Published in J Biol Chem on May 03, 2001
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. Nat Genet (2008) 6.10
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Cell (2010) 2.17
Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann N Y Acad Sci (2012) 2.04
Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event. Proc Natl Acad Sci U S A (2007) 2.03
How versatile are inositol phosphate kinases? Biochem J (2004) 1.68
Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J Biol Chem (2007) 1.52
Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc Natl Acad Sci U S A (2008) 1.46
Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release. Proc Natl Acad Sci U S A (2009) 1.42
Diphosphoinositol polyphosphates: metabolic messengers? Mol Pharmacol (2009) 1.41
HSP90 regulates cell survival via inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2008) 1.39
Inositol pyrophosphates as mammalian cell signals. Sci Signal (2011) 1.38
Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. Proc Natl Acad Sci U S A (2012) 1.34
The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization. Biochem J (2002) 1.29
p53-mediated apoptosis requires inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2010) 1.20
Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. Oncogene (2002) 1.18
Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate. Nat Rev Immunol (2010) 1.17
Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat Immunol (2011) 1.15
Inositol polyphosphate multikinase is a coactivator of p53-mediated transcription and cell death. Sci Signal (2013) 1.06
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Oncogene (2009) 1.05
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell (2014) 1.05
Human genome-wide RNAi screen identifies an essential role for inositol pyrophosphates in Type-I interferon response. PLoS Pathog (2014) 1.02
Complex changes in cellular inositol phosphate complement accompany transit through the cell cycle. Biochem J (2004) 1.01
Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L. Cell Rep (2013) 0.98
Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. Proc Natl Acad Sci U S A (2015) 0.96
Apo2L/TRAIL induction and nuclear translocation of inositol hexakisphosphate kinase 2 during IFN-beta-induced apoptosis in ovarian carcinoma. Biochem J (2005) 0.95
Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. BMC Biochem (2002) 0.93
IP6K2 is a client for HSP90 and a target for cancer therapeutics development. Proc Natl Acad Sci U S A (2008) 0.92
The enzymes of human diphosphoinositol polyphosphate metabolism. FEBS J (2013) 0.92
Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. Proc Natl Acad Sci U S A (2011) 0.92
Inositol pyrophosphates: why so many phosphates? Adv Biol Regul (2014) 0.90
A scalable synthesis of the IP7 isomer, 5-PP-Ins(1,2,3,4,6)P5. Org Lett (2009) 0.88
Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. J Biol Chem (2007) 0.87
Interferons as inducers of apoptosis in malignant cells. J Interferon Cytokine Res (2013) 0.87
IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. Nat Commun (2014) 0.87
Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways. Mol Psychiatry (2013) 0.83
Differential effects of interferon alpha-2b and beta on the signaling pathways in human liver cancer cells. J Gastroenterol (2005) 0.81
Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. Proc Natl Acad Sci U S A (2013) 0.81
Zebrafish inositol polyphosphate kinases: new effectors of cilia and developmental signaling. Adv Enzyme Regul (2009) 0.81
Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases. Biochem J (2003) 0.81
The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry). Angew Chem Int Ed Engl (2015) 0.80
Interferon-gamma enhances radiation-induced cell death via downregulation of Chk1. Cancer Biol Ther (2012) 0.80
KCS1 deletion in Saccharomyces cerevisiae leads to a defect in translocation of autophagic proteins and reduces autophagosome formation. Autophagy (2012) 0.79
Helper T lymphocyte response in the peripheral blood of patients with intraepithelial neoplasia submitted to immunotherapy with pegylated interferon-α. Int J Mol Sci (2015) 0.79
Effects of interferons and double-stranded RNA on human prostate cancer cell apoptosis. Oncotarget (2015) 0.78
Intracellular poly(I:C) initiated gastric adenocarcinoma cell apoptosis and subsequently ameliorated NK cell functions. J Interferon Cytokine Res (2013) 0.77
The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes. Mol Microbiol (2017) 0.75
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst (1990) 23.46
STATs and gene regulation. Science (1997) 16.55
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A (1998) 13.39
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell (1996) 4.74
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol (1999) 2.76
Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2. Science (1993) 2.63
Bacteriophage lambda cloning system for the construction of directional cDNA libraries. Proc Natl Acad Sci U S A (1987) 2.39
A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J (1993) 2.28
Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells. J Biol Chem (1993) 2.23
Deletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasia. Science (1993) 2.17
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s). J Biol Chem (1993) 2.09
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. J Biol Chem (2000) 1.98
A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal. Science (1991) 1.89
Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines. Cancer Res (1992) 1.64
Purified inositol hexakisphosphate kinase is an ATP synthase: diphosphoinositol pentakisphosphate as a high-energy phosphate donor. Proc Natl Acad Sci U S A (1996) 1.62
Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation. Mol Cell Biol (1995) 1.53
Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo. J Biol Chem (1995) 1.47
Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells. Proc Natl Acad Sci U S A (1992) 1.24
Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death. FASEB J (2000) 1.22
The PKR protein kinase--an interferon-inducible regulator of cell growth and differentiation. Int J Hematol (1997) 1.18
Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells. Mol Cell Biol (1993) 1.16
Increased survival in mice inoculated with tumor cells and treated with interferon preparations. Proc Natl Acad Sci U S A (1969) 1.10
Enhanced expression of surface tumor-associated antigens on human breast and colon tumor cells after recombinant human leukocyte alpha-interferon treatment. Cancer Res (1984) 1.03
Recombinant interferon enhances monoclonal antibody-targeting of carcinoma lesions in vivo. Science (1987) 1.01
Structural identification of the myo-inositol 1,4,5-trisphosphate-binding domain in rat brain inositol 1,4,5-trisphosphate 3-kinase. Biochem J (1997) 1.01
Double-stranded RNA-dependent protein kinase mediates c-Myc suppression induced by type I interferons. J Biol Chem (1996) 1.00
Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1. Proc Natl Acad Sci U S A (2000) 0.99
Identification and purification of diphosphoinositol pentakisphosphate kinase, which synthesizes the inositol pyrophosphate bis(diphospho)inositol tetrakisphosphate. Biochemistry (1998) 0.95
Synergistic antitumor effects of a combination of interferon and tamoxifen on estrogen receptor-positive and receptor-negative human tumor cell lines in vivo and in vitro. J Interferon Cytokine Res (1997) 0.93
Interferon alpha induces the expression of retinoblastoma gene product in human Burkitt lymphoma Daudi cells: role in growth regulation. Proc Natl Acad Sci U S A (1992) 0.93
Antiproliferative and antiviral activities of human leukocyte interferons. Arch Biochem Biophys (1981) 0.93
Interferons and cell growth control. Histol Histopathol (2000) 0.91
p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines. Carcinogenesis (1995) 0.89
Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells. Pharm Res (1998) 0.86
Effects of recombinant and hybrid recombinant human leukocyte interferons on cytotoxic activity of natural killer cells. J Biol Chem (1983) 0.80
C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation (2001) 5.49
Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis. Apoptosis (2003) 3.73
Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol Cell Biol (1994) 2.63
Impaired myofibrillar energetics and oxidative injury during human atrial fibrillation. Circulation (2001) 2.55
Ascorbate attenuates atrial pacing-induced peroxynitrite formation and electrical remodeling and decreases the incidence of postoperative atrial fibrillation. Circ Res (2001) 2.25
Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ (2004) 2.17
Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach. J Biol Chem (2000) 2.08
A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Oncogene (2006) 1.78
Subtlety in the reactivity of a diketo phosphorus ylide towards mercuric halides: the unprecedented O-coordination of alpha-acetyl-alpha-benzoylmethylenetriphenylphosphorane to Hg(II). Chem Commun (Camb) (2001) 1.75
ERK1 and ERK2 activate CCAAAT/enhancer-binding protein-beta-dependent gene transcription in response to interferon-gamma. J Biol Chem (2001) 1.44
RNase-L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response. J Biol Chem (2000) 1.43
Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice. J Pharmacol Exp Ther (2000) 1.40
Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid. J Biol Chem (2000) 1.38
Gene induction by interferons: functional complementation between trans-acting factors induced by alpha interferon and gamma interferon. Mol Cell Biol (1990) 1.32
The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. Oncogene (2011) 1.30
Influence of resistance training volume and periodization on physiological and performance adaptations in collegiate women tennis players. Am J Sports Med (2001) 1.23
Therapeutic implications of human endothelial nitric oxide synthase gene polymorphism. Trends Pharmacol Sci (2001) 1.18
Non-invasive echocardiographic studies in mice: influence of anesthetic regimen. Life Sci (2001) 1.18
CCAAT/enhancer-binding protein-beta regulates interferon-induced transcription through a novel element. J Biol Chem (2000) 1.15
Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure. Cardiovasc Res (2001) 1.15
Gamma interferon augments macrophage activation by lipopolysaccharide by two distinct mechanisms, at the signal transduction level and via an autocrine mechanism involving tumor necrosis factor alpha and interleukin-1. Infect Immun (1999) 1.15
Acute appendicitis in children: factors affecting morbidity. Am J Surg (1984) 1.12
Development of sensorially-guided reaching in infant monkeys. Brain Res (1974) 1.10
Interferon gamma-induced transcription of the murine ISGF3gamma (p48) gene is mediated by novel factors. Proc Natl Acad Sci U S A (1997) 1.08
Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated. Am J Respir Crit Care Med (2000) 1.08
Endothelial dysfunction and peroxynitrite formation are early events in angiotensin-induced cardiovascular disorders. FASEB J (2000) 1.08
Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid. Mol Cell Biol (1998) 1.06
Transcriptional repression of interleukin-6 gene by adenoviral E1A proteins. J Biol Chem (1992) 1.06
Synergistic antitumor effects of a combination of interferons and retinoic acid on human tumor cells in vitro and in vivo. Clin Cancer Res (1997) 1.06
Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Oncogene (2009) 1.05
Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications. Pharmacol Ther (2001) 1.03
Diabetes related cardiomyopathy time dependent echocardiographic evaluation in an experimental rat model. Life Sci (2001) 1.03
Modulation of interferon (IFN)-inducible gene expression by retinoic acid. Up-regulation of STAT1 protein in IFN-unresponsive cells. J Biol Chem (1996) 1.02
Lysophosphatidic acid downregulates tissue inhibitor of metalloproteinases, which are negatively involved in lysophosphatidic acid-induced cell invasion. Oncogene (2006) 1.02
Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain. Brain Res (1999) 0.98
Time-dependent urinary bladder remodeling in the streptozotocin-induced diabetic rat model. Acta Diabetol (2002) 0.98
The development of eye alignment, convergence, and sensory binocularity in young infants. Invest Ophthalmol Vis Sci (1994) 0.98
Mechanisms of nitrate tolerance. Cardiovasc Drugs Ther (1994) 0.96
Retinoic acid and interferon in human cancer: mechanistic and clinical studies. Semin Hematol (1994) 0.96
Modulation of interferon action by retinoids. Induction of murine STAT1 gene expression by retinoic acid. J Biol Chem (1997) 0.96
The polyoma virus T antigen interferes with interferon-inducible gene expression. Proc Natl Acad Sci U S A (1998) 0.96
Free 3-nitrotyrosine causes striatal neurodegeneration in vivo. J Neurosci (2001) 0.94
Nitrotyrosine causes selective vascular endothelial dysfunction and DNA damage. J Cardiovasc Pharmacol (2000) 0.93
Visual acuity and its meridional variations in children aged 7-60 months. Vision Res (1983) 0.90
Enhanced tumor suppression in vitro and in vivo by co-expression of survivin-specific siRNA and wild-type p53 protein. Cancer Gene Ther (2010) 0.90
GRIM-19 associates with the serine protease HtrA2 for promoting cell death. Oncogene (2007) 0.90
Induction of interferon synthesis and activation of interferon-stimulated genes by liposomal transfection reagents. J Interferon Cytokine Res (1998) 0.89
Distribution of melanin-concentrating hormone neurons projecting to the medial mammillary nucleus. Neuroscience (2002) 0.88
Perineurium inflammation and altered connexin isoform expression in a rat model of diabetes related peripheral neuropathy. Neurosci Lett (2001) 0.88
GRIM-19 inhibits v-Src-induced cell motility by interfering with cytoskeletal restructuring. Oncogene (2009) 0.87
The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc. Proc Natl Acad Sci U S A (1997) 0.87
Tamoxifen enhances interferon-regulated gene expression in breast cancer cells. Mol Cell Biochem (1997) 0.87
Chromosomal localization of human GRIM-19, a novel IFN-beta and retinoic acid-activated regulator of cell death. J Interferon Cytokine Res (2000) 0.86
Long-term hemodynamic and clinical sequelae of lower extremity deep vein thrombosis. J Vasc Surg (1986) 0.86
