Cooperative enhancement of specificity in a lattice of T cell receptors.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMC 33286)

Published in Proc Natl Acad Sci U S A on May 08, 2001

Authors

C Chan1, A J George, J Stark

Author Affiliations

1: Centre for Nonlinear Dynamics and Its Applications, University College London, Gower Street, London WC1E 6BT, United Kingdom.

Articles citing this

Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol (2005) 4.26

Synthetic multivalent ligands as probes of signal transduction. Angew Chem Int Ed Engl (2006) 3.29

Mechanisms for T cell receptor triggering. Nat Rev Immunol (2010) 2.30

Systems biology in immunology: a computational modeling perspective. Annu Rev Immunol (2011) 2.15

Quantitative challenges in understanding ligand discrimination by alphabeta T cells. Mol Immunol (2007) 1.24

Stochastic effects and bistability in T cell receptor signaling. J Theor Biol (2008) 1.17

A role for rebinding in rapid and reliable T cell responses to antigen. PLoS Comput Biol (2009) 1.11

T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit. Proc Natl Acad Sci U S A (2004) 1.10

Feedback control of T-cell receptor activation. Proc Biol Sci (2004) 0.98

Ligand detection and discrimination by spatial relocalization: A kinase-phosphatase segregation model of TCR activation. Biophys J (2006) 0.95

Phenotypic models of T cell activation. Nat Rev Immunol (2014) 0.94

An induced rebinding model of antigen discrimination. Trends Immunol (2014) 0.93

Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes. Cell Signal (2014) 0.85

T-cell activation: A queuing theory analysis at low agonist density. Biophys J (2006) 0.82

Frequency encoding of T-cell receptor engagement dynamics in calcium time series. Biophys J (2004) 0.81

Perspectives for computer modeling in the study of T cell activation. Cold Spring Harb Perspect Biol (2010) 0.79

A mathematical framework for analyzing T cell receptor scanning of peptides. Biophys J (2010) 0.77

TCR/pMHC Interaction: Phenotypic Model for an Unsolved Enigma. Front Immunol (2016) 0.75

A model of cell surface receptor aggregation. J Math Biol (2017) 0.75

Articles cited by this

The immunological synapse: a molecular machine controlling T cell activation. Science (1999) 17.41

Three-dimensional segregation of supramolecular activation clusters in T cells. Nature (1998) 14.14

Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature (1995) 7.40

T cell activation determined by T cell receptor number and tunable thresholds. Science (1996) 5.51

Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci U S A (1995) 5.01

T-cell-receptor affinity and thymocyte positive selection. Nature (1996) 4.96

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation. Nature (1990) 4.59

The minimal number of class II MHC-antigen complexes needed for T cell activation. Science (1990) 4.09

Heightened sensitivity of a lattice of membrane receptors. Proc Natl Acad Sci U S A (1999) 3.36

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature (1996) 3.08

Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. Proc Natl Acad Sci U S A (1994) 3.07

The repertoire of T cells shaped by a single MHC/peptide ligand. Cell (1996) 3.04

A TCR binds to antagonist ligands with lower affinities and faster dissociation rates than to agonists. Immunity (1996) 2.69

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation. Annu Rev Immunol (1999) 2.60

TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity (1999) 2.33

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity (1997) 2.25

H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell (1996) 2.21

Kinetic discrimination in T-cell activation. Proc Natl Acad Sci U S A (1996) 2.17

CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes. Nature (1995) 2.15

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. Immunity (1999) 1.99

T cell receptor antagonists and partial agonists. Immunity (1995) 1.83

Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses. Proc Natl Acad Sci U S A (1992) 1.83

Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire. Immunity (1999) 1.64

Serial triggering of TCRs: a basis for the sensitivity and specificity of antigen recognition. Immunol Today (1997) 1.57

Ligands for the T-cell receptor: hard times for avidity models. Immunol Today (1995) 1.46

Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity (1998) 1.46

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus. Proc Natl Acad Sci U S A (1996) 1.44

Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events. J Immunol (1999) 1.34

Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. J Exp Med (1996) 1.34

Cross-antagonism of a T cell clone expressing two distinct T cell receptors. Immunity (1999) 1.30

Positive selection of an H2-M3 restricted T cell receptor. Immunity (1999) 1.24

The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement. J Immunol (1998) 1.22

