Genetic steps to organ laterality in zebrafish.

Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol (2011) 1.77

A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev Biol (2007) 1.65

MMAPPR: mutation mapping analysis pipeline for pooled RNA-seq. Genome Res (2013) 1.39

Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development (2009) 1.31

A betaPix Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proc Natl Acad Sci U S A (2007) 1.24

A role for chemokine signaling in neural crest cell migration and craniofacial development. Dev Biol (2009) 1.21

Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Dev Cell (2010) 1.16

Targeted mutation of the talpid3 gene in zebrafish reveals its conserved requirement for ciliogenesis and Hedgehog signalling across the vertebrates. Development (2011) 1.10

Symmetry breakage in the vertebrate embryo: when does it happen and how does it work? Dev Biol (2014) 0.91

Bmp and nodal independently regulate lefty1 expression to maintain unilateral nodal activity during left-right axis specification in zebrafish. PLoS Genet (2011) 0.86

Rargb regulates organ laterality in a zebrafish model of right atrial isomerism. Dev Biol (2012) 0.86

Small heat shock proteins are necessary for heart migration and laterality determination in zebrafish. Dev Biol (2013) 0.81

Laminin β1a controls distinct steps during the establishment of digestive organ laterality. Development (2013) 0.78

Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage. Dis Model Mech (2017) 0.75

Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate. Curr Biol (1994) 4.05

Five years on the wings of fork head. Mech Dev (1996) 3.47

Mutation of an axonemal dynein affects left-right asymmetry in inversus viscerum mice. Nature (1997) 2.73

A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell (1995) 2.65

lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell (1998) 2.63

fork head domain genes in zebrafish. Dev Genes Evol (1998) 2.58

Reversal of left-right asymmetry: a situs inversus mutation. Science (1993) 2.56

Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature (1996) 2.35

The development of handedness in left/right asymmetry. Development (1990) 2.16

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (1996) 2.13

Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development (1996) 2.12

The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev (1997) 2.09

The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature (1999) 2.08

Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development (1997) 1.84

Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development (2000) 1.50

Conservation of PDX-1 structure, function, and expression in zebrafish. Endocrinology (1998) 1.46

Multiple left-right asymmetry defects in Shh(-/-) mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1. Proc Natl Acad Sci U S A (1999) 1.43

Gap junctions are involved in the early generation of left-right asymmetry. Dev Biol (1998) 1.35

Molecular mechanisms of vertebrate left-right development. Trends Genet (1998) 1.23

Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. Dev Biol (1996) 1.23

Linkage of cardiac left-right asymmetry and dorsal-anterior development in Xenopus. Development (1995) 1.20

Regulation of left-right asymmetries in the zebrafish by Shh and BMP4. Dev Biol (1999) 1.16

Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression. Cell (1999) 1.16

Genetics of human left-right axis malformations. Semin Cell Dev Biol (1998) 1.06

Heart and gut chiralities are controlled independently from initial heart position in the developing zebrafish. Dev Biol (2000) 0.91

Effects of teacher attention on study behavior. J Appl Behav Anal (1968) 22.34

Comparative genomics of Listeria species. Science (2001) 12.94

Selective primary health care: an interim strategy for disease control in developing countries. N Engl J Med (1979) 10.02

Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature (1995) 9.86

BRL 17421, a novel beta-lactam antibiotic, highly resistant to beta-lactamases, giving high and prolonged serum levels in humans. Antimicrob Agents Chemother (1981) 8.81

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell (1996) 7.86

Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development (1999) 7.12

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J Clin Invest (1998) 5.95

Germline p16 mutations in familial melanoma. Nat Genet (1994) 5.59

Clinical manifestations in 105 persons with nevoid basal cell carcinoma syndrome. Am J Med Genet (1997) 5.34

Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science (1994) 5.15

Targeted disruption of the neuronal nitric oxide synthase gene. Cell (1993) 5.02

Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Causes Control (2001) 4.74

Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs. J Exp Med (1970) 4.50

Giardiasis in the mouse: an animal model. Gastroenterology (1976) 4.47

Replicating SV40 molecules containing closed circular template DNA strands. Nat New Biol (1971) 4.36

Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature (1989) 4.18

Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion. Nature (2001) 4.10

A randomized trial of group outpatient visits for chronically ill older HMO members: the Cooperative Health Care Clinic. J Am Geriatr Soc (1997) 4.09

Prevention of vertebrate neuronal death by the crmA gene. Science (1994) 4.09

Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate. Curr Biol (1994) 4.05

Granuloma formation around schistosome eggs as a manifestation of delayed hypersensitivity. Am J Pathol (1967) 4.04

Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (1996) 3.63

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell (1996) 3.60

Gridlock, a localized heritable vascular patterning defect in the zebrafish. Nat Med (1995) 3.59

Zebrafish genetic map with 2000 microsatellite markers. Genomics (1999) 3.56

Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet (1996) 3.53

CDKN2A mutations in multiple primary melanomas. N Engl J Med (1998) 3.52

Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion. Nature (1998) 3.33

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet (1998) 3.33

Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science (1996) 3.32

Gridlock signalling pathway fashions the first embryonic artery. Nature (2001) 3.30

Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (1996) 3.21

Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase. Nature (1995) 3.15

Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (1996) 3.15

Open reading frame expression vectors: a general method for antigen production in Escherichia coli using protein fusions to beta-galactosidase. Proc Natl Acad Sci U S A (1983) 3.09

Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development (1998) 3.07

A microsatellite genetic linkage map for zebrafish (Danio rerio). Nat Genet (1998) 3.06

Cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development (1995) 3.05

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2. Nature (1996) 2.98

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet (1996) 2.96

Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature (1996) 2.94

Randomised controlled trