Published in J Immunol on May 15, 2001
Adipokines in inflammation and metabolic disease. Nat Rev Immunol (2011) 8.92
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest (2002) 5.83
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses. J Clin Invest (2003) 1.87
Isolation and preservation of peripheral blood mononuclear cells for analysis of islet antigen-reactive T cell responses: position statement of the T-Cell Workshop Committee of the Immunology of Diabetes Society. Clin Exp Immunol (2010) 1.82
Leptin increase in multiple sclerosis associates with reduced number of CD4(+)CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2005) 1.67
Role of leptin as an immunomodulator of blood mononuclear cells: mechanisms of action. Clin Exp Immunol (2003) 1.65
Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne) (2013) 1.62
Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology (2014) 1.54
Cytokines, leptin, and stress-induced thymic atrophy. J Leukoc Biol (2008) 1.47
Adipokines: a link between obesity and cardiovascular disease. J Cardiol (2013) 1.29
Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis. J Leukoc Biol (2008) 1.26
Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. J Clin Invest (2006) 1.25
Leptin and Inflammation. Curr Immunol Rev (2008) 1.19
Leptin receptor expression on T lymphocytes modulates chronic intestinal inflammation in mice. Gut (2004) 1.17
Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes. Am J Pathol (2007) 1.16
Delayed resolution of acute inflammation during zymosan-induced arthritis in leptin-deficient mice. Arthritis Res Ther (2004) 1.12
Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Mult Scler (2013) 1.11
Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation. Br J Dermatol (2008) 1.08
Metabolic control of regulatory T cell development and function. Trends Immunol (2014) 1.06
Type 1 diabetes associated with acquired generalized lipodystrophy and insulin resistance: the effect of long-term leptin therapy. J Clin Endocrinol Metab (2007) 1.03
Defining the role of T cell-derived leptin in the modulation of hepatic or intestinal inflammation in mice. Clin Exp Immunol (2005) 0.99
The role of leptin in innate and adaptive immune responses. Arthritis Res Ther (2006) 0.99
Leptin-deficient mice are protected from accelerated nephrotoxic nephritis. Am J Pathol (2004) 0.99
A role for leptin in rheumatic diseases? Ann Rheum Dis (2003) 0.98
Leptin as a metabolic link to multiple sclerosis. Nat Rev Neurol (2010) 0.96
Transplantation of wild-type white adipose tissue normalizes metabolic, immune and inflammatory alterations in leptin-deficient ob/ob mice. Cytokine (2007) 0.94
The intricate interplay among body weight, stress, and the immune response to friend or foe. J Clin Invest (2003) 0.93
Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. Autoimmunity (2010) 0.93
Brief report: plasma leptin levels are elevated in autism: association with early onset phenotype? J Autism Dev Disord (2007) 0.93
Leptin in septic arthritis: decreased levels during infection and amelioration of disease activity upon its administration. Arthritis Res (2001) 0.92
Natural triterpenes modulate immune-inflammatory markers of experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis. Br J Pharmacol (2012) 0.92
The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function. Front Immunol (2012) 0.91
The neuropathology of obesity: insights from human disease. Acta Neuropathol (2013) 0.91
Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur J Immunol (2014) 0.91
Neuro-endocrine networks controlling immune system in health and disease. Front Immunol (2014) 0.91
Cytokine network and T cell immunity in atherosclerosis. Semin Immunopathol (2009) 0.90
Leptin in immuno-rheumatological diseases. Cell Mol Immunol (2011) 0.89
Optic neuritis, a new variant of experimental encephalomyelitis, a durable model for all seasons, now in its seventieth year. J Exp Med (2003) 0.89
Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected]. Am J Transplant (2012) 0.88
Leptin enhances the release of cytokines by peripheral blood mononuclear cells from relapsing multiple sclerosis patients. J Clin Immunol (2004) 0.88
Leptin deficiency down-regulates IL-23 production in glomerular podocytes resulting in an attenuated immune response in nephrotoxic serum nephritis. Int Immunol (2015) 0.86
Adipocytokine profile, cytokine levels and foxp3 expression in multiple sclerosis: a possible link to susceptibility and clinical course of disease. PLoS One (2013) 0.86
Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats. Physiol Genomics (2009) 0.85
Differentially expressed genes in MHC-compatible rat strains that are susceptible or resistant to experimental autoimmune uveitis. Invest Ophthalmol Vis Sci (2008) 0.84
Leptin-based adjuvants: an innovative approach to improve vaccine response. Vaccine (2013) 0.84
Leptin modulates autophagy in human CD4+CD25- conventional T cells. Metabolism (2014) 0.82
Menarche increases relapse risk in pediatric multiple sclerosis. Mult Scler (2015) 0.81
The emerging role of leptin antagonist as potential therapeutic option for inflammatory bowel disease. Int Rev Immunol (2013) 0.81
New Lactobacillus acidophilus isolates reduce the release of leptin by murine adipocytes leading to lower interferon-gamma production. Clin Exp Immunol (2005) 0.80
Obesity, Inflammation and Acute Myocardial Infarction - Expression of leptin, IL-6 and high sensitivity-CRP in Chennai based population. Thromb J (2012) 0.80
Leptin antagonist ameliorates chronic colitis in IL-10⁻/⁻ mice. Immunobiology (2013) 0.80
Methotrexate treatment ameliorated testicular suppression and anorexia related leptin reduction in rats with adjuvant arthritis. Rheumatol Int (2009) 0.80
Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling. Brain Behav Immun (2014) 0.80
Involvement of leptin in the progression of experimentally induced peritoneal fibrosis in mice. Acta Histochem Cytochem (2013) 0.80
Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity. Eur J Immunol (2016) 0.80
XVI European Charcot Foundation lecture: nutrition and environment: can MS be prevented? J Neurol Sci (2011) 0.79
Fyn mediates leptin actions in the thymus of rodents. PLoS One (2009) 0.79
Saturable leptin transport across the BBB persists in EAE mice. J Mol Neurosci (2013) 0.79
Expression of the leptin receptor outside of bone marrow-derived cells regulates tuberculosis control and lung macrophage MHC expression. J Immunol (2011) 0.79
Obesity-related immune responses and their impact on surgical outcomes. Int J Obes (Lond) (2015) 0.79
Adipokines as potential biomarkers in rheumatoid arthritis. Mediators Inflamm (2014) 0.78
Serum leptin levels in treatment-naive patients with clinically isolated syndrome or relapsing-remitting multiple sclerosis. Autoimmune Dis (2014) 0.78
Gut microbiome and the risk factors in central nervous system autoimmunity. FEBS Lett (2014) 0.78
Role of leptin in autoimmune diseases. Maedica (Buchar) (2013) 0.77
Increased leptin and A-FABP levels in relapsing and progressive forms of MS. BMC Neurol (2013) 0.77
Leptin induces an inflammatory phenotype in lean Wistar rats. Mediators Inflamm (2010) 0.77
Correlation of circulating omentin-1 with bone mineral density in multiple sclerosis: the crosstalk between bone and adipose tissue. PLoS One (2011) 0.76
Cord blood leptin levels of healthy neonates are associated with IFN-γ production by cord blood T-cells. PLoS One (2012) 0.76
Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level. Cell Mol Life Sci (2014) 0.76
Leptin deficiency in vivo enhances the ability of splenic dendritic cells to activate T cells. Int Immunol (2014) 0.76
Leptin in intestinal inflammation: good and bad gut feelings. Gut (2004) 0.76
Adiponectin Suppresses T Helper 17 Cell Differentiation and Limits Autoimmune CNS Inflammation via the SIRT1/PPARγ/RORγt Pathway. Mol Neurobiol (2016) 0.76
The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders? Curr Obes Rep (2016) 0.76
The Leptin Receptor Complex: Heavier Than Expected? Front Endocrinol (Lausanne) (2017) 0.75
