Published in J Biol Chem on May 02, 1997
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J (1999) 2.70
p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J (2011) 2.61
Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria. J Neurosci (2007) 2.51
Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J (1998) 2.41
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3. Mol Biol Cell (2003) 2.03
Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell (2012) 2.03
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Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Gut (2002) 1.96
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc Natl Acad Sci U S A (1999) 1.83
c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells. EMBO J (1998) 1.67
The chemical biology of protein phosphorylation. Annu Rev Biochem (2009) 1.59
Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals. Mol Cell Biol (1999) 1.55
ATMPK4, an Arabidopsis homolog of mitogen-activated protein kinase, is activated in vitro by AtMEK1 through threonine phosphorylation. Plant Physiol (2000) 1.46
p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis. J Cell Biol (2002) 1.38
Activation of p38 mitogen-activated protein kinase by sodium salicylate leads to inhibition of tumor necrosis factor-induced IkappaB alpha phosphorylation and degradation. Mol Cell Biol (1998) 1.32
Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. J Neurosci (2007) 1.31
Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. EMBO J (1999) 1.30
p38 regulates pigmentation via proteasomal degradation of tyrosinase. J Biol Chem (2010) 1.28
Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope. J Exp Med (2005) 1.22
Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions. J Virol (2006) 1.21
Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells. Mol Cell Biol (2000) 1.20
FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle. Proc Natl Acad Sci U S A (2001) 1.19
Interleukin-1 stimulates catabolism in C2C12 myotubes. Am J Physiol Cell Physiol (2009) 1.13
Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway. BMC Cancer (2012) 1.09
Regulation of angiogenesis by vascular endothelial growth factor and angiopoietin-1 in the rat aorta model: distinct temporal patterns of intracellular signaling correlate with induction of angiogenic sprouting. Am J Pathol (2002) 1.09
Saccharomyces cerevisiae Yak1p protein kinase autophosphorylates on tyrosine residues and phosphorylates myelin basic protein on a C-terminal serine residue. Biochem J (2000) 1.08
Role of p38 MAP kinase in LPS-induced airway inflammation in the rat. Br J Pharmacol (2001) 1.06
The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase. Mol Cell Biol (2003) 1.05
The Shigella type three secretion system effector OspG directly and specifically binds to host ubiquitin for activation. PLoS One (2013) 1.04
Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde. Eur J Pharmacol (2007) 1.04
Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway. Neurochem Res (2008) 1.03
ERK1/2 and p38 regulate trophoblasts differentiation in human term placenta. J Physiol (2005) 1.02
Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells. Aging (Albany NY) (2014) 0.99
Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers. J Biol Chem (2011) 0.99
Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity. J Immunol (2002) 0.97
Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy. Biochem Pharmacol (2010) 0.95
Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem (2009) 0.93
The Mycobacterium tuberculosis early secreted antigenic target of 6 kDa inhibits T cell interferon-γ production through the p38 mitogen-activated protein kinase pathway. J Biol Chem (2011) 0.93
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils. Br J Pharmacol (1999) 0.92
Modulation of JNK and p38 stress activated protein kinases in isolated islets of Langerhans: insulin as an autocrine survival signal. Ann Surg (2001) 0.91
Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190. BMB Rep (2009) 0.91
Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling. Dev Dyn (2008) 0.90
Role of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression. J Virol (2002) 0.90
p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability. J Clin Invest (2001) 0.89
Extracellular nucleotides activate the p38-stress-activated protein kinase cascade in glomerular mesangial cells. Br J Pharmacol (2000) 0.89
Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gbetagamma-mediated activation of Ras and p38 MAPK. Biochem J (2005) 0.89
Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture. Exp Cell Res (2011) 0.89
A p38α-selective chemosensor for use in unfractionated cell lysates. ACS Chem Biol (2010) 0.88
Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media. Infect Immun (2004) 0.88
