Published in J Invest Dermatol on February 01, 2001
Accounting for human polymorphisms predicted to affect protein function. Genome Res (2002) 14.10
Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer (2008) 4.34
Genetic determinants of hair color and Parkinson's disease risk. Ann Neurol (2009) 2.78
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Nat Genet (2011) 2.43
Cancer and neurologic degeneration in xeroderma pigmentosum: long term follow-up characterises the role of DNA repair. J Med Genet (2010) 2.14
Main roads to melanoma. J Transl Med (2009) 1.67
MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. Am J Hum Genet (2001) 1.67
Genome-wide association studies of pigmentation and skin cancer: a review and meta-analysis. Pigment Cell Melanoma Res (2010) 1.28
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma. Hum Mol Genet (2011) 1.23
Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma. J Invest Dermatol (2011) 1.19
A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locus. Cancer Res (2011) 1.04
Role of key-regulator genes in melanoma susceptibility and pathogenesis among patients from South Italy. BMC Cancer (2009) 1.02
Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. J Invest Dermatol (2016) 1.01
A Genome-Wide Association Study of Cutaneous Squamous Cell Carcinoma among European Descendants. Cancer Epidemiol Biomarkers Prev (2016) 0.97
MC1R mutations modify the classic phenotype of oculocutaneous albinism type 2 (OCA2). Am J Hum Genet (2003) 0.95
Multilocus OCA2 genotypes specify human iris colors. Hum Genet (2007) 0.94
Melanocortin MC₁ receptor in human genetics and model systems. Eur J Pharmacol (2011) 0.92
The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans. PLoS One (2010) 0.92
Distinct pigmentary and melanocortin 1 receptor-dependent components of cutaneous defense against ultraviolet radiation. PLoS Genet (2006) 0.90
New basal cell carcinoma susceptibility loci. Nat Commun (2015) 0.87
Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer. Oncotarget (2014) 0.84
Modification of second cancer risk after malignant melanoma by parental history of cancer. Br J Cancer (2008) 0.83
Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies. BMC Med Res Methodol (2012) 0.81
Multifocal aggressive squamous cell carcinomas induced by prolonged voriconazole therapy: a case report. Case Rep Med (2010) 0.79
Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Nat Commun (2016) 0.76
Family history of skin cancer is associated with early-onset basal cell carcinoma independent of MC1R genotype. Cancer Epidemiol (2015) 0.76
Indoor tanning and the MC1R genotype: risk prediction for basal cell carcinoma risk in young people. Am J Epidemiol (2015) 0.75
Role of MC1R variants in uveal melanoma. Br J Cancer (2003) 0.75
Melanocortin-1 Receptor Polymorphisms and the Risk of Complicated Sepsis After Trauma: A Candidate Gene Association Study. Shock (2016) 0.75
Pigmentary Markers in Danes - Associations with Quantitative Skin Colour, Nevi Count, Familial Atypical Multiple-Mole, and Melanoma Syndrome. PLoS One (2016) 0.75
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (1995) 34.97
Differential regulation and properties of MAPKs. Oncogene (2007) 6.36
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev (1988) 6.23
Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. JAMA (2001) 5.13
Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry (2005) 4.86
Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype? Am J Hum Genet (2000) 4.74
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell (2000) 4.45
Anesthesiologist direction and patient outcomes. Anesthesiology (2000) 4.31
GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res (1998) 3.94
Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial. Lancet (1999) 3.92
Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature (2009) 3.83
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature (1994) 3.70
A large-scale insertional mutagenesis screen in zebrafish. Genes Dev (1999) 3.57
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia (2008) 3.41
Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase. Cell (1987) 3.26
Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element. EMBO J (1985) 2.87
Intranasal lidocaine for treatment of migraine: a randomized, double-blind, controlled trial. JAMA (1996) 2.83
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry (2006) 2.80
Critical care transport: outcome evaluation after interfacility transfer and hospitalization. Ann Emerg Med (1999) 2.71
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet (1999) 2.60
Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. J Natl Cancer Inst (1995) 2.49
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet (1999) 2.46
Microstrip RF surface coil design for extremely high-field MRI and spectroscopy. Magn Reson Med (2001) 2.43
Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev Dyn (1995) 2.43
Combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the oesophagus. Gut (2007) 2.28
CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine. Oncogene (1995) 2.23
Childhood sun exposure as a risk factor for melanoma: a systematic review of epidemiologic studies. Cancer Causes Control (2001) 2.21
Transcriptome analysis and molecular signature of human retinal pigment epithelium. Hum Mol Genet (2010) 2.20
Evidence of linkage disequilibrium between schizophrenia and the SCa1 CAG repeat on chromosome 6p23. Am J Hum Genet (1996) 2.19
Multivariate matching and bias reduction in the surgical outcomes study. Med Care (2001) 2.19
Symbiotic fungal associations in 'lower' land plants. Philos Trans R Soc Lond B Biol Sci (2000) 2.19
Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol (2012) 2.18
A microplate assay for the detection of oxidative products using 2',7'-dichlorofluorescin-diacetate. J Immunol Methods (1992) 2.17
Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci U S A (2000) 2.15
A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs. Am J Hum Genet (1999) 2.15
HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients. Arthritis Rheum (1989) 2.14
The number and location of glycans on influenza hemagglutinin determine folding and association with calnexin and calreticulin. J Cell Biol (1997) 2.14
Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A (1995) 2.13
Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med (1998) 2.12
The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol (1999) 2.12
Cleft lip with or without cleft palate: associations with transforming growth factor alpha and retinoic acid receptor loci. Am J Hum Genet (1992) 2.12
Communication skills of house officers. A study in a medical clinic. Ann Intern Med (1980) 2.12
Essential role of growth hormone in ischemia-induced retinal neovascularization. Science (1997) 2.11
Gastric emptying in acute overdose: a prospective randomised controlled trial. Med J Aust (1995) 2.10
Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res (1994) 2.10
Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons. Lancet (1997) 2.09
Falling cholecystectomy thresholds since the introduction of laparoscopic cholecystectomy. JAMA (1995) 2.08
Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells. J Exp Med (1988) 2.07
Natural selection and quantitative genetics of life-history traits in Western women: a twin study. Evolution (2001) 2.06
Completely diverted tube ileostomy compared with loop ileostomy for protection of low colorectal anastomosis: a pilot study. Colorectal Dis (2014) 2.06
Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nat Genet (1994) 2.06
Refinement of the alpha aminooleic acid bioprosthetic valve anticalcification technique. Ann Thorac Surg (1997) 2.05
Biodegradation of organophosphorus pesticides by surface-expressed organophosphorus hydrolase. Nat Biotechnol (1997) 2.04
Movement disorders with cerebral toxoplasmosis and AIDS. Mov Disord (1993) 2.03
The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem (1987) 2.02
Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr (2000) 1.97
Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. Neurology (2008) 1.96
Is obesity a high-risk factor for laparoscopic colorectal surgery? Surg Endosc (2002) 1.95
Sphincter-sparing treatment for distal rectal adenocarcinoma. Ann Surg Oncol (1999) 1.95
An epidemiological study of lung cancer in Xuan Wei County, China: current progress. Case-control study on lung cancer and cooking fuel. Environ Health Perspect (1991) 1.95
The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res (1996) 1.94
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94
Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J Biol Chem (1997) 1.92
Epidemiology of endometrial cancer. Best Pract Res Clin Obstet Gynaecol (2001) 1.90
EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis (2007) 1.90
Effects of HFE C282Y and H63D polymorphisms and polygenic background on iron stores in a large community sample of twins. Am J Hum Genet (2000) 1.89
Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus. Genes Dev (1995) 1.87
The "D" (13-15) trisomy syndrome: an analysis of 7 examples. Arch Dis Child (1966) 1.86
Infected cell protein (ICP)47 enhances herpes simplex virus neurovirulence by blocking the CD8+ T cell response. J Exp Med (1998) 1.85
Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration. J Cell Physiol (2000) 1.82
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest (1998) 1.82
Adrenoleukodystrophy: increased plasma content of saturated very long chain fatty acids. Neurology (1981) 1.81
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes (2001) 1.80
Identification of a methylation imprint mark within the mouse Gnas locus. Mol Cell Biol (2000) 1.78
Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene (2010) 1.78
An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds. Proc Natl Acad Sci U S A (2000) 1.75
MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90. Oncogene (2006) 1.75
Co-translational folding of an alphavirus capsid protein in the cytosol of living cells. Nat Cell Biol (1999) 1.74
Relation of isovolumic relaxation to left ventricular wall movement in man. Br Heart J (1979) 1.71
Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res (2000) 1.71
Characterization of melanocyte stimulating hormone receptor variant alleles in twins with red hair. Hum Mol Genet (1997) 1.70
Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol (1999) 1.69
Aid to diagnosis of melanoma in primary medical care. BMJ (1995) 1.68
MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. Am J Hum Genet (2001) 1.67
Primary structure, neural-specific expression, and dendritic location of human BC200 RNA. J Neurosci (1993) 1.67
Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. Neurology (2000) 1.67
The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study. Int J Obes (Lond) (2008) 1.66
Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly. Am J Hum Genet (2006) 1.66
Interactions between distinct types of DNA binding proteins enhance binding to ocs element promoter sequences. Plant Cell (1995) 1.65
Application of transmission disequilibrium tests to nonsyndromic oral clefts: including candidate genes and environmental exposures in the models. Am J Med Genet (1997) 1.65
Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice. Am J Physiol (1995) 1.64
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem (2001) 1.63
Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience (2000) 1.61
Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem (1997) 1.61