Published in Nat Cell Biol on May 01, 2001
Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer (2010) 5.26
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell (2009) 3.40
Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res (2010) 2.80
The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting. Mol Cancer Res (2008) 2.21
Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nat Neurosci (2010) 2.17
The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest (2008) 2.11
Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity. J Neurosci (2009) 1.83
EPHA2 is associated with age-related cortical cataract in mice and humans. PLoS Genet (2009) 1.82
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An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans. Genes Dev (2003) 1.65
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Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer. Clin Exp Metastasis (2003) 1.53
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Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. Oncogene (2008) 1.41
Eph receptor signaling and ephrins. Cold Spring Harb Perspect Biol (2013) 1.33
EphA kinase activation regulates HGF-induced epithelial branching morphogenesis. J Cell Biol (2003) 1.32
EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. Mol Biol Cell (2009) 1.30
Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signalling in pancreatic cancer. Br J Cancer (2008) 1.27
EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis. Development (2009) 1.26
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Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells. Nat Cell Biol (2014) 1.21
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol (2003) 1.20
Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis. J Oncol (2010) 1.17
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Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains. Proc Natl Acad Sci U S A (2005) 1.14
The Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain. Mol Cell Biol (2003) 1.14
EphrinA1 inhibits vascular endothelial growth factor-induced intracellular signaling and suppresses retinal neovascularization and blood-retinal barrier breakdown. Am J Pathol (2006) 1.11
Eph receptors in breast cancer: roles in tumor promotion and tumor suppression. Breast Cancer Res (2008) 1.10
Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol Biol Cell (2002) 1.09
EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties. Oncogene (2014) 1.08
Crosstalk of the EphA2 receptor with a serine/threonine phosphatase suppresses the Akt-mTORC1 pathway in cancer cells. Cell Signal (2010) 1.08
Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway. J Cell Biol (2008) 1.07
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A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. Oncogene (2010) 1.06
Clinical relevance of Ephs and ephrins in cancer: lessons from breast, colorectal, and lung cancer profiling. Semin Cell Dev Biol (2011) 1.00
EphA receptor signaling--complexity and emerging themes. Semin Cell Dev Biol (2011) 1.00
Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. Mol Cell Biol (2007) 0.99
Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases. Adv Cancer Res (2012) 0.98
Distribution of EphA5 receptor protein in the developing and adult mouse nervous system. J Comp Neurol (2009) 0.98
Eph receptors and ephrins as targets for cancer therapy. J Cell Mol Med (2012) 0.98
Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. Mol Biol Cell (2010) 0.97
Structure-activity relationship analysis of peptides targeting the EphA2 receptor. Biochemistry (2010) 0.97
Attenuation of eph receptor kinase activation in cancer cells by coexpressed ephrin ligands. PLoS One (2013) 0.94
EphB6 crosslinking results in costimulation of T cells. J Clin Invest (2002) 0.93
Irradiation affects cellular properties and Eph receptor expression in human melanoma cells. Cell Adh Migr (2012) 0.93
NMR structure of a heterodimeric SAM:SAM complex: characterization and manipulation of EphA2 binding reveal new cellular functions of SHIP2. Structure (2012) 0.93
JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer. Cancer Res (2014) 0.91
Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode. Nat Commun (2015) 0.89
A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation. J Exp Med (2011) 0.89
A subset of signal transduction pathways is required for hippocampal growth cone collapse induced by ephrin-A5. Dev Neurobiol (2008) 0.88
EphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration. Invest Ophthalmol Vis Sci (2012) 0.86
Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther (2014) 0.86
The role of EPH receptors in cancer-related epithelial-mesenchymal transition. Chin J Cancer (2013) 0.85
Variable metastatic potentials correlate with differential plectin and vimentin expression in syngeneic androgen independent prostate cancer cells. PLoS One (2013) 0.85
Targeted delivery of let-7a microRNA encapsulated ephrin-A1 conjugated liposomal nanoparticles inhibit tumor growth in lung cancer. Int J Nanomedicine (2013) 0.85
Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis. J Invest Dermatol (2012) 0.84
Redox regulation of ephrin/integrin cross-talk. Cell Adh Migr (2007) 0.84
Structural and functional characterization of monomeric EphrinA1 binding site to EphA2 receptor. J Biol Chem (2012) 0.84
Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization. Oncotarget (2015) 0.84
Ephrin-A5 suppresses neurotrophin evoked neuronal motility, ERK activation and gene expression. PLoS One (2011) 0.84
EphrinA/EphA signal facilitates insulin-like growth factor-I-induced myogenic differentiation through suppression of the Ras/extracellular signal-regulated kinase 1/2 cascade in myoblast cell lines. Mol Biol Cell (2011) 0.84
p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos. Development (2013) 0.84
Expression and functional effects of Eph receptor tyrosine kinase A family members on Langerhans like dendritic cells. BMC Immunol (2004) 0.83
Multiple signaling pathways coordinate to induce a threshold response in a chordate embryo. PLoS Genet (2013) 0.83
Design and Synthesis of Potent Bivalent Peptide Agonists Targeting the EphA2 Receptor. ACS Med Chem Lett (2013) 0.83
Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase. J Biol Chem (2013) 0.83
Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein. Cancer Res (2015) 0.83
Eph/ephrin signaling in epidermal differentiation and disease. Semin Cell Dev Biol (2011) 0.82
Ephrin-A1-mediated dopaminergic neurogenesis and angiogenesis in a rat model of Parkinson's disease. PLoS One (2012) 0.82
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A systems biology approach to the global analysis of transcription factors in colorectal cancer. BMC Cancer (2012) 0.80
Regulation of cell differentiation by Eph receptor and ephrin signaling. Cell Adh Migr (2014) 0.79
EPH-EPHRIN in human gastrointestinal cancers. World J Gastrointest Oncol (2010) 0.79
Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget (2016) 0.79
Xtalk: a path-based approach for identifying crosstalk between signaling pathways. Bioinformatics (2015) 0.78
Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice. Oncotarget (2015) 0.78
High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries. J Biomol Screen (2012) 0.78
EphA2 silencing promotes growth, migration, and metastasis in salivary adenoid cystic carcinoma: in vitro and in vivo study. Am J Transl Res (2016) 0.77
Prognostic significance of combinations of RNA-dependent protein kinase and EphA2 biomarkers for NSCLC. J Thorac Oncol (2013) 0.77
EphA activation overrides the presynaptic actions of BDNF. J Neurophysiol (2011) 0.76
Compression induces Ephrin-A2 in PDL fibroblasts via c-fos. J Dent Res (2015) 0.75
Expression of microRNA‑26b and identification of its target gene EphA2 in pituitary tissues in Yanbian cattle. Mol Med Rep (2015) 0.75
EphA2 and ephrin-A5 are not a receptor-ligand pair in the ocular lens. Exp Eye Res (2017) 0.75
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