Published in Blood on February 15, 2000
Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy. Oncogene (2010) 1.67
HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog (2011) 1.53
High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response. Blood (2007) 1.43
Exacerbated inflammatory cellular immune response characteristics of HAM/TSP is observed in a large proportion of HTLV-I asymptomatic carriers. BMC Infect Dis (2004) 1.39
In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection. Proc Natl Acad Sci U S A (2007) 1.36
Physical interaction of human T-cell leukemia virus type 1 Tax with cyclin-dependent kinase 4 stimulates the phosphorylation of retinoblastoma protein. Mol Cell Biol (2002) 1.34
Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity. Retrovirology (2004) 1.32
Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding. J Virol (2004) 1.17
Human T-lymphotropic virus-1 visualized at the virological synapse by electron tomography. PLoS One (2008) 1.16
Retrovirally induced CTL degranulation mediated by IL-15 expression and infection of mononuclear phagocytes in patients with HTLV-I-associated neurologic disease. Blood (2008) 1.07
Two-step nature of human T-cell leukemia virus type 1 replication in experimentally infected squirrel monkeys (Saimiri sciureus). J Virol (2001) 1.05
Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection. PLoS Pathog (2013) 1.04
Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells. J Immunol (2010) 1.02
Increased cell proliferation, but not reduced cell death, induces lymphocytosis in bovine leukemia virus-infected sheep. Proc Natl Acad Sci U S A (2002) 1.01
In vivo expression of human T-lymphotropic virus type 1 basic leucine-zipper protein generates specific CD8+ and CD4+ T-lymphocyte responses that correlate with clinical outcome. J Infect Dis (2011) 1.00
Quantification of the virus-host interaction in human T lymphotropic virus I infection. Retrovirology (2005) 0.99
High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease. PLoS Pathog (2009) 0.97
Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis. Viruses (2011) 0.97
HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals. Retrovirology (2012) 0.95
Malignant catarrhal fever induced by alcelaphine herpesvirus 1 is associated with proliferation of CD8+ T cells supporting a latent infection. PLoS One (2008) 0.95
HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection. Semin Cancer Biol (2013) 0.94
Mouse model for the equilibration interaction between the host immune system and human T-cell leukemia virus type 1 gene expression. J Virol (2002) 0.92
De novo human T-cell leukemia virus type 1 infection of human lymphocytes in NOD-SCID, common gamma-chain knockout mice. J Virol (2006) 0.92
Immunogenetics and the Pathological Mechanisms of Human T-Cell Leukemia VirusType 1- (HTLV-1-)Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Interdiscip Perspect Infect Dis (2010) 0.91
Stromal cell-mediated suppression of human T-cell leukemia virus type 1 expression in vitro and in vivo by type I interferon. J Virol (2009) 0.91
Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo. Retrovirology (2010) 0.90
Fine tuning of the temporal expression of HTLV-1 and HTLV-2. Front Microbiol (2013) 0.89
Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus. Front Microbiol (2013) 0.88
LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. Retrovirology (2013) 0.88
The HTLV-1 Virological Synapse. Viruses (2010) 0.88
Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis. Front Microbiol (2013) 0.88
Modulation of dendritic cell maturation and function by the Tax protein of human T cell leukemia virus type 1. J Leukoc Biol (2007) 0.88
Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex. PLoS Pathog (2014) 0.87
Rates of CTL killing in persistent viral infection in vivo. PLoS Comput Biol (2014) 0.87
HTLV-1 tax specific CD8+ T cells express low levels of Tim-3 in HTLV-1 infection: implications for progression to neurological complications. PLoS Negl Trop Dis (2011) 0.86
Is human T-cell lymphotropic virus type I really silent? Philos Trans R Soc Lond B Biol Sci (2000) 0.86
Immunopathogenesis of human T-cell leukemia virus type-1-associated myelopathy/tropical spastic paraparesis: recent perspectives. Leuk Res Treatment (2012) 0.86
Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. Potential New Therapeutic Approaches to Prevent and Treat HTLV-1-Related Diseases. Viruses (2015) 0.86
Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. Retrovirology (2013) 0.85
Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers. Retrovirology (2011) 0.84
Alpha interferon restricts human T-lymphotropic virus type 1 and 2 de novo infection through PKR activation. J Virol (2013) 0.84
Controversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects? Viruses (2011) 0.84
In vivo selection of T-cell receptor junctional region sequences by HLA-A2 human T-cell lymphotropic virus type 1 Tax11-19 peptide complexes. J Virol (2001) 0.83
The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases. Front Microbiol (2012) 0.83
Memory lineage relationships in HTLV-1-specific CD8+ cytotoxic T cells. J Neuroimmunol (2006) 0.82
Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease. Immunogenetics (2006) 0.82
A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytes. Retrovirology (2005) 0.82
Cytotoxic T lymphocyte lysis of HTLV-1 infected cells is limited by weak HBZ protein expression, but non-specifically enhanced on induction of Tax expression. Retrovirology (2014) 0.82
The neutralizing function of the anti-HTLV-1 antibody is essential in preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/γcnull (NOG) mice. Retrovirology (2014) 0.82
HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ. Viruses (2016) 0.82
Viral expression directs the fate of B cells in bovine leukemia virus-infected sheep. J Virol (2011) 0.81
Cell surface markers in HTLV-1 pathogenesis. Viruses (2011) 0.80
Minocycline modulates antigen-specific CTL activity through inactivation of mononuclear phagocytes in patients with HTLV-I associated neurologic disease. Retrovirology (2012) 0.79
Development of a cytotoxic T-cell assay in rabbits to evaluate early immune response to human T-lymphotropic virus type 1 infection. Viral Immunol (2009) 0.79
Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. J Infect Dis (2007) 0.78
In vitro peptide immunization of target tax protein human T-cell leukemia virus type 1-specific CD4+ helper T lymphocytes. Clin Cancer Res (2006) 0.78
Integration site and clonal expansion in human chronic retroviral infection and gene therapy. Viruses (2014) 0.78
Human T lymphotropic virus type 1 (HTLV-1) proviral load induces activation of T-lymphocytes in asymptomatic carriers. BMC Infect Dis (2014) 0.78
Involvement of glutathione as a mechanism of indirect protection against spontaneous ex vivo apoptosis associated with bovine leukemia virus. J Virol (2004) 0.78
Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms. Retrovirology (2015) 0.77
Lack of recall response to Tax in ATL and HAM/TSP patients but not in asymptomatic carriers of human T-cell leukemia virus type 1. J Clin Immunol (2013) 0.77
Transcriptional and Epigenetic Regulatory Mechanisms Affecting HTLV-1 Provirus. Viruses (2016) 0.76
Separate cellular localizations of human T-lymphotropic virus 1 (HTLV-1) Env and glucose transporter type 1 (GLUT1) are required for HTLV-1 Env-mediated fusion and infection. J Virol (2014) 0.76
Tax posttranslational modifications and interaction with calreticulin in MT-2 cells and human peripheral blood mononuclear cells of human T cell lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis patients. AIDS Res Hum Retroviruses (2014) 0.76
Human T-cell leukaemia virus type 1: parasitism and pathogenesis. Philos Trans R Soc Lond B Biol Sci (2017) 0.76
Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons. J Virol (2016) 0.75
T Cell Receptor Vβ Staining Identifies the Malignant Clone in Adult T cell Leukemia and Reveals Killing of Leukemia Cells by Autologous CD8+ T cells. PLoS Pathog (2016) 0.75
HTLV-1 drives vigorous clonal expansion of infected CD8(+) T cells in natural infection. Retrovirology (2015) 0.75
STLV-1 infection of Papio Anubis: tax Sequence Heterogeneity and T Cell Recognition. J Virol (2017) 0.75
RNA stability regulates human T cell leukemia virus type 1 gene expression in chronically-infected CD4 T cells. Virology (2017) 0.75
