Structural model of HLA-DR1 restricted T cell antigen recognition.

PubWeight™: 2.41‹?› | Rank: Top 2%

🔗 View Article (PMID 2963699)

Published in Cell on February 26, 1988

Authors

J B Rothbard1, R I Lechler, K Howland, V Bal, D D Eckels, R Sekaly, E O Long, W R Taylor, J R Lamb

Author Affiliations

1: Laboratory of Molecular Immunology, Imperial Cancer Research Fund, London, England.

Articles citing this

Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1989) 4.45

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding. EMBO J (1990) 2.42

HLA class I-restricted responses to vaccinia recognize a broad array of proteins mainly involved in virulence and viral gene regulation. Proc Natl Acad Sci U S A (2005) 2.11

Human cytotoxic T-lymphocyte repertoire to influenza A viruses. J Virol (1998) 2.10

Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes. J Exp Med (1990) 2.09

Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries. Immunome Res (2008) 2.07

Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. EMBO J (2000) 2.00

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89. J Virol (1988) 1.97

Detection of T cells in paraffin wax embedded tissue using antibodies against a peptide sequence from the CD3 antigen. J Clin Pathol (1989) 1.85

Identification of a motif for HLA-DR1 binding peptides using M13 display libraries. J Exp Med (1992) 1.78

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes. EMBO J (1992) 1.72

Human histocompatibility leukocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis. J Clin Invest (1997) 1.50

In vitro translation and assembly of a complete T cell receptor-CD3 complex. J Exp Med (1997) 1.45

Endocytosis and recycling of specific antigen by human B cell lines. EMBO J (1988) 1.42

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. EMBO J (1994) 1.37

Mapping functional regions in the lumenal domain of the class II-associated invariant chain. J Exp Med (1994) 1.32

Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins. Proc Natl Acad Sci U S A (1990) 1.30

Specific lysis of human immunodeficiency virus type 1-infected cells by a HLA-A3.1-restricted CD8+ cytotoxic T-lymphocyte clone that recognizes a conserved peptide sequence within the gp41 subunit of the envelope protein. Proc Natl Acad Sci U S A (1991) 1.26

Carcinoembryonic antigen functions as an accessory adhesion molecule mediating colon epithelial cell-collagen interactions. Proc Natl Acad Sci U S A (1990) 1.23

Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients. J Virol (2008) 1.22

Identical peptides recognized by MHC class I- and II-restricted T cells. J Exp Med (1989) 1.20

Francisella tularensis--a model for studies of the immune response to intracellular bacteria in man. Immunology (1992) 1.18

Ribosomal protein L7a is encoded by a gene (Surf-3) within the tightly clustered mouse surfeit locus. Mol Cell Biol (1989) 1.10

Antigen processing by isolated rat intestinal villus enterocytes. Immunology (1989) 1.08

Peptide-mediated modulation of T-cell allorecognition. Proc Natl Acad Sci U S A (1988) 1.05

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chem Biol (2010) 1.05

Identification of T-helper epitopes in the VP1 capsid protein of poliovirus. J Virol (1992) 1.00

An in vitro model of allergen-dependent IgE synthesis by human B lymphocytes: comparison of the response of an atopic and a non-atopic individual to Dermatophagoides spp. (house dust mite). Immunology (1989) 0.98

Enhancement of the antibody response to flavivirus B-cell epitopes by using homologous or heterologous T-cell epitopes. J Virol (1992) 0.98

Identification and characterization of novel, naturally processed measles virus class II HLA-DRB1 peptides. J Virol (2004) 0.93

Reconstruction of the immunogenic peptide RNase(43-56) by identification and transfer of the critical residues into an unrelated peptide backbone. J Exp Med (1989) 0.91

Antigenic specificity and subset analysis of T cells isolated from the bronchoalveolar lavage and pleural effusion of patients with lung disease. Clin Exp Immunol (1992) 0.91

Presentation of an immunodominant T-cell epitope of hepatitis B surface antigen by the HLA-DPw4 molecule. J Virol (1989) 0.91

Sequence conservation predicts T cell reactivity against ragweed allergens. Clin Exp Allergy (2016) 0.89

An insulin peptide that binds an alternative site in class II major histocompatibility complex. J Exp Med (1996) 0.89

Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region. EMBO J (1997) 0.89

Structural basis of antigen recognition by T lymphocytes. Implications for vaccines. J Clin Invest (1988) 0.85

Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin. Am J Pathol (1995) 0.85

Identification of residues necessary for clonally specific recognition of a cytotoxic T cell determinant. EMBO J (1989) 0.85

The effects of changes at peptide residues contacting MHC class II T-cell receptor on antigen recognition and human Th0 cell effector function. Immunology (1995) 0.84

An epitope delivery system for use with recombinant mycobacteria. Infect Immun (1998) 0.83

Immunodominant T-cell epitopes of rubella virus structural proteins defined by synthetic peptides. J Virol (1993) 0.83

