Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle.

PubWeight™: 0.88‹?›

🔗 View Article (PMID 26503074)

Published in J Physiol on November 21, 2015

Authors

Anna-Maria Joseph1, Peter J Adhihetty2, Christiaan Leeuwenburgh3

Author Affiliations

1: Department of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Gainesville, FL, 32611, USA. amjoseph@ufl.edu.
2: Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32611, USA.
3: Department of Aging and Geriatric Research, Division of Biology of Aging, University of Florida, Gainesville, FL, 32611, USA.

Articles cited by this

(truncated to the top 100)

Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41

Hydroperoxide metabolism in mammalian organs. Physiol Rev (1979) 14.13

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89

Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (2004) 11.59

Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (2003) 11.39

Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature (2010) 11.24

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (2005) 9.57

Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55

Autophagy: molecular machinery for self-eating. Cell Death Differ (2005) 8.46

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell (2006) 7.72

The biologic clock: the mitochondria? J Am Geriatr Soc (1972) 6.36

Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev (2010) 6.35

Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med (2000) 6.25

Endonuclease G is an apoptotic DNase when released from mitochondria. Nature (2001) 6.20

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A (1997) 5.95

Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev (2008) 5.74

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell (2006) 5.51

Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem (1967) 5.20

What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men. J Neurol Sci (1988) 5.07

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell (2013) 4.85

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84

Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46

Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37

On the origin of mitosing cells J Theor Biol (1967) 4.36

SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A (2002) 4.27

Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci U S A (2005) 4.03

HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem (2002) 4.03

Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci (2002) 4.00

Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol (1985) (2001) 3.35

Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes (2003) 3.23

Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc (2002) 3.21

Endurance exercise as a countermeasure for aging. Diabetes (2008) 2.83

A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A (1992) 2.83

Mitochondrial role in cell aging. Exp Gerontol (1980) 2.82

The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol (2011) 2.77

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis (2010) 2.69

Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle. Proc Natl Acad Sci U S A (1996) 2.52

Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J (2005) 2.48

Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One (2010) 2.44

Oxidative capacity and ageing in human muscle. J Physiol (2000) 2.44

Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am J Hum Genet (2006) 2.43

Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28

Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull (2005) 2.25

Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness. Crit Care Med (2011) 2.25

The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J Immunol (2003) 2.19

Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukoc Biol (2004) 2.17

Mitochondrial DNA and disease. Ann Med (2005) 2.13

Autophagy in skeletal muscle. FEBS Lett (2010) 2.13

Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women. J Appl Physiol (1985) (1992) 2.06

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. Trends Immunol (2011) 2.05

Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J (2001) 2.05

New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci (2010) 2.03

Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol (2010) 1.98

The contribution of reactive oxygen species to sarcopenia and muscle ageing. Exp Gerontol (2004) 1.98

Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol (2005) 1.94

Urinary incontinence in the elderly and age-dependent apoptosis of rhabdosphincter cells. Lancet (1999) 1.92

The molecular inflammatory process in aging. Antioxid Redox Signal (2006) 1.86

Lifelong physical exercise delays age-associated skeletal muscle decline. J Gerontol A Biol Sci Med Sci (2014) 1.82

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice. Proc Natl Acad Sci U S A (2011) 1.81

Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9. Cardiovasc Res (2008) 1.80

A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process. Mutat Res (1996) 1.76

Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Exp Gerontol (2009) 1.74

Extracellular heat shock protein 70 induces cardiomyocyte inflammation and contractile dysfunction via TLR2. Circ J (2011) 1.73

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle. Cell Metab (2014) 1.72

Mitochondrial function and apoptotic susceptibility in aging skeletal muscle. Aging Cell (2007) 1.71

The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging. J Am Geriatr Soc (2003) 1.68

Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction. FASEB J (2005) 1.65

Oxidative stress and the mitochondrial theory of aging in human skeletal muscle. Exp Gerontol (2004) 1.61

Apoptosis in skeletal muscle with aging. Am J Physiol Regul Integr Comp Physiol (2002) 1.61

Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults. PLoS One (2010) 1.58

Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. PLoS One (2010) 1.57

Consequences of sarcopenia. Clin Geriatr Med (2011) 1.51

Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor. Autophagy (2008) 1.47

Age-dependent changes of antioxidant activities and markers of free radical damage in human skeletal muscle. Free Radic Biol Med (1999) 1.45

Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol (1985) (2008) 1.45

Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults. J Gerontol A Biol Sci Med Sci (2012) 1.44

High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy. Biochim Biophys Acta (2008) 1.44

Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. Rejuvenation Res (2008) 1.44

Large energetic adaptations of elderly muscle to resistance and endurance training. J Appl Physiol (1985) (2001) 1.43

Mitochondrial DNA repair of oxidative damage in mammalian cells. Gene (2002) 1.42

The role of mitochondrial DNA mutations and free radicals in disease and ageing. J Intern Med (2013) 1.42

Apoptosis in muscle atrophy: relevance to sarcopenia. Exp Gerontol (2005) 1.40

AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1. J Cell Biochem (2012) 1.38

Age-related differences in apoptosis with disuse atrophy in soleus muscle. Am J Physiol Regul Integr Comp Physiol (2005) 1.38

Autophagy in protein and organelle turnover. Cold Spring Harb Symp Quant Biol (2011) 1.38

Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res (2009) 1.34

Experimental evidence against the mitochondrial theory of aging. A study of isolated human skeletal muscle mitochondria. Exp Gerontol (2003) 1.34

The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure. J Gerontol A Biol Sci Med Sci (2009) 1.33

Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflugers Arch (2002) 1.31

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals. Aging Cell (2012) 1.29

Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia. Mol Cell Biol (2012) 1.28

Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle. FASEB J (2005) 1.27

Skeletal muscle mitochondria and aging: a review. J Aging Res (2012) 1.27

Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. Exp Gerontol (2006) 1.26

Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett (1992) 1.26

Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age. Pflugers Arch (2005) 1.24

Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle. Aging Cell (2007) 1.21

Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors. Mol Cancer (2009) 1.20