Developmental roles of platelet-derived growth factors.

Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev (2002) 5.15

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol (2005) 4.57

The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol (2005) 4.54

MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nat Genet (2008) 3.01

Pericytes limit tumor cell metastasis. J Clin Invest (2006) 2.55

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J Clin Invest (2002) 2.26

Platelet-derived growth factor-B enhances glioma angiogenesis by stimulating vascular endothelial growth factor expression in tumor endothelia and by promoting pericyte recruitment. Am J Pathol (2003) 1.99

Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol (2003) 1.91

Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization. Blood (2010) 1.81

Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. Genes Dev (2003) 1.72

Directed differentiation of human embryonic stem cells toward chondrocytes. Nat Biotechnol (2010) 1.72

Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models. Cancer Biol Ther (2010) 1.71

Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest (2005) 1.55

Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression. Breast Cancer Res (2005) 1.47

Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest (2007) 1.47

Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals. J Cell Sci (2011) 1.33

Mesenchymal stem cells and neovascularization: role of platelet-derived growth factor receptors. J Cell Mol Med (2007) 1.33

Impact of vessel maturation on antiangiogenic therapy in ovarian cancer. Am J Obstet Gynecol (2008) 1.25

cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol Cell Biol (2007) 1.14

Impact of the loss of Hoxa5 function on lung alveogenesis. Am J Pathol (2006) 1.12

Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF. Biochem J (2003) 1.10

Effects of the tyrosine protein kinase inhibitor genistein on the proliferation, activation of cultured rat hepatic stellate cells. World J Gastroenterol (2002) 1.06

Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase. Mol Cell Biol (2004) 1.06

Cooperation between the PDGF receptors in cardiac neural crest cell migration. Dev Biol (2007) 1.06

Blockade of platelet-derived growth factor receptor-beta pathway induces apoptosis of vascular endothelial cells and disrupts glomerular capillary formation in neonatal mice. Am J Pathol (2002) 1.05

Common cues regulate neural and vascular patterning. Curr Opin Genet Dev (2007) 1.04

Analysis of metagene portraits reveals distinct transitions during kidney organogenesis. Sci Signal (2008) 1.03

Initiation of oligodendrocyte progenitor cell migration by a PDGF-A activated extracellular regulated kinase (ERK) signaling pathway. Neurochem Res (2008) 1.03

Inhibitory effects of resveratrol on PDGF-BB-induced retinal pigment epithelial cell migration via PDGFRβ, PI3K/Akt and MAPK pathways. PLoS One (2013) 0.99

The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P. Eur J Hum Genet (2008) 0.99

Development of a fully human anti-PDGFRbeta antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody. Neoplasia (2009) 0.99

Molecular mediators of angiogenesis. J Burn Care Res (2010) 0.98

Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells. Am J Pathol (2006) 0.93

Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Mol Cell Biol (2008) 0.92

Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer. Mol Cancer Res (2012) 0.91

Role of receptor tyrosine kinases and their ligands in glioblastoma. Cells (2014) 0.91

Role and regulation of PDGFRα signaling in liver development and regeneration. Am J Pathol (2013) 0.89

C-reactive protein and vein graft disease: evidence for a direct effect on smooth muscle cell phenotype via modulation of PDGF receptor-beta. Am J Physiol Heart Circ Physiol (2008) 0.88

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Growth factors in tumor microenvironment. Front Biosci (Landmark Ed) (2010) 0.88

Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes. Dev Dyn (2009) 0.88

The 4q12 amplicon in malignant peripheral nerve sheath tumors: consequences on gene expression and implications for sunitinib treatment. PLoS One (2010) 0.88

Interdependence of platelet-derived growth factor and estrogen-signaling pathways in inducing neonatal rat testicular gonocytes proliferation. Biol Reprod (2010) 0.88

The murine allantois: a model system for the study of blood vessel formation. Blood (2012) 0.87

Contribution of endothelial cells to organogenesis: a modern reappraisal of an old Aristotelian concept. J Anat (2007) 0.85

PDGF function in diverse neural crest cell populations. Cell Adh Migr (2011) 0.84

Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells. J Virol (2007) 0.84

Integral role of platelet-derived growth factor in mediating transforming growth factor-β1-dependent mesenchymal stem cell stiffening. Stem Cells Dev (2013) 0.83

Partial pulmonary embolization disrupts alveolarization in fetal sheep. Respir Res (2010) 0.82

Platelet-derived growth factor B-chain of hematopoietic origin is not necessary for granulation tissue formation and its absence enhances vascularization. Am J Pathol (2001) 0.81

Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential. Stem Cells (2014) 0.81

Metformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: an in vitro study. PLoS One (2014) 0.79

Transcriptome analysis reveals differentially expressed genes associated with germ cell and gonad development in the Southern bluefin tuna (Thunnus maccoyii). BMC Genomics (2016) 0.79

Retracted Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter. J Biol Chem (2009) 0.78

CP-673451, a platelet-derived growth-factor receptor inhibitor, suppresses lung cancer cell proliferation and migration. Onco Targets Ther (2014) 0.78

Topical infliximab for the suppression of wound healing following experimental glaucoma filtration surgery. Drug Des Devel Ther (2014) 0.78

Glial abnormalities in mood disorders. Harv Rev Psychiatry (2014) 0.77

Pdgfra and Pdgfrb genetically interact during craniofacial development. Dev Dyn (2016) 0.77

