Published in Diabetes on May 01, 2001
A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet (2001) 8.47
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol (2005) 2.14
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev (2008) 1.66
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes (2010) 1.62
Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. Am J Hum Genet (2001) 1.49
Genetics of the HLA region in the prediction of type 1 diabetes. Curr Diab Rep (2011) 1.30
Genetics of type 1 diabetes. Cold Spring Harb Perspect Med (2012) 1.25
Evidence for association of the TCF7 locus with type I diabetes. Genes Immun (2009) 1.15
Extreme genetic risk for type 1A diabetes in the post-genome era. J Autoimmun (2008) 1.00
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk. Nat Genet (2015) 1.00
Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. Hum Immunol (2008) 0.94
Immunogenetics of type 1 diabetes mellitus. Mol Aspects Med (2015) 0.89
Association analysis of SNPs in the IL4R locus with type I diabetes. Genes Immun (2009) 0.87
Search for haplotype interactions that influence susceptibility to type 1 diabetes, through use of unphased genotype data. Am J Hum Genet (2003) 0.84
Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC. Hum Genet (2010) 0.82
Variation of the myelin oligodendrocyte glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population. BMC Genet (2007) 0.80
A functional framework for interpretation of genetic associations in T1D. Curr Opin Immunol (2012) 0.76
Recursive organizer (ROR): an analytic framework for sequence-based association analysis. Hum Genet (2013) 0.75
Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science (1996) 18.38
Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med (1997) 16.44
Haplotype tagging for the identification of common disease genes. Nat Genet (2001) 11.27
Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature (1994) 9.06
Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature (1997) 7.33
Quantitation of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med (1995) 6.90
Diabetes in identical twins. A study of 200 pairs. Diabetologia (1981) 5.02
Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med (1996) 4.44
Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis. Diabetologia (2010) 4.33
Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet (1996) 4.09
The genetically isolated populations of Finland and sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes. Nat Genet (2000) 3.92
Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress. Mol Psychiatry (2004) 3.90
Genetic analysis of autoimmune disease. Cell (1996) 3.87
Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol (1995) 3.71
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat Genet (1997) 3.62
Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites. Nucleic Acids Res (1990) 3.59
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J (1999) 3.51
Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus. Genes Immun (2008) 3.48
The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet (1996) 3.37
Rapid and precise quantification of HIV-1 RNA in plasma using a branched DNA signal amplification assay. J Acquir Immune Defic Syndr Hum Retrovirol (1995) 3.23
Towards fully automated genome-wide polymorphism screening. Nat Genet (1995) 3.13
Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. Am J Hum Genet (1995) 3.02
Repair of DNA base-pair mismatches in extracts of Escherichia coli. Cold Spring Harb Symp Quant Biol (1984) 2.96
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res (2000) 2.86
A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat Genet (1998) 2.85
Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1. Nature (1991) 2.84
Initiation of methyl-directed mismatch repair. J Biol Chem (1992) 2.82
Insulin adherence behaviours and barriers in the multinational Global Attitudes of Patients and Physicians in Insulin Therapy study. Diabet Med (2012) 2.80
CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun (2008) 2.76
Hopping hotspots: global shifts in marine biodiversity. Science (2008) 2.68
Effect of linagliptin monotherapy on glycaemic control and markers of β-cell function in patients with inadequately controlled type 2 diabetes: a randomized controlled trial. Diabetes Obes Metab (2011) 2.68
A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem (1998) 2.64
Application of branched DNA signal amplification to monitor human immunodeficiency virus type 1 burden in human plasma. J Infect Dis (1994) 2.60
Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design. Ann Hum Genet (2002) 2.51
Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Nat Genet (1998) 2.49
A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins. Hum Mol Genet (2001) 2.43
Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. Am J Hum Genet (2000) 2.22
Enhanced diabetes care to patients of south Asian ethnic origin (the United Kingdom Asian Diabetes Study): a cluster randomised controlled trial. Lancet (2008) 2.21
Strategies in complex disease mapping. Curr Opin Genet Dev (2000) 2.20
Aspartic acid at position 57 of the HLA-DQ beta chain protects against type I diabetes: a family study. Proc Natl Acad Sci U S A (1988) 2.19
Nitric oxide synthase gene polymorphisms and diabetic nephropathy. Diabetologia (2003) 2.18
The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene. Am J Hum Genet (1999) 2.17
Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes (1994) 2.16
The MHC haplotype project: a resource for HLA-linked association studies. Tissue Antigens (2002) 2.16
Cost-effective analysis of candidate genes using htSNPs: a staged approach. Genes Immun (2004) 2.07
Microsatellites for linkage analysis of genetic traits. Trends Genet (1992) 2.05
Cloning of a novel member of the low-density lipoprotein receptor family. Gene (1998) 1.97
Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab (2009) 1.94
Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family. Biochem Biophys Res Commun (1998) 1.93
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A (1999) 1.93
No association of multiple type 2 diabetes loci with type 1 diabetes. Diabetologia (2009) 1.92
Allelic variation in the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci U S A (1987) 1.92
Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet (1997) 1.91
Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut (2003) 1.84
Reduced heat resistance of mutant spores after cloning and mutagenesis of the Bacillus subtilis gene encoding penicillin-binding protein 5. J Bacteriol (1986) 1.83
Low plasma C4 concentrations: association with microangiopathy in insulin dependent diabetes. Br Med J (Clin Res Ed) (1984) 1.82
Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. Autism Res (2009) 1.80
Additional microsatellite markers for mouse genome mapping. Mamm Genome (1991) 1.79
Cloning and expression in Escherichia coli of the insecticidal delta-endotoxin gene of Bacillus thuringiensis var. israelensis. FEBS Lett (1984) 1.77
Major factors influencing linkage disequilibrium by analysis of different chromosome regions in distinct populations: demography, chromosome recombination frequency and selection. Hum Mol Genet (2000) 1.76
Bacillus thuringiensis var. israelensis delta-endotoxin. Cloning and expression of the toxin in sporogenic and asporogenic strains of Bacillus subtilis. J Mol Biol (1986) 1.74
Chlorpropamide alcohol flushing and diabetic retinopathy. Lancet (1979) 1.72
Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves' disease: replication using a population case control and family-based study. J Clin Endocrinol Metab (1998) 1.72
Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation. Genome Res (2000) 1.71
Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia (2005) 1.69
Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Nature (1989) 1.64
Molecular basis for CD40 signaling mediated by TRAF3. Proc Natl Acad Sci U S A (2000) 1.64
Prevalence of symptoms of depression and anxiety in a diabetes clinic population. Diabet Med (2000) 1.61
The generation of a library of PCR-analyzed microsatellite variants for genetic mapping of the mouse genome. Genomics (1991) 1.61
Simultaneous pulmonary and cerebral oedema, and multiple CNS infarctions as complications of diabetic ketoacidosis: a case report. Diabet Med (2006) 1.60
Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY3 on chromosome 12. Diabetes (1996) 1.60
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. J Immunol (2000) 1.60
New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. J Immunol (1998) 1.58
A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis. J Biol Chem (2000) 1.57
Resistin, central obesity, and type 2 diabetes. Lancet (2002) 1.56
Effect of heparin on polymerase chain reaction. Lancet (1994) 1.55
Asian patients attending a diabetic clinic. Br Med J (Clin Res Ed) (1985) 1.55
Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1. Genes Immun (2009) 1.53
Adaptation of the extended transmission/disequilibrium test to distinguish disease associations of multiple loci: the Conditional Extended Transmission/Disequilibrium Test. Ann Hum Genet (2000) 1.53
Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease. Genes Immun (2004) 1.53
In siblings of celiac children, rectal gluten challenge reveals gluten sensitization not restricted to celiac HLA. Gastroenterology (1996) 1.52
Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. Hum Immunol (1993) 1.52
Genetic markers may predict disease behavior in patients with ulcerative colitis. Gastroenterology (1997) 1.52