Cpx signaling pathway monitors biogenesis and affects assembly and expression of P pili.

PubWeight™: 2.08‹?› | Rank: Top 2%

🔗 View Article (PMC 145513)

Published in EMBO J on April 02, 2001

Authors

D L Hung1, T L Raivio, C H Jones, T J Silhavy, S J Hultgren

Author Affiliations

1: Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.

Articles citing this

Phase and antigenic variation in bacteria. Clin Microbiol Rev (2004) 5.02

Curli biogenesis and function. Annu Rev Microbiol (2006) 4.77

Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway. Proc Natl Acad Sci U S A (2002) 2.68

Epigenetic gene regulation in the bacterial world. Microbiol Mol Biol Rev (2006) 2.66

Complex regulatory network controls initial adhesion and biofilm formation in Escherichia coli via regulation of the csgD gene. J Bacteriol (2001) 2.35

Signal detection and target gene induction by the CpxRA two-component system. J Bacteriol (2003) 2.16

Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein. Mol Microbiol (2006) 2.14

Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation. Infect Immun (2006) 2.11

Characterization of the Cpx regulon in Escherichia coli strain MC4100. J Bacteriol (2008) 1.96

The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC. J Bacteriol (2005) 1.68

Synergistic role of curli and cellulose in cell adherence and biofilm formation of attaching and effacing Escherichia coli and identification of Fis as a negative regulator of curli. Environ Microbiol (2009) 1.65

The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP. Proc Natl Acad Sci U S A (2005) 1.58

Decreased expression of type 1 fimbriae by a pst mutant of uropathogenic Escherichia coli reduces urinary tract infection. Infect Immun (2012) 1.53

Self-perpetuating epigenetic pili switches in bacteria. Proc Natl Acad Sci U S A (2002) 1.45

Role for serine protease HtrA (DegP) of Streptococcus pyogenes in the biogenesis of virulence factors SpeB and the hemolysin streptolysin S. Infect Immun (2004) 1.31

The Cpx envelope stress response affects expression of the type IV bundle-forming pili of enteropathogenic Escherichia coli. J Bacteriol (2005) 1.31

Role of the two-component regulator CpxAR in the virulence of Salmonella enterica serotype Typhimurium. Infect Immun (2004) 1.30

Identification of CpxR as a positive regulator of icm and dot virulence genes of Legionella pneumophila. J Bacteriol (2003) 1.30

Identification of inducers of the Yersinia enterocolitica phage shock protein system and comparison to the regulation of the RpoE and Cpx extracytoplasmic stress responses. J Bacteriol (2004) 1.30

DegS is necessary for virulence and is among extraintestinal Escherichia coli genes induced in murine peritonitis. Infect Immun (2003) 1.28

MxiM and MxiJ, base elements of the Mxi-Spa type III secretion system of Shigella, interact with and stabilize the MxiD secretin in the cell envelope. J Bacteriol (2001) 1.26

Programmed heterogeneity: epigenetic mechanisms in bacteria. J Biol Chem (2013) 1.25

Bacteria-surface interactions. Soft Matter (2013) 1.22

Structural biology of membrane-intrinsic beta-barrel enzymes: sentinels of the bacterial outer membrane. Biochim Biophys Acta (2007) 1.22

Activation of the Cpx envelope stress response down-regulates expression of several locus of enterocyte effacement-encoded genes in enteropathogenic Escherichia coli. Infect Immun (2008) 1.20

Protein quality control in the bacterial periplasm. Microb Cell Fact (2004) 1.19

CpxRA regulates mutualism and pathogenesis in Xenorhabdus nematophila. Appl Environ Microbiol (2007) 1.09

Extracytoplasmic-stress-responsive pathways modulate type III secretion in Yersinia pseudotuberculosis. Infect Immun (2007) 1.06

Identification and characterization of a novel uropathogenic Escherichia coli-associated fimbrial gene cluster. Infect Immun (2004) 1.06

Function and expression of an N-acetylneuraminic acid-inducible outer membrane channel in Escherichia coli. J Bacteriol (2005) 1.06

RtsA coordinately regulates DsbA and the Salmonella pathogenicity island 1 type III secretion system. J Bacteriol (2004) 1.05

Leucine-responsive regulatory protein (Lrp) acts as a virulence repressor in Salmonella enterica serovar Typhimurium. J Bacteriol (2008) 1.03

