Published in Nat Genet on March 01, 2001
Developmental and adult phenotyping directly from mutant embryonic stem cells. Proc Natl Acad Sci U S A (2007) 2.61
Embryonic stem cells and somatic cells differ in mutation frequency and type. Proc Natl Acad Sci U S A (2002) 2.17
Transposon-mediated genome manipulation in vertebrates. Nat Methods (2009) 1.96
Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks. Mol Cell Biol (2003) 1.65
Trisomy correction in Down syndrome induced pluripotent stem cells. Cell Stem Cell (2012) 1.35
HLA engineering of human pluripotent stem cells. Mol Ther (2013) 1.19
Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability. Proc Natl Acad Sci U S A (2006) 0.95
Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7. Mol Cell Biol (2007) 0.86
Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors. EMBO J (2014) 0.85
Mutagenesis of diploid mammalian genes by gene entrapment. Nucleic Acids Res (2006) 0.85
ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells. Nucleic Acids Res (2014) 0.84
Efficient biallelic mutagenesis with Cre/loxP-mediated inter-chromosomal recombination. EMBO Rep (2002) 0.83
Bi-allelic gene targeting in mouse embryonic stem cells. Methods (2011) 0.83
Endoplasmic reticulum resident protein 44 (ERp44) deficiency in mice and zebrafish leads to cardiac developmental and functional defects. J Am Heart Assoc (2014) 0.78
Expression and loss of alleles in cultured mouse embryonic fibroblasts and stem cells carrying allelic fluorescent protein genes. BMC Mol Biol (2006) 0.78
Applications of the site-specific recombinase Cre to the study of genomic imprinting. Brief Funct Genomics (2010) 0.78
Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells. PLoS One (2012) 0.78
siRNA screen of ES cell-derived motor neurons identifies novel regulators of tetanus toxin and neurotrophin receptor trafficking. Front Cell Neurosci (2014) 0.77
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 18.47
Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon Cre-mediated excision. Genesis (2001) 12.85
Promotion of trophoblast stem cell proliferation by FGF4. Science (1998) 8.02
Z/AP, a double reporter for cre-mediated recombination. Dev Biol (1999) 6.88
Generating green fluorescent mice by germline transmission of green fluorescent ES cells. Mech Dev (1998) 5.21
Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med (1999) 4.33
Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotype. Am J Pathol (2000) 4.19
Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression. Development (2000) 3.44
Essential role of Mash-2 in extraembryonic development. Nature (1994) 3.36
Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. J Cell Biol (2001) 2.94
Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med (1999) 2.81
Long-term reconstitution of the mouse hematopoietic system by embryonic stem cell-derived fetal liver. Proc Natl Acad Sci U S A (1991) 2.66
FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome. Br J Cancer (2007) 2.65
Imprinted X inactivation maintained by a mouse Polycomb group gene. Nat Genet (2001) 2.63
Multiple developmental roles of VEGF suggested by a LacZ-tagged allele. Dev Biol (1999) 2.59
Genome manipulation in embryonic stem cells. Philos Trans R Soc Lond B Biol Sci (1993) 2.50
Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nat Genet (1995) 2.46
The orderly allocation of mesodermal cells to the extraembryonic structures and the anteroposterior axis during gastrulation of the mouse embryo. Development (1999) 2.45
Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos. Development (1997) 2.41
A survey of the genomic distribution of alpha satellite DNA on all the human chromosomes, and derivation of a new consensus sequence. Nucleic Acids Res (1991) 2.39
Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses. Genes Dev (2000) 2.32
Non-injection methods for the production of embryonic stem cell-embryo chimaeras. Nature (1993) 2.27
Genetic origin of mutations predisposing to retinoblastoma. Science (1985) 2.22
Non-invasive sexing of preimplantation stage mammalian embryos. Nat Genet (1998) 2.16
Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS Lett (2001) 2.15
Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas. Cancer Res (2001) 2.13
Developmental abnormalities of glycosylphosphatidylinositol-anchor-deficient embryos revealed by Cre/loxP system. Lab Invest (1999) 2.06
Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells. Genesis (2000) 2.05
The preparation and characterization of synaptic vesicles of high purity. Brain Res (1976) 2.00
Development and psychometric testing of a quality of recovery score after general anesthesia and surgery in adults. Anesth Analg (1999) 1.85
The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development (2001) 1.83
Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial. J Thromb Haemost (2008) 1.81
An X-linked GFP transgene reveals unexpected paternal X-chromosome activity in trophoblastic giant cells of the mouse placenta. Genesis (2001) 1.73
Mash2 acts cell autonomously in mouse spongiotrophoblast development. Dev Biol (1997) 1.71
Genome engineering: the new mouse genetics. Nat Med (1995) 1.69
Hypothalamic hormones and cancer. Front Neuroendocrinol (2001) 1.61
A needle-puncture that helped to change the world of surgery. Homage to János Veres. Surg Endosc (2000) 1.56
Human ovarian cancers express somatostatin receptors. J Clin Endocrinol Metab (2000) 1.49
Brca1 required for T cell lineage development but not TCR loci rearrangement. Nat Immunol (2000) 1.48
Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization. Cancer Genet Cytogenet (2001) 1.46
Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer. Br J Cancer (2006) 1.44
