Published in J Appl Physiol (1985) on March 01, 2001
Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev (2007) 6.53
AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc Natl Acad Sci U S A (2002) 5.93
Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol (2004) 5.66
Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol (2003) 4.34
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A (2003) 4.31
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med (2011) 3.96
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med (2007) 3.92
Short-term sprint interval versus traditional endurance training: similar initial adaptations in human skeletal muscle and exercise performance. J Physiol (2006) 2.90
The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc Natl Acad Sci U S A (2009) 2.50
Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci (2006) 2.23
New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci (2010) 2.03
Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol (2010) 1.98
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol (2005) 1.94
Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J Exp Med (2007) 1.91
Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem (2007) 1.85
DNA replication stress, genome instability and aging. Nucleic Acids Res (2007) 1.80
Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985) (2010) 1.67
Exercise induces hepatosplanchnic release of heat shock protein 72 in humans. J Physiol (2002) 1.45
Reactive oxygen and nitrogen species as intracellular signals in skeletal muscle. J Physiol (2011) 1.45
Functional assessment of isolated mitochondria in vitro. Methods Enzymol (2009) 1.40
Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity. J Biol Chem (2010) 1.36
The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism? Eur J Appl Physiol (2010) 1.36
Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab (2012) 1.34
AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells. PLoS One (2008) 1.32
Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals. Proc Natl Acad Sci U S A (2008) 1.30
Exercise: the lifelong supplement for healthy ageing and slowing down the onset of frailty. J Physiol (2016) 1.26
Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state. Pflugers Arch (2005) 1.24
Exercise and gene expression: physiological regulation of the human genome through physical activity. J Physiol (2002) 1.21
Intramuscular lipid oxidation and obesity. Am J Physiol Regul Integr Comp Physiol (2008) 1.20
Reduced glycogen availability is associated with an elevation in HSP72 in contracting human skeletal muscle. J Physiol (2002) 1.20
Molecular adaptations to aerobic exercise training in skeletal muscle of older women. J Gerontol A Biol Sci Med Sci (2010) 1.11
Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubes. PLoS One (2011) 1.08
Physical activity changes the regulation of mitochondrial respiration in human skeletal muscle. J Physiol (2002) 1.08
Temperature- and exercise-induced gene expression and metabolic enzyme changes in skeletal muscle of adult zebrafish (Danio rerio). J Physiol (2006) 1.08
Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity. Am J Physiol Endocrinol Metab (2008) 1.04
A method for measuring mitochondrial mass and activity. Cytotechnology (2008) 1.03
Age associated low mitochondrial biogenesis may be explained by lack of response of PGC-1α to exercise training. Age (Dordr) (2011) 1.02
Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs. PLoS One (2010) 1.02
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice. Aging Cell (2013) 1.02
Clinical measures of adiposity and percentage fat loss: which measure most accurately reflects fat loss and what should we aim for? Arch Dis Child (2007) 1.02
Electrical pulse stimulation of cultured human skeletal muscle cells as an in vitro model of exercise. PLoS One (2012) 1.00
Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis. J Cell Sci (2009) 0.99
Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle. J Physiol (2004) 0.99
No evidence of an intracellular lactate shuttle in rat skeletal muscle. J Physiol (2002) 0.98
Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventions. Exp Diabetes Res (2011) 0.98
Diabetic cardiomyopathy: signaling defects and therapeutic approaches. Expert Rev Cardiovasc Ther (2010) 0.97
Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria. J Physiol (2008) 0.97
Morphofunctional and Biochemical Approaches for Studying Mitochondrial Changes during Myoblasts Differentiation. J Aging Res (2011) 0.96
Successive bouts of cycling stimulates genes associated with mitochondrial biogenesis. Eur J Appl Physiol (2009) 0.95
Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS One (2013) 0.94
Mitochondria as a potential regulator of myogenesis. ScientificWorldJournal (2013) 0.92
Peroxisome Proliferator-Activated Receptor Delta: A Conserved Director of Lipid Homeostasis through Regulation of the Oxidative Capacity of Muscle. PPAR Res (2008) 0.92
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. PLoS One (2013) 0.92
Endurance training modulates the muscular transcriptome response to acute exercise. Pflugers Arch (2005) 0.91
Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle. Am J Physiol Cell Physiol (2013) 0.91