Influence of the Cpx extracytoplasmic-stress-responsive pathway on Yersinia sp.-eukaryotic cell contact. Infect Immun (2007) 1.03

P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli. J Bacteriol (2004) 1.02

Characterization of Escherichia coli MG1655 grown in a low-shear modeled microgravity environment. BMC Microbiol (2007) 1.01

Involvement and necessity of the Cpx regulon in the event of aberrant beta-barrel outer membrane protein assembly. Mol Microbiol (2010) 0.98

Genetic analysis of activation of the Vibrio cholerae Cpx pathway. J Bacteriol (2009) 0.97

The positive regulator, TraJ, of the Escherichia coli F plasmid is unstable in a cpxA* background. J Bacteriol (2002) 0.97

Eliminating a set of four penicillin binding proteins triggers the Rcs phosphorelay and Cpx stress responses in Escherichia coli. J Bacteriol (2013) 0.97

The Cpx envelope stress response both facilitates and inhibits elaboration of the enteropathogenic Escherichia coli bundle-forming pilus. Mol Microbiol (2010) 0.95

Structural basis for two-component system inhibition and pilus sensing by the auxiliary CpxP protein. J Biol Chem (2011) 0.94

The Cpx stress response system potentiates the fitness and virulence of uropathogenic Escherichia coli. Infect Immun (2013) 0.92

Oxygen-limiting conditions enrich for fimbriate cells of uropathogenic Proteus mirabilis and Escherichia coli. J Bacteriol (2008) 0.90

CpxRA influences Xenorhabdus nematophila colonization initiation and outgrowth in Steinernema carpocapsae nematodes through regulation of the nil locus. Appl Environ Microbiol (2009) 0.89

Transcriptional profiling of Actinobacillus pleuropneumoniae during the acute phase of a natural infection in pigs. BMC Genomics (2010) 0.89

Genetic characterization of a multicomponent signal transduction system controlling the expression of cable pili in Burkholderia cenocepacia. J Bacteriol (2004) 0.89

PpiD is a player in the network of periplasmic chaperones in Escherichia coli. BMC Microbiol (2010) 0.88

DegP is involved in Cpx-mediated posttranscriptional regulation of the type III secretion apparatus in enteropathogenic Escherichia coli. Infect Immun (2012) 0.88

Aberrant community architecture and attenuated persistence of uropathogenic Escherichia coli in the absence of individual IHF subunits. PLoS One (2012) 0.87

BarA-UvrY two-component system regulates virulence of uropathogenic E. coli CFT073. PLoS One (2012) 0.87

STM2209-STM2208 (opvAB): a phase variation locus of Salmonella enterica involved in control of O-antigen chain length. PLoS One (2012) 0.87

Negative regulation of DNA repair gene (ung) expression by the CpxR/CpxA two-component system in Escherichia coli K-12 and induction of mutations by increased expression of CpxR. J Bacteriol (2004) 0.85

Adenylate cyclase mutations rescue the degP temperature-sensitive phenotype and induce the sigma E and Cpx extracytoplasmic stress regulons in Escherichia coli. J Bacteriol (2005) 0.84

From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections. Curr Urol Rep (2013) 0.84

Escherichia coli isolate for studying colonization of the mouse intestine and its application to two-component signaling knockouts. J Bacteriol (2014) 0.82

The CpxQ sRNA Negatively Regulates Skp To Prevent Mistargeting of β-Barrel Outer Membrane Proteins into the Cytoplasmic Membrane. MBio (2016) 0.82

Dynamic interaction between the CpxA sensor kinase and the periplasmic accessory protein CpxP mediates signal recognition in E. coli. PLoS One (2014) 0.81

Identification of Actinobacillus suis genes essential for the colonization of the upper respiratory tract of swine. Infect Immun (2005) 0.81

Links between type III secretion and extracytoplasmic stress responses in Yersinia. Front Cell Infect Microbiol (2012) 0.80

Optimization of the inefficient translation initiation region of the cpxP gene from Escherichia coli. Protein Sci (2007) 0.80

Regulation of bacterial virulence gene expression by cell envelope stress responses. Virulence (2014) 0.79

Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections. Microbiol Spectr (2016) 0.77

Molecular and proteome analyses highlight the importance of the Cpx envelope stress system for acid stress and cell wall stability in Escherichia coli. Microbiologyopen (2016) 0.75

Exploitation of a "hockey-puck" phenotype to identify pilus and biofilm regulators in Serratia marcescens through genetic analysis. Can J Microbiol (2015) 0.75

Interaction Analysis of a Two-Component System Using Nanodiscs. PLoS One (2016) 0.75

The Two-Component System CpxRA Negatively Regulates the Locus of Enterocyte Effacement of Enterohemorrhagic Escherichia coli Involving σ(32) and Lon protease. Front Cell Infect Microbiol (2016) 0.75

Comprehensive mutagenesis of the fimS promoter regulatory switch reveals novel regulation of type 1 pili in uropathogenic Escherichia coli. Proc Natl Acad Sci U S A (2016) 0.75

cAMP receptor protein regulates mouse colonization, motility, fimbria-mediated adhesion, and stress tolerance in uropathogenic Proteus mirabilis. Sci Rep (2017) 0.75

An Overview of Two-Component Signal Transduction Systems Implicated in Extra-Intestinal Pathogenic E. coli Infections. Front Cell Infect Microbiol (2017) 0.75

Articles cited by this

Transposition and fusion of the lac genes to selected promoters in Escherichia coli using bacteriophage lambda and Mu. J Mol Biol (1976) 33.01

Improved single and multicopy lac-based cloning vectors for protein and operon fusions. Gene (1987) 24.38

Construction and expression of recombinant plasmids encoding type 1 or D-mannose-resistant pili from a urinary tract infection Escherichia coli isolate. Infect Immun (1981) 14.05

An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins. Proc Natl Acad Sci U S A (1988) 6.31

X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. Science (1999) 4.78

Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature. J Bacteriol (1989) 4.56

Genes of pyelonephritogenic E. coli required for digalactoside-specific agglutination of human cells. EMBO J (1984) 4.22

Genetics of digalactoside-binding adhesin from a uropathogenic Escherichia coli strain. Infect Immun (1983) 4.03

Two pathogenicity islands in uropathogenic Escherichia coli J96: cosmid cloning and sample sequencing. Infect Immun (1996) 3.89

Nucleotide sequence of the papA gene encoding the Pap pilus subunit of human uropathogenic Escherichia coli. J Bacteriol (1984) 3.73

Structural basis of chaperone function and pilus biogenesis. Science (1999) 3.69

The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP. Genes Dev (1995) 3.61

P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips. Nature (1992) 3.47

Deletions of chromosomal regions coding for fimbriae and hemolysins occur in vitro and in vivo in various extraintestinal Escherichia coli isolates. Microb Pathog (1990) 3.18

The Gal(alpha 1-4)Gal-specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract. Proc Natl Acad Sci U S A (1994) 3.02

Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses. Proc Natl Acad Sci U S A (2000) 2.98

Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system. Genes Dev (1997) 2.96

Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes. Proc Natl Acad Sci U S A (1993) 2.91

The sigma(E) and the Cpx signal transduction systems control the synthesis of periplasmic protein-folding enzymes in Escherichia coli. Genes Dev (1997) 2.84

Role of type 1 pili and effects of phase variation on lower urinary tract infections produced by Escherichia coli. Infect Immun (1985) 2.82

Transduction of envelope stress in Escherichia coli by the Cpx two-component system. J Bacteriol (1997) 2.56

Overproduction of NlpE, a new outer membrane lipoprotein, suppresses the toxicity of periplasmic LacZ by activation of the Cpx signal transduction pathway. J Bacteriol (1995) 2.52

The chaperone-assisted membrane release and folding pathway is sensed by two signal transduction systems. EMBO J (1997) 2.52

Specificity of binding of a strain of uropathogenic Escherichia coli to Gal alpha 1----4Gal-containing glycosphingolipids. J Biol Chem (1985) 2.48

CpxP, a stress-combative member of the Cpx regulon. J Bacteriol (1998) 2.42

Genomic analysis of a pathogenicity island in uropathogenic Escherichia coli CFT073: distribution of homologous sequences among isolates from patients with pyelonephritis, cystitis, and Catheter-associated bacteriuria and from fecal samples. Infect Immun (1998) 2.39

Methylation patterns in pap regulatory DNA control pyelonephritis-associated pili phase variation in E. coli. Cell (1994) 2.38

The PapG adhesin of uropathogenic Escherichia coli contains separate regions for receptor binding and for the incorporation into the pilus. Proc Natl Acad Sci U S A (1989) 2.36