HTLV-1 Infection and Neuropathogenesis in the Context of Rag1(-/-)γc(-/-) (RAG1-Hu) and BLT Mice. J Neuroimmune Pharmacol (2017) 0.75
A protein conjugation system essential for autophagy. Nature (1998) 12.71
Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature (1991) 10.85
HTLV-I associated myelopathy, a new clinical entity. Lancet (1986) 10.49
A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature (1997) 10.14
The myoD gene family: nodal point during specification of the muscle cell lineage. Science (1991) 9.53
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science (2001) 8.31
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell (1998) 8.16
Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci U S A (1997) 8.05
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem (2000) 7.41
Guideline update for MASCC and ESMO in the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting: results of the Perugia consensus conference. Ann Oncol (2010) 5.96
Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse. Proc Natl Acad Sci U S A (1991) 5.52
Variable and conserved neutralization antigens of human immunodeficiency virus. Nature (1987) 5.29
Molecular cloning and expression of an IL-6 signal transducer, gp130. Cell (1990) 5.06
Natural and synthetic non-peptide antigens recognized by human gamma delta T cells. Nature (1995) 5.04
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature (1999) 5.03
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev (1994) 4.50
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ (2000) 4.34
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med (2001) 4.22
Prevalence of left-ventricular systolic dysfunction and heart failure in the Echocardiographic Heart of England Screening study: a population based study. Lancet (2001) 4.12
Predictive factors of response to intravenous ciclosporin in severe ulcerative colitis: the development of a novel prediction formula. Aliment Pharmacol Ther (2012) 3.91
The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol (1993) 3.75
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A (1997) 3.66
Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature (1995) 3.61
Y-Chromosome evidence for a northward migration of modern humans into Eastern Asia during the last Ice Age. Am J Hum Genet (1999) 3.60
Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters. J Biol Chem (1983) 3.60
Soluble CD4 blocks the infectivity of diverse strains of HIV and SIV for T cells and monocytes but not for brain and muscle cells. Nature (1989) 3.54
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell (2001) 3.49
Population dynamics of immune responses to persistent viruses. Science (1996) 3.49
Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri. J Gen Virol (1990) 3.41
Muscle-specific transcriptional activation by MyoD. Genes Dev (1991) 3.37
Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: high proviral load strongly predisposes to HAM/TSP. J Neurovirol (1998) 3.32
Lymphocyte interactions with endothelial cells. Immunol Today (1992) 3.31
TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell (1997) 3.30
Nucleotide sequence homology at 12 intron--exon junctions in the chick ovalbumin gene. Nature (1978) 3.30
Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3. J Biol Chem (1999) 3.25
Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney Int (2007) 3.17
Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. J Cell Biol (1999) 3.14
MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation. Proc Natl Acad Sci U S A (1990) 3.14
Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells. Immunity (1995) 3.12
CBP as a transcriptional coactivator of c-Myb. Genes Dev (1996) 3.09
Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT. Nat Genet (1996) 3.07
Neutralizing monoclonal antibodies to the AIDS virus. AIDS (1988) 3.06
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet (1998) 3.01
Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemialike cells. Ann Neurol (1987) 2.99
A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. The Multiple Sclerosis Genetics Group. Nat Genet (1996) 2.98
Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Valpha14 NKT cells. Proc Natl Acad Sci U S A (1998) 2.96
Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. J Biol Chem (2000) 2.92
