Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.

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Published in Genes Dev on October 15, 2002

Authors

Christiana Ruhrberg1, Holger Gerhardt, Matthew Golding, Rose Watson, Sofia Ioannidou, Hajime Fujisawa, Christer Betsholtz, David T Shima

Author Affiliations

1: Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom.

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature (1996) 18.47

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Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities. Genes Dev (1994) 5.66

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Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc Natl Acad Sci U S A (1987) 4.83

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VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J Biol Chem (1997) 2.12

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Relationship between astrocytes, ganglion cells and vasculature of the retina. J Comp Neurol (1987) 1.88

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Syndecan-regulated receptor signaling. J Cell Biol (2000) 1.52

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Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila. Curr Opin Cell Biol (2000) 1.17

Fluorimetric DNA assay for cell growth estimation. Anal Biochem (1992) 1.17

Vascular developmental biology: getting nervous. Curr Opin Genet Dev (2000) 1.15

Origins and formation of microvasculature in the developing kidney. Kidney Int Suppl (1998) 1.08

A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material. Trends Genet (1994) 1.04

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Factors determining the migration of astrocytes into the developing retina: migration does not depend on intact axons or patent vessels. J Comp Neurol (1991) 0.92

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