The platelet-derived growth factor signaling system in snapping turtle embryos, Chelydra serpentina: potential role in temperature-dependent sex determination and testis development. Gen Comp Endocrinol (2009) 0.77

HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Exp Hematol (2016) 0.76

Peptide-based targeting of the platelet-derived growth factor receptor beta. Mol Imaging Biol (2013) 0.75

Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges. Arch Med Sci (2015) 0.75

Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development (1999) 7.12

PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol (2000) 3.81

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell (1996) 3.60

Intracellular transport of class II MHC molecules directed by invariant chain. Nature (1990) 3.35

Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proc Natl Acad Sci U S A (1972) 2.41

Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development (1998) 2.31

Defective antigen processing in GILT-free mice. Science (2001) 2.16

Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells. Proc Natl Acad Sci U S A (1973) 2.11

Antigen presentation and T cell development in H2-M-deficient mice. Science (1996) 2.07

Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development. Development (1997) 2.07

Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice. Development (1999) 1.98

Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells. Proc Natl Acad Sci U S A (1976) 1.88

Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development (2000) 1.82

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A large family of endosome-localized proteins related to sorting nexin 1. Biochem J (2001) 1.63

Importance of creatinine analyses of urine when screening for abused drugs. Clin Chem (1991) 1.60

Two subsets of epithelial cells in the thymic medulla. J Exp Med (1992) 1.59

Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice. J Cell Biol (2000) 1.44

PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta. Dev Biol (1999) 1.37

Transgenic HLA-DR alpha faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to E alpha in E alpha 0 mutant mice. Cell (1989) 1.37

Altered antigen presentation in mice lacking H2-O. Immunity (1998) 1.36

Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells. Immunity (1997) 1.30

HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport. EMBO J (1996) 1.29

Activity and protein expression of Na+/K+ ATPase are reduced in microvillous syncytiotrophoblast plasma membranes isolated from pregnancies complicated by intrauterine growth restriction. J Clin Endocrinol Metab (2003) 1.24

Adalimumab in juvenile idiopathic arthritis-associated chronic anterior uveitis. Rheumatology (Oxford) (2008) 1.20

The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif. Immunity (1995) 1.19

Nonclassical MHC class II molecules. Annu Rev Immunol (2000) 1.18

Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice. Blood (2001) 1.16

Molecular epidemiology and clinical manifestations of human cryptosporidiosis in Sweden. Epidemiol Infect (2012) 1.16

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Observation of high-energy neutrinos using Cerenkov detectors embedded deep in Antarctic ice. Nature (2001) 1.12

Inhibitory effect of interferon preparations and inducers on the multiplication of transplanted allogeneic spleen cells and syngeneic bone marrow cells. Nat New Biol (1973) 1.10

Expression of platelet-derived growth factor-beta receptors on human fibroblasts. Regulation by recombinant platelet-derived growth factor-BB, IL-1, and tumor necrosis factor-alpha. J Immunol (1992) 1.08

Letter: Inhibitory effect of potent interferon preparations on the regeneration of mouse liver after partial hepatectomy. Nature (1973) 1.06

NMR structural studies of human cystatin C dimers and monomers. J Mol Biol (1997) 1.06

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Relationship between the enhanced expression of histocompatibility antigens on interferon-treated L 1210 cells and their position in the cell cycle. Eur J Immunol (1976) 1.01

A key role for ICAM-1 in generating effector cells mediating inflammatory responses. Nat Immunol (2001) 1.01

Increased binding of concanavalin A to interferon-treated murine leukemia L 1210 cells. Proc Soc Exp Biol Med (1974) 0.98

Genetic steps to organ laterality in zebrafish. Comp Funct Genomics (2001) 0.98

Probing the valence character of O 1s-->Rydberg excited O2 by participator Auger decay measurements and partial ion yield spectroscopy following x-ray absorption. J Chem Phys (2007) 0.96

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Molecular Detection of Persistent Francisella tularensis Subspecies holarctica in Natural Waters. Int J Microbiol (2010) 0.95

Role of platelet-derived growth factors in angiogenesis and alveogenesis. Curr Top Pathol (1999) 0.95

Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells. Proc Natl Acad Sci U S A (1999) 0.95

Exit of major histocompatibility complex class II-invariant chain p35 complexes from the endoplasmic reticulum is modulated by phosphorylation. Proc Natl Acad Sci U S A (1998) 0.94

Evaluation of phagocytic activity in human monocyte-derived dendritic cells. J Aerosol Med (2001) 0.93

Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins. J Biol Chem (1997) 0.92

KIR down-regulation on NK cells is associated with down-regulation of activating receptors and NK cell inactivation. Eur J Immunol (2001) 0.91

Costimulation via lymphocyte function-associated antigen 1 in the absence of CD28 ligation promotes anergy of naive CD4+ T cells. Proc Natl Acad Sci U S A (2001) 0.89

Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines. Eur J Immunol (1997) 0.89

Decreased endosomal delivery of major histocompatibility complex class II-invariant chain complexes in dynamin-deficient cells. J Biol Chem (1997) 0.88

TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB- and p38 MAPK-dependent. J Thromb Haemost (2006) 0.88

Francisella tularensis subspecies holarctica occurs in Swedish mosquitoes, persists through the developmental stages of laboratory-infected mosquitoes and is transmissible during blood feeding. Microb Ecol (2013) 0.87

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