Variant TCR ligands: new insights into the molecular basis of antigen-dependent signal transduction and T-cell activation. Semin Immunol (1996) 1.15

Significance of T-cell stimulation by altered peptide ligands in T cell biology. Curr Opin Immunol (1995) 1.05

Cutting edge: dueling TCRs: peptide antagonism of CD4+ T cells with dual antigen specificities. J Immunol (1999) 1.03

A kinetic differentiation model for the action of altered TCR ligands. Immunol Today (1999) 0.90

A physiological ligand of positive selection is seen with high specificity. J Immunol (2000) 0.79

Self/nonself discrimination among immunoregulatory (CD4) T cells. Semin Immunol (2000) 0.79

Articles by these authors

Search for a resonance decaying into WZ boson pairs in pp collisions. Phys Rev Lett (2010) 2.83

Outcomes after delayed sternal closure in pediatric heart operations: a 10-year experience. Ann Thorac Surg (1997) 2.42

Modified Blalock-Taussig shunt. Use of subclavian artery orifice as flow regulator in prosthetic systemic-pulmonary artery shunts. J Thorac Cardiovasc Surg (1981) 2.08

An introduction to independent learning skills for incoming medical students. Bull Med Libr Assoc (1988) 2.06

Surgical treatment of aortico-left ventricular tunnel. Eur J Cardiothorac Surg (1991) 1.79

Vascular anomalies compressing the oesophagus and trachea. Thorax (1969) 1.73

Acute renal failure complicating cardiopulmonary bypass surgery. Arch Dis Child (1982) 1.61

Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60

Congenital heart disease in the neonate: results of surgical treatment. Arch Dis Child (1983) 1.59

Surfactant protein-A enhances respiratory syncytial virus clearance in vivo. J Clin Invest (1999) 1.57

Expanded PTFE membrane to prevent cardiac injury during resternotomy for congenital heart disease. Ann Thorac Surg (1996) 1.56

Differential effect of alterations in the calcium and magnesium concentrations on the responses to sympathomimetic amines of the perfused rat mesentery. Br J Pharmacol (1971) 1.54

Measurement of the forward-backward charge asymmetry in top-quark pair production. Phys Rev Lett (2008) 1.53

Hyperviscosity and thrombotic changes in idiopathic and secondary Raynaud's syndrome. Br J Haematol (1980) 1.47

Measurement of the W boson mass with the D0 detector. Phys Rev Lett (2012) 1.46

Arrhythmia and late mortality after Mustard and Senning operation for transposition of the great arteries. An eight-year prospective study. J Thorac Cardiovasc Surg (1988) 1.46

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene (2011) 1.45

Mustard's operation for transposition of the great arteries. Review of 200 cases. Lancet (1972) 1.43

Atrioventricular septal defect and tetralogy of Fallot: a 15-year experience. Eur J Cardiothorac Surg (1997) 1.43

The involvement of Ca2+ and Mg2+ in the spontaneous and drug induced release of (3H)noradrenaline from mesenteric arteries. Biochem Pharmacol (1975) 1.43

Current surgical technique to repair Fallot's tetralogy with absent pulmonary valve syndrome. Ann Thorac Surg (1991) 1.42

Observation of a centrality-dependent dijet asymmetry in lead-lead collisions at sqrt[S(NN)] =2.76 TeV with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.41

Formation and early development of follicles in the polycystic ovary. Lancet (2003) 1.41

Biological effects of shock waves: lung hemorrhage by shock waves in dogs--pressure dependence. Ultrasound Med Biol (1987) 1.39

Measurement of dijet azimuthal decorrelations in pp collisions at sqrt(s)=7  TeV. Phys Rev Lett (2011) 1.39

Platelet monoamine oxidase activity and 5-hydroxytryptamine uptake in agoraphobic patients. Br J Psychiatry (1989) 1.38

Surgical treatment of persistent ductus arteriosus complicated by bacterial endocarditis. Eur J Cardiothorac Surg (1992) 1.38

Determination of the strange-quark density of the proton from ATLAS measurements of the W→ℓν and Z→ℓℓ cross sections. Phys Rev Lett (2012) 1.34

Early and late results of surgical correction of pulmonary artery sling. Ann Thorac Surg (1979) 1.34

