Published in Cancer Res on December 01, 1998
CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A (1999) 13.02
Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res (2010) 6.03
Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet (1999) 4.16
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A (2007) 4.16
DNA hypomethylation in cancer cells. Epigenomics (2009) 3.71
Investigating stem cells in human colon by using methylation patterns. Proc Natl Acad Sci U S A (2001) 3.56
Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res (2010) 2.99
Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns. Hum Mol Genet (2009) 2.85
Age-associated DNA methylation in pediatric populations. Genome Res (2012) 2.53
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19-associated CTCF-binding sites in colorectal cancer. Proc Natl Acad Sci U S A (2000) 2.38
Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands. Gut (2002) 2.31
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res (2008) 2.08
Aging and chronic sun exposure cause distinct epigenetic changes in human skin. PLoS Genet (2010) 2.03
Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy. Clin Cancer Res (2007) 2.02
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell (2014) 1.99
Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology (2008) 1.97
Tissue-specific dysregulation of DNA methylation in aging. Aging Cell (2010) 1.90
Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol (2003) 1.79
Age-associated epigenetic drift: implications, and a case of epigenetic thrift? Hum Mol Genet (2013) 1.76
Fidelity of the methylation pattern and its variation in the genome. Genome Res (2003) 1.71
Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. Fam Cancer (2004) 1.66
A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus. Cancer Res (2009) 1.65
Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma. Gut (2005) 1.65
Aging and epigenetic drift: a vicious cycle. J Clin Invest (2014) 1.63
Colorectal cancer: a model for epigenetic tumorigenesis. Gut (2006) 1.62
Epigenetics of colorectal cancer. Gastroenterology (2012) 1.60
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol (2004) 1.58
An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs. Am J Physiol Regul Integr Comp Physiol (2008) 1.56
Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization. Cancer Res (2012) 1.53
Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am J Pathol (2002) 1.48
Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. Hum Mol Genet (2008) 1.47
Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues. Epigenetics (2010) 1.41
DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. Br J Cancer (2006) 1.36
Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology (2014) 1.32
Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. Mol Cancer (2008) 1.31
Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate. Cancer Res (2008) 1.30
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers. Proc Natl Acad Sci U S A (1999) 1.28
A comparison of feature selection and classification methods in DNA methylation studies using the Illumina Infinium platform. BMC Bioinformatics (2012) 1.26
Aging by epigenetics--a consequence of chromatin damage? Exp Cell Res (2008) 1.25
DNA methylation: an alternative pathway to cancer. Ann Surg (2001) 1.24
Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci U S A (2005) 1.24
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. Gastroenterology (2015) 1.24
Aging and epigenetics: longitudinal changes in gene-specific DNA methylation. Epigenetics (2012) 1.23
Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res (2008) 1.22
Epigenetic alterations in aging. J Appl Physiol (1985) (2010) 1.20
Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS One (2011) 1.19
Array-based profiling of reference-independent methylation status (aPRIMES) identifies frequent promoter methylation and consecutive downregulation of ZIC2 in pediatric medulloblastoma. Nucleic Acids Res (2007) 1.19
DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PLoS One (2011) 1.16
CIMP and colon cancer gets more complicated. Gut (2007) 1.16
Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa. Cancer Prev Res (Phila) (2010) 1.15
HDAC3 impacts multiple oncogenic pathways in colon cancer cells with effects on Wnt and vitamin D signaling. Cancer Biol Ther (2008) 1.13
Intergenic, gene terminal, and intragenic CpG islands in the human genome. BMC Genomics (2010) 1.13
Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer. Ann Oncol (2008) 1.12
Digital transcriptome profiling of normal and glioblastoma-derived neural stem cells identifies genes associated with patient survival. Genome Med (2012) 1.11
Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS). Nucleic Acids Res (2002) 1.11
Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. Clin Cancer Res (2006) 1.10
Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer. Carcinogenesis (2013) 1.08
Concordant DNA methylation in synchronous colorectal carcinomas. Cancer Prev Res (Phila) (2009) 1.08
Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer. Genome Res (2010) 1.08
Genome-wide DNA methylation changes with age in disease-free human skeletal muscle. Aging Cell (2013) 1.08
The central role of chromatin maintenance in aging. Aging (Albany NY) (2009) 1.07
Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals. Am J Pathol (2001) 1.07
Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer. Dose Response (2009) 1.07
Rare and frequent promoter methylation, respectively, of TSHZ2 and 3 genes that are both downregulated in expression in breast and prostate cancers. PLoS One (2011) 1.06
Age-related human small intestine methylation: evidence for stem cell niches. BMC Med (2005) 1.06
RUNX3 methylation reveals that bladder tumors are older in patients with a history of smoking. Cancer Res (2008) 1.05
Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning. Endocr Relat Cancer (2011) 1.03
SFRP2 methylation in fecal DNA--a marker for colorectal polyps. Int J Colorectal Dis (2007) 1.02
Serrated polyposis: an enigmatic model of colorectal cancer predisposition. Patholog Res Int (2011) 1.01
Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age. Epigenetics (2014) 1.00
Quantitative methylation profiling in tumor and matched morphologically normal tissues from breast cancer patients. BMC Cancer (2010) 0.99
p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis. Cancer Metastasis Rev (2010) 0.99
RET is a potential tumor suppressor gene in colorectal cancer. Oncogene (2012) 0.98
Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts. Nucleic Acids Res (1999) 0.98
Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon. BMC Gastroenterol (2004) 0.98
Epigenetic DNA hypermethylation in cholangiocarcinoma: potential roles in pathogenesis, diagnosis and identification of treatment targets. Liver Int (2007) 0.95
Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability. Br J Cancer (2002) 0.95
DNA methylation in circulating tumour DNA as a biomarker for cancer. Biomark Insights (2008) 0.95
Epigenetic changes (aberrant DNA methylation) in colorectal neoplasia. Gut Liver (2007) 0.94
Epigenetic changes in colorectal cancer. Chin J Cancer (2011) 0.94
Distinctive topology of age-associated epigenetic drift in the human interactome. Proc Natl Acad Sci U S A (2013) 0.94
Epigenetic susceptibility factors for prostate cancer with aging. Prostate (2013) 0.94
The important molecular markers on chromosome 17 and their clinical impact in breast cancer. Int J Mol Sci (2011) 0.93
DNA methylation profiling in Barrett's esophagus and esophageal adenocarcinoma reveals unique methylation signatures and molecular subclasses. Epigenetics (2011) 0.93
DNA methylation of SPARC and chronic low back pain. Mol Pain (2011) 0.93
A Robust Unified Approach to Analyzing Methylation and Gene Expression Data. Comput Stat Data Anal (2009) 0.92
Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution. PLoS Genet (2016) 0.92
An overview of epigenetics and chemoprevention. FEBS Lett (2010) 0.92
Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. Int J Cancer (2011) 0.91
DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PLoS One (2011) 0.90
Postnatal development- and age-related changes in DNA-methylation patterns in the human genome. Nucleic Acids Res (2012) 0.89
Hypermethylation of the CpG island spanning from exon II to intron III is associated with steroidogenic factor 1 expression in stromal cells of endometriosis. Reprod Sci (2011) 0.89
Azacytidine (Vidaza(R)) in the treatment of myelodysplastic syndromes. Ther Clin Risk Manag (2006) 0.89
Field cancerization in the colon: a role for aberrant DNA methylation? Gastroenterol Rep (Oxf) (2014) 0.88
Clinical characteristics of hepatocellular carcinoma in elderly patients. Oncol Lett (2011) 0.88
CpG island hypermethylation in gastric carcinoma and its premalignant lesions. Korean J Pathol (2012) 0.87
Promoter region methylation does not account for the frequent loss of expression of the Fas gene in colorectal carcinoma. Br J Cancer (2000) 0.86
Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer. Br J Cancer (2001) 0.86
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A (1996) 29.54
CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A (1999) 13.02
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med (2000) 12.34
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet (1999) 9.53
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med (1995) 9.10
Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res (1998) 8.95
A gene hypermethylation profile of human cancer. Cancer Res (2001) 8.93
The "beta-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci U S A (1985) 8.35
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet (1994) 8.34
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res (1995) 7.42
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst (2000) 6.38
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res (1999) 6.10
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet (2000) 5.72
Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol (1995) 5.67
Individual-level predictors of cessation behaviours among participants in the International Tobacco Control (ITC) Four Country Survey. Tob Control (2006) 5.63
Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques (2003) 5.49
E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res (1995) 5.11
Membrane compartmentation is required for efficient T cell activation. Immunity (1998) 5.00
Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell (2001) 4.61
Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci U S A (1992) 4.38
Higher cigarette prices influence cigarette purchase patterns. Tob Control (2005) 3.98
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci U S A (1998) 3.80
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem (2000) 3.74
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci U S A (2000) 3.65
Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res (2000) 3.65
Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res (1996) 3.50
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res (1999) 3.48
Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol (2000) 3.38
Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A (2000) 3.38
Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J Biol Chem (2001) 3.23
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res (1994) 3.18
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res (1997) 3.17
Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res (1999) 3.15
Association between CpG island methylation and microsatellite instability in colorectal cancer. Cancer Res (1997) 3.09
China's forest policy for the 21st century. Science (2000) 3.04
Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer. Cancer Res (2000) 2.99
Methylation patterns of the E-cadherin 5' CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem (2000) 2.97
CpG methylation is maintained in human cancer cells lacking DNMT1. Nature (2000) 2.94
Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res (2001) 2.79
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res (2000) 2.79
Epstein-Barr virus uses different complexes of glycoproteins gH and gL to infect B lymphocytes and epithelial cells. J Virol (1998) 2.71
Hypoxia inhibits G1/S transition through regulation of p27 expression. J Biol Chem (2000) 2.70
Biomechanical energy harvesting: generating electricity during walking with minimal user effort. Science (2008) 2.66
Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. J Int Med Res (2011) 2.64
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res (1999) 2.62
Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med (2001) 2.60
Complete genome sequence of the shrimp white spot bacilliform virus. J Virol (2001) 2.58
Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies. Blood (1999) 2.57
DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis. Hum Mol Genet (2001) 2.50
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med (1995) 2.47
Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. Mol Pharmacol (1996) 2.45
Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res (2000) 2.40
The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem (2001) 2.37
Methylation-specific PCR simplifies imprinting analysis. Nat Genet (1997) 2.33
An achaete-scute homologue essential for neuroendocrine differentiation in the lung. Nature (1997) 2.29
Association of HbA1c levels with vascular complications and death in patients with type 2 diabetes: evidence of glycaemic thresholds. Diabetologia (2011) 2.28
Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation. J Biol Chem (1997) 2.27
The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. J Cell Biol (2000) 2.26
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Mol Cell Biol (1996) 2.26
DNA methylation, chromatin inheritance, and cancer. Oncogene (2001) 2.26
Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization and wound healing. Exp Eye Res (1996) 2.25
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway. Nat Cell Biol (2001) 2.25
Overlapping genomic sequences: a treasure trove of single-nucleotide polymorphisms. Genome Res (1998) 2.24
Single-nucleotide polymorphisms in the public domain: how useful are they? Nat Genet (2001) 2.24
Methylation profiling in acute myeloid leukemia. Blood (2001) 2.22
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers. Cancer Res (1999) 2.17
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet (1999) 2.16
The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia. Proc Natl Acad Sci U S A (1988) 2.14
Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br J Cancer (2008) 2.13
Second messenger cascade specificity and pharmacological selectivity of the human P2Y1-purinoceptor. Br J Pharmacol (1996) 2.12
Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res (1997) 2.12
Function of the c-Myc oncogenic transcription factor. Exp Cell Res (1999) 2.11
Isolation and characterization of the cDNA encoding human DNA methyltransferase. Nucleic Acids Res (1992) 2.10
Establishment of continuous, clonable cultures of small-cell carcinoma of lung which have amine precursor uptake and decarboxylation cell properties. Cancer Res (1980) 2.10
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci U S A (1991) 2.07
Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human epsilon-globin gene. J Biol Chem (1985) 2.02
Establishment of a small animal model for human Helicobacter pylori infection using germ-free mouse. Am J Gastroenterol (1994) 2.00
Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. Proc Natl Acad Sci U S A (1997) 2.00
Dynamin is required for recombinant adeno-associated virus type 2 infection. J Virol (1999) 1.99
Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci U S A (1996) 1.99
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene (1998) 1.99
Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. Proc Natl Acad Sci U S A (1993) 1.97
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis. Cancer Res (2001) 1.97
Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res (2000) 1.95
Circadian expression of clock genes in human oral mucosa and skin: association with specific cell-cycle phases. Am J Pathol (2001) 1.94
Increased cytosine DNA-methyltransferase activity during colon cancer progression. J Natl Cancer Inst (1993) 1.94