Published in Cell Signal on January 08, 2014
GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production. Front Immunol (2015) 0.90
The autoinhibitory C-terminal SH2 domain of phospholipase C-γ2 stabilizes B cell receptor signalosome assembly. Sci Signal (2014) 0.81
TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems. J Immunol Methods (2014) 0.79
Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands. Biochim Biophys Acta (2015) 0.78
Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism. PLoS One (2016) 0.78
Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics. Sci Rep (2016) 0.76
Scaffold Protein SLP-76 Primes PLCγ1 for Activation by ITK-Mediated Phosphorylation. J Mol Biol (2015) 0.75
Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function. PLoS One (2016) 0.75
The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion. PLoS Pathog (2017) 0.75
T cell activation. Annu Rev Immunol (2009) 7.40
Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci U S A (1995) 5.01
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J Cell Biol (2002) 4.89
Modeling T cell antigen discrimination based on feedback control of digital ERK responses. PLoS Biol (2005) 4.26
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254. Cell (1991) 3.95
CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. Nat Immunol (2004) 3.21
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Chem (2000) 3.03
A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science (2002) 2.35
Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity (2007) 2.11
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science (2002) 2.01
Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem (2001) 1.81
Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation. Structure (2012) 1.73
Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. Mol Cell Biol (2001) 1.69
LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J Exp Med (2005) 1.65
Altered T cell receptor ligands trigger a subset of early T cell signals. Immunity (1996) 1.64
Persistence of cooperatively stabilized signaling clusters drives T-cell activation. Mol Cell Biol (2006) 1.55
Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences. Biochemistry (2004) 1.52
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Biochem J (2001) 1.51
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line. Mol Cell Biol (2000) 1.51
Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. J Immunol (2003) 1.50
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains. EMBO J (2006) 1.47
Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. J Immunol (2005) 1.38
High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates. Sci STKE (2003) 1.35
Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med (2010) 1.32
Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor. J Cell Biol (2001) 1.17
The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. J Immunol (2010) 1.14
Cooperative enhancement of specificity in a lattice of T cell receptors. Proc Natl Acad Sci U S A (2001) 1.13
Phospholipase C-gamma: diverse roles in receptor-mediated calcium signaling. Trends Biochem Sci (2005) 1.13
Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1. J Biol Chem (2006) 1.06
Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. Biochemistry (2002) 1.01
Feedback control of T-cell receptor activation. Proc Biol Sci (2004) 0.98
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. Sci STKE (2007) 0.98
A 'pocket guide' to total internal reflection fluorescence. J Microsc (2013) 0.97
A kinetic differentiation model for the action of altered TCR ligands. Immunol Today (1999) 0.90
A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. J Immunol (2012) 0.88
The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. Wiley Interdiscip Rev Syst Biol Med (2012) 0.88