Regulation of pap pilin phase variation by a mechanism involving differential dam methylation states. EMBO J (1990) 2.33

Host-specificity of uropathogenic Escherichia coli depends on differences in binding specificity to Gal alpha 1-4Gal-containing isoreceptors. EMBO J (1990) 2.31

The Cpx envelope stress response is controlled by amplification and feedback inhibition. J Bacteriol (1999) 2.26

Gene clusters encoding the cytotoxic necrotizing factor type 1, Prs-fimbriae and alpha-hemolysin form the pathogenicity island II of the uropathogenic Escherichia coli strain J96. FEMS Microbiol Lett (1995) 2.25

Transcriptional activation of a pap pilus virulence operon from uropathogenic Escherichia coli. EMBO J (1985) 2.24

Pathogenicity island sequences of pyelonephritogenic Escherichia coli CFT073 are associated with virulent uropathogenic strains. Infect Immun (1997) 2.21

Bacterial virulence in urinary tract infection. Infect Dis Clin North Am (1997) 2.20

Structural polymorphism of bacterial adhesion pili. Nature (1995) 2.12

Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins. EMBO J (1993) 2.12

Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly. EMBO J (1992) 2.12

Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters. J Bacteriol (1996) 2.10

Phase-variation of pyelonephritis-associated pili in Escherichia coli: evidence for transcriptional regulation. EMBO J (1989) 2.03

The PapC usher forms an oligomeric channel: implications for pilus biogenesis across the outer membrane. Proc Natl Acad Sci U S A (1998) 2.01

PapD-like chaperones provide the missing information for folding of pilin proteins. Proc Natl Acad Sci U S A (2000) 1.98

The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component. J Mol Biol (1988) 1.90

Molecular basis of two subfamilies of immunoglobulin-like chaperones. EMBO J (1996) 1.88

The chaperone/usher pathway: a major terminal branch of the general secretory pathway. Curr Opin Microbiol (1998) 1.86

Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. EMBO J (1992) 1.79

Ramifications of kinetic partitioning on usher-mediated pilus biogenesis. EMBO J (1998) 1.76

Chaperone-assisted self-assembly of pili independent of cellular energy. J Biol Chem (1994) 1.74

Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses. Mol Microbiol (1995) 1.70

Saccharide orientation at the cell surface affects glycolipid receptor function. Proc Natl Acad Sci U S A (1991) 1.69

The deduced amino-acid sequence of the cloned cpxR gene suggests the protein is the cognate regulator for the membrane sensor, CpxA, in a two-component signal transduction system of Escherichia coli. Gene (1993) 1.68

Involvement of cpxA, a sensor of a two-component regulatory system, in the pH-dependent regulation of expression of Shigella sonnei virF gene. J Bacteriol (1995) 1.68

Evidence for a methylation-blocking factor (mbf) locus involved in pap pilus expression and phase variation in Escherichia coli. J Bacteriol (1991) 1.64

Epigenetic phase variation of the pap operon in Escherichia coli. Trends Microbiol (1996) 1.63

Helical structure of P pili from Escherichia coli. Evidence from X-ray fiber diffraction and scanning transmission electron microscopy. J Mol Biol (1992) 1.63

Environmental temperature regulates transcription of a virulence pili operon in E. coli. EMBO J (1984) 1.62

PapD chaperone function in pilus biogenesis depends on oxidant and chaperone-like activities of DsbA. Proc Natl Acad Sci U S A (1994) 1.58

Antirepression function in Escherichia coli for the cAMP-cAMP receptor protein transcriptional activator. Proc Natl Acad Sci U S A (1992) 1.54

In vivo phase variation of Escherichia coli type 1 fimbrial genes in women with urinary tract infection. Infect Immun (1998) 1.50

The Cpx two-component signal transduction pathway is activated in Escherichia coli mutant strains lacking phosphatidylethanolamine. J Bacteriol (1997) 1.50

Differential binding of Lrp to two sets of pap DNA binding sites mediated by Pap I regulates Pap phase variation in Escherichia coli. EMBO J (1995) 1.46

Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli. J Bacteriol (1998) 1.43

Periplasmic chaperone recognition motif of subunits mediates quaternary interactions in the pilus. EMBO J (1998) 1.40

Thermoregulation of Escherichia coli pap transcription: H-NS is a temperature-dependent DNA methylation blocking factor. Mol Microbiol (1998) 1.27

