Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise.

PubWeight™: 1.94‹?› | Rank: Top 3%

🔗 View Article (PMC 1474174)

Published in J Physiol on June 16, 2005

Authors

Romain Cartoni1, Bertrand Léger, M Benjamin Hock, Manu Praz, Antoinette Crettenand, Sara Pich, Jean-Luc Ziltener, François Luthi, Olivier Dériaz, Antonio Zorzano, Charles Gobelet, Anastasia Kralli, Aaron P Russell

Author Affiliations

1: Clinique Romande de Réadaptation, SUVACare, 1951 Sion, Switzerland.

Articles citing this

Mitochondrial fragmentation in neurodegeneration. Nat Rev Neurosci (2008) 4.32

The interplay between mitochondrial dynamics and mitophagy. Antioxid Redox Signal (2011) 2.05

Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc Natl Acad Sci U S A (2007) 2.03

New insights into the role of mitochondria in aging: mitochondrial dynamics and more. J Cell Sci (2010) 2.03

Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle. J Physiol (2010) 1.98

ERRalpha: a metabolic function for the oldest orphan. Trends Endocrinol Metab (2008) 1.83

Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66

Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. J Physiol (2006) 1.66

Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal (2012) 1.60

Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol (2011) 1.55

Hibernating squirrel muscle activates the endurance exercise pathway despite prolonged immobilization. Exp Neurol (2013) 1.52

Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. J Mol Cell Cardiol (2009) 1.48

Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity. J Biol Chem (2010) 1.36

WNT11 expression is induced by estrogen-related receptor alpha and beta-catenin and acts in an autocrine manner to increase cancer cell migration. Cancer Res (2010) 1.19

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training. J Physiol (2013) 1.16

The NR3B subgroup: an ovERRview. Nucl Recept Signal (2007) 1.16

Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res (2012) 1.16

Enhancement of muscle mitochondrial function by growth hormone. J Clin Endocrinol Metab (2007) 1.11

Exercise training-induced regulation of mitochondrial quality. Exerc Sport Sci Rev (2012) 1.11

Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle. J Appl Physiol (1985) (2013) 1.10

PGC1α-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med (2013) 1.06

Interplay between estrogen-related receptor alpha (ERRalpha) and gamma (ERRgamma) on the regulation of ERRalpha gene expression. Mol Cell Endocrinol (2006) 1.04

Passive and post-exercise cold-water immersion augments PGC-1α and VEGF expression in human skeletal muscle. Eur J Appl Physiol (2016) 1.03

Peroxisome proliferator-activated receptor delta regulates mitofusin 2 expression in the heart. J Mol Cell Cardiol (2009) 1.02

AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development. Hypertension (2011) 1.01

Mitochondrial morphology transitions and functions: implications for retrograde signaling? Am J Physiol Regul Integr Comp Physiol (2013) 1.01

Striated muscle activator of Rho signalling (STARS) is a PGC-1α/oestrogen-related receptor-α target gene and is upregulated in human skeletal muscle after endurance exercise. J Physiol (2011) 1.00

Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventions. Exp Diabetes Res (2011) 0.98

New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev (2014) 0.98

Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats. Endocrinology (2009) 0.97

Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training. J Gerontol A Biol Sci Med Sci (2013) 0.95

The optic nerve: a "mito-window" on mitochondrial neurodegeneration. Mol Cell Neurosci (2012) 0.95

Adopting new orphans into the family of metabolic regulators. Mol Endocrinol (2008) 0.95

Running forward: new frontiers in endurance exercise biology. Circulation (2014) 0.94

Time course analysis reveals gene-specific transcript and protein kinetics of adaptation to short-term aerobic exercise training in human skeletal muscle. PLoS One (2013) 0.94

Mitochondrial biogenesis through activation of nuclear signaling proteins. Cold Spring Harb Perspect Biol (2013) 0.94

Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression. Proc Natl Acad Sci U S A (2012) 0.92

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus. Nat Rev Endocrinol (2016) 0.90

Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging. Diabetes (2013) 0.89

Regulation of PGC-1alpha and PGC-1alpha-responsive genes with forskolin-induced Schwann cell differentiation. Neurosci Lett (2008) 0.89

Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle. J Physiol (2015) 0.88

Leg vascular and skeletal muscle mitochondrial adaptations to aerobic high-intensity exercise training are enhanced in the early postmenopausal phase. J Physiol (2017) 0.88

Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance. JACC Heart Fail (2016) 0.87

Adaptability to hypobaric hypoxia is facilitated through mitochondrial bioenergetics: an in vivo study. Br J Pharmacol (2013) 0.87

Altered skeletal muscle mitochondrial biogenesis but improved endurance capacity in trained OPA1-deficient mice. J Physiol (2013) 0.86

The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle. Exp Gerontol (2012) 0.85

Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J Biol Chem (2013) 0.83

Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training. Front Physiol (2015) 0.83

Can endurance exercise preconditioning prevention disuse muscle atrophy? Front Physiol (2015) 0.81

Role of mitochondrial fission and fusion in cardiomyocyte contractility. Int J Cardiol (2015) 0.81

In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. Physiol Genomics (2014) 0.81

Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function. Mol Cell Biol (2015) 0.81

Hyperhomocysteinemia associated skeletal muscle weakness involves mitochondrial dysfunction and epigenetic modifications. Biochim Biophys Acta (2015) 0.81

Dysregulation of Mfn2 and Drp-1 proteins in heart failure. Can J Physiol Pharmacol (2014) 0.81

Regulation of the STARS signaling pathway in response to endurance and resistance exercise and training. Pflugers Arch (2013) 0.80

PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity. Aging (Albany NY) (2015) 0.80

Mitochondrial and skeletal muscle health with advancing age. Mol Cell Endocrinol (2013) 0.80

Substrate use and biochemical response to a 3,211-km bicycle tour in trained cyclists. Eur J Appl Physiol (2011) 0.80

Diet impact on mitochondrial bioenergetics and dynamics. Front Physiol (2015) 0.80

The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron (2016) 0.79

Skeletal Muscle Satellite Cells, Mitochondria, and MicroRNAs: Their Involvement in the Pathogenesis of ALS. Front Physiol (2016) 0.79

Increased insulin sensitivity and distorted mitochondrial adaptations during muscle unloading. Int J Mol Sci (2012) 0.78

Dietary fucoxanthin increases metabolic rate and upregulated mRNA expressions of the PGC-1alpha network, mitochondrial biogenesis and fusion genes in white adipose tissues of mice. Mar Drugs (2014) 0.78

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases. Ageing Res Rev (2016) 0.78

cAMP signaling prevents podocyte apoptosis via activation of protein kinase A and mitochondrial fusion. PLoS One (2014) 0.77

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity. Proc Natl Acad Sci U S A (2017) 0.77

The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting. Semin Cell Dev Biol (2015) 0.77

Do we age because we have mitochondria? Protoplasma (2013) 0.77

Mitochondrial pathways to cardiac recovery: TFAM. Heart Fail Rev (2016) 0.76

The TreadWheel: A Novel Apparatus to Measure Genetic Variation in Response to Gently Induced Exercise for Drosophila. PLoS One (2016) 0.76

Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice. Physiol Rep (2015) 0.76

Mitochondrial adaptations to exercise in human skeletal muscle: a possible role for cristae density as a determinant of muscle fitness. J Physiol (2017) 0.75

Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats. Biogerontology (2014) 0.75

Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease. PPAR Res (2017) 0.75

Decreased transcriptional corepressor p107 is associated with exercise-induced mitochondrial biogenesis in human skeletal muscle. Physiol Rep (2017) 0.75

Citrus flavonoid, naringenin, increases locomotor activity and reduces diacylglycerol accumulation in skeletal muscle of obese ovariectomized mice. Mol Nutr Food Res (2015) 0.75

Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells. World J Stem Cells (2017) 0.75

