Published in EMBO Rep on November 01, 2000
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation. Mol Cell Biol (2004) 3.98
Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation. EMBO J (2003) 2.97
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut (2003) 2.37
The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway. Mol Cell Biol (2002) 1.57
Role of zeta PKC in B-cell signaling and function. EMBO J (2002) 1.45
Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. Pharmacol Res (2007) 1.42
Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. J Cancer Res Clin Oncol (2007) 1.36
Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex. Cell Death Differ (2009) 1.35
NF-kappaB activation by protein kinase C isoforms and B-cell function. EMBO Rep (2003) 1.30
The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta. Mol Cell Biol (2002) 1.30
Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene (2008) 1.27
Human members of the eukaryotic protein kinase family. Genome Biol (2002) 1.25
Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38. EMBO Rep (2003) 1.24
Kinome-wide RNAi screen implicates at least 5 host hepatocyte kinases in Plasmodium sporozoite infection. PLoS Pathog (2008) 1.20
The atypical PKCs in inflammation: NF-κB and beyond. Immunol Rev (2012) 1.17
PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein. EMBO J (2002) 1.08
Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis. EMBO J (2004) 1.07
Atypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formation. Proc Natl Acad Sci U S A (2011) 1.07
MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Mol Cell Biol (2001) 1.05
Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway. Mol Cell Biol (2001) 1.04
Induction of nitric oxide synthase and activation of signaling proteins in Anopheles mosquitoes by the malaria pigment, hemozoin. Infect Immun (2007) 1.01
The PB1 domain and the PC motif-containing region are structurally similar protein binding modules. EMBO J (2003) 0.99
Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J (2003) 0.99
Regulation of primary cilia formation by ceramide. J Lipid Res (2009) 0.96
c-Myc phosphorylation by PKCζ represses prostate tumorigenesis. Proc Natl Acad Sci U S A (2013) 0.96
Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ. J Neurophysiol (2011) 0.94
Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. Biochem J (2005) 0.93
Ceramide signaling in cancer and stem cells. Future Lipidol (2008) 0.92
Protein kinase Czeta (PKCzeta) regulates ocular inflammation and apoptosis in endotoxin-induced uveitis (EIU): signaling molecules involved in EIU resolution by PKCzeta inhibitor and interleukin-13. Am J Pathol (2007) 0.92
Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide. J Biol Chem (2009) 0.91
Identification of PKCzetaII: an endogenous inhibitor of cell polarity. EMBO J (2003) 0.90
The Par-4/PTEN connection in tumor suppression. Cell Cycle (2009) 0.90
Molecular basis of lysophosphatidic acid-induced NF-κB activation. Cell Signal (2010) 0.89
PKM and the maintenance of memory. F1000 Biol Rep (2013) 0.89
G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). J Biol Chem (2010) 0.89
Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein. J Biol Chem (2012) 0.89
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Sci Signal (2014) 0.88
A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells. Autophagy (2015) 0.87
Ceramide in stem cell differentiation and embryo development: novel functions of a topological cell-signaling lipid and the concept of ceramide compartments. J Lipids (2010) 0.86
Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons. Brain Res (2009) 0.83
Dynamics and Membrane Interactions of Protein Kinase C. Biochemistry (2015) 0.82
Th1/Th2 Differentiation and B Cell Function by the Atypical PKCs and Their Regulators. Front Immunol (2012) 0.80
Proteomic profiling of lipopolysaccharide-activated macrophages by isotope coded affinity tagging. J Proteome Res (2010) 0.79
The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw. Neuroscience (2013) 0.78
p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA. Oncogene (2016) 0.77
Atypical protein kinase C zeta: potential player in cell survival and cell migration of ovarian cancer. PLoS One (2015) 0.76
Par6 regulates skeletogenesis and gut differentiation in sea urchin larvae. Dev Genes Evol (2012) 0.76
The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond. Genes (Basel) (2016) 0.76
Protein kinase Czeta regulates phospholipase D activity in rat-1 fibroblasts expressing the alpha1A adrenergic receptor. BMC Cell Biol (2004) 0.75
Letter to the Editor: Rapid backbone (1)H, (13)C, and (15)N assignment of the V1 domain of human PKC iota using the new program IBIS. J Biomol NMR (2003) 0.75
Protein kinase Cι is a new prognostic factor in gastric cancer. Surg Today (2014) 0.75
A genomewide survey of developmentally relevant genes in Ciona intestinalis. VII. Molecules involved in the regulation of cell polarity and actin dynamics. Dev Genes Evol (2003) 0.75
PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury. Cell Death Dis (2017) 0.75
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Protein kinase C and lipid signaling for sustained cellular responses. FASEB J (1995) 6.80
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol (2000) 6.01
Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat Med (1999) 4.40
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J (2000) 3.83
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem (1999) 3.42
The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. J Biol Chem (1999) 3.04
