0.77

Characterization and distribution of Hxt1, a Na(+)/Cl(-)-dependent orphan transporter, in the human brain. J Neurosci Res (1999) 0.77

The "orphan" Na+/Cl(-)-dependent transporter, Rxt1, is primarily localized within nerve endings of cortical origin in the rat striatum. J Neurochem (1999) 0.76

Distribution pattern and ultrastructural localization of Rxt1, an orphan Na+/Cl(-)-dependent transporter, in the central nervous system of rats and mice. Neuroscience (1997) 0.76

Ontogeny of Rxt1, a vesicular "orphan" Na(+)/Cl(-)-dependent transporter, in the rat. Neuroscience (2000) 0.76

Articles by these authors

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol (2003) 9.99

Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov (2008) 6.18

The repertoire of G-protein-coupled receptors in fully sequenced genomes. Mol Pharmacol (2005) 4.07

Trends in the exploitation of novel drug targets. Nat Rev Drug Discov (2011) 3.60

The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain. Endocrinology (2008) 2.97

Many QTLs with minor additive effects are associated with a large difference in growth between two selection lines in chickens. Genet Res (2005) 2.07

Mapping the human membrane proteome: a majority of the human membrane proteins can be classified according to function and evolutionary origin. BMC Biol (2009) 2.07

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics (2004) 1.90

The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Annu Rev Pharmacol Toxicol (2013) 1.85

Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics (2006) 1.80

Both early and delayed treatment with melanocortin 4 receptor-stimulating melanocortins produces neuroprotection in cerebral ischemia. Endocrinology (2005) 1.63

Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett (2003) 1.59

The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene. Genetics (2004) 1.57

Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. Genomics (2006) 1.55

Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem Biophys Res Commun (2008) 1.55

Ghrelin increases anxiety-like behavior and memory retention in rats. Biochem Biophys Res Commun (2002) 1.54

Acute sleep deprivation enhances the brain's response to hedonic food stimuli: an fMRI study. J Clin Endocrinol Metab (2012) 1.51

Hypothalamic FTO is associated with the regulation of energy intake not feeding reward. BMC Neurosci (2009) 1.48

The G protein-coupled receptor subset of the rat genome. BMC Genomics (2007) 1.45

Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. Genomics (2012) 1.36

The solute carrier (SLC) complement of the human genome: phylogenetic classification reveals four major families. FEBS Lett (2008) 1.34

Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies. PLoS One (2013) 1.33

Differential neural responses to food images in women with bulimia versus anorexia nervosa. PLoS One (2011) 1.33

G protein-coupled receptor deorphanizations. Annu Rev Pharmacol Toxicol (2012) 1.33

There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun (2003) 1.30

Comparison of the current RefSeq, Ensembl and EST databases for counting genes and gene discovery. FEBS Lett (2005) 1.30

Differential role of the hippocampus, amygdala, and dorsal raphe nucleus in regulating feeding, memory, and anxiety-like behavioral responses to ghrelin. Biochem Biophys Res Commun (2004) 1.29

The origin of GPCRs: identification of mammalian like Rhodopsin, Adhesion, Glutamate and Frizzled GPCRs in fungi. PLoS One (2012) 1.23

SPRIT: Identifying horizontal gene transfer in rooted phylogenetic trees. BMC Evol Biol (2010) 1.23

The G protein-coupled receptor subset of the chicken genome. PLoS Comput Biol (2006) 1.20

The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish. Mol Phylogenet Evol (2005) 1.18

The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene (2005) 1.18

Independent HHsearch, Needleman--Wunsch-based, and motif analyses reveal the overall hierarchy for most of the G protein-coupled receptor families. Mol Biol Evol (2011) 1.17

The GRAFS classification system of G-protein coupled receptors in comparative perspective. Gen Comp Endocrinol (2005) 1.16

The evolutionary history and tissue mapping of amino acid transporters belonging to solute carrier families SLC32, SLC36, and SLC38. J Mol Neurosci (2008) 1.16

Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly. Diabetes Care (2012) 1.16

The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs. Mol Biol Evol (2003) 1.16

The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924. BMC Med Genet (2009) 1.16

Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J Biol Chem (2011) 1.15

Pharmacological characterization of loss of function mutations of the human melanocortin 1 receptor that are associated with red hair. J Invest Dermatol (2004) 1.13

Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. J Immunol (2003) 1.13

Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim Biophys Acta (2005) 1.11

The dispanins: a novel gene family of ancient origin that contains 14 human members. PLoS One (2012) 1.11

The repertoire of solute carriers of family 6: identification of new human and rodent genes. Biochem Biophys Res Commun (2005) 1.09

Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. Genomics (2007) 1.09

The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors. BMC Evol Biol (2008) 1.09

The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children. BMC Med Genet (2010) 1.09

Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects. Mol Aspects Med (2013) 1.08

The Secretin GPCRs descended from the family of Adhesion GPCRs. Mol Biol Evol (2008) 1.07

Molecular mechanisms underlying anorexia nervosa: focus on human gene association studies and systems controlling food intake. Brain Res Rev (2009) 1.07

Intranasal treatment of central nervous system dysfunction in humans. Pharm Res (2012) 1.07

Acute sleep deprivation increases portion size and affects food choice in young men. Psychoneuroendocrinology (2013) 1.07

Growth hormone-releasing hormone improves cognitive function in older adults: sleep on it. JAMA Neurol (2013) 1.06

Oxytocin as feeding inhibitor: maintaining homeostasis in consummatory behavior. Pharmacol Biochem Behav (2010) 1.05

Increased mRNA levels of tyrosine hydroxylase and dopamine transporter in the VTA of male rats after chronic food restriction. Eur J Neurosci (2006) 1.04

Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function. J Neurosci (2009) 1.04

Restraint of appetite and reduced regional brain volumes in anorexia nervosa: a voxel-based morphometric study. BMC Psychiatry (2011) 1.04

Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickens. J Bone Miner Res (2007) 1.04

Intranasal insulin enhances postprandial thermogenesis and lowers postprandial serum insulin levels in healthy men. Diabetes (2010) 1.02

Analysis of the network of feeding neuroregulators using the Allen Brain Atlas. Neurosci Biobehav Rev (2008) 1.02

Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte-stimulating hormone. J Biol Chem (2003) 1.02

Anorexia nervosa is linked to reduced brain structure in reward and somatosensory regions: a meta-analysis of VBM studies. BMC Psychiatry (2013) 1.02

Intranasal insulin as a therapeutic option in the treatment of cognitive impairments. Exp Gerontol (2010) 1.01

Association of feather colour with constitutively active melanocortin 1 receptors in chicken. Eur J Biochem (2003) 1.01

Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. Genomics (2008) 1.01

Agouti-related proteins (AGRPs) and agouti-signaling peptide (ASIP) in fish and chicken. Ann N Y Acad Sci (2005) 1.00