Interleukin-6 modulates interferon-regulated gene expression by inducing the ISGF3 gamma gene using CCAAT/enhancer binding protein-beta(C/EBP-beta). Biochim Biophys Acta (2000) 0.85
Regulation of interferon and retinoic acid-induced cell death activation through thioredoxin reductase. J Biol Chem (2001) 0.85
Vascular peroxynitrite formation during organic nitrate tolerance. J Pharmacol Exp Ther (1999) 0.85
Innervation and connexin isoform expression during diabetes-related bladder dysfunction: early structural vs. neuronal remodelling. Acta Diabetol (2005) 0.84
Sustained antiplatelet properties of nitroglycerin during hemodynamic tolerance in rats. J Cardiovasc Pharmacol (1996) 0.84
Differences in lower extremity alignment between males and females. Potential predisposing factors for knee injury. J Sports Med Phys Fitness (2005) 0.83
IFN-gamma inhibits lipopolysaccharide-induced interleukin-1 beta in primary murine macrophages via a Stat1-dependent pathway. J Interferon Cytokine Res (2001) 0.83
Biochemical mechanism of organic nitrate action. Am J Cardiol (1992) 0.83
Phorbol ester-induced expression of airway squamous cell differentiation marker, SPRR1B, is regulated by protein kinase Cdelta /Ras/MEKK1/MKK1-dependent/AP-1 signal transduction pathway. J Biol Chem (2000) 0.83
Digital imaging analysis for the study of endotoxin-induced mitochondrial ultrastructure injury. Anal Cell Pathol (2000) 0.83
Origin of sensory and autonomic innervation of the rat temporomandibular joint: a retrograde axonal tracing study with the fluorescent dye fast blue. J Dent Res (1999) 0.83
Regulation of K+ and Ca2+ channels in experimental cardiac failure. Am J Physiol (1991) 0.81
The interferon-beta and tamoxifen combination induces apoptosis using thioredoxin reductase. Biochim Biophys Acta (2000) 0.80
Caring as the central focus in nursing curriculum development. NLN Publ (1990) 0.80
The distribution of melanin-concentrating hormone in the monkey brain (Cebus apella). Brain Res (1998) 0.80
Targeted therapy via oral administration of attenuated Salmonella expression plasmid-vectored Stat3-shRNA cures orthotopically transplanted mouse HCC. Cancer Gene Ther (2012) 0.80
Visually guided reaching in infant monkeys after restricted rearing. Science (1967) 0.80
Analysis of isobutyl nitrite inhalant in rat and human blood: application for pharmacokinetic investigations. J Chromatogr B Biomed Sci Appl (1999) 0.79
'Jiggling' a lifted object does not aid judgment of its perceived weight. Am J Psychol (1975) 0.78
Increasing effectiveness of interferon-alpha for malignancies. Semin Oncol (1997) 0.78
Monkeys show an oblique effect. Perception (1979) 0.78
Influence of hydrocortisone on the binding of nitrosoureas to nuclear chromatin subfractions. Cancer Res (1980) 0.78
Modulation of tumor-associated antigen expression on human pancreatic and prostate carcinoma cells in vitro by alpha- and gamma-interferons. J Immunother Emphasis Tumor Immunol (1995) 0.78
Effects of hyperoxia on postnatal intestinal development. Biotech Histochem (2007) 0.78
Stereological analysis of the otic ganglia in adult rat: light microscopic study. Anat Anz (1991) 0.77
A comparative and ultrastructural study of synaptic contacts established by primary sensory fibers in the spinal trigeminal nucleus of the rat. Tissue Cell (1996) 0.77
Mechanism of repression of squamous differentiation marker, SPRR1B, in malignant bronchial epithelial cells: role of critical TRE-sites and its transacting factors. Oncogene (2001) 0.77
Synaptic contacts established by primary sensory fibers innervating the teeth of rats: an ultrastructural study of the pars interpolaris of the spinal trigeminal nucleus. Tissue Cell (1992) 0.77
Differential control during maximal concentric and eccentric loading revealed by characteristics of the electromyogram. J Electromyogr Kinesiol (2000) 0.77
Modulation of p53 dependent gene expression and cell death through thioredoxin-thioredoxin reductase by the Interferon-Retinoid combination. Oncogene (2001) 0.77
Retinoids and interferons in non-melanoma skin cancer. J Investig Dermatol Symp Proc (1996) 0.76
Recent developments in gene therapy for cardiac disease. Biomed Pharmacother (2000) 0.76
Immediate rise in intracellular calcium and glycogen phosphorylase a activities upon acetaminophen covalent binding leading to hepatotoxicity in mice. Toxicology (1988) 0.76
Complications of chest thump for termination of supraventricular tachycardia in children. Eur J Pediatr (1992) 0.76
A binocular contribution to the production of optokinetic nystagmus in normal and stereoblind subjects. Vision Res (1981) 0.76
Enhancement of nitrosourea cytotoxicity in vitro using hydrocortisone. Biochem Pharmacol (1982) 0.76
Thioredoxin participates in a cell death pathway induced by interferon and retinoid combination. Oncogene (2001) 0.76