Published in Nucleic Acids Res on February 15, 2001
Computational redesign of endonuclease DNA binding and cleavage specificity. Nature (2006) 4.06
Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility. Nucleic Acids Res (2001) 3.04
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev (2003) 2.23
Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. Curr Gene Ther (2011) 1.76
Mutations altering the cleavage specificity of a homing endonuclease. Nucleic Acids Res (2002) 1.60
Coevolution of a homing endonuclease and its host target sequence. J Mol Biol (2007) 1.49
Active self-splicing group I introns in 23S rRNA genes of hyperthermophilic bacteria, derived from introns in eukaryotic organelles. Proc Natl Acad Sci U S A (2003) 1.11
Analysis of the LAGLIDADG interface of the monomeric homing endonuclease I-DmoI. Nucleic Acids Res (2004) 1.10
Evolution of divergent DNA recognition specificities in VDE homing endonucleases from two yeast species. Nucleic Acids Res (2004) 0.99
The spread of LAGLIDADG homing endonuclease genes in rDNA. Nucleic Acids Res (2004) 0.97
Native homing endonucleases can target conserved genes in humans and in animal models. Nucleic Acids Res (2011) 0.90
5'-Cytosine-phosphoguanine (CpG) methylation impacts the activity of natural and engineered meganucleases. J Biol Chem (2012) 0.90
Post-transcriptional control of chloroplast gene expression. Gene Regul Syst Bio (2009) 0.89
Group I introns and inteins: disparate origins but convergent parasitic strategies. J Bacteriol (2009) 0.87
The C-terminal loop of the homing endonuclease I-CreI is essential for site recognition, DNA binding and cleavage. Nucleic Acids Res (2007) 0.87
Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space. Nucleic Acids Res (2012) 0.86
Degeneration of a homing endonuclease and its target sequence in a wild yeast strain. Nucleic Acids Res (2001) 0.86
A group II intron encodes a functional LAGLIDADG homing endonuclease and self-splices under moderate temperature and ionic conditions. RNA (2010) 0.86
Homology modeling and mutational analysis of Ho endonuclease of yeast. Genetics (2004) 0.84
Comprehensive homing endonuclease target site specificity profiling reveals evolutionary constraints and enables genome engineering applications. Nucleic Acids Res (2011) 0.79
Evolution of I-SceI homing endonucleases with increased DNA recognition site specificity. J Mol Biol (2010) 0.79
Crystallization and preliminary X-ray diffraction analysis of the homing endonuclease I-CvuI from Chlorella vulgaris in complex with its target DNA. Acta Crystallogr F Struct Biol Commun (2014) 0.78
The mitochondrial genome of the prasinophyte Prasinoderma coloniale reveals two trans-spliced group I introns in the large subunit rRNA gene. PLoS One (2013) 0.77
Crystal Structure of the Homing Endonuclease I-CvuI Provides a New Template for Genome Modification. J Biol Chem (2015) 0.75
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47
ALSCRIPT: a tool to format multiple sequence alignments. Protein Eng (1993) 10.04
Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation. Comput Appl Biosci (1993) 9.38
Introns as mobile genetic elements. Annu Rev Biochem (1993) 5.63
Homing endonucleases: keeping the house in order. Nucleic Acids Res (1997) 5.03
Recognition and cleavage site of the intron-encoded omega transposase. Proc Natl Acad Sci U S A (1988) 4.92
Group I introns as mobile genetic elements: facts and mechanistic speculations--a review. Gene (1989) 4.17
NUCPLOT: a program to generate schematic diagrams of protein-nucleic acid interactions. Nucleic Acids Res (1997) 2.81
Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family. Nucleic Acids Res (1997) 2.33
The structure of I-Crel, a group I intron-encoded homing endonuclease. Nat Struct Biol (1997) 2.28
Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 A resolution. Nat Struct Biol (2000) 2.22
Mechanisms of intron mobility. J Biol Chem (1995) 2.21
Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity. Cell (1997) 2.20
A group I intron in the chloroplast large subunit rRNA gene of Chlamydomonas eugametos encodes a double-strand endonuclease that cleaves the homing site of this intron. Curr Genet (1991) 1.90
The chloroplast ribosomal intron of Chlamydomonas reinhardii codes for a polypeptide related to mitochondrial maturases. Nucleic Acids Res (1985) 1.88
DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI. Mol Cell (1998) 1.85