The Hamilton depression scale. Evaluation of objectivity using logistic models. Acta Psychiatr Scand (1981) 1.43
Chromosome 6p amplification and cancer progression. J Clin Pathol (2006) 1.42
Modeling the Pauli potential in the pair density functional theory. J Chem Phys (2008) 1.39
Rapid preparation of synaptosomes from mammalian brain using nontoxic isoosmotic gradient material (Percoll). J Neurochem (1984) 1.32
Heterogeneous vascular dependence of tumor cell populations. Am J Pathol (2001) 1.31
Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics (2008) 1.31
Primary chromosomal rearrangements of leukemia are frequently accompanied by extensive submicroscopic deletions and may lead to altered prognosis. Blood (2001) 1.30
Molecular genetics of Wiedemann-Beckwith syndrome. Am J Med Genet (1998) 1.29
The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis. Mech Dev (2000) 1.29
Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity. J Allergy Clin Immunol (2001) 1.29
Enzymatic activation of a doxorubicin-peptide prodrug by prostate-specific antigen. Cancer Res (1998) 1.28
Mice null for sox18 are viable and display a mild coat defect. Mol Cell Biol (2000) 1.24
Aggregation chimeras. Combining ES cells, diploid and tetraploid embryos. Methods Mol Biol (2001) 1.23
Green Mold Diseases of Agaricus and Pleurotus spp. Are Caused by Related but Phylogenetically Different Trichoderma Species. Phytopathology (2007) 1.23
Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat. Neurosci Lett (1985) 1.22
Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg (2000) 1.21
Parental origin-specific expression of Mash2 is established at the time of implantation with its imprinting mechanism highly resistant to genome-wide demethylation. Mech Dev (1999) 1.20
Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone. Proc Natl Acad Sci U S A (1994) 1.19
Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238. Proc Natl Acad Sci U S A (2000) 1.19
The Role of RUNX2 in Osteosarcoma Oncogenesis. Sarcoma (2010) 1.18
An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Proc Natl Acad Sci U S A (1996) 1.18
Stem cell bioengineering. Annu Rev Biomed Eng (2001) 1.17
Embryonic stem cells, creating transgenic animals. Methods Cell Biol (1998) 1.17
Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors. Eur J Endocrinol (1999) 1.17
Developmental basis of retinal-specific induction of cancer by RB mutation. Cancer Res (1999) 1.16
Molecular biology of Beckwith-Wiedemann syndrome. Med Pediatr Oncol (1996) 1.15
The color of mice: in the light of GFP-variant reporters. Histochem Cell Biol (2001) 1.14
Insights in vessel development and vascular disorders using targeted inactivation and transfer of vascular endothelial growth factor, the tissue factor receptor, and the plasminogen system. Ann N Y Acad Sci (1997) 1.14
Isolation and distribution of a novel iron-oxidizing crenarchaeon from acidic geothermal springs in Yellowstone National Park. Appl Environ Microbiol (2007) 1.13
Minimal regions of chromosomal imbalance in retinoblastoma detected by comparative genomic hybridization. Cancer Genet Cytogenet (2001) 1.12
Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo. Genesis (2001) 1.10
Mechanisms of loss of heterozygosity in retinoblastoma. Cytogenet Cell Genet (1992) 1.09
Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH. Cytogenet Genome Res (2008) 1.08
Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q. Blood (1993) 1.08
Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts. Mol Cell Biol (1999) 1.08
Long-range analyses of the centromeric regions of human chromosomes 13, 14 and 21: identification of a narrow domain containing two key centromeric DNA elements. Hum Mol Genet (1993) 1.07
Advances in the detection of chromosomal aberrations using spectral karyotyping. Clin Genet (2001) 1.07
Imipramine: clinical effects and pharmacokinetic variability. Psychopharmacology (Berl) (1977) 1.07
Synthesis and in vitro evaluation of new potent antagonists of growth hormone-releasing hormone (GH-RH). Peptides (1997) 1.06
Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability. Mol Cell Biol (2000) 1.06
Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development (2001) 1.06
New approaches to therapy of cancers of the stomach, colon and pancreas based on peptide analogs. Cell Mol Life Sci (2004) 1.05
Conditional genome alteration in mice. Bioessays (1998) 1.05
Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood (1999) 1.04
Glypicans: a growing trend. Nat Genet (1996) 1.04
Separation of acetylcholine and catecholamine containing synaptic vesicles from brain cortex. J Neurochem (1977) 1.04
Mash2 is expressed in oogenesis and preimplantation development but is not required for blastocyst formation. Mech Dev (1998) 1.03
Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation. Am J Pathol (2001) 1.03
FACS for the isolation of individual cells from transgenic mice harboring a fluorescent protein reporter. Genesis (2000) 1.03
Comparative genomic hybridization analysis identifies gains of 1p35 approximately p36 and chromosome 19 in osteosarcoma. Cancer Genet Cytogenet (2001) 1.02
Chromosomal instability in osteosarcoma and its association with centrosome abnormalities. Cancer Genet Cytogenet (2003) 1.02
Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma. Neoplasia (1999) 1.02
Evidence of chromosomal instability in prostate cancer determined by spectral karyotyping (SKY) and interphase fish analysis. Neoplasia (2001) 1.02
Use of whole genome amplification and comparative genomic hybridisation to detect chromosomal copy number alterations in cell line material and tumour tissue. Cytogenet Genome Res (2004) 1.00