Fine structure analysis of the yeast centrin, Cdc31p, identifies residues specific for cell morphology and spindle pole body duplication.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMC 1461518)

Published in Genetics on February 01, 2001

Authors

I Ivanovska1, M D Rose

Author Affiliations

1: Department of Molecular Biology, Princeton University, Washington Rd., Princeton, NJ 08544, USA.

Articles citing this

Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol Cell (2009) 2.25

The organization of the core proteins of the yeast spindle pole body. Mol Biol Cell (2005) 1.68

The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability. Mol Biol Cell (2008) 1.51

Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication. J Cell Biol (2006) 1.51

Centrin1 is required for organelle segregation and cytokinesis in Trypanosoma brucei. Mol Biol Cell (2007) 1.25

Mitotic exit and separation of mother and daughter cells. Genetics (2012) 1.10

Centrin 2 localizes to the vertebrate nuclear pore and plays a role in mRNA and protein export. Mol Cell Biol (2008) 1.10

Fission yeast cdc31p is a component of the half-bridge and controls SPB duplication. Mol Biol Cell (2003) 1.10

N-terminal regions of Mps1 kinase determine functional bifurcation. J Cell Biol (2010) 1.03

Centrin4p, a novel mammalian centrin specifically expressed in ciliated cells. Mol Biol Cell (2003) 0.98

The two domains of centrin have distinct basal body functions in Tetrahymena. Mol Biol Cell (2011) 0.93

Dictyostelium discoideum CenB is a bona fide centrin essential for nuclear architecture and centrosome stability. Eukaryot Cell (2009) 0.88

Regulation of spindle pole body assembly and cytokinesis by the centrin-binding protein Sfi1 in fission yeast. Mol Biol Cell (2014) 0.88

The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion. J Cell Biol (2017) 0.85

A mutation in the centriole-associated protein centrin causes genomic instability via increased chromosome loss in Chlamydomonas reinhardtii. BMC Biol (2005) 0.85

Role of centrins 2 and 3 in organelle segregation and cytokinesis in Trypanosoma brucei. PLoS One (2012) 0.82

A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions. Nucleic Acids Res (2014) 0.80

Influence of centriole number on mitotic spindle length and symmetry. Cytoskeleton (Hoboken) (2010) 0.79

Centrins in unicellular organisms: functional diversity and specialization. Protoplasma (2011) 0.78

The E144 residue of Scherffelia dubia centrin discriminates between the DNA repair protein XPC and the centrosomal protein Sfi1. FEBS Open Bio (2013) 0.77

Vps13 and Cdc31/centrin: Puzzling partners in membrane traffic. J Cell Biol (2017) 0.75

The biochemical effect of Ser166 phosphorylation on Euplotes octocarinatus centrin. J Biol Inorg Chem (2012) 0.75

Articles cited by this

A novel genetic system to detect protein-protein interactions. Nature (1989) 43.83

RASMOL: biomolecular graphics for all. Trends Biochem Sci (1995) 33.76

Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics (1996) 24.62

5-Fluoroorotic acid as a selective agent in yeast molecular genetics. Methods Enzymol (1987) 17.67

Saccharomyces cerevisiae cell cycle. Bacteriol Rev (1974) 10.58

Duplication of spindle plaques and integration of the yeast cell cycle. Cold Spring Harb Symp Quant Biol (1974) 9.49

A rapid method for localized mutagenesis of yeast genes. Yeast (1992) 7.79

ProMod and Swiss-Model: Internet-based tools for automated comparative protein modelling. Biochem Soc Trans (1996) 6.49

Solution structure of a calmodulin-target peptide complex by multidimensional NMR. Science (1992) 6.16

Target enzyme recognition by calmodulin: 2.4 A structure of a calmodulin-peptide complex. Science (1992) 4.89

Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeast. Yeast (1993) 4.68

Components of the yeast spindle and spindle pole body. J Cell Biol (1990) 4.57

Solution structure of calcium-free calmodulin. Nat Struct Biol (1995) 3.36

Most of centrin in animal cells is not centrosome-associated and centrosomal centrin is confined to the distal lumen of centrioles. J Cell Sci (1996) 3.27

Isolation of the yeast calmodulin gene: calmodulin is an essential protein. Cell (1986) 3.17

Yeast gene required for spindle pole body duplication: homology of its product with Ca2+-binding proteins. Proc Natl Acad Sci U S A (1986) 3.05

Mechanisms of nuclear positioning. J Cell Sci (1998) 3.00

Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics (1997) 2.81

Cloning-free PCR-based allele replacement methods. Genome Res (1997) 2.56

Localization of core spindle pole body (SPB) components during SPB duplication in Saccharomyces cerevisiae. J Cell Biol (1999) 2.50

Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase. EMBO J (1995) 2.38

The calcium-binding protein cell division cycle 31 of Saccharomyces cerevisiae is a component of the half bridge of the spindle pole body. J Cell Biol (1993) 2.28

Separate domains of KAR1 mediate distinct functions in mitosis and nuclear fusion. J Cell Biol (1992) 2.19

Evolution of EF-hand calcium-modulated proteins. I. Relationships based on amino acid sequences. J Mol Evol (1990) 2.12

The spindle-assembly checkpoint: aiming for a perfect mitosis, every time. Trends Cell Biol (1996) 2.06

The Cdc31p-binding protein Kar1p is a component of the half bridge of the yeast spindle pole body. J Cell Biol (1995) 1.95

Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeasts. Appl Environ Microbiol (1997) 1.88

Mutational analysis of centrin: an EF-hand protein associated with three distinct contractile fibers in the basal body apparatus of Chlamydomonas. J Cell Biol (1992) 1.87

Diverse essential functions revealed by complementing yeast calmodulin mutants. Science (1994) 1.60

Direct interaction between yeast spindle pole body components: Kar1p is required for Cdc31p localization to the spindle pole body. J Cell Biol (1994) 1.53

Centrosomes and cancer. Biol Cell (1999) 1.46

Identification and localization of a novel, cytoskeletal, centrosome-associated protein in PtK2 cells. J Cell Biol (1988) 1.44

A role for centrin 3 in centrosome reproduction. J Cell Biol (2000) 1.43

Genetic interactions between CDC31 and KAR1, two genes required for duplication of the microtubule organizing center in Saccharomyces cerevisiae. Genetics (1994) 1.42

The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity. J Cell Biol (1998) 1.19

Testis-specific murine centrin, Cetn1: genomic characterization and evidence for retroposition of a gene encoding a centrosome protein. Genomics (1999) 1.12

Centrin is a conserved protein that forms diverse associations with centrioles and MTOCs in Naegleria and other organisms. Cell Motil Cytoskeleton (1996) 1.11

Structure-based systematic isolation of conditional-lethal mutations in the single yeast calmodulin gene. Genetics (1994) 1.03

Binding of centrins and yeast calmodulin to synthetic peptides corresponding to binding sites in the spindle pole body components Kar1p and Spc110p. J Biol Chem (1996) 1.03

Centrin in the photoreceptor cells of mammalian retinae. Cell Motil Cytoskeleton (1995) 1.00

Localization of a centrin-like protein to higher plant plasmodesmata. Eur J Cell Biol (1999) 0.95

Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells. Am J Physiol (1998) 0.92

Molecular cloning and evolutionary analysis of the calcium-modulated contractile protein, centrin, in green algae and land plants. Plant Mol Biol (1993) 0.91

Importance of phenylalanine residues of yeast calmodulin for target binding and activation. J Biol Chem (1998) 0.88

The centrosome in animal cells and its functional homologs in plant and yeast cells. Int Rev Cytol (1996) 0.86

Toward a model of the calmodulin-myosin light-chain kinase complex: implications for calmodulin function. J Cardiovasc Pharmacol (1988) 0.85

Characterization of microsome-associated tobacco BY-2 centrins. Eur J Cell Biol (1999) 0.81

A better grip on calmodulin. Curr Biol (1992) 0.80

Articles by these authors

A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature (2000) 10.16

KAR3, a kinesin-related gene required for yeast nuclear fusion. Cell (1990) 7.65

KAR1, a gene required for function of both intranuclear and extranuclear microtubules in yeast. Cell (1987) 6.70

Kinesin-related proteins required for assembly of the mitotic spindle. J Cell Biol (1992) 5.26

Cloning genes by complementation in yeast. Methods Enzymol (1991) 4.72

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast. J Cell Biol (1990) 4.19

Sec61p and BiP directly facilitate polypeptide translocation into the ER. Cell (1992) 3.66

Yeast Kar3 is a minus-end microtubule motor protein that destabilizes microtubules preferentially at the minus ends. EMBO J (1994) 3.63

Kar9p is a novel cortical protein required for cytoplasmic microtubule orientation in yeast. J Cell Biol (1998) 2.97

Structure of the yeast endoplasmic reticulum: localization of ER proteins using immunofluorescence and immunoelectron microscopy. Yeast (1991) 2.69

Asymmetric mitotic segregation of the yeast spindle pole body. Cell (1992) 2.46

DNM1, a dynamin-related gene, participates in endosomal trafficking in yeast. J Cell Biol (1995) 2.46

Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center. J Cell Biol (1996) 2.32

Separate domains of KAR1 mediate distinct functions in mitosis and nuclear fusion. J Cell Biol (1992) 2.19

The cortical localization of the microtubule orientation protein, Kar9p, is dependent upon actin and proteins required for polarization. J Cell Biol (1999) 2.18

Bim1p/Yeb1p mediates the Kar9p-dependent cortical attachment of cytoplasmic microtubules. Mol Biol Cell (2000) 2.17

Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interacting protein. J Cell Biol (1994) 2.17

The kinesin-related proteins, Kip2p and Kip3p, function differently in nuclear migration in yeast. Mol Biol Cell (1998) 2.09

Suppression of the bimC4 mitotic spindle defect by deletion of klpA, a gene encoding a KAR3-related kinesin-like protein in Aspergillus nidulans. J Cell Biol (1993) 2.06

Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum. Mol Biol Cell (1993) 1.94

BiP/Kar2p serves as a molecular chaperone during carboxypeptidase Y folding in yeast. J Cell Biol (1995) 1.87

Nuclear congression and membrane fusion: two distinct events in the yeast karyogamy pathway. J Cell Biol (1994) 1.81

Distinct morphological phenotypes of cell fusion mutants. Mol Biol Cell (1998) 1.78

Multiple kinesin-related proteins in yeast mitosis. Cold Spring Harb Symp Quant Biol (1991) 1.58

Saccharomyces cerevisiae nuclear fusion requires prior activation by alpha factor. Mol Cell Biol (1986) 1.57

Direct interaction between yeast spindle pole body components: Kar1p is required for Cdc31p localization to the spindle pole body. J Cell Biol (1994) 1.53

Kar4p, a karyogamy-specific component of the yeast pheromone response pathway. Mol Cell Biol (1996) 1.53

Rvs161p interacts with Fus2p to promote cell fusion in Saccharomyces cerevisiae. J Cell Biol (1998) 1.47

Genetic interactions between CDC31 and KAR1, two genes required for duplication of the microtubule organizing center in Saccharomyces cerevisiae. Genetics (1994) 1.42

A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. FEBS Lett (2000) 1.39

Isolation of genes by complementation in yeast. Methods Enzymol (1987) 1.38

Cell fusion during yeast mating requires high levels of a-factor mating pheromone. J Cell Biol (1996) 1.36

Yeast mating: getting close to membrane merger. Curr Biol (2001) 1.25

Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER. Mol Biol Cell (1998) 1.25