Homing endonucleases: structure, function and evolution. Cell Mol Life Sci (1999) 1.85
Complete nucleotide sequence of the chloroplast genome from the green alga Chlorella vulgaris: the existence of genes possibly involved in chloroplast division. Proc Natl Acad Sci U S A (1997) 1.75
I-PpoI and I-CreI homing site sequence degeneracy determined by random mutagenesis and sequential in vitro enrichment. J Mol Biol (1998) 1.75
The complete mitochondrial DNA sequences of Nephroselmis olivacea and Pedinomonas minor. Two radically different evolutionary patterns within green algae. Plant Cell (1999) 1.59
Invasion of a multitude of genetic niches by mobile endonuclease genes. FEMS Microbiol Lett (2000) 1.56
The td intron endonuclease I-TevI makes extensive sequence-tolerant contacts across the minor groove of its DNA target. EMBO J (1993) 1.55
Chloroplast ribosomal intron of Chlamydomonas reinhardtii: in vitro self-splicing, DNA endonuclease activity and in vivo mobility. EMBO J (1991) 1.48
Evolutionary transfer of ORF-containing group I introns between different subcellular compartments (chloroplast and mitochondrion). Mol Biol Evol (1995) 1.47
Crystal structure of an archaeal intein-encoded homing endonuclease PI-PfuI. J Mol Biol (2000) 1.46
The I-CeuI endonuclease recognizes a sequence of 19 base pairs and preferentially cleaves the coding strand of the Chlamydomonas moewusii chloroplast large subunit rRNA gene. Nucleic Acids Res (1992) 1.41
An unspliced group I intron in 23S rRNA links Chlamydiales, chloroplasts, and mitochondria. J Bacteriol (1999) 1.39
Evolution of mobile group I introns: recognition of intron sequences by an intron-encoded endonuclease. Proc Natl Acad Sci U S A (1994) 1.34
Crystal structure of the thermostable archaeal intron-encoded endonuclease I-DmoI. J Mol Biol (1999) 1.32
Genetic analysis of the Chlamydomonas reinhardtii I-CreI mobile intron homing system in Escherichia coli. Genetics (1997) 1.30
The I-CeuI endonuclease: purification and potential role in the evolution of Chlamydomonas group I introns. Eur J Biochem (1994) 1.22
Analysis of the chloroplast large subunit ribosomal RNA gene from 17 Chlamydomonas taxa. Three internal transcribed spacers and 12 group I intron insertion sites. J Mol Biol (1993) 1.21
Characterization of the cleavage site and the recognition sequence of the I-CreI DNA endonuclease encoded by the chloroplast ribosomal intron of Chlamydomonas reinhardtii. Mol Gen Genet (1993) 1.15
Complex recognition site for the group I intron-encoded endonuclease I-SceII. Mol Cell Biol (1992) 1.14
The ribosomal RNA gene region in Acanthamoeba castellanii mitochondrial DNA. A case of evolutionary transfer of introns between mitochondria and plastids? J Mol Biol (1994) 1.13
Profile of the DNA recognition site of the archaeal homing endonuclease I-DmoI. Nucleic Acids Res (1997) 1.13
Purification, biochemical characterization and protein-DNA interactions of the I-CreI endonuclease produced in Escherichia coli. Nucleic Acids Res (1997) 1.13
Evolutionarily conserved and functionally important residues in the I-CeuI homing endonuclease. Nucleic Acids Res (1997) 1.10
Degenerate DNA recognition by I-PpoI endonuclease. Gene (1998) 1.08
An ancestral mitochondrial DNA resembling a eubacterial genome in miniature. Nature (1997) 4.03
Genome structure and gene content in protist mitochondrial DNAs. Nucleic Acids Res (1998) 2.57
Mobile introns: definition of terms and recommended nomenclature. Gene (1989) 2.26
A mutation in the 530 loop of Escherichia coli 16S ribosomal RNA causes resistance to streptomycin. Nucleic Acids Res (1988) 2.13
Cleavage pattern of the homing endonuclease encoded by the fifth intron in the chloroplast large subunit rRNA-encoding gene of Chlamydomonas eugametos. Gene (1991) 2.03
The chloroplast ycf3 and ycf4 open reading frames of Chlamydomonas reinhardtii are required for the accumulation of the photosystem I complex. EMBO J (1997) 1.95
A group I intron in the chloroplast large subunit rRNA gene of Chlamydomonas eugametos encodes a double-strand endonuclease that cleaves the homing site of this intron. Curr Genet (1991) 1.90
The complete chloroplast DNA sequence of the green alga Nephroselmis olivacea: insights into the architecture of ancestral chloroplast genomes. Proc Natl Acad Sci U S A (1999) 1.87
Ancestral chloroplast genome in Mesostigma viride reveals an early branch of green plant evolution. Nature (2000) 1.84
