Published in EMBO J on December 15, 1995
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J (2000) 3.83
The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol (2000) 3.34
An atypical PKC directly associates and colocalizes at the epithelial tight junction with ASIP, a mammalian homologue of Caenorhabditis elegans polarity protein PAR-3. J Cell Biol (1998) 3.04
The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J (1999) 2.80
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Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol (1998) 2.35
Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol (1999) 2.35
Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol Cell Biol (1998) 2.32
Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein. Proc Natl Acad Sci U S A (1997) 2.11
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The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO Rep (2000) 1.80
p70 S6 kinase is regulated by protein kinase Czeta and participates in a phosphoinositide 3-kinase-regulated signalling complex. Mol Cell Biol (1999) 1.73
The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res (2008) 1.59
TNF ligands and receptors--a matter of life and death. Br J Pharmacol (2002) 1.57
Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation. EMBO J (1997) 1.57
Glycogen synthase kinase 3beta and extracellular signal-regulated kinase inactivate heat shock transcription factor 1 by facilitating the disappearance of transcriptionally active granules after heat shock. Mol Cell Biol (1998) 1.55
Role of zeta PKC in B-cell signaling and function. EMBO J (2002) 1.45
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle. Cancer Res (2009) 1.43
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Both src-dependent and -independent mechanisms mediate phosphatidylinositol 3-kinase regulation of colony-stimulating factor 1-activated mitogen-activated protein kinases in myeloid progenitors. Mol Cell Biol (2000) 1.27
Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol Cell Biol (1997) 1.26
Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38. EMBO Rep (2003) 1.24
PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor. EMBO J (1999) 1.23
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Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin. Mol Cell Biol (1997) 1.20
Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. J Cell Biol (1999) 1.17
Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells. Hepatology (2009) 1.15
Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer. Cancer Res (2008) 1.11
Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I. J Exp Med (1999) 1.11
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MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Mol Cell Biol (2001) 1.05
Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway. Mol Cell Biol (2001) 1.04
Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter. Mol Cell Biol (1997) 1.02
Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells. Mol Cell Biol (2004) 1.02
Activation of keratinocyte protein kinase C zeta in psoriasis plaques. J Invest Dermatol (2008) 1.02
Role of reactive oxygen species in brucein D-mediated p38-mitogen-activated protein kinase and nuclear factor-kappaB signalling pathways in human pancreatic adenocarcinoma cells. Br J Cancer (2010) 1.02
Atypical protein kinase Clambda binds and regulates p70 S6 kinase. Biochem J (1998) 1.02
Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells. Mol Cell Biol (2000) 0.99
Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-zeta and Raf-1. Biochem J (1997) 0.99
Isoenzymes of protein kinase C: differential involvement in apoptosis and pathogenesis. Mol Pathol (1997) 0.97
Different protein kinase C isoforms determine growth factor specificity in neuronal cells. Mol Cell Biol (2000) 0.97
Fine tuning the transcriptional regulation of the CXCL1 chemokine. Prog Nucleic Acid Res Mol Biol (2003) 0.96
Interleukin 1-beta-induced protein kinase C-zeta activation is mimicked by exogenous phospholipase D. Biochem J (1997) 0.96
Transcriptional activation of c-fos by oncogenic Ha-Ras in mouse mammary epithelial cells requires the combined activities of PKC-lambda, epsilon and zeta. EMBO J (1998) 0.94
Porins from Salmonella enterica serovar Typhimurium activate the transcription factors activating protein 1 and NF-kappaB through the Raf-1-mitogen-activated protein kinase cascade. Infect Immun (2002) 0.92
Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin. Br J Pharmacol (2006) 0.90
Inhibition by pentoxifylline of TNF-alpha-stimulated fractalkine production in vascular smooth muscle cells: evidence for mediation by NF-kappa B down-regulation. Br J Pharmacol (2003) 0.89
TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signaling in HT-29/B6 cells. Mucosal Immunol (2013) 0.88
Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62. Immunology (2005) 0.88
Down-regulation of PKCζ in renal cell carcinoma and its clinicopathological implications. J Biomed Sci (2012) 0.87
Protein kinase C delta and eta isoenzymes control the shedding of the interleukin 6 receptor alpha in myeloma cells. Biochem J (2001) 0.86
Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways. PLoS One (2015) 0.85
Activation of extracellular signal-regulated kinase in proliferative glomerulonephritis in rats. J Clin Invest (1997) 0.85
Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS One (2013) 0.81
Protein kinase C-ζ mediates lung injury induced by diesel exhaust particles. Am J Respir Cell Mol Biol (2012) 0.80
The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages. PLoS One (2011) 0.78
Overexpression of atypical protein kinase C in HeLa cells facilitates macropinocytosis via Src activation. Cell Signal (2014) 0.78
Reactive oxygen species regulate the generation of urokinase plasminogen activator in human hepatoma cells via MAPK pathways after treatment with hepatocyte growth factor. Exp Mol Med (2009) 0.78
PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity. Leukemia (2014) 0.77
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell (1994) 16.30
The stress-activated protein kinase subfamily of c-Jun kinases. Nature (1994) 11.45
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science (1995) 7.87
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A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science (1993) 7.00
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (1995) 6.20
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science (1994) 6.07
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature (1995) 5.00
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell (1993) 4.83
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature (1994) 4.67
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Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1993) 4.23
The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem (1994) 4.21
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell (1994) 3.91
Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature (1994) 3.67
