Published in Lancet on June 11, 1994
Inhibition and facilitation of nucleic acid amplification. Appl Environ Microbiol (1997) 9.00
Directed evolution of polymerase function by compartmentalized self-replication. Proc Natl Acad Sci U S A (2001) 8.89
Purification and characterization of PCR-inhibitory components in blood cells. J Clin Microbiol (2001) 5.78
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J Extracell Vesicles (2013) 4.05
Preclinical diagnosis of African swine fever in contact-exposed swine by a real-time PCR assay. J Clin Microbiol (2005) 1.27
Direct DNA amplification from crude clinical samples using a PCR enhancer cocktail and novel mutants of Taq. J Mol Diagn (2010) 1.13
A three-center European external quality control study of PCR for detection of cytomegalovirus DNA in blood. J Clin Microbiol (1996) 1.07
Detection of Mycobacterium tuberculosis in blood by use of the Xpert MTB/RIF assay. J Clin Microbiol (2013) 1.03
KIR genotyping by multiplex PCR-SSP. Methods Mol Biol (2010) 1.01
MicroRNA Biomarkers for Coronary Artery Disease? Curr Atheroscler Rep (2015) 0.84
Compartmentalized self-replication under fast PCR cycling conditions yields Taq DNA polymerase mutants with increased DNA-binding affinity and blood resistance. Front Microbiol (2014) 0.79
Management of hepatitis C in patients with chronic kidney disease. World J Gastroenterol (2015) 0.78
Cerebrospinal fluid can be used for HIV genotyping when it fails in blood. Arq Neuropsiquiatr (2014) 0.78
A quantitative PCR method to quantify ruminant DNA in porcine crude heparin. Anal Bioanal Chem (2010) 0.77
Clinical usefulness of multiplex PCR lateral flow in MRSA detection: a novel, rapid genetic testing method. Inflammation (2012) 0.77
Characterization of the avian aryl hydrocarbon receptor 1 from blood using non-lethal sampling methods. Ecotoxicology (2010) 0.77
Use of synthetic single-stranded oligonucleotides as artificial test soiling for validation of surgical instrument cleaning processes. Biomed Res Int (2014) 0.75
Stable isotopic analysis of porcine, bovine, and ovine heparins. J Pharm Sci (2014) 0.75
Phenotypic analysis of antigen-specific T lymphocytes. Science (1996) 24.26
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature (1987) 10.70
Association study designs for complex diseases. Nat Rev Genet (2001) 8.91
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature (1998) 7.12
A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis (2000) 6.90
Evolution and transmission of stable CTL escape mutations in HIV infection. Nature (2001) 6.57
Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons. Proc Natl Acad Sci U S A (1992) 4.90
Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease. Gut (1989) 4.59
Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease. Lancet (1996) 4.33
Circulating immune complexes in inflammatory bowel disease. Clin Exp Immunol (1973) 4.32
Increased expression of CD44v6 and CD44v3 in ulcerative colitis but not colonic Crohn's disease. Lancet (1995) 4.12
Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet (1996) 4.09
Intensive intravenous regimen for severe attacks of ulcerative colitis. Lancet (1974) 4.06
Large clonal expansions of CD8+ T cells in acute infectious mononucleosis. Nat Med (1996) 3.94
A molecular basis for MHC class II--associated autoimmunity. Science (1988) 3.75
Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres. Gut (1988) 3.66
Identification and characterization of three members of the human SR family of pre-mRNA splicing factors. EMBO J (1995) 3.56
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J (1999) 3.51
Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection. J Exp Med (2001) 3.44
A trial of mercaptopurine is a safe strategy in patients with inflammatory bowel disease intolerant to azathioprine: an observational study, systematic review and meta-analysis. Aliment Pharmacol Ther (2013) 3.33
A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am J Hum Genet (2001) 3.26
Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. Clin Exp Immunol (1983) 3.21
Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors. J Virol (2000) 3.18
In vivo antigen challenge in celiac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T-cell epitope. Nat Med (2000) 3.04
Novel, cross-restricted, conserved, and immunodominant cytotoxic T lymphocyte epitopes in slow progressors in HIV type 1 infection. AIDS Res Hum Retroviruses (1996) 3.01
Repair of DNA base-pair mismatches in extracts of Escherichia coli. Cold Spring Harb Symp Quant Biol (1984) 2.96
New IBD genetics: common pathways with other diseases. Gut (2011) 2.95
Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide. Proc Natl Acad Sci U S A (1991) 2.90
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res (2000) 2.86
Initiation of methyl-directed mismatch repair. J Biol Chem (1992) 2.82
Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques. Gut (1984) 2.74
T lymphocyte subsets in human intestinal mucosa: the distribution and relationship to MHC-derived antigens. Clin Exp Immunol (1981) 2.68
Systematic review: The use of thiopurines or anti-TNF in post-operative Crohn's disease maintenance--progress and prospects. Aliment Pharmacol Ther (2014) 2.66
A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem (1998) 2.64
HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. Proc Natl Acad Sci U S A (1989) 2.60
Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nat Genet (1993) 2.56
Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment. J Exp Med (1995) 2.55
Heterogeneity of HLA-DR-positive histiocytes in human intestinal lamina propria: a combined histochemical and immunohistological analysis. J Clin Pathol (1983) 2.49
HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc Natl Acad Sci U S A (1999) 2.45
Macrophage subpopulations in lamina propria of normal and inflamed colon and terminal ileum. Gut (1989) 2.44
Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature (1997) 2.41
Immunohistological characterisation of intraepithelial lymphocytes of the human gastrointestinal tract. Gut (1981) 2.38
Cap polyposis--an unusual cause of diarrhoea. Gut (1993) 2.38
Lymphocyte subpopulations in the human small intestine. The findings in normal mucosa and in the mucosa of patients with adult coeliac disease. Clin Exp Immunol (1983) 2.34
TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity (1999) 2.33
Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors. Proc Natl Acad Sci U S A (1995) 2.30
Azathioprine in ulcerative colitis: final report on controlled therapeutic trial. Br Med J (1974) 2.24
Interleukin 1 in Crohn's disease. Clin Exp Immunol (1987) 2.18
Thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease: relapse and recapture rates, with predictive factors in 237 patients. Aliment Pharmacol Ther (2014) 2.11
Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease. Gut (1989) 2.06
Immune complexes in ulcerative colitis and Crohn's disease. Clin Exp Immunol (1977) 2.04
Multiple variants of the human lymphocyte homing receptor CD44 generated by insertions at a single site in the extracellular domain. J Biol Chem (1992) 2.03
HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. Am J Hum Genet (1992) 2.03
The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review. Gut (2002) 2.00
Predicting outcome in severe ulcerative colitis. Gut (1996) 1.99
T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics. Immunity (1999) 1.98
The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth. Scand J Gastroenterol (1979) 1.98
Interleukin 2 receptor expression by macrophages in inflammatory bowel disease. Clin Exp Immunol (1988) 1.95
NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? Genes Immun (2004) 1.94
Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. Proc Natl Acad Sci U S A (1999) 1.93
Immune complexes in acute and chronic liver disease. Clin Exp Immunol (1978) 1.93
CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus. J Immunol (1995) 1.92
Allelic variation in the DR subregion of the human major histocompatibility complex. Proc Natl Acad Sci U S A (1987) 1.92
Food intolerance and the irritable bowel syndrome. Gut (1989) 1.88
The genetics of inflammatory bowel disease. Gut (1997) 1.83
BirA enzyme: production and application in the study of membrane receptor-ligand interactions by site-specific biotinylation. Anal Biochem (1999) 1.81
The association of autoimmune disorders with inflammatory bowel disease. Q J Med (1989) 1.80
Genetics of inflammatory bowel disease. Gut (1994) 1.79
Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children. J Virol (2000) 1.79
Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation. J Immunol (1990) 1.78
Clinical patterns of familial inflammatory bowel disease. Gut (1996) 1.76
Variation in human T cell receptor V beta and J beta repertoire: analysis using anchor polymerase chain reaction. Eur J Immunol (1992) 1.73
Perianal Crohn's disease. Br J Surg (2004) 1.73
The influence of HLA class I alleles and heterozygosity on the outcome of human T cell lymphotropic virus type I infection. J Immunol (2000) 1.73
Genetic polymorphism within HLA-A*02: significant allelic variation revealed in different populations. Tissue Antigens (1995) 1.70
Anti-neutrophil nuclear antibody in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis. Clin Exp Immunol (1989) 1.69
TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL. Curr Biol (1997) 1.68
Crohn's disease and pregnancy. Gut (1984) 1.66
Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses. Eur J Immunol (1993) 1.65
Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. J Cell Biol (1995) 1.65
Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis. Nature (1986) 1.64
Molecular basis for CD40 signaling mediated by TRAF3. Proc Natl Acad Sci U S A (2000) 1.64
Rapid definition of five novel HLA-A*3002-restricted human immunodeficiency virus-specific cytotoxic T-lymphocyte epitopes by elispot and intracellular cytokine staining assays. J Virol (2001) 1.63
Role of the faecal stream in the maintenance of Crohn's colitis. Gut (1985) 1.63
A functional polymorphism of the stromelysin gene (MMP-3) influences susceptibility to primary sclerosing cholangitis. Gastroenterology (2001) 1.60
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. J Immunol (2000) 1.60
The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain. J Biol Chem (2001) 1.59
LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing. Proc Natl Acad Sci U S A (1997) 1.58
Serum autoantibodies, ulcerative colitis and primary sclerosing cholangitis. Gut (1986) 1.58
The HLA-DPB1--associated component of the IDDM1 and its relationship to the major loci HLA-DQB1, -DQA1, and -DRB1. Diabetes (2001) 1.58
Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history. Gut (1998) 1.58
Lack of association between cervical dysplasia and IBD: a large case-control study. Inflamm Bowel Dis (2009) 1.57