T-cell responses to predicted amphipathic peptides of varicella-zoster virus glycoproteins II and IV. J Virol (1990) 0.82

Analysis of the basis of resistance and susceptibility of CD4+ T cells to human immunodeficiency virus (HIV)-gp120 induced anergy. Immunology (1992) 0.81

Membrane interactions influence the peptide binding behavior of DR1. J Exp Med (1994) 0.80

Class II-restricted T-cell clones to a synthetic peptide of influenza virus hemagglutinin differ in their fine specificities and in the ability to respond to virus. J Virol (1989) 0.79

Insulin B chain functions as an effective competitor of antigen presentation via peptide homologies present in the thymus. J Exp Med (1989) 0.79

Characterization of human immunodeficiency virus type 1 (HIV-1) Gag- and Gag peptide-specific CD4(+) T-cell clones from an HIV-1-seronegative donor following in vitro immunization. J Virol (2002) 0.76

Regulation of cytokine production by human Th0 cells following stimulation with peptide analogues: differential expression of TGF-beta in activation and anergy. Immunology (1997) 0.75

Human T-cell responses to ragweed allergens: Amb V homologues. Immunology (1991) 0.75

Lymphocyte responses to DR1/4 restricted peptides in rheumatoid arthritis. Ann Rheum Dis (1994) 0.75

Articles by these authors

The rapid generation of mutation data matrices from protein sequences. Comput Appl Biosci (1992) 44.38

Identification of protein sequence homology by consensus template alignment. J Mol Biol (1986) 13.73

A mutation data matrix for transmembrane proteins. FEBS Lett (1994) 13.49

Repeated genes in eukaryotes. Annu Rev Biochem (1980) 11.23

Prediction of protein secondary structure and active sites using the alignment of homologous sequences. J Mol Biol (1987) 9.74

A new approach to protein fold recognition. Nature (1992) 8.17

Comparison of glyceraldehyde-3-phosphate dehydrogenase and 28S-ribosomal RNA gene expression as RNA loading controls for northern blot analysis of cell lines of varying malignant potential. Anal Biochem (1994) 7.81

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature (1998) 7.36

A model recognition approach to the prediction of all-helical membrane protein structure and topology. Biochemistry (1994) 6.64

Structure comparison and structure patterns. J Comput Biol (2000) 5.73

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J (1998) 5.25

Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med (1982) 5.09

A structural model for the retroviral proteases. Nature (1987) 4.78

Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2. Nature (1987) 4.66

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc Natl Acad Sci U S A (1995) 4.22

A sequence pattern common to T cell epitopes. EMBO J (1988) 4.02

Essential role of LAT in T cell development. Immunity (1999) 3.94

Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity (1995) 3.72

Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood (2001) 3.66

Identification and classification of protein fold families. Protein Eng (1993) 3.58

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J Exp Med (1983) 3.52

The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51

Recruitment of tyrosine phosphatase HCP by the killer cell inhibitor receptor. Immunity (1996) 3.33

Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest. Gene (1997) 3.28

SSAP: sequential structure alignment program for protein structure comparison. Methods Enzymol (1996) 3.25

Nucleotide sequence of the initiation site for ribosomal RNA transcription in Drosophila melanogaster: comparison of genes with and without insertions. Proc Natl Acad Sci U S A (1981) 3.21

DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression. EMBO J (1985) 3.20

Peptide specificity in the recognition of MHC class I by natural killer cell clones. Science (1995) 3.19

Expression of ribosomal DNA insertions in Drosophila melanogaster. Cell (1979) 3.19

The p53 network. J Biol Chem (1998) 3.19

The classification of amino acid conservation. J Theor Biol (1986) 3.12

Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. Nature (1985) 3.11

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature (1987) 2.89

PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis. Brain (2007) 2.88

Human T-cell clones recognize chemically synthesized peptides of influenza haemagglutinin. Nature (1982) 2.84

Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J Immunol (1998) 2.79

Childhood chronic illness: prevalence, severity, and impact. Am J Public Health (1992) 2.77

Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy. Hypertension (1998) 2.70

Ribosomal DNA in Drosophila melanogaster. I. Isolation and characterization of cloned fragments. J Mol Biol (1978) 2.68

Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. Nat Immunol (2001) 2.52

Coevolving protein residues: maximum likelihood identification and relationship to structure. J Mol Biol (1999) 2.49

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest (1999) 2.48

Angiotensin II-induced hypertension accelerates the development of atherosclerosis in apoE-deficient mice. Circulation (2001) 2.48

T lymphocytes respond to solid-phase antigen: a novel approach to the molecular analysis of cellular immunity. Immunology (1986) 2.45

Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. Immunity (1995) 2.37

A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells. J Exp Med (1999) 2.36

Allelic polymorphism and complexity of the genes for HLA-DR beta-chains--direct analysis by DNA-DNA hybridization. Nature (1982) 2.34

Antigen-specific human T lymphocyte clones: induction, antigen specificity, and MHC restriction of influenza virus-immune clones. J Immunol (1982) 2.30

Should HLA mismatch acceptability for sensitized transplant candidates be determined at the high-resolution rather than the antigen level? Am J Transplant (2015) 2.24

CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene. J Immunol (1988) 2.22

Location of 'continuous' antigenic determinants in the protruding regions of proteins. EMBO J (1986) 2.22

Recognition of super-secondary structure in proteins. J Mol Biol (1984) 2.21

Stress proteins may provide a link between the immune response to infection and autoimmunity. Int Immunol (1989) 2.21

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol (2001) 2.20

Isolation of cDNA clones encoding HLA-DR alpha chains. Proc Natl Acad Sci U S A (1982) 2.17

Specific lysis of allogeneic cells after activation of CD3- lymphocytes in mixed lymphocyte culture. J Exp Med (1988) 2.14

HLA class II-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cells. J Virol (1989) 2.11

Tolerance of T-cell clones is associated with membrane antigen changes. Nature (1983) 2.10

Mapping of T cell epitopes using recombinant antigens and synthetic peptides. EMBO J (1987) 2.09

Ribosomal insertion-like elements in Drosophila melanogaster are interspersed with mobile sequences. Cell (1981) 2.08

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. J Immunol (1990) 2.07

Restriction analysis of spacers in ribosomal DNA of Drosophila melanogaster. Nucleic Acids Res (1979) 2.04

p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ Res (1997) 2.04

A rapid method of protein structure alignment. J Theor Biol (1990) 2.03

Biological activity of protein antigens isolated from Mycobacterium tuberculosis culture filtrate. Infect Immun (1988) 2.01

Class I MHC molecules rather than other mouse genes dictate influenza epitope recognition by cytotoxic T cells. Immunogenetics (1987) 1.97

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells. J Exp Med (1990) 1.94

"Exon-shuffling" maps control of antibody- and T-cell-recognition sites to the NH2-terminal domain of the class II major histocompatibility polypeptide A beta. Proc Natl Acad Sci U S A (1985) 1.93

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization. Proc Natl Acad Sci U S A (1993) 1.92

The direct binding of a p58 killer cell inhibitory receptor to human histocompatibility leukocyte antigen (HLA)-Cw4 exhibits peptide selectivity. J Exp Med (1997) 1.91

Analysis of the antigen specificity of influenza haemagglutinin-immune human T lymphocyte clones: identification of an immunodominant region for T cells. Immunology (1983) 1.88

Antigen presentation mediated by recycling of surface HLA-DR molecules. Nature (1995) 1.85

Prediction of super-secondary structure in proteins. Nature (1983) 1.84

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis. J Exp Med (1991) 1.84

Two forms of the Ia antigen-associated invariant chain result from alternative initiations at two in-phase AUGs. Cell (1986) 1.82

Isolation of endothelial cells from murine tissue. J Immunol Methods (2000) 1.81

Binary and ternary complexes between T-cell receptor, class II MHC and superantigen in vitro. Nature (1994) 1.79

Assessment of the contribution that direct allorecognition makes to the progression of chronic cardiac transplant rejection in humans. Circulation (1998) 1.79

Isolation of distinct cDNA clones encoding HLA-DR beta chains by use of an expression assay. Proc Natl Acad Sci U S A (1982) 1.77

Intranasal exposure to protein antigen induces immunological tolerance mediated by functionally disabled CD4+ T cells. J Immunol (1999) 1.77

Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis. J Clin Endocrinol Metab (2000) 1.75

Salivary infectious agents and periodontal disease status. J Periodontal Res (2011) 1.73

The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity. EMBO J (1984) 1.72

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice. J Exp Med (1993) 1.71

Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells. J Immunol (2001) 1.69

Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells. J Immunol (1996) 1.69

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells. Nature (1992) 1.68

Which guesstimate is the best guesstimate? Predicting chemotherapeutic outcomes. Nat Med (1997) 1.66

Sudden death among Southeast Asian refugees. An unexplained nocturnal phenomenon. JAMA (1983) 1.65

Global fold determination from a small number of distance restraints. J Mol Biol (1995) 1.64

Mapping of the class II region of the human major histocompatibility complex by pulsed-field gel electrophoresis. Nature (1986) 1.64

A novel approach to the identification of T-cell epitopes in Mycobacterium tuberculosis using human T-lymphocyte clones. Immunology (1987) 1.63

A single amino acid in the p58 killer cell inhibitory receptor controls the ability of natural killer cells to discriminate between the two groups of HLA-C allotypes. J Immunol (1997) 1.63

Stool DNA testing for the detection of colorectal neoplasia in patients with inflammatory bowel disease. Aliment Pharmacol Ther (2013) 1.63

Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain. J Exp Med (1986) 1.61

Alternative pathways in the processing of ribosomal RNA precursor in Drosophila melanogaster. J Mol Biol (1980) 1.59

Fast structure alignment for protein databank searching. Proteins (1992) 1.59