Protease helps yeast find mating partners. Nature (1998) 1.19

The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity. J Cell Biol (1998) 1.19

Brefeldin A causes a defect in secretion in Saccharomyces cerevisiae. J Biol Chem (1993) 1.17

KAR5 encodes a novel pheromone-inducible protein required for homotypic nuclear fusion. J Cell Biol (1997) 1.10

Genetic interactions between KAR7/SEC71, KAR8/JEM1, KAR5, and KAR2 during nuclear fusion in Saccharomyces cerevisiae. Mol Biol Cell (1999) 1.07

The two forms of karyogamy transcription factor Kar4p are regulated by differential initiation of transcription, translation, and protein turnover. Mol Cell Biol (1999) 0.97

Two redundant systems maintain levels of resident proteins within the yeast endoplasmic reticulum. Proc Natl Acad Sci U S A (1995) 0.97

New Sivapithecus humeri from Pakistan and the relationship of Sivapithecus and Pongo. Nature (1990) 0.89

Functional interaction between the PKC1 pathway and CDC31 network of SPB duplication genes. Genetics (2000) 0.87

Locomotor behavior of Lagothrix lagothricha and Ateles belzebuth in Yasuní National Park, Ecuador: general patterns and nonsuspensory modes. J Hum Evol (2001) 0.87

Pendular motion in the brachiation of captive Lagothrix and Ateles. Am J Primatol (1999) 0.86

A hominine hip bone, KNM-ER 3228, from East Lake Turkana, Kenya. Am J Phys Anthropol (1984) 0.86

Hominid radius from the middle Pliocene of Lake Turkana, Kenya. Am J Phys Anthropol (1993) 0.86

Results by motor cortex stimulation in treatment of focal dystonia, Parkinson's disease and post-ictal spasticity. The experience of the Italian Study Group of the Italian Neurosurgical Society. Acta Neurochir Suppl (2008) 0.82

Folding and intracellular transport of the yeast plasma-membrane H(+)-ATPase: effects of mutations in KAR2 and SEC65. Proc Natl Acad Sci U S A (1993) 0.81

Pain-reducing properties of rewarding electrical brain stimulation in the rat. J Comp Physiol Psychol (1974) 0.81

Postcranial estimates of body weight in Proconsul, with a note on a distal tibia of P. major from Napak, Uganda. Am J Phys Anthropol (1995) 0.80

Detection of antimicrobial substances in individual cow and quarter milk samples using Delvotest microbial inhibitor tests. J Dairy Sci (1999) 0.80

SLG1 plays a role during G1 in the decision to enter or exit the cell cycle. Mol Gen Genet (2000) 0.80

Fossil hominoid vertebra from the Miocene of Uganda. Nature (1968) 0.78

New hominoid primates from the Siwaliks of Pakistan and their bearing on hominoid evolution. Nature (1978) 0.78

Intake estimation of polychlorinated dibenzo-p-dioxins, dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) in salmon: the inclusion of uncertainty. Food Addit Contam (2002) 0.78

Bipedal behavior of olive baboons (Papio anubis) and its relevance to an understanding of the evolution of human bipedalism. Am J Phys Anthropol (1976) 0.76

Identification and characterization of CEN12 in the budding yeast Saccharomyces cerevisiae. Curr Genet (1995) 0.76

How to make professional practice models work. Crit Care Nurs Q (1995) 0.75

Determination of dimetridazole, ronidazole and their common metabolite in poultry muscle and eggs by high performance liquid chromatography with UV detection and confirmatory analysis by atmospheric pressure chemical ionisation mass spectrometry. Analyst (1998) 0.75

Migration from plasticized films into foods. 1. Migration of di-(2-ethylhexyl)adipate from PVC films during home-use and microwave cooking. Food Addit Contam (1988) 0.75

Resource planning: an experimental report. Top Hosp Pharm Manage (1985) 0.75

The evolution of the primate foot from the earliest primates to the Miocene hominoids. Foot Ankle (1983) 0.75