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Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J (1993) 3.28
NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science (1993) 3.25
Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Proc Natl Acad Sci U S A (1989) 3.21
Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell (1993) 2.54
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation. Mol Cell Biol (1993) 2.20
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J Biol Chem (1994) 2.20
Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation. Proc Natl Acad Sci U S A (1993) 2.12
zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. EMBO J (1994) 1.95
Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science (1994) 1.89
Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1. J Biol Chem (1993) 1.74
Effect of phorbol esters on protein kinase C-zeta. J Biol Chem (1992) 1.69
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. J Biol Chem (1994) 1.67
Purification and characterization of the zeta isoform of protein kinase C from bovine kidney. J Biol Chem (1992) 1.66
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1995) 1.65
Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Cell (1990) 1.64
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Mol Cell Biol (1992) 1.63
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Mol Cell Biol (1993) 1.60
Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J Virol (1993) 1.44
Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C. J Biol Chem (1995) 1.29
B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP. Mol Cell Biol (1994) 1.21
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A role for zeta protein kinase C in nerve growth factor-induced differentiation of PC12 cells. Cell Growth Differ (1994) 1.11
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c-Ha-ras transfection induces human immunodeficiency virus (HIV) transcription through the HIV-enhancer in human fibroblasts and astrocytes. Oncogene (1989) 0.98
Overexpression of protein kinase C-zeta stimulates leukemic cell differentiation. Cell Growth Differ (1994) 0.96
The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. EMBO J (2000) 3.83
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The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J (1999) 2.80
The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell (1996) 2.66
Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell (1993) 2.54
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Nature (1987) 2.46
Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. J Biol Chem (1997) 2.46
Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. Mol Cell Biol (1998) 2.35
Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol (1999) 2.35
A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation. Mol Cell Biol (1993) 2.20
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J Biol Chem (1994) 2.20
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Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol Cell Biol (1997) 1.76
Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT4 vesicles and other membrane fractions in rat adipocytes. J Biol Chem (1999) 1.72
Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport. J Biol Chem (1997) 1.71
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta. J Biol Chem (1994) 1.67
Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Cell (1990) 1.64
Evidence for a role of protein kinase C zeta subspecies in maturation of Xenopus laevis oocytes. Mol Cell Biol (1992) 1.63
Clinical significance of the epidermal growth factor receptor and HER2 receptor in resectable gastric cancer. Ann Surg Oncol (2003) 1.60
Inhibition of protein kinase C zeta subspecies blocks the activation of an NF-kappa B-like activity in Xenopus laevis oocytes. Mol Cell Biol (1993) 1.60
Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. Mol Cell Biol (1996) 1.51
Environmental selection of antibiotic resistance genes. Environ Microbiol (2001) 1.50
Clinical course, treatment, and multivariate analysis of risk factors for pyogenic liver abscess. Am J Surg (2001) 1.50
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. J Biol Chem (2001) 1.49
The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J (1999) 1.48
The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway. J Biol Chem (1998) 1.46
Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Endocrinology (1997) 1.46
Phosphatidylcholine hydrolysis activates NF-kappa B and increases human immunodeficiency virus replication in human monocytes and T lymphocytes. J Virol (1993) 1.44
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Protein kinase C-zeta mediates NF-kappa B activation in human immunodeficiency virus-infected monocytes. J Virol (1996) 1.29
Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. J Biol Chem (1999) 1.28
The crystal structures of two spermadhesins reveal the CUB domain fold. Nat Struct Biol (1997) 1.28
Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade. Mol Cell Biol (1997) 1.26
Inhibition of tumor growth in vivo by in situ secretion of bispecific anti-CEA x anti-CD3 diabodies from lentivirally transduced human lymphocytes. Cancer Gene Ther (2007) 1.25
Cloning and nucleotide sequence of celA1, and endo-beta-1,4-glucanase-encoding gene from Streptomyces halstedii JM8. J Bacteriol (1992) 1.24
The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J Biol Chem (2000) 1.24
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Kinetic evidence of a rapid activation of phosphatidylcholine hydrolysis by Ki-ras oncogene. Possible involvement in late steps of the mitogenic cascade. J Biol Chem (1990) 1.20
Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes. EMBO J (1990) 1.16
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Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test. Clin Exp Allergy (2013) 1.10
jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans. EMBO J (2001) 1.10
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Screening for the psychological consequences of a major disaster in a developing country: Armero, Colombia. Acta Psychiatr Scand (1987) 1.06
MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling. Mol Cell Biol (2001) 1.05
Two genes encoding an endoglucanase and a cellulose-binding protein are clustered and co-regulated by a TTA codon in Streptomyces halstedii JM8. Biochem J (1997) 1.03
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Disaster severity and emotional disturbance: implications for primary mental health care in developing countries. Acta Psychiatr Scand (1989) 0.99
NIH 3T3 cells stably transfected with the gene encoding phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus acquire a transformed phenotype. Mol Cell Biol (1994) 0.99
Chronic neuropathy with IgM anti-ganglioside antibodies: lack of long term response to rituximab. Neurology (2003) 0.98
First birth of an animal from an extinct subspecies (Capra pyrenaica pyrenaica) by cloning. Theriogenology (2009) 0.98
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