The opioid mu agonist/delta antagonist DIPP-NH(2)[Psi] produces a potent analgesic effect, no physical dependence, and less tolerance than morphine in rats. J Med Chem (1999) 1.84
The complete mitochondrial DNA sequences of Nephroselmis olivacea and Pedinomonas minor. Two radically different evolutionary patterns within green algae. Plant Cell (1999) 1.59
Prevalence and antifungal susceptibility of 442 Candida isolates from blood and other normally sterile sites: results of a 2-year (1996 to 1998) multicenter surveillance study in Quebec, Canada. J Clin Microbiol (2001) 1.55
Mapping of chloroplast mutations conferring resistance to antibiotics in Chlamydomonas: evidence for a novel site of streptomycin resistance in the small subunit rRNA. Mol Gen Genet (1988) 1.49
Evolutionary transfer of ORF-containing group I introns between different subcellular compartments (chloroplast and mitochondrion). Mol Biol Evol (1995) 1.47
Synthesis and in vitro opioid activity profiles of DALDA analogues. Eur J Med Chem (2000) 1.47
The chloroplast genome of the green alga Chlamydomonas moewusii: localization of protein-coding genes and transcriptionally active regions. Mol Gen Genet (1988) 1.42
The I-CeuI endonuclease recognizes a sequence of 19 base pairs and preferentially cleaves the coding strand of the Chlamydomonas moewusii chloroplast large subunit rRNA gene. Nucleic Acids Res (1992) 1.41
Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists. Proc Natl Acad Sci U S A (1992) 1.40
Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J Med Chem (1982) 1.38
[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists. J Med Chem (2001) 1.37
Dermorphin analogues carrying an increased positive net charge in their "message" domain display extremely high mu opioid receptor selectivity. J Med Chem (1989) 1.32
Six group I introns and three internal transcribed spacers in the chloroplast large subunit ribosomal RNA gene of the green alga Chlamydomonas eugametos. J Mol Biol (1991) 1.28
The I-CeuI endonuclease: purification and potential role in the evolution of Chlamydomonas group I introns. Eur J Biochem (1994) 1.22
Analysis of the chloroplast large subunit ribosomal RNA gene from 17 Chlamydomonas taxa. Three internal transcribed spacers and 12 group I intron insertion sites. J Mol Biol (1993) 1.21
The TIPP opioid peptide family: development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists. Biopolymers (1999) 1.19
The complete mitochondrial DNA sequence of Scenedesmus obliquus reflects an intermediate stage in the evolution of the green algal mitochondrial genome. Genome Res (2000) 1.19
Interindividual and intraindividual variability in acetylation: characterization with caffeine. Clin Pharmacol Ther (1988) 1.15
TIPP[psi]: a highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity. J Med Chem (1993) 1.13
Chloroplast DNA recombination in interspecific hybrids of Chlamydomonas: Linkage between a nonmendelian locus for streptomycin resistance and restriction fragments coding for 16S rRNA. Proc Natl Acad Sci U S A (1984) 1.11
Evolutionarily conserved and functionally important residues in the I-CeuI homing endonuclease. Nucleic Acids Res (1997) 1.10
The site-specific DNA endonuclease encoded by a group I intron in the Chlamydomonas pallidostigmatica chloroplast small subunit rRNA gene introduces a single-strand break at low concentrations of Mg2+. Nucleic Acids Res (1995) 1.08
Cyclic enkephalin analogs containing a cystine bridge. Biochem Biophys Res Commun (1981) 1.08
The Chlamydomonas chloroplast clpP gene contains translated large insertion sequences and is essential for cell growth. Mol Gen Genet (1994) 1.08
Conserved gene clusters in the highly rearranged chloroplast genomes of Chlamydomonas moewusii and Chlamydomonas reinhardtii. Plant Mol Biol (1994) 1.04
Nucleotide sequence of the chloroplast large subunit rRNA gene from Chlamydomonas reinhardtii. Nucleic Acids Res (1989) 1.03
A large open reading frame (orf1995) in the chloroplast DNA of Chlamydomonas reinhardtii encodes an essential protein. Mol Gen Genet (1997) 1.02
An optional group I intron between the chloroplast small subunit rRNA genes of Chlamydomonas moewusii and C. eugametos. Curr Genet (1989) 1.00
Phylogeny of the Chlamydomonadales (Chlorophyceae): a comparison of ribosomal RNA gene sequences from the nucleus and the chloroplast. Mol Phylogenet Evol (1996) 1.00
The single group-I intron in the chloroplast rrnL gene of Chlamydomonas humicola encodes a site-specific DNA endonuclease (I-ChuI). Gene (1993) 0.99
Modification of flower color in florist's chrysanthemum: production of a white-flowering variety through molecular genetics. Biotechnology (N Y) (1994) 0.98
Two group I introns with long internal open reading frames in the chloroplast psbA gene of Chlamydomonas moewusii. Nucleic Acids Res (1989) 0.97
Response of the rat and dog kidney to H+ concentration in vitro--a comparative study with slices and tubules. Int J Biochem (1980) 0.95
Extensive gene rearrangements in the chloroplast DNAs of Chlamydomonas species featuring multiple dispersed repeats. Mol Biol Evol (1996) 0.95
Gene rearrangements in Chlamydomonas chloroplast DNAs are accounted for by inversions and by the expansion/contraction of the inverted repeat. Plant Mol Biol (1995) 0.94
Biochemical characterization of I-CmoeI reveals that this H-N-H homing endonuclease shares functional similarities with H-N-H colicins. Nucleic Acids Res (2000) 0.93
Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis. Can J Physiol Pharmacol (1984) 0.93
Value of direct catheter staining in the diagnosis of intravascular-catheter-related infection. J Clin Microbiol (1988) 0.92
Group I introns interrupt the chloroplast psaB and psbC and the mitochondrial rrnL gene in Chlamydomonas. Nucleic Acids Res (1993) 0.91
Landmarks during the first forty-two days of gestation demonstrated by the beta-subunit of human chorionic gonadotropin and ultrasound. Am J Obstet Gynecol (1983) 0.91
A chimeric opioid peptide with mixed mu agonist/delta antagonist properties. J Pept Res (2004) 0.90
Cyclic enkephalin analogs containing various para-substituted phenylalanine derivatives in place of Tyr1 are potent opioid agonists. J Pept Res (2005) 0.89
Vitamin E and retinopathy of prematurity. Pediatrics (1988) 0.89
Clindamycin with primaquine vs. Trimethoprim-sulfamethoxazole therapy for mild and moderately severe Pneumocystis carinii pneumonia in patients with AIDS: a multicenter, double-blind, randomized trial (CTN 004). CTN-PCP Study Group. Clin Infect Dis (1998) 0.88
Optional elements in the chloroplast DNAs of chlamydomonas eugametos and C. moewusii: unidirectional gene conversion and co-conversion of adjacent markers in high-viability crossses. Curr Genet (1996) 0.87
Cytomegalovirus gastritis associated with pseudolymphoma. J Clin Gastroenterol (1994) 0.86
Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position. J Med Chem (1987) 0.86
Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. J Med Chem (1991) 0.85
Hodgkin's disease complicating pregnancy. J Can Assoc Radiol (1985) 0.84
The effects of topiramate and sex hormones on energy balance of male and female rats. Int J Obes Relat Metab Disord (2002) 0.84
A 21 kilobase-pair deletion/addition difference in the inverted repeat sequence of chloroplast DNA from Chlamydomonas eugametos and C. moewusii. Plant Mol Biol (1985) 0.84
In vitro self-splicing reactions of chloroplast and mitochondrial group-I introns in Chlamydomonas eugametos and Chlamydomonas moewusii. Curr Genet (1995) 0.84
The receptor-bound conformation of H-Tyr-Tic-(Phe-Phe)-OH-related delta-opioid antagonists contains all trans peptide bonds. J Pept Res (1998) 0.83
Novel ligands lacking a positive charge for the delta- and mu-opioid receptors. J Med Chem (2000) 0.83
Cyclic beta-casomorphin analogues with mixed mu agonist/delta antagonist properties: synthesis, pharmacological characterization, and conformational aspects. J Med Chem (1994) 0.83
Hybrid bivalent ligands with opiate and enkephalin pharmacophores. J Med Chem (1987) 0.83
Preliminary report on the individualised non-mutilating treatment of operable breast cancer. Clin Oncol (1976) 0.83
Vitamin E supplementation and the retinopathy of prematurity. Ann N Y Acad Sci (1982) 0.83
Identification of variability of ribosomal DNA spacer from Pseudomonas soil isolates. Can J Microbiol (1994) 0.83
The trans-spliced intron 1 in the psaA gene of the Chlamydomonas chloroplast: a comparative analysis. Curr Genet (1995) 0.82
Effect of sustained pharmacologic vitamin E levels on incidence and severity of retinopathy of prematurity: a controlled clinical trial. J Pediatr (1989) 0.82
Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics. J Recept Signal Transduct Res (1999) 0.81