Yeast telomerase appears to frequently copy the entire template in vivo.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 55706)

Published in Nucleic Acids Res on June 01, 2001

Authors

A Ray1, K W Runge

Author Affiliations

1: The Lerner Research Institute, Cleveland Clinic Foundation, Department of Molecular Biology, NC20, 9500 Euclid Avenue, Cleveland, OH 44195, USA. raya@ccf.org

Articles cited by this

MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res (1995) 21.22

Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science (1987) 17.15

Reverse transcriptase motifs in the catalytic subunit of telomerase. Science (1997) 10.10

TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science (1994) 9.08

Telomere length regulation. Annu Rev Biochem (1996) 6.98

An alternative pathway for yeast telomere maintenance rescues est1- senescence. Cell (1993) 6.89

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature (1990) 6.82

Cloning yeast telomeres on linear plasmid vectors. Cell (1982) 6.39

Effective protein sequence comparison. Methods Enzymol (1996) 6.38

All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3' terminus. Proc Natl Acad Sci U S A (1981) 5.75

Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell (1997) 4.86

A protein-counting mechanism for telomere length regulation in yeast. Science (1997) 4.79

Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics (1996) 4.78

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell (1995) 4.34

Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell (1993) 4.33

Est1 and Cdc13 as comediators of telomerase access. Science (1999) 4.32

RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell (1990) 4.25

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. Cell (1995) 4.20

Yeast Ku as a regulator of chromosomal DNA end structure. Science (1998) 3.86

Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol Cell Biol (1999) 3.79

Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein. Mol Cell Biol (1988) 3.69

Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science (1990) 3.52

Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev (1997) 3.42

Telomerase in yeast. Science (1995) 3.38

Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell (1999) 3.35

Identification of yeast mutants with altered telomere structure. Proc Natl Acad Sci U S A (1986) 3.05

Evidence for a new step in telomere maintenance. Cell (1996) 3.03

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.92

The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. Nucleic Acids Res (1996) 2.90

Recombination occurs during telomere formation in yeast. Nature (1989) 2.89

Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.88

An overhanging 3' terminus is a conserved feature of telomeres. Mol Cell Biol (1989) 2.85

Telomerase is processive. Mol Cell Biol (1991) 2.79

Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev (1997) 2.73

Mitotic and meiotic stability of linear plasmids in yeast. Proc Natl Acad Sci U S A (1983) 2.70

Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev (1993) 2.64

The terminal DNA structure of mammalian chromosomes. EMBO J (1997) 2.63

New telomeres in yeast are initiated with a highly selected subset of TG1-3 repeats. Genes Dev (1993) 2.48

The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA. Cell (1996) 2.42

Progressive cis-inhibition of telomerase upon telomere elongation. EMBO J (1999) 2.37

Functionally interacting telomerase RNAs in the yeast telomerase complex. Genes Dev (1997) 2.37

Introduction of extra telomeric DNA sequences into Saccharomyces cerevisiae results in telomere elongation. Mol Cell Biol (1989) 2.33

Structure, function, and replication of Saccharomyces cerevisiae telomeres. Annu Rev Genet (1996) 2.32

Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants. Genes Dev (1999) 2.30

Elaboration of telomeres in yeast: recognition and modification of termini from Oxytricha macronuclear DNA. Proc Natl Acad Sci U S A (1984) 2.24

Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites. J Mol Biol (1993) 2.23

An in vitro assay for Saccharomyces telomerase requires EST1. Cell (1995) 2.10

DNA-binding requirements of the yeast protein Rap1p as selected in silico from ribosomal protein gene promoter sequences. Bioinformatics (1999) 2.02

Functional reconstitution of wild-type and mutant Tetrahymena telomerase. Genes Dev (1994) 1.97

Telomerase-dependent repeat divergence at the 3' ends of yeast telomeres. Nucleic Acids Res (2000) 1.74

Association of the Est1 protein with telomerase activity in yeast. Proc Natl Acad Sci U S A (1996) 1.69

HDF2, the second subunit of the Ku homologue from Saccharomyces cerevisiae. J Biol Chem (1996) 1.68

Processing of nontelomeric 3' ends by telomerase: default template alignment and endonucleolytic cleavage. Mol Cell Biol (1996) 1.66

Sequencing of Saccharomyces telomeres cloned using T4 DNA polymerase reveals two domains. Mol Cell Biol (1990) 1.48

The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction. Mol Cell Biol (1999) 1.45

Hoogsteen G-G base pairing is dispensable for telomere healing in yeast. Nucleic Acids Res (1992) 1.20

Use of a selection technique to identify the diversity of binding sites for the yeast RAP1 transcription factor. Nucleic Acids Res (1994) 1.17

The C terminus of the major yeast telomere binding protein Rap1p enhances telomere formation. Mol Cell Biol (1998) 1.09

Characterization of the interaction between the nuclease and reverse transcriptase activity of the yeast telomerase complex. Mol Cell Biol (2000) 1.04

Varying the number of telomere-bound proteins does not alter telomere length in tel1Delta cells. Proc Natl Acad Sci U S A (1999) 1.03

How does the end begin? Formation and maintenance of telomeres in ciliates and yeast. Trends Genet (1990) 1.03

Sequencing telomeric DNA template with short tandem repeats using dye terminator cycle sequencing. J Biomol Tech (2000) 0.91

Species-specific and sequence-specific recognition of the dG-rich strand of telomeres by yeast telomerase. Nucleic Acids Res (1998) 0.90