Parachute deformity of the tricuspid valve. Thorax (1979) 1.34

Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32

Observation of associated near-side and away-side long-range correlations in sqrt[s(NN)]=5.02 TeV proton-lead collisions with the ATLAS detector. Phys Rev Lett (2013) 1.27

Pulmonary atresia and intact ventricular septum: surgical management based on a revised classification. Circulation (1982) 1.25

Pulmonary artery constriction (banding): a report of 146 cases. Surgery (1969) 1.25

Congenital lobar emphysema. Ann Surg (1971) 1.22

The fate of survivors of cardiac surgery in infancy. Circulation (1980) 1.22

Isolated anterior mitral cleft. Two dimensional echocardiographic assessment and differentiation from "clefts" associated with atrioventricular septal defect. Br Heart J (1982) 1.22

Pulmonary hypertensive crises following surgery for congenital heart defects in young children. Eur J Cardiothorac Surg (1991) 1.22

Cytokines, chaos, and complexity. Immunity (1999) 1.22

Obstruction to systemic venous return following the Mustard operation for transposition of the great arteries. J Thorac Cardiovasc Surg (1974) 1.21

Antibody engineering: comparison of bacterial, yeast, insect and mammalian expression systems. J Immunol Methods (1998) 1.20

Search for dark matter candidates and large extra dimensions in events with a photon and missing transverse momentum in pp collision data at sqrt[s]=7 TeV with the ATLAS detector. Phys Rev Lett (2013) 1.19

Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector. Hum Gene Ther (1998) 1.16

Calcified left ventricular aneurysm in a 6-year-old Caucasian boy. Br Heart J (1981) 1.16

Correction of isolated secundum atrial septal defect in infancy. Arch Dis Child (1981) 1.14

Characterization of a new monoclonal anti-Fc gamma RII antibody, AT10, and its incorporation into a bispecific F(ab')2 derivative for recruitment of cytotoxic effectors. Mol Immunol (1991) 1.14

Search for a supersymmetric partner to the top quark in final states with jets and missing transverse momentum at sqrt[s] = 7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.13

From cell death to embryo arrest: mathematical models of human preimplantation embryo development. Proc Natl Acad Sci U S A (2001) 1.13

[Enzyme-histochemical studies on mature human placental villi. I. Differentiation and degeneration of the trophoblast]. Histochemie (1972) 1.13

Haematological stress syndrome in atherosclerosis. J Clin Pathol (1981) 1.12

Infective endocarditis in children with congenital heart disease: comparison of selected features in patients with surgical correction or palliation and those without. Br Heart J (1987) 1.11

Management of critical aortic stenosis in infancy. J Thorac Cardiovasc Surg (1984) 1.11

Multiple regions of yeast ribosomal protein L1 are important for its interaction with 5 S rRNA and assembly into ribosomes. J Biol Chem (1995) 1.10

Transventricular aortic valvotomy for critical aortic stenosis in infants. J Thorac Cardiovasc Surg (1987) 1.10

Measurement of the electron charge asymmetry in pp[over ]-->W+X-->enu+X events at sqrt[s]=1.96 TeV. Phys Rev Lett (2008) 1.09

Evidence for a particle produced in association with weak bosons and decaying to a bottom-antibottom quark pair in higgs boson searches at the tevatron. Phys Rev Lett (2012) 1.08

[Protoplasmic trophoblastic protrusions and their secretion into the maternal circulation in normal and pathological pregnancy]. Arch Gynakol (1971) 1.08

Anti-idiotypic mechanisms involved in suppression of a mouse B cell lymphoma, BCL1. J Immunol (1987) 1.08

Search for tb resonances in proton-proton collisions at √s=7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.07

Cardiac surgery in the first year of life: experience with 1,049 operations. Surgery (1971) 1.07

Adenovirus-mediated gene delivery to the corneal endothelium. Transplantation (1996) 1.07

Total anomalous pulmonary venous drainage in infancy. Br Heart J (1977) 1.06

Surface-immobilized dextran limits cell adhesion and spreading. Biomaterials (2000) 1.06

Indium-111 labelled lymphocytes: isotope distribution and cell division. Eur J Nucl Med (1997) 1.06