Short-term intense exercise training reduces stress markers and alters the transcriptional response to exercise in skeletal muscle. Am J Physiol Regul Integr Comp Physiol (2016) 0.75

Oestrogen-related receptor α is required for transepithelial H+ secretion in zebrafish. Proc Biol Sci (2016) 0.75

Mitochondrial Effects of PGC-1alpha Silencing in MPP(+) Treated Human SH-SY5Y Neuroblastoma Cells. Front Mol Neurosci (2017) 0.75

Articles cited by this

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59

Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology (N Y) (1993) 22.41

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48

Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes (2002) 10.49

Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev (2004) 6.98

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53

Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell (1999) 5.23

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J (2002) 4.75

Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol Respir Environ Exerc Physiol (1984) 4.55

Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol (2003) 4.34

The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci U S A (2004) 3.65

Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J Biol Chem (2002) 3.64

Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem (2003) 3.45

Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol (1985) (2001) 3.35

Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes (2003) 3.23

A new air displacement method for the determination of human body composition. Med Sci Sports Exerc (1995) 2.87

The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J Biol Chem (2003) 2.81

Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Biochem Biophys Res Commun (2002) 2.75

Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. Diabetes (2003) 2.71

The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol (1997) 2.64

Estrogen-related receptor alpha 1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol (1997) 2.34

cDNA Cloning and mRNA analysis of PGC-1 in epitrochlearis muscle in swimming-exercised rats. Biochem Biophys Res Commun (2000) 2.33

PGC-1, a versatile coactivator. Trends Endocrinol Metab (2001) 2.31

Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. J Biochem (2003) 2.29

PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. J Appl Physiol (1985) (2003) 1.73

Molecular adaptations in human skeletal muscle to endurance training under simulated hypoxic conditions. J Appl Physiol (1985) (2001) 1.50

A polymorphic autoregulatory hormone response element in the human estrogen-related receptor alpha (ERRalpha) promoter dictates peroxisome proliferator-activated receptor gamma coactivator-1alpha control of ERRalpha expression. J Biol Chem (2004) 1.46

Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene. Mol Cell Biol (1991) 1.33

Effect of training on insulin-mediated glucose uptake in human muscle. Am J Physiol (1992) 1.31

Regulation of mitochondrial biogenesis in muscle by endurance exercise. Sports Med (2003) 1.24

Induction of nuclear respiratory factor-1 expression by an acute bout of exercise in rat muscle. Biochim Biophys Acta (1998) 1.06

The relationship between 3 km running performance and selected physiological variables. J Sports Sci (1997) 0.90

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc Natl Acad Sci U S A (2004) 3.65

Mitochondrial dynamics in mammalian health and disease. Physiol Rev (2009) 3.59

Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem (2003) 3.45

The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J Biol Chem (2003) 2.81

Transcriptional control of mitochondrial biogenesis and function. Annu Rev Physiol (2009) 2.76

The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum Mol Genet (2005) 2.72

Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. Diabetes (2003) 2.71

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43

The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J Biol Chem (2002) 2.28

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Sci Signal (2009) 2.23

Adaptation of energy metabolism in breast cancer brain metastases. Cancer Res (2007) 2.17

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature (2012) 2.04

Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis. Proc Natl Acad Sci U S A (2007) 2.03

Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 2.01

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci U S A (2012) 2.00

Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation. Genes Dev (2005) 1.92

Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes (2006) 1.91

ERRalpha: a metabolic function for the oldest orphan. Trends Endocrinol Metab (2008) 1.83

SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev (2008) 1.78

Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6. Diabetes (2005) 1.77

Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification. J Am Soc Nephrol (2002) 1.73

CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab (2009) 1.68

Alternative mRNA splicing produces a novel biologically active short isoform of PGC-1alpha. J Biol Chem (2009) 1.67

Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy. J Physiol (2006) 1.66

Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J (2013) 1.65

Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci (2011) 1.65

Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovasc Res (2007) 1.63

dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr Biol (2010) 1.62

Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol (2013) 1.61

Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment. J Clin Endocrinol Metab (2005) 1.58

Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J (2012) 1.58

A reservoir of brown adipocyte progenitors in human skeletal muscle. Stem Cells (2008) 1.51

Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One (2008) 1.50

Early prediction of response to sunitinib after imatinib failure by 18F-fluorodeoxyglucose positron emission tomography in patients with gastrointestinal stromal tumor. J Clin Oncol (2008) 1.50

Significant molecular and systemic adaptations after repeated sprint training in hypoxia. PLoS One (2013) 1.48

A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA. Mol Cell Biol (2008) 1.47

Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation. Rejuvenation Res (2008) 1.44

Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy. Arch Otolaryngol Head Neck Surg (2006) 1.42

Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care (2009) 1.42

Pegfilgrastim to accelerate neutrophil engraftment following peripheral blood stem cell transplant and reduce the duration of neutropenia, hospitalization, and use of intravenous antibiotics: a phase II study in multiple myeloma and lymphoma and comparison with filgrastim-treated matched controls. Leuk Lymphoma (2011) 1.41

The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy. Pflugers Arch (2011) 1.41

Pathophysiology and treatment of cystinuria. Nat Rev Nephrol (2010) 1.40

Regulation of NT-PGC-1alpha subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J Biol Chem (2010) 1.38

Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36. Diabetes (2002) 1.38

Molecular basis of substrate-induced permeation by an amino acid antiporter. Proc Natl Acad Sci U S A (2011) 1.37

Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem (2005) 1.36

MicroRNAs in skeletal muscle: their role and regulation in development, disease and function. J Physiol (2010) 1.33

Human skeletal muscle atrophy in amyotrophic lateral sclerosis reveals a reduction in Akt and an increase in atrogin-1. FASEB J (2006) 1.31

Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem (2005) 1.31

PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. Cell Metab (2010) 1.29

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest (2013) 1.29

Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes. Endocrinology (2009) 1.26

Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol (2013) 1.23

Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids? FEBS Lett (2003) 1.22

Regulation of STARS and its downstream targets suggest a novel pathway involved in human skeletal muscle hypertrophy and atrophy. J Physiol (2009) 1.21

Ventilation, oxidative stress, and nitric oxide in hypobaric versus normobaric hypoxia. Med Sci Sports Exerc (2013) 1.20

Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function. FASEB J (2010) 1.19

The genetics of heteromeric amino acid transporters. Physiology (Bethesda) (2005) 1.18

Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts. Hum Mol Genet (2004) 1.18

A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res (2013) 1.18

Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting. FEBS Lett (2002) 1.17

Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis. Hum Mol Genet (2003) 1.15

The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells. EMBO Rep (2009) 1.14

Redistribution of glucose from skeletal muscle to adipose tissue during catch-up fat: a link between catch-up growth and later metabolic syndrome. Diabetes (2005) 1.12

Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more. Int J Biochem Cell Biol (2009) 1.11

CD14 modulates inflammation-driven insulin resistance. Diabetes (2011) 1.11

Functional and structural characterization of the first prokaryotic member of the L-amino acid transporter (LAT) family: a model for APC transporters. J Biol Chem (2007) 1.11

Cellular mechanisms underlying temporal changes in skeletal muscle protein synthesis and breakdown during chronic {beta}-adrenoceptor stimulation in mice. J Physiol (2010) 1.11

rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney. Am J Physiol Renal Physiol (2002) 1.11

Kinematic variability, fractal dynamics and local dynamic stability of treadmill walking. J Neuroeng Rehabil (2011) 1.09

ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett (2002) 1.09

Identification of a novel modulator of thyroid hormone receptor-mediated action. PLoS One (2007) 1.08

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proc Natl Acad Sci U S A (2012) 1.07

Neuregulin signaling on glucose transport in muscle cells. J Biol Chem (2004) 1.07

Regulation of cardiac long-chain fatty acid and glucose uptake by translocation of substrate transporters. Pflugers Arch (2004) 1.05

Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α. PLoS One (2011) 1.05

Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients. Muscle Nerve (2009) 1.02