Golgi vesiculation and lysosome dispersion in cells lacking cytoplasmic dynein. J Cell Biol (1998) 2.87
Biological activity of 25-hydroxyergocalciferol in rats. J Nutr (1970) 2.85
Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage (2002) 2.78
Takayasu arteritis. A study of 32 North American patients. Medicine (Baltimore) (1985) 2.78
Aseptic meningitis and encephalitis: the role of PCR in the diagnostic laboratory. J Clin Microbiol (1997) 2.76
Gender gap in cystic fibrosis mortality. Am J Epidemiol (1997) 2.74
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc Natl Acad Sci U S A (1996) 2.70
Sense, nonsense and antisense. Trends Genet (1994) 2.66
The risk of development of HTLV-I-associated myelopathy/tropical spastic paraparesis among persons infected with HTLV-I. J Acquir Immune Defic Syndr (1990) 2.65
Broad line emission from iron K- and L-shell transitions in the active galaxy 1H 0707-495. Nature (2009) 2.64
Enteropathogenic Escherichia coli associated with diarrhea in children and adults. Jpn J Med Sci Biol (1967) 2.62
The process of infection with Bacteriophage phi-X174. XXIX. In vivo studies on the synthesis of the single-stranded DNA of progeny phi-X174 bacteriophage. J Mol Biol (1969) 2.59
New classification of capsular block syndrome. J Cataract Refract Surg (1998) 2.57
Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science (1979) 2.57
Abnormal nodal flow precedes situs inversus in iv and inv mice. Mol Cell (1999) 2.55
Short course prednisolone for adhesive capsulitis (frozen shoulder or stiff painful shoulder): a randomised, double blind, placebo controlled trial. Ann Rheum Dis (2004) 2.54
Nucleotide sequence of the PR-1 gene of Nicotiana tabacum. FEBS Lett (1987) 2.53
The control of 25-hydroxyvitamin D metabolism by inorganic phosphorus. Arch Biochem Biophys (1973) 2.53
Diagnosis of viral infections of the central nervous system: clinical interpretation of PCR results. Lancet (1997) 2.50
Cloning and expression of cytochrome P450 genes controlling flower colour. Nature (1993) 2.47
HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci U S A (1999) 2.45
KIF5C, a novel neuronal kinesin enriched in motor neurons. J Neurosci (2000) 2.43
c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol Cell Biol (1994) 2.41
Spinal cord injury in a child caused by an accidental dural puncture with a single-shot thoracic epidural needle. Anesth Analg (2003) 2.38
Functionally different GPI proteins are organized in different domains on the neuronal surface. EMBO J (1999) 2.35
Human immunodeficiency virus infection in two cohorts of homosexual men: neutralising sera and association of anti-gag antibody with prognosis. Lancet (1987) 2.34
Guidelines for the management of HIV infection in pregnant women and the prevention of mother-to-child transmission. HIV Med (2001) 2.33
Safety and activity of saquinavir in HIV infection. Lancet (1995) 2.32
Assignment of tra cistrons to EcoRI fragments of F sex factor DNA. J Bacteriol (1978) 2.32
Translational induction of heat shock transcription factor sigma32: evidence for a built-in RNA thermosensor. Genes Dev (1999) 2.30
Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity. Oncogene (2007) 2.28
Chronic inflammatory arthropathy associated with HTLV-I. Lancet (1989) 2.28
A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant (2012) 2.25
Neurotoxic shellfish poisoning and brevetoxin metabolites: a case study from Florida. Toxicon (2000) 2.24
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am J Physiol Endocrinol Metab (2001) 2.24
The discovery of potent cRaf1 kinase inhibitors. Bioorg Med Chem Lett (2000) 2.22
Conjugal transfer of imipenem resistance in Bacteroides fragilis. J Antibiot (Tokyo) (1992) 2.22
Randomized, double-blind, placebo-controlled trial of ezogabine (retigabine) in partial epilepsy. Neurology (2011) 2.20
Incidence of malignant disease in biopsy-proven inflammatory myopathy. A population-based cohort study. Ann Intern Med (2001) 2.19
Down-regulation of CD40 and CD80 on B cells in patients with life-threatening systemic lupus erythematosus after successful treatment with rituximab. Rheumatology (Oxford) (2004) 2.19
Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem (1998) 2.19