Inferring biological mechanisms from spatial analysis: prediction of a local inhibitor in the ovary. Proc Natl Acad Sci U S A (2009) 1.05

Determination of the width of the top quark. Phys Rev Lett (2011) 1.05

Search for a light Higgs boson decaying to long-lived weakly interacting particles in proton-proton collisions at sqrt[s] = 7 TeV with the ATLAS detector. Phys Rev Lett (2012) 1.05

Search for large extra dimensions via single photon plus missing energy final states at sqrt s = 1.96 TeV. Phys Rev Lett (2008) 1.04

Surgical management of vascular ring. Ann Surg (1983) 1.03

Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator. Proc Natl Acad Sci U S A (2005) 1.03

Anti-neutrophil cytoplasmic antibodies (ANCA) from patients with systemic vasculitis recognize restricted epitopes of proteinase 3 involving the catalytic site. Clin Exp Immunol (2001) 1.02

Ex vivo adenovirus-mediated gene transfer and immunomodulatory protein production in human cornea. Gene Ther (1997) 1.02

Late results of surgical treatment of transposition of the great arteries. Adv Cardiol (1980) 1.02

Platelet hyperactivity in sickle-cell disease: a consequence of hyposplenism. J Clin Pathol (1980) 1.02

Search for doubly charged Higgs boson pair production in pp¯ collisions at √s=1.96 TeV. Phys Rev Lett (2012) 1.02

Analysis of soluble HLA class II antigenic material in patients with immunological diseases using monoclonal antibodies. J Immunol Methods (1986) 1.02

The effects of changes in ionic environment and modification of adrenergic function on the vascular responses to sympathomimetic amines. J Pharm Pharmacol (1973) 1.01

Mathematical models of the balance between apoptosis and proliferation. Apoptosis (2002) 1.01

The Anrep effect reconsidered. J Clin Invest (1972) 1.00

Surgical management of coarctation of aorta with ventricular septal defect. Multivariate analysis. Br Heart J (1981) 1.00

Cytokine and chemokine expression kinetics after corneal transplantation. Transplantation (2000) 1.00

Search for supersymmetry in events with three leptons and missing transverse momentum in √[s]=7 TeV pp collisions with the ATLAS detector. Phys Rev Lett (2012) 0.99

Angiocardiographic appearances of atrioventricular defects with particular reference to distinction of ostium primum atrial septal defect from common atrioventricular orifice. Br Heart J (1979) 0.99

Unusual vascular ring in infant with pulmonary atresia and ventricular septal defect. Br Heart J (1982) 0.99

Replication-deficient adenovirus induces expression of interleukin-8 by airway epithelial cells in vitro. Hum Gene Ther (1995) 0.99

Surgical management of doubly committed subarterial ventricular septal defects. Circulation (1988) 0.98

The glycophosphatidylinositol anchor affects the conformation of Thy-1 protein. J Cell Sci (1995) 0.98

Use of a subpulmonary ventricular chamber in the Fontan circulation. J Thorac Cardiovasc Surg (1983) 0.98

Immobilized RGD peptides on surface-grafted dextran promote biospecific cell attachment. J Biomed Mater Res (2001) 0.98

Single-chain Fv radioimmunotargeting. Q J Nucl Med (1996) 0.98

Surgical treatment of ventricular septal defect in infancy. Primary repair versus banding of pulmonary artery and later repair. Br Heart J (1979) 0.97

Corrective surgery of transposition of the great arteries in the first year of life. Results in 63 infants. J Thorac Cardiovasc Surg (1974) 0.97

Germination of conidia of Aspergillus niger is accompanied by major changes in RNA profiles. Stud Mycol (2012) 0.97

Cytokine-modulated regulation of helper T cell populations. J Theor Biol (2000) 0.97

Anabolic steroids. Baillieres Best Pract Res Clin Endocrinol Metab (2000) 0.96

The villous stroma of the human placenta. I. The ultrastructure of fixed connective tissue cells. Cell Tissue Res (1977) 0.96

Studies on monoamine oxidase in rat spinal cord [proceedings]. Br J Pharmacol (1976) 0.96

Cardioplegic protection of the child's heart. J Thorac Cardiovasc Surg (1984) 0.96

Source of oncofetal ED-B-containing fibronectin: implications of production by both tumor and endothelial cells. Cancer Res (2000) 0.96