Published in Genome Res on December 01, 2000
Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression. PLoS Genet (2008) 3.92
'Conserved hypothetical' proteins: prioritization of targets for experimental study. Nucleic Acids Res (2004) 3.50
Transcription is required for establishment of germline methylation marks at imprinted genes. Genes Dev (2009) 2.76
A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q. Genome Res (2004) 2.56
Amplification-free whole-genome bisulfite sequencing by post-bisulfite adaptor tagging. Nucleic Acids Res (2012) 1.61
Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases. PLoS Genet (2013) 1.57
Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Mol Cell Biol (2003) 1.47
Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region. Genome Res (2001) 1.41
Comparative sequence and x-inactivation analyses of a domain of escape in human xp11.2 and the conserved segment in mouse. Genome Res (2004) 1.29
Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. Neoplasia (2010) 0.99
A domain-centric analysis of oomycete plant pathogen genomes reveals unique protein organization. Plant Physiol (2010) 0.97
Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region. Mol Cell Biol (2004) 0.92
Structural and functional analysis of a 0.5-Mb chicken region orthologous to the imprinted mammalian Ascl2/Mash2-Igf2-H19 region. Genome Res (2004) 0.91
Imprinted genes: identification by chromosome rearrangements and post-genomic strategies. Trends Genet (2002) 0.91
The evolution of mammalian genomic imprinting was accompanied by the acquisition of novel CpG islands. Genome Biol Evol (2011) 0.88
Mouse pancreatic islets are resistant to indoleamine 2,3 dioxygenase-induced general control nonderepressible-2 kinase stress pathway and maintain normal viability and function. Am J Pathol (2008) 0.81
Imprinting and expression analysis of a non-coding RNA gene in the mouse Dlk1-Dio3 domain. J Mol Histol (2011) 0.80
Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. BMC Genomics (2012) 0.77
Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting. Genome Biol (2008) 0.77
Factors to preserve CpG-rich sequences in methylated CpG islands. BMC Genomics (2015) 0.75
No Evidence for a Parent-of-Origin Specific Differentially Methylated Region Linked to RASGRF1. Front Genet (2012) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci U S A (2001) 33.71
Isolation of putative progenitor endothelial cells for angiogenesis. Science (1997) 30.27
Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet (2001) 18.55
Dideoxy sequencing method using denatured plasmid templates. Anal Biochem (1986) 17.34
Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and genomic comparison with a laboratory strain K-12. DNA Res (2001) 15.22
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol (2000) 13.29
A physical map of the human genome. Nature (2001) 12.39
Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS. Nature (2000) 11.64
Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins. Proc Natl Acad Sci U S A (2000) 10.98
The DNA sequence of human chromosome 21. Nature (2000) 10.66
A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob Agents Chemother (2000) 9.84
VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med (1999) 9.18
Resetting central and peripheral circadian oscillators in transgenic rats. Science (2000) 8.63
Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virology (1998) 7.99
The emergence and evolution of methicillin-resistant Staphylococcus aureus. Trends Microbiol (2001) 7.73
Entrainment of the circadian clock in the liver by feeding. Science (2001) 7.09
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc Natl Acad Sci U S A (2000) 6.59
Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature (1990) 6.29
Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08
Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong. J Virol (1999) 5.21
Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors. J Exp Med (1986) 4.99
Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity. Science (2011) 4.72
Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A (2001) 4.56
Circadian oscillation of a mammalian homologue of the Drosophila period gene. Nature (1997) 4.44
Standard steroid treatment for autoimmune pancreatitis. Gut (2009) 4.33
Potential for transmission of avian influenza viruses to pigs. J Gen Virol (1994) 4.24
DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature (2004) 4.12
Identification and characterization of the potential promoter regions of 1031 kinds of human genes. Genome Res (2001) 4.03
Affective picture processing: the late positive potential is modulated by motivational relevance. Psychophysiology (2000) 3.84
Resistance studies with daptomycin. Antimicrob Agents Chemother (2001) 3.63
Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites. EMBO Rep (2001) 3.47
Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Nat Genet (1999) 3.42
Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains: role of IS431-mediated mecI deletion in expression of resistance in mecA-carrying, low-level methicillin-resistant Staphylococcus haemolyticus. Antimicrob Agents Chemother (2001) 3.39
Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry (1996) 3.36
Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A (1998) 3.35
Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multi-centre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis (2007) 3.31
