The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 11206415)

Published in Diabetologia on January 01, 2001

Authors

T Cai1, M W Krause, W F Odenwald, R Toyama, A L Notkins

Author Affiliations

1: Experimental Medicine Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892-4322, USA.

Articles citing this

Autoimmune type 1 diabetes: resolved and unresolved issues. J Clin Invest (2001) 2.35

Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes (2008) 1.55

The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion. Proc Natl Acad Sci U S A (2005) 1.19

The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein. Genomics (2002) 1.09

Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles. Diabetologia (2011) 1.01

IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A (2006) 0.97

Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One (2010) 0.87

Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction. Clin Exp Immunol (2007) 0.86

Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2. PLoS Genet (2009) 0.83

Ida-1, the Caenorhabditis elegans orthologue of mammalian diabetes autoantigen IA-2, potentially acts as a common modulator between Parkinson's disease and Diabetes: role of Daf-2/Daf-16 insulin like signalling pathway. PLoS One (2014) 0.77

Pathophysiologic changes in IA-2/IA-2β null mice are secondary to alterations in the secretion of hormones and neurotransmitters. Acta Diabetol (2015) 0.76

Articles by these authors

(truncated to the top 100)

Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med (1979) 5.58

Effect of virus infections on the function of the immune system. Annu Rev Microbiol (1970) 4.30

Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature (2000) 3.78

LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Trends Genet (1998) 3.63

Decreased virulence of recombinant vaccinia virus expression vectors is associated with a thymidine kinase-negative phenotype. Nature (1985) 3.62

Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med (1979) 3.62

CD5+ B lymphocytes, polyreactive antibodies and the human B-cell repertoire. Immunol Today (1989) 2.96

Thymus dependence of viral antigens. Nature (1975) 2.95

Heterogeneity in the properties of 7 S and 19S rabbit-neutralizing antibodies to herpes simplex virus. J Immunol (1968) 2.90

Continued expression of a poly(A)+ transcript of herpes simplex virus type 1 in trigeminal ganglia of latently infected mice. J Virol (1987) 2.78

Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset. Science (1987) 2.75

Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy. Science (1974) 2.71

Infectious virus-antibody complex in the blood of chronically infected mice. J Exp Med (1966) 2.68

Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes. Annu Rev Immunol (1989) 2.63

Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci U S A (1992) 2.48

Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nat Med (1997) 2.47

Inhibition or enhancement of immunological injury of virus-infected cells. Proc Natl Acad Sci U S A (1971) 2.45

Prevention of cell-to-cell spread of herpes simplex virus by leukocytes. J Exp Med (1973) 2.42

Vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D prevents latent herpes in mice. Science (1985) 2.34

In vitro stimulation of sensitized lymphocytes by herpes simplex virus and vaccinia virus. Proc Natl Acad Sci U S A (1972) 2.29

Immune mechanisms by which the spread of viral infections is stopped. Cell Immunol (1974) 2.23

Comparison of direct and indirect solid-phase microradioimmunoassays for the detection of viral antigens and antiviral antibody. Appl Microbiol (1973) 2.23

HIV-associated nephropathy in transgenic mice expressing HIV-1 genes. Virology (1991) 2.16

Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol (1994) 2.13

A gene expression screen in zebrafish embryogenesis. Genome Res (2001) 2.08

Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus. J Exp Med (1980) 2.07

Herpes simplex virus DNA and mRNA sequences in acutely and chronically infected trigeminal ganglia of mice. Virology (1978) 1.99

IA-1, a new marker for neuroendocrine differentiation in human lung cancer cell lines. Cancer Res (1993) 1.96

Latent infection of sensory ganglia with herpes simplex virus: efficacy of immunization. Science (1975) 1.95

Immunological response restricts number of cells in sensory ganglia infected with herpes simplex virus. Nature (1976) 1.95

Herpes simplex virus DNA sequences in the CNS of latently infected mice. Nature (1980) 1.95

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues. J Virol (1986) 1.95

Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J Antibiot (Tokyo) (1994) 1.93

Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes: isotype restriction and polyclonality. Diabetes Care (2000) 1.91

Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families. J Immunol (1989) 1.88

Neutralization of an infectious herpes simplex virus-antibody complex by anti-gamma-globulin. Proc Natl Acad Sci U S A (1966) 1.84

Immunization with a vaccinia virus recombinant expressing herpes simplex virus type 1 glycoprotein D: long-term protection and effect of revaccination. J Virol (1988) 1.81

Rapid micro-radioimmunoassay for the measurement of antiviral antibody. J Immunol (1972) 1.79

Virus-induced autoimmunity: monoclonal antibodies that react with endocrine tissues. Science (1983) 1.78

Latent infection of the peripheral ANS with herpes simplex virus. Nature (1975) 1.76

cyclops encodes a nodal-related factor involved in midline signaling. Proc Natl Acad Sci U S A (1998) 1.75

Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS. Genes Dev (1998) 1.74

Human monoclonal autoantibodies that react with multiple endocrine organs. N Engl J Med (1983) 1.73

Multiple interferons in the circulation of patients with systemic lupus erythematosus and vasculitis. Arthritis Rheum (1982) 1.73

Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J Exp Med (1977) 1.73

Virus-induced diabetes mellitus. XX. Polyendocrinopathy and autoimmunity. J Exp Med (1981) 1.72

IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1996) 1.71

Elevated gamma-globulin and increased antibody production in mice infected with lactic dehydrogenase virus. J Exp Med (1966) 1.71

Acute and latent infection of sensory ganglia with herpes simplex virus: immune control and virus reactivation. J Gen Virol (1979) 1.71