Polyphenol supplementation: benefits for exercise performance or oxidative stress? Sports Med (2014) 0.91
Exercise training and peripheral arterial disease. Compr Physiol (2012) 0.90
Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis. Antioxid Redox Signal (2008) 0.88
Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. J Physiol (2015) 0.88
Matching ATP supply and demand in mammalian heart: in vivo, in vitro, and in silico perspectives. Ann N Y Acad Sci (2010) 0.88
Transcriptional adaptations following exercise in thoroughbred horse skeletal muscle highlights molecular mechanisms that lead to muscle hypertrophy. BMC Genomics (2009) 0.88
Overexpression of PGC-1α increases fatty acid oxidative capacity of human skeletal muscle cells. Biochem Res Int (2011) 0.86
Molecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle. Aging (Albany NY) (2009) 0.86
Redox Characterization of Functioning Skeletal Muscle. Front Physiol (2015) 0.86
The pleiotropic effect of physical exercise on mitochondrial dynamics in aging skeletal muscle. Oxid Med Cell Longev (2015) 0.85
The formation and functional consequences of heterogeneous mitochondrial distributions in skeletal muscle. J Exp Biol (2012) 0.85
Skeletal muscle function during exercise-fine-tuning of diverse subsystems by nitric oxide. Int J Mol Sci (2013) 0.85
Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver. J Gerontol A Biol Sci Med Sci (2014) 0.85
New insights into the benefits of exercise for muscle health in patients with idiopathic inflammatory myositis. Curr Rheumatol Rep (2014) 0.84
Short-term intensified cycle training alters acute and chronic responses of PGC1α and Cytochrome C oxidase IV to exercise in human skeletal muscle. PLoS One (2012) 0.84
Vivo-morpholinos induced transient knockdown of physical activity related proteins. PLoS One (2013) 0.84
Muscle endurance and mitochondrial function after chronic normobaric hypoxia: contrast of respiratory and limb muscles. Pflugers Arch (2011) 0.84
Muscle oxygen changes following Sprint Interval Cycling training in elite field hockey players. PLoS One (2015) 0.83
Redox state and mitochondrial respiratory chain function in skeletal muscle of LGMD2A patients. PLoS One (2014) 0.83
Three-dimensional mapping of the creatine kinase enzyme reaction rate in muscles of the lower leg. NMR Biomed (2013) 0.83
Estimating relative carbonyl levels in muscle microstructures by fluorescence imaging. Anal Bioanal Chem (2008) 0.83
Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats. BMC Geriatr (2014) 0.82
Chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity. Am J Physiol Cell Physiol (2016) 0.81
Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals. Exp Gerontol (2013) 0.80
Hypoxic preconditioning protects cardiomyocytes against hypoxia/reoxygenation injury through AMPK/eNOS/PGC-1α signaling pathway. Int J Clin Exp Pathol (2014) 0.80
The Preventive Effects of 8 Weeks of Resistance Training on Glucose Tolerance and Muscle Fiber Type Composition in Zucker Rats. Diabetes Metab J (2015) 0.80
Reduced plasma free fatty acid availability during exercise: effect on gene expression. Eur J Appl Physiol (2006) 0.80
Functional classification of skeletal muscle networks. I. Normal physiology. J Appl Physiol (1985) (2012) 0.80
Functional Electrical Stimulation as a Safe and Effective Treatment for Equine Epaxial Muscle Spasms: Clinical Evaluations and Histochemical Morphometry of Mitochondria in Muscle Biopsies. Eur J Transl Myol (2015) 0.79
Living at high altitude in combination with sea-level sprint training increases hematological parameters but does not improve performance in rats. Eur J Appl Physiol (2010) 0.79
Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium. PLoS One (2012) 0.79
The ascorbic acid transporter SVCT2 is expressed in slow-twitch skeletal muscle fibres. Histochem Cell Biol (2009) 0.79
Skeletal muscle mitochondrial energetic efficiency and aging. Int J Mol Sci (2015) 0.79
Semi-automated image analysis: detecting carbonylation in subcellular regions of skeletal muscle. Anal Bioanal Chem (2011) 0.79
Skeletal muscle alkaline Pi pool is decreased in overweight-to-obese sedentary subjects and relates to mitochondrial capacity and phosphodiester content. Sci Rep (2016) 0.79
Pathophysiology of Radiation-Induced Dysphagia in Head and Neck Cancer. Dysphagia (2016) 0.78
Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle. J Aging Res (2012) 0.78
Multiple signaling pathways regulate contractile activity-mediated PGC-1α gene expression and activity in skeletal muscle cells. Physiol Rep (2014) 0.78
Nox4 Is Dispensable for Exercise Induced Muscle Fibre Switch. PLoS One (2015) 0.78
Asymmetric superoxide release inside and outside the mitochondria in skeletal muscle under conditions of aging and disuse. J Appl Physiol (1985) (2010) 0.78
Gene expression in skeletal muscle of coronary artery disease patients after concentric and eccentric endurance training. Eur J Appl Physiol (2005) 0.78
Pharmacology of manipulating lean body mass. Clin Exp Pharmacol Physiol (2015) 0.78
Calcineurin is not involved in some mitochondrial enzyme adaptations to endurance exercise training in rat skeletal muscle. Eur J Appl Physiol (2003) 0.78
Skeletal muscle metabolic adaptations to endurance exercise training are attainable in mice with simvastatin treatment. PLoS One (2017) 0.77