The role of influenza A virus hemagglutinin residues 226 and 228 in receptor specificity and host range restriction. J Virol (1998) 3.25
Prospective randomized pilot trial of selective biliary cannulation using pancreatic guide-wire placement. Endoscopy (2003) 3.24
Sialic acid species as a determinant of the host range of influenza A viruses. J Virol (2000) 3.10
The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex. Science (1986) 3.09
Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia (2012) 3.04
Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat Med (1998) 2.99
Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol (1997) 2.89
Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. J Cell Biol (2000) 2.87
Epidemiology, enteropathogenicity, and classification of Vi.rio parahaemolyticus. J Infect Dis (1965) 2.84
Association between 5-HT2A gene promoter polymorphism and anorexia nervosa. Lancet (1997) 2.83
Atypical adenomatous hyperplasia of the lung. Implications for the pathogenesis of peripheral lung adenocarcinoma. Am J Clin Pathol (1999) 2.81
A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem (2001) 2.80
Role in cell permeability of an essential two-component system in Staphylococcus aureus. J Bacteriol (1999) 2.73
L1 family of repetitive DNA sequences in primates may be derived from a sequence encoding a reverse transcriptase-related protein. Nature (1986) 2.66
Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors. Cancer Res (1999) 2.61
Transmission of bacteriocinogenicity by conjugation in group D streptococci. Jpn J Microbiol (1973) 2.60
A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Mol Psychiatry (1996) 2.60
Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res (1998) 2.54
Rescue of cyclin D1 deficiency by knockin cyclin E. Cell (1999) 2.54
Impact of sarcopenia on survival in patients undergoing living donor liver transplantation. Am J Transplant (2013) 2.51
Measurement of genetic structure within populations using Moran's spatial autocorrelation statistics. Proc Natl Acad Sci U S A (1996) 2.48
Long-term safety of recombinant human growth hormone in children. J Clin Endocrinol Metab (2009) 2.48
Complete nucleotide sequences of 93-kb and 3.3-kb plasmids of an enterohemorrhagic Escherichia coli O157:H7 derived from Sakai outbreak. DNA Res (1998) 2.43
Cloning and sequence analysis of cDNA for the luminescent protein aequorin. Proc Natl Acad Sci U S A (1985) 2.42
Null RPGRIP1 alleles in patients with Leber congenital amaurosis. Am J Hum Genet (2001) 2.40
Synthesis of epothilones A and B in solid and solution phase. Nature (1997) 2.35
Pro----leu change at position 102 of prion protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome. Biochem Biophys Res Commun (1989) 2.35
The effect of multiple reexcisions on the risk of local recurrence after breast conserving surgery. Ann Surg Oncol (2007) 2.32
Nucleotide sequence of a ribosomal RNA gene intron from slime mold Physarum polycephalum. Proc Natl Acad Sci U S A (1981) 2.32
Cross-coupling reactions of potassium alkyltrifluoroborates with aryl and 1-alkenyl trifluoromethanesulfonates. Org Lett (2001) 2.28
The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial. Arthritis Rheum (2010) 2.27
Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by RPW8. Science (2001) 2.23
Purification and properties of the gamma-protein specified by bacteriophage lambda: an inhibitor of the host RecBC recombination enzyme. Proc Natl Acad Sci U S A (1973) 2.20
Angiographic no-reflow phenomenon as a predictor of adverse long-term outcome in patients treated with percutaneous transluminal coronary angioplasty for first acute myocardial infarction. J Am Coll Cardiol (2000) 2.20
A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A (2000) 2.19
Molecular genetics of retinitis pigmentosa. Hum Mol Genet (1995) 2.18
Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA. Nucleic Acids Res (2000) 2.16
A recombinant hepatitis C virus RNA-dependent RNA polymerase capable of copying the full-length viral RNA. J Virol (1999) 2.16
Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J Biol Chem (1992) 2.14
Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. Mol Cell Biol (2000) 2.14
Nitric-oxide dioxygenase activity and function of flavohemoglobins. sensitivity to nitric oxide and carbon monoxide inhibition. J Biol Chem (2000) 2.13
Retinitis pigmentosa GTPase regulator (RPGRr)-interacting protein is stably associated with the photoreceptor ciliary axoneme and anchors RPGR to the connecting cilium. J Biol Chem (2000) 2.08
Primary signet-ring cell carcinoma of the lung: histochemical and immunohistochemical characterization. Hum Pathol (1999) 2.07
Sequence analysis of a KpnI family member near the 3' end of human beta-globin gene. Nucleic Acids Res (1985) 2.07
Clinical features of a new disease concept, IgG4-related thyroiditis. Scand J Rheumatol (2013) 2.05
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease. Gut (2005) 2.03
Predominant expression of invariant V alpha 14+ TCR alpha chain in NK1.1+ T cell populations. Int Immunol (1995) 2.02
The gamma protein specified by bacteriophage gamma. Structure and inhibitory activity for the recBC enzyme of Escherichia coli. J Biol Chem (1975) 2.01
Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy. Ann Rheum Dis (2007) 2.01
Pathophysiological topography of acute ischemia by combined diffusion-weighted and perfusion MRI. Stroke (1999) 1.98