Modification of the Fc region of a primatized IgG antibody to human CD4 retains its ability to modulate CD4 receptors but does not deplete CD4(+) T cells in chimpanzees.

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Published in Clin Immunol on February 01, 2001

Authors

R Newman1, K Hariharan, M Reff, D R Anderson, G Braslawsky, D Santoro, N Hanna, P J Bugelski, M Brigham-Burke, C Crysler, R C Gagnon, P Dal Monte, M L Doyle, P C Hensley, M P Reddy, R W Sweet, A Truneh

Author Affiliations

1: IDEC Pharmaceuticals Corporation, 11011 Torreyana Road, San Diego, California, 92121, USA.

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