Lymphocytes capable of making monoclonal autoantibodies that react with multiple organs are a common feature of the normal B cell repertoire. J Immunol (1984) 1.69

Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus. J Immunol (1988) 1.69

Virus-induced diabetes mellitus. I. Hyperglycemia and hypoinsulinemia in mice infected with encephalomyocarditis virus. J Exp Med (1973) 1.68

Homology between murine and human cellular DNA sequences and the terminal repetition of the S component of herpes simplex virus type 1 DNA. Cell (1982) 1.67

Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation. J Immunol (1993) 1.65

Multiple organ-reactive monoclonal autoantibodies. Nature (1983) 1.64

Stereo images of vesicular stomatitis virus assembly. J Virol (1986) 1.63

Neutralization of sensitized virus by purified components of complement. Proc Natl Acad Sci U S A (1970) 1.63

Monoreactive high affinity and polyreactive low affinity rheumatoid factors are produced by CD5+ B cells from patients with rheumatoid arthritis. J Exp Med (1988) 1.62

LIM domain proteins. C R Acad Sci III (1995) 1.61

Prevention of ultraviolet-light-induced herpes labialis by sunscreen. Lancet (1991) 1.60

Cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitus. N Engl J Med (1980) 1.59

Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry. Dev Biol (1998) 1.56

Misexpression of the white (w) gene triggers male-male courtship in Drosophila. Proc Natl Acad Sci U S A (1995) 1.54

Cellular immunity to herpes simplex virus mediated by interferon. J Exp Med (1974) 1.52

Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish. Development (1998) 1.52

Virus-induced diabetes mellitus. XV. Beta cell damage and insulin-dependent hyperglycemia in mice infected with coxsackie virus B4. J Exp Med (1978) 1.52

Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Proc Natl Acad Sci U S A (1996) 1.51

Complete sequence of the genes encoding the VH and VL regions of low- and high-affinity monoclonal IgM and IgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient. Int Immunol (1991) 1.50

Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. J Biol Chem (1988) 1.46

Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia. Infect Immun (1976) 1.45

castor encodes a novel zinc finger protein required for the development of a subset of CNS neurons in Drosophila. Neuron (1992) 1.44

A novel human insulinoma-associated cDNA, IA-1, encodes a protein with "zinc-finger" DNA-binding motifs. J Biol Chem (1992) 1.44

Altering the insertional specificity of a Drosophila transposable element. Proc Natl Acad Sci U S A (1992) 1.43

The Drosophila gene escargot encodes a zinc finger motif found in snail-related genes. Mech Dev (1992) 1.42

Virus-induced diabetes mellitus. III. Influence of the sex and strain of the host. J Infect Dis (1975) 1.41

Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen. J Biol Chem (1989) 1.41

Human monoclonal rheumatoid factor-like antibodies from CD5 (Leu-1)+ B cells are polyreactive. J Immunol (1988) 1.40

Neutralization of sensitized lactic dehydrogenase virus by anti-gammglobulin. J Immunol (1968) 1.40

Viral-specific thymidine kinase in sensory ganglia of mice infected with herpes simplex virus. Virology (1977) 1.39

Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus. J Exp Med (1990) 1.38

Programmed transformations in neuroblast gene expression during Drosophila CNS lineage development. Dev Biol (2000) 1.38

Autoantibodies as predictors of disease. J Clin Invest (2001) 1.37

Enzymatic and immunologic alterations in mice infected with lactic dehydrogenase virus. Am J Pathol (1971) 1.37

Effect of immunization on acute and latent infections of vaginouterine tissue with herpes simplex virus types 1 and 2. J Infect Dis (1977) 1.32

Virus-induced diabetes mellitus: VIII. Passage of encephalomyocarditis virus and severity of diabetes in susceptible and resistant strains of mice. J Gen Virol (1977) 1.30

Virus-induced diabetes mellitus: reovirus infection of pancreatic beta cells in mice. Science (1978) 1.29

Model for studying virus attachment: identification and quantitation of Epstein-Barr virus-binding cells by using biotinylated virus in flow cytometry. J Virol (1988) 1.29

Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial. Ann Intern Med (1993) 1.27

Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells. Science (1970) 1.27

Expression of herpes simplex virus 1 glycoprotein B by a recombinant vaccinia virus and protection of mice against lethal herpes simplex virus 1 infection. Proc Natl Acad Sci U S A (1987) 1.26

Differential expression of the homeobox gene Hox-1.3 in F9 embryonal carcinoma cells. Proc Natl Acad Sci U S A (1988) 1.26

Inhibition of cellular immune reactions in mice infected with lactic dehydrogenase virus. Nature (1969) 1.25

Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system. Dev Dyn (1994) 1.24

Retinoid X receptor (RXR) within the RXR-retinoic acid receptor heterodimer binds its ligand and enhances retinoid-dependent gene expression. Mol Cell Biol (1997) 1.23

Induction of cellular immunity to herpes simplex virus: relationship to the humoral immune response. J Immunol (1974) 1.23

High frequency of antigenic variants among naturally occurring human Coxsackie B4 virus isolates identified by monoclonal antibodies. Nature (1982) 1.22

Functional development of the zebrafish pineal gland: light-induced expression of period2 is required for onset of the circadian clock. J Neuroendocrinol (2005) 1.21

Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex. Development (1999) 1.21

Genetic differences in susceptibility of pancreatic beta cells to virus-induced diabetes mellitus. Nature (1976) 1.21

Neutralization of sensitized virus by the fourth component of complement. Science (1969) 1.21