In vivo expression and variation of Escherichia coli type 1 and P pili in the urine of adults with acute urinary tract infections. Infect Immun (1989) 1.24

Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon. Mol Microbiol (1995) 1.23

Autoregulation and multiple DNA interactions by a transcriptional regulatory protein in E. coli pili biogenesis. EMBO J (1989) 1.22

Specific binding of PapI to Lrp-pap DNA complexes. J Bacteriol (1995) 1.09

Regulation of Pap phase variation. Lrp is sufficient for the establishment of the phase off pap DNA methylation pattern and repression of pap transcription in vitro. J Biol Chem (2000) 1.01

Structural basis of chaperone self-capping in P pilus biogenesis. Proc Natl Acad Sci U S A (1999) 0.95

Urinary nitric oxide synthase activity and cyclic GMP levels are decreased with interstitial cystitis and increased with urinary tract infections. J Urol (1996) 0.93

Nitric oxide in the lower urinary tract: physiological and pathological implications. BJU Int (2000) 0.90

Use of a two-color genetic screen to identify a domain of the global regulator Lrp that is specifically required for pap phase variation. J Bacteriol (1998) 0.81

Articles by these authors

Genetic analysis of the ompB locus in Escherichia coli K-12. J Mol Biol (1981) 8.18

Induction and evasion of host defenses by type 1-piliated uropathogenic Escherichia coli. Science (1998) 8.16

The ompB locus and the regulation of the major outer membrane porin proteins of Escherichia coli K12. J Mol Biol (1981) 7.69

Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science (1999) 6.49

Use of gene fusion to study secretion of maltose-binding protein into Escherichia coli periplasm. J Bacteriol (1979) 6.38

Suppressor mutations that restore export of a protein with a defective signal sequence. Cell (1981) 6.33

Mechanisms of protein localization. Microbiol Rev (1983) 6.12

Genetic analysis of the major outer membrane proteins of Escherichia coli. Annu Rev Genet (1981) 5.30

Maltose transport in Escherichia coli K12. A comparison of transport kinetics in wild-type and lambda-resistant mutants as measured by fluorescence quenching. Eur J Biochem (1976) 5.25

Type 1 pilus-mediated bacterial invasion of bladder epithelial cells. EMBO J (2000) 5.03

Establishment of a persistent Escherichia coli reservoir during the acute phase of a bladder infection. Infect Immun (2001) 4.82

X-ray structure of the FimC-FimH chaperone-adhesin complex from uropathogenic Escherichia coli. Science (1999) 4.78

Conversion of beta-galactosidase to a membrane-bound state by gene fusion. Proc Natl Acad Sci U S A (1976) 4.61

Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Science (1997) 4.57

Uses of lac fusions for the study of biological problems. Microbiol Rev (1985) 4.38

Phosphorylation and dephosphorylation of a bacterial transcriptional activator by a transmembrane receptor. Genes Dev (1989) 4.05

Transcriptional regulation of Escherichia coli K-12 major outer membrane protein 1b. J Bacteriol (1979) 3.85

Use of gene fusions to study outer membrane protein localization in Escherichia coli. Proc Natl Acad Sci U S A (1977) 3.78

Structural basis of chaperone function and pilus biogenesis. Science (1999) 3.69

Mutations affecting localization of an Escherichia coli outer membrane protein, the bacteriophage lambda receptor. J Mol Biol (1980) 3.62

The Cpx two-component signal transduction pathway of Escherichia coli regulates transcription of the gene specifying the stress-inducible periplasmic protease, DegP. Genes Dev (1995) 3.61

Transposable lambda placMu bacteriophages for creating lacZ operon fusions and kanamycin resistance insertions in Escherichia coli. J Bacteriol (1985) 3.54

FimH adhesin of type 1 pili is assembled into a fibrillar tip structure in the Enterobacteriaceae. Proc Natl Acad Sci U S A (1995) 3.51

P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips. Nature (1992) 3.47

Dominant constitutive mutations in malT, the positive regulator gene of the maltose regulon in Escherichia coli. J Mol Biol (1978) 3.46

The E. coli ffh gene is necessary for viability and efficient protein export. Nature (1992) 3.45

Sequence analysis of mutations that prevent export of lambda receptor, an Escherichia coli outer membrane protein. Nature (1980) 3.36

Periplasmic stress and ECF sigma factors. Annu Rev Microbiol (2001) 3.21

Open reading frame expression vectors: a general method for antigen production in Escherichia coli using protein fusions to beta-galactosidase. Proc Natl Acad Sci U S A (1983) 3.09

EnvZ, a transmembrane environmental sensor of Escherichia coli K-12, is phosphorylated in vitro. J Bacteriol (1988) 3.04

Bacterial adhesins: common themes and variations in architecture and assembly. J Bacteriol (1999) 3.01

cis-acting ompF mutations that result in OmpR-dependent constitutive expression. J Bacteriol (1991) 2.99

Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses. Proc Natl Acad Sci U S A (2000) 2.98

A mechanism of protein localization: the signal hypothesis and bacteria. J Cell Biol (1980) 2.91

Outer-membrane PapC molecular usher discriminately recognizes periplasmic chaperone-pilus subunit complexes. Proc Natl Acad Sci U S A (1993) 2.91

From acids to osmZ: multiple factors influence synthesis of the OmpF and OmpC porins in Escherichia coli. Mol Microbiol (1996) 2.86

The sigma(E) and the Cpx signal transduction systems control the synthesis of periplasmic protein-folding enzymes in Escherichia coli. Genes Dev (1997) 2.84

A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery. Cell (1982) 2.84

Structure of the malB region in Escherichia coli K12. II. Genetic map of the malE,F,G operon. Mol Gen Genet (1979) 2.83

Role of type 1 pili and effects of phase variation on lower urinary tract infections produced by Escherichia coli. Infect Immun (1985) 2.82

Genetic analysis of protein export in Escherichia coli K12. Annu Rev Biochem (1985) 2.78

EnvZ controls the concentration of phosphorylated OmpR to mediate osmoregulation of the porin genes. J Mol Biol (1991) 2.78

The response regulator SprE controls the stability of RpoS. Proc Natl Acad Sci U S A (1996) 2.71

Regulation of production of type 1 pili among urinary tract isolates of Escherichia coli. Infect Immun (1986) 2.65

Labeling of proteins with beta-galactosidase by gene fusion. Identification of a cytoplasmic membrane component of the Escherichia coli maltose transport system. J Biol Chem (1980) 2.63

Isolation and characterization of chain-terminating nonsense mutations in a porin regulator gene, envZ. J Bacteriol (1983) 2.61

A bacterial environmental sensor that functions as a protein kinase and stimulates transcriptional activation. Genes Dev (1989) 2.60

Transduction of envelope stress in Escherichia coli by the Cpx two-component system. J Bacteriol (1997) 2.56

Overproduction of NlpE, a new outer membrane lipoprotein, suppresses the toxicity of periplasmic LacZ by activation of the Cpx signal transduction pathway. J Bacteriol (1995) 2.52

The chaperone-assisted membrane release and folding pathway is sensed by two signal transduction systems. EMBO J (1997) 2.52

Lambda placMu: a transposable derivative of bacteriophage lambda for creating lacZ protein fusions in a single step. J Bacteriol (1984) 2.52

Function of conserved histidine-243 in phosphatase activity of EnvZ, the sensor for porin osmoregulation in Escherichia coli. J Bacteriol (1997) 2.48

Bacterial pili: molecular mechanisms of pathogenesis. Curr Opin Microbiol (2000) 2.43

CpxP, a stress-combative member of the Cpx regulon. J Bacteriol (1998) 2.42

Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli. J Infect Dis (2000) 2.37

Mutations altering the cellular localization of the phage lambda receptor, an Escherichia coli outer membrane protein. Proc Natl Acad Sci U S A (1978) 2.37

Identification of OmpR: a positive regulatory protein controlling expression of the major outer membrane matrix porin proteins of Escherichia coli K-12. J Bacteriol (1981) 2.36

Genetic evidence for parallel pathways of chaperone activity in the periplasm of Escherichia coli. J Bacteriol (2001) 2.33

Kinetic analysis of lamB mutants suggests the signal sequence plays multiple roles in protein export. J Biol Chem (1986) 2.33

Structural basis of pilus subunit recognition by the PapD chaperone. Science (1993) 2.30

Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism. J Immunol (2001) 2.27

The Cpx envelope stress response is controlled by amplification and feedback inhibition. J Bacteriol (1999) 2.26

Immunoglobulin-like PapD chaperone caps and uncaps interactive surfaces of nascently translocated pilus subunits. Proc Natl Acad Sci U S A (1991) 2.25

Targeting and assembly of periplasmic and outer-membrane proteins in Escherichia coli. Annu Rev Genet (1998) 2.20

The sigmaE and Cpx regulatory pathways: overlapping but distinct envelope stress responses. Curr Opin Microbiol (1999) 2.20

EnvZ functions through OmpR to control porin gene expression in Escherichia coli K-12. J Bacteriol (1988) 2.20

Sequence information within the lamB genes in required for proper routing of the bacteriophage lambda receptor protein to the outer membrane of Escherichia coli K-12. J Mol Biol (1982) 2.20

Mutations that alter the kinase and phosphatase activities of the two-component sensor EnvZ. J Bacteriol (1998) 2.19

PapD, a periplasmic transport protein in P-pilus biogenesis. J Bacteriol (1989) 2.19

Effects of temperature on Vitalograph spirometer readings. Thorax (1983) 2.13

Multiple pathways allow protein secretion across the bacterial outer membrane. Curr Opin Cell Biol (2000) 2.12

Interactive surface in the PapD chaperone cleft is conserved in pilus chaperone superfamily and essential in subunit recognition and assembly. EMBO J (1992) 2.12

The sec and prl genes of Escherichia coli. J Bioenerg Biomembr (1990) 2.07

Heat-shock proteins DnaK and GroEL facilitate export of LacZ hybrid proteins in E. coli. Nature (1990) 2.05

The PapC usher forms an oligomeric channel: implications for pilus biogenesis across the outer membrane. Proc Natl Acad Sci U S A (1998) 2.01

A signal sequence is not sufficient to lead beta-galactosidase out of the cytoplasm. Nature (1980) 2.00

PrlA (SecY) and PrlG (SecE) interact directly and function sequentially during protein translocation in E. coli. Cell (1990) 1.99

Isolation and characterization of delta ompB strains of Escherichia coli by a general method based on gene fusions. J Bacteriol (1985) 1.99

PapD-like chaperones provide the missing information for folding of pilin proteins. Proc Natl Acad Sci U S A (2000) 1.98

Importance of secondary structure in the signal sequence for protein secretion. Proc Natl Acad Sci U S A (1983) 1.98

Isolation and characterization of mutations altering expression of the major outer membrane porin proteins using the local anaesthetic procaine. J Mol Biol (1983) 1.97

Information within the mature LamB protein necessary for localization to the outer membrane of E coli K12. Cell (1983) 1.94

A genetic approach for analyzing the pathway of LamB assembly into the outer membrane of Escherichia coli. J Biol Chem (1991) 1.92

cis-acting sites required for osmoregulation of ompF expression in Escherichia coli K-12. J Bacteriol (1986) 1.90

D-ribose metabolism in Escherichia coli K-12: genetics, regulation, and transport. J Bacteriol (1984) 1.89

One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery. EMBO J (1991) 1.89

Genetic analysis of protein export in Escherichia coli. Methods Enzymol (1983) 1.88

Molecular basis of two subfamilies of immunoglobulin-like chaperones. EMBO J (1996) 1.88

The chaperone/usher pathway: a major terminal branch of the general secretory pathway. Curr Opin Microbiol (1998) 1.86

FimC is a periplasmic PapD-like chaperone that directs assembly of type 1 pili in bacteria. Proc Natl Acad Sci U S A (1993) 1.86

Genetic analysis of the switch that controls porin gene expression in Escherichia coli K-12. J Mol Biol (1989) 1.85

The essential tension: opposed reactions in bacterial two-component regulatory systems. Trends Microbiol (1993) 1.85

On the significance of the retention of ligand by protein. Proc Natl Acad Sci U S A (1975) 1.83

Identification of the malK gene product. A peripheral membrane component of the Escherichia coli maltose transport system. J Biol Chem (1981) 1.80

Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor. Cell (2001) 1.79

Conserved immunoglobulin-like features in a family of periplasmic pilus chaperones in bacteria. EMBO J (1992) 1.79

Suppressor mutations in rpoA suggest that OmpR controls transcription by direct interaction with the alpha subunit of RNA polymerase. J Bacteriol (1991) 1.77

Genetic evidence for interaction of sigma E with the spoIIID promoter in Bacillus subtilis. J Bacteriol (1991) 1.77