Published in Nucleic Acids Res on February 14, 2012
Monomeric site-specific nucleases for genome editing. Proc Natl Acad Sci U S A (2012) 1.03
Homing endonucleases: from genetic anomalies to programmable genomic clippers. Methods Mol Biol (2014) 0.89
Germline excision of transgenes in Aedes aegypti by homing endonucleases. Sci Rep (2013) 0.87
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus. Nucleic Acids Res (2014) 0.83
Rapid assembly of customized TALENs into multiple delivery systems. PLoS One (2013) 0.83
Massively parallel determination and modeling of endonuclease substrate specificity. Nucleic Acids Res (2014) 0.80
Salient Features of Endonuclease Platforms for Therapeutic Genome Editing. Mol Ther (2016) 0.78
Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX). Nucleic Acids Res (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Protein production by auto-induction in high density shaking cultures. Protein Expr Purif (2005) 29.74
REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use. Acta Crystallogr D Biol Crystallogr (2004) 14.28
One step at a time: endoplasmic reticulum-associated degradation. Nat Rev Mol Cell Biol (2008) 8.68
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res (2003) 7.56
Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease. Mol Cell Biol (1994) 6.08
Tracking genome engineering outcome at individual DNA breakpoints. Nat Methods (2011) 4.05
Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae. Mol Cell Biol (1995) 3.96
An intron-encoded protein is active in a gene conversion process that spreads an intron into a mitochondrial gene. Cell (1985) 3.70
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences. Nucleic Acids Res (2006) 2.38
Two different but related mechanisms are used in plants for the repair of genomic double-strand breaks by homologous recombination. Proc Natl Acad Sci U S A (1996) 2.32
Asymmetrical recognition and activity of the I-SceI endonuclease on its site and on intron-exon junctions. EMBO J (1993) 2.24
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev (2003) 2.23
Yeast surface display for directed evolution of protein expression, affinity, and stability. Methods Enzymol (2000) 2.14
Yeast polypeptide fusion surface display levels predict thermal stability and soluble secretion efficiency. J Mol Biol (1999) 1.98
DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI. Mol Cell (1998) 1.85
Exploitation of binding energy for catalysis and design. Nature (2009) 1.77
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res (2010) 1.58
Purification and characterization of the inducible a agglutinin of Saccharomyces cerevisiae. EMBO J (1988) 1.57
Coevolution of a homing endonuclease and its host target sequence. J Mol Biol (2007) 1.49
Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Res (2008) 1.44
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display. Nucleic Acids Res (2009) 1.43
Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proc Natl Acad Sci U S A (2011) 1.39
A decade of yeast surface display technology: where are we now? Comb Chem High Throughput Screen (2008) 1.37
Rapid evolution of the DNA-binding site in LAGLIDADG homing endonucleases. Nucleic Acids Res (2001) 1.36
Crystal structure of the thermostable archaeal intron-encoded endonuclease I-DmoI. J Mol Biol (1999) 1.32
Rational stabilization of enzymes by computational redesign of surface charge-charge interactions. Proc Natl Acad Sci U S A (2009) 1.27
In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination. Nucleic Acids Res (2005) 1.26
Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins. Nucleic Acids Res (2009) 1.14
Generation of redesigned homing endonucleases comprising DNA-binding domains derived from two different scaffolds. Nucleic Acids Res (2009) 1.13
Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases. Nucleic Acids Res (2007) 1.07
Thermostabilization of an esterase by alignment-guided focussed directed evolution. Protein Eng Des Sel (2010) 1.05
Genes within genes: multiple LAGLIDADG homing endonucleases target the ribosomal protein S3 gene encoded within an rnl group I intron of Ophiostoma and related taxa. Mol Biol Evol (2009) 1.02
Mitochondrial introns as mobile genetic elements: the role of intron-encoded proteins. Basic Life Sci (1986) 1.01
Discrimination of thermophilic and mesophilic proteins. BMC Struct Biol (2010) 0.96
Rapid identification of CD4+ T-cell epitopes using yeast displaying pathogen-derived peptide library. J Immunol Methods (2008) 0.93
High-throughput engineering and analysis of peptide binding to class II MHC. Proc Natl Acad Sci U S A (2010) 0.91
Mining endonuclease cleavage determinants in genomic sequence data. J Biol Chem (2011) 0.86
A chemically modified alpha-amylase with a molten-globule state has entropically driven enhanced thermal stability. Protein Eng Des Sel (2010) 0.78
Design of a novel globular protein fold with atomic-level accuracy. Science (2003) 13.06
De novo computational design of retro-aldol enzymes. Science (2008) 7.62
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Res (2003) 7.56
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction. Science (2010) 4.32
Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell (2003) 4.15
Computational redesign of endonuclease DNA binding and cleavage specificity. Nature (2006) 4.06
Tracking genome engineering outcome at individual DNA breakpoints. Nat Methods (2011) 4.05
The crystal structure of TAL effector PthXo1 bound to its DNA target. Science (2012) 3.69
Computational redesign of protein-protein interaction specificity. Nat Struct Mol Biol (2004) 3.66
TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell (2002) 3.13
A unified nomenclature for the superfamily of TRP cation channels. Mol Cell (2002) 2.99
TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions. J Gen Physiol (2003) 2.86
Computational thermostabilization of an enzyme. Science (2005) 2.79
Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase. Structure (2002) 2.56
TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes. Cell Cycle (2010) 2.29
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Res (2012) 2.26
Design, activity, and structure of a highly specific artificial endonuclease. Mol Cell (2002) 2.25