An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol (1998) 3.04
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J (1999) 2.80
Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol (2000) 2.77
The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell (1996) 2.66
Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell (1993) 2.54
Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans. Development (1998) 2.47
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol (1998) 2.35
Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol (1999) 2.35
par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development (1996) 2.31
Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nat Med (1998) 2.30
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation. Mol Cell Biol (1993) 2.20
Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells. Cell Growth Differ (1994) 2.13
Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Proc Natl Acad Sci U S A (1997) 2.11
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol (1999) 2.11
EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J (1996) 2.11
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta. EMBO J (1995) 2.04
A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation. Curr Biol (2000) 1.95
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. J Biol Chem (1994) 1.67
Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases. J Biol Chem (1998) 1.64
Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation. EMBO J (1997) 1.57
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. Mol Cell Biol (1996) 1.51
Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis. J Biol Chem (1997) 1.49
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J (1999) 1.48
Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J Biol Chem (1997) 1.31
Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. J Biol Chem (1999) 1.28
PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor. EMBO J (1999) 1.23
Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells. Mol Cell Biol (2000) 0.99
Function for NF-kB in neuronal survival: regulation by atypical protein kinase C. J Neurosci Res (1999) 0.99
Signal transduction by tumor necrosis factor: the Parker B. Francis Lectureship. Chest (1999) 0.91
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J (2000) 3.83
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol (2000) 3.34
Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell (2001) 3.05
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J (1999) 2.80
Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell (1993) 2.54
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol (1998) 2.35
Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol (1999) 2.35
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J Biol Chem (1994) 2.20
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol (1997) 1.76
Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Cell (1990) 1.64
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Mol Cell Biol (1992) 1.63
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Mol Cell Biol (1993) 1.60
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem (2001) 1.49
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J (1999) 1.48
The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. J Biol Chem (1998) 1.46
Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J Virol (1993) 1.44
PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways. Cell Death Differ (2006) 1.40
Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction. Mol Cell Biol (1993) 1.40
Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex. Cell Death Differ (2009) 1.35
Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C. J Biol Chem (1995) 1.29
Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes. J Virol (1996) 1.29
Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol Cell Biol (1997) 1.26
Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade. J Biol Chem (1990) 1.20
Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes. EMBO J (1990) 1.16
Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta. J Biol Chem (1995) 1.15
Hydrolysis of phosphatidylcholine is stimulated by Ras proteins during mitogenic signal transduction. Mol Cell Biol (1992) 1.11
Requirement of phospholipase C-catalyzed hydrolysis of phosphatidylcholine for maturation of Xenopus laevis oocytes in response to insulin and ras p21. J Biol Chem (1991) 1.09
Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway. Mol Cell Biol (2001) 1.04
Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C. EMBO J (1991) 1.00
NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype. Mol Cell Biol (1994) 0.99
Mechanism of inhibition of adenylate cyclase by phospholipase C-catalyzed hydrolysis of phosphatidylcholine. Involvement of a pertussis toxin-sensitive G protein and protein kinase C. J Biol Chem (1991) 0.94
Cleavage of zetaPKC but not lambda/iotaPKC by caspase-3 during UV-induced apoptosis. J Biol Chem (1999) 0.93
Cross-talk between different enhancer elements during mitogenic induction of the human stromelysin-1 gene. J Biol Chem (1996) 0.90
Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. J Biol Chem (1994) 0.89
Molecular characterization of a novel transcription factor that controls stromelysin expression. Mol Cell Biol (1995) 0.87
Regulation and role of the atypical PKC isoforms in cell survival during tumor transformation. Adv Enzyme Regul (2001) 0.79
Activation of phosphatidylcholine-specific phospholipase C in cell growth and oncogene transformation. Biochem Soc Trans (1989) 0.78