Barrier dysfunction of the corneal endothelium in response to TNF-alpha: role of p38 MAP kinase. Invest Ophthalmol Vis Sci (2009) 0.88
p38 mitogen-activated kinase is a bidirectional regulator of human fibroblast collagenase-1 induction by three-dimensional collagen lattices. Biochem J (2001) 0.87
Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus. Biochem J (1998) 0.87
Development of an online p38α mitogen-activated protein kinase binding assay and integration of LC-HR-MS. Anal Bioanal Chem (2010) 0.87
Tyrosine phosphorylation of Kir3 following kappa-opioid receptor activation of p38 MAPK causes heterologous desensitization. J Biol Chem (2009) 0.86
A role for p38 MAPK in the regulation of ciliary motion in a eukaryote. BMC Cell Biol (2011) 0.86
Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds. Bioorg Med Chem (2010) 0.85
dickkopf-3-related gene regulates the expression of zebrafish myf5 gene through phosphorylated p38a-dependent Smad4 activity. J Biol Chem (2010) 0.85
p38 mitogen-activated protein kinase and calcium channels mediate signaling in depolarization-induced activation of peroxisome proliferator-activated receptor gamma coactivator-1alpha in neurons. J Neurosci Res (2010) 0.84
P38 and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish. Immunol Cell Biol (2012) 0.84
Alpha1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells. Glycoconj J (2007) 0.83
Activation of p38 mitogen-activated protein kinase by norepinephrine in T-lineage cells. Immunology (2010) 0.83
Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1-40. J Neuroinflammation (2010) 0.82
Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast. PLoS One (2011) 0.82
Accurate calculation of mutational effects on the thermodynamics of inhibitor binding to p38α MAP kinase: a combined computational and experimental study. J Chem Theory Comput (2013) 0.82
7-Ketocholesterol-induced inflammation signals mostly through the TLR4 receptor both in vitro and in vivo. PLoS One (2014) 0.81
Tributyltin alters secretion of interleukin 1 beta from human immune cells. J Appl Toxicol (2014) 0.81
Role of p38 inhibition in cardiac ischemia/reperfusion injury. Eur J Clin Pharmacol (2011) 0.81
p38 MAPK as a negative regulator of VEGF/VEGFR2 signaling pathway in serum deprived human SK-N-SH neuroblastoma cells. Neurosci Lett (2007) 0.81
Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets. Biochem J (2000) 0.80
Enhanced estradiol-induced vasorelaxation in aortas from type 2 diabetic mice may reflect a compensatory role of p38 MAPK-mediated eNOS activation. Pflugers Arch (2012) 0.79
Vitamin E down-modulates mitogen-activated protein kinases, nuclear factor-kappaB and inflammatory responses in lung epithelial cells. Clin Exp Immunol (2007) 0.79
Reduced parasite motility and micronemal protein secretion by a p38 MAPK inhibitor leads to a severe impairment of cell invasion by the apicomplexan parasite Eimeria tenella. PLoS One (2015) 0.78
Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle. Br J Pharmacol (2000) 0.78
Activation of integrins by urea in perfused rat liver. J Biol Chem (2010) 0.78
The priming effect of extracellular UTP on human neutrophils: Role of calcium released from thapsigargin-sensitive intracellular stores. Purinergic Signal (2005) 0.77
CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca(2+) channels upstream of p38 MAPK. J Neuroinflammation (2016) 0.76
Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia. Nat Med (2017) 0.76
Suppression of problematic compound oligomerization by cosolubilization of nondetergent sulfobetaines. ChemMedChem (2015) 0.75
Strategies to design pyrazolyl urea derivatives for p38 kinase inhibition: a molecular modeling study. J Comput Aided Mol Des (2007) 0.75
Zinc Chelation Mediates the Lysosomal Disruption without Intracellular ROS Generation. Oxid Med Cell Longev (2016) 0.75
The rational design of specific peptide inhibitor against p38α MAPK at allosteric-site: a therapeutic modality for HNSCC. PLoS One (2014) 0.75
Role of p38 in the priming of human neutrophils by peritoneal dialysis effluent. Clin Diagn Lab Immunol (1999) 0.75
Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats. PLoS One (2016) 0.75
Dibutyltin-induced alterations of interleukin 1beta secretion from human immune cells. J Appl Toxicol (2016) 0.75
p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation. J Exp Med (2017) 0.75
Chemical enhancement in embryo development and stem cell derivation from single blastomeres. Cloning Stem Cells (2008) 0.75
Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design? J Chem Inf Model (2016) 0.75
Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence. FASEB J (2017) 0.75
Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1. Mol Biol Cell (2017) 0.75
Systematic variation in gene expression patterns in human cancer cell lines. Nat Genet (2000) 24.22
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