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes Dev (2003) 2.23
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. Nat Biotechnol (2012) 2.19
Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM. J Physiol (2002) 2.16
Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem (2004) 2.08
Simian immunodeficiency virus SIVagm.sab infection of Caribbean African green monkeys: a new model for the study of SIV pathogenesis in natural hosts. J Virol (2006) 2.05
The tertiary structure and domain organization of coagulation factor VIII. Blood (2007) 1.96
Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface. J Mol Biol (2006) 1.93
Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI. J Mol Biol (2003) 1.93
DNA binding and cleavage by the HNH homing endonuclease I-HmuI. J Mol Biol (2004) 1.86
Essential role for protein kinase D family kinases in the regulation of class II histone deacetylases in B lymphocytes. Mol Cell Biol (2006) 1.85
The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold. Structure (2006) 1.81
The structure of Escherichia coli cytosine deaminase. J Mol Biol (2002) 1.81
Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc Natl Acad Sci U S A (2009) 1.79
Exploitation of binding energy for catalysis and design. Nature (2009) 1.77
Homing endonuclease I-CreI derivatives with novel DNA target specificities. Nucleic Acids Res (2006) 1.75
Natural and engineered nicking endonucleases--from cleavage mechanism to engineering of strand-specificity. Nucleic Acids Res (2010) 1.66
Molecular epidemiology of simian immunodeficiency virus SIVsm in U.S. primate centers unravels the origin of SIVmac and SIVstm. J Virol (2005) 1.66
Structures of the rare-cutting restriction endonuclease NotI reveal a unique metal binding fold involved in DNA binding. Structure (2008) 1.64
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Res (2010) 1.58
Alteration of enzyme specificity by computational loop remodeling and design. Proc Natl Acad Sci U S A (2009) 1.56
Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem (2006) 1.55
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis. Nat Chem Biol (2012) 1.50
Coevolution of a homing endonuclease and its host target sequence. J Mol Biol (2007) 1.49
Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain. Proc Natl Acad Sci U S A (2004) 1.46
The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes. J Biol Chem (2008) 1.45
SLC41A2 encodes a plasma-membrane Mg2+ transporter. Biochem J (2007) 1.45
Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation. Nucleic Acids Res (2008) 1.44
Isolation and characterization of new homing endonuclease specificities at individual target site positions. J Mol Biol (2004) 1.44
High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display. Nucleic Acids Res (2009) 1.43
Tapping natural reservoirs of homing endonucleases for targeted gene modification. Proc Natl Acad Sci U S A (2011) 1.39
Catalytic mechanisms of restriction and homing endonucleases. Biochemistry (2002) 1.34
Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template. Nucleic Acids Res (2010) 1.32
Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. J Exp Med (2002) 1.30
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering. Nucleic Acids Res (2013) 1.30
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption. Nat Methods (2012) 1.28
TRPM2 Ca2+ permeable cation channels: from gene to biological function. Cell Calcium (2003) 1.27
The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure (2003) 1.26
TAL effectors: highly adaptable phytobacterial virulence factors and readily engineered DNA-targeting proteins. Trends Cell Biol (2013) 1.24
In vitro assessment of chemokine receptor-ligand interactions mediating mouse eosinophil migration. J Leukoc Biol (2002) 1.23
Zinc-finger nucleases: a powerful tool for genetic engineering of animals. Transgenic Res (2009) 1.22
Microseed matrix screening to improve crystals of yeast cytosine deaminase. Acta Crystallogr D Biol Crystallogr (2004) 1.22
Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family. Nucleic Acids Res (2011) 1.21
TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes. Cell Metab (2008) 1.21
Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI. PLoS One (2011) 1.21
Metal-dependent DNA cleavage mechanism of the I-CreI LAGLIDADG homing endonuclease. Biochemistry (2004) 1.18
Recognition of DNA substrates by T4 bacteriophage polynucleotide kinase. Nucleic Acids Res (2004) 1.18
NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase. J Biol Chem (2002) 1.15
The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motif. EMBO J (2007) 1.15
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy. Protein Eng Des Sel (2004) 1.14
Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins. Nucleic Acids Res (2009) 1.14
TRPML cation channels regulate the specialized lysosomal compartment of vertebrate B-lymphocytes. Eur J Cell Biol (2006) 1.12
Unusual target site disruption by the rare-cutting HNH restriction endonuclease PacI. Structure (2010) 1.11
Folding, DNA recognition, and function of GIY-YIG endonucleases: crystal structures of R.Eco29kI. Structure (2010) 1.10
Activity and specificity of the bacterial PD-(D/E)XK homing endonuclease I-Ssp6803I. J Mol Biol (2008) 1.10
The crystal structure and mutational analysis of human NUDT9. J Mol Biol (2003) 1.07
Pillars article: Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity. 1996. 4: 77-85. J Immunol (2013) 1.07
Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases. Nucleic Acids Res (2007) 1.07
Fractured genes: a novel genomic arrangement involving new split inteins and a new homing endonuclease family. Nucleic Acids Res (2009) 1.05
Activation of Syk tyrosine kinase is required for c-Cbl-mediated ubiquitination of Fcepsilon RI and Syk in RBL cells. J Biol Chem (2002) 1.05
Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI. Nucleic Acids Res (2011) 1.03
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases. Nucleic Acids Res (2012) 1.02
Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks. Nucleic Acids Res (2013) 1.02
Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms. Pediatr Res (2004) 1.02