Distinct effects of obesity and puberty on risk and age at onset of pediatric MS. Ann Clin Transl Neurol (2016) 0.75
Role of Metabolism in the Immunobiology of Regulatory T Cells. J Immunol (2016) 0.75
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature (1998) 7.36
Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab (2001) 6.41
A role for glucagon-like peptide-1 in the central regulation of feeding. Nature (1996) 6.03
Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med (1982) 5.09
Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet (1987) 4.97
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology (2000) 3.80
Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood (2001) 3.66
Ghrelin causes hyperphagia and obesity in rats. Diabetes (2001) 3.62
A glucagonoma syndrome. Lancet (1974) 3.56
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51
Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology (1985) 3.36
Vasoactive intestinal peptide and watery-diarrhoea syndrome. Lancet (1973) 3.22
Possible dual role for vasoactive intestinal peptide as gastrointestinal hormone and neurotransmitter substance. Lancet (1976) 3.08
Distribution and release of human pancreatic polypeptide. Gut (1976) 3.02
Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology (2005) 2.80
Endocrine tumour in kidney affecting small bowel structure, motility, and absorptive function. Gut (1971) 2.75
Nephropathy caused by Chinese herbs in the UK. Lancet (1999) 2.68
Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet (1974) 2.65
Neuron-specific enolase is produced by neuroendocrine tumours. Lancet (1981) 2.63
Breast vs bottle: endocrine responses are different with formula feeding. Lancet (1980) 2.52
Measurement of fasting and postprandial plasma VIP in man. Gut (1978) 2.48
Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest (1999) 2.48
Structural model of HLA-DR1 restricted T cell antigen recognition. Cell (1988) 2.41
Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia. Arch Dis Child (1981) 2.36
Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J Neuroendocrinol (2004) 2.27
Gut-hormone profile in coeliac disease. Lancet (1978) 2.25
Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis. Lancet (1989) 2.25
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers. Am J Physiol Endocrinol Metab (2001) 2.24
Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue. Biochem Biophys Res Commun (1979) 2.16
Gut hormones and appetite control. Gastroenterology (2007) 2.16
A C-terminal fragment of Agouti-related protein increases feeding and antagonizes the effect of alpha-melanocyte stimulating hormone in vivo. Endocrinology (1998) 2.14
Pancreatic polypeptide in insulinomas, gastrinomas, vipomas, and glucagonomas. Lancet (1976) 2.13
The ileal brake--inhibition of jejunal motility after ileal fat perfusion in man. Gut (1984) 2.11
Neuropeptide Y distribution in the rat brain. Science (1983) 2.10
Growth-hormone release-inhibiting hormone in gastrointestinal and pancreatic D cells. Lancet (1975) 2.04
The role of the sympathetic innervation in the control of plasma glucagon concentration in the calf. J Physiol (1973) 2.01
Advanced carcinoma of the prostate: treatment with a gonadotrophin releasing hormone agonist. Br Med J (Clin Res Ed) (1983) 1.93
"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. Proc Natl Acad Sci U S A (1985) 1.93
Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg (2006) 1.91
Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39. Diabetes (1999) 1.90
Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest (1997) 1.89
Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species. J Neurosci (1984) 1.88
Effects of stimulation of the chorda tympani in bursts on submaxillary responses in the cat. J Physiol (1982) 1.84
Suppression of pancreatic endocrine tumour secretion by long-acting somatostatin analogue. Lancet (1979) 1.81
Isolation of endothelial cells from murine tissue. J Immunol Methods (2000) 1.81
Development of neuroendocrine tumors in the gastrointestinal tract of transgenic mice. Heterogeneity of hormone expression. Am J Pathol (1990) 1.80
Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans. Circulation (1998) 1.79
Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. J Clin Endocrinol Metab (2000) 1.75
Enkephalin-like immunoreactivity in the human gastrointestinal tract. Lancet (1977) 1.75
Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology (1997) 1.74
Urothelial malignant disease and Chinese herbal nephropathy. Lancet (2001) 1.73
The effect of truncal and selective vagotomy on the release of pancreatic glucagon, insulin and enteroglucagon. Br J Surg (1974) 1.73
Bombesin-like immunoreactivity in the lung. Nature (1978) 1.73
Localization of insulinomas by selective intraarterial calcium injection. J Clin Endocrinol Metab (1996) 1.72
Zymographic analysis of circulating and tissue forms of colon carcinoma gelatinase A (MMP-2) and B (MMP-9) separated by mono- and two-dimensional electrophoresis. Matrix Biol (2001) 1.71
Effects of growth-hormone release-inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients. Lancet (1974) 1.71
Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab (2003) 1.71
Abnormalities of vasoactive intestinal polypeptide-containing nerves in Crohn's disease. Gastroenterology (1980) 1.70
Bromocriptine treatment of acromegaly. Br Med J (1975) 1.70
An enteroglucagon tumour. Gut (1972) 1.69
Mechanism of pancreatic polypeptide release in man. Lancet (1977) 1.68
Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers. Gut (1987) 1.68
Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci (1979) 1.67
A radioimmunoassay for neurotensin in human plasma. J Endocrinol (1979) 1.66
Neuropeptide Y distribution in human brain. Nature (1984) 1.66
Glucagon-like peptide-1 is a physiological incretin in rat. J Clin Invest (1995) 1.66
Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat. Endocrinology (1999) 1.65
Bombesin: action on gut hormones and calcium in man. J Clin Endocrinol Metab (1982) 1.65
Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab (2002) 1.65
Recognition of autologous dendritic cells by human NK cells. Eur J Immunol (1999) 1.63
Vasoactive intestinal peptide in relation to atropine resistant vasodilatation in the submaxillary gland of the cat. J Physiol (1980) 1.62
Changing trends in the management of phaeochromocytoma. Br J Surg (1998) 1.62
Ghrelin increases food intake in obese as well as lean subjects. Int J Obes (Lond) (2005) 1.62
Occupation, social class and male cancer mortality in New Zealand, 1974-78. Int J Epidemiol (1986) 1.61
Gastrointestinal hormones in short bowel syndrome. Peptide YY may be the 'colonic brake' to gastric emptying. Gut (1996) 1.60
A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction. J Exp Med (1997) 1.59
Allopurinol hypersensitivity is primarily mediated by dose-dependent oxypurinol-specific T cell response. Clin Exp Allergy (2013) 1.59
Elevated plasma endothelin in patients with diabetes mellitus. Diabetologia (1990) 1.58
The role of the autonomic innervation in the control of glucagon release during hypoglycaemia in the calf. J Physiol (1974) 1.58
Effect of neurotensin on gastric function in man. Lancet (1980) 1.55
Calcitonin gene-related peptide in cardiovascular tissues of the rat. Neuroscience (1985) 1.55
Endocrine responses to insulin hypoglycaemia in the young calf. J Physiol (1975) 1.52
Release of glucagon, induced by stress. Q J Exp Physiol Cogn Med Sci (1973) 1.51
Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut (2005) 1.49
Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine. Proc Natl Acad Sci U S A (1984) 1.49
Neuroendocrinologic findings in primary fibromyalgia (soft tissue chronic pain syndrome) and in other chronic rheumatic conditions (rheumatoid arthritis, low back pain) J Rheumatol (1990) 1.48
Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistry. Nature (1977) 1.47
Nitric oxide-mediated expression of Bcl-2 and Bcl-xl and protection from tumor necrosis factor-alpha-mediated apoptosis in porcine endothelial cells after exposure to low concentrations of xenoreactive natural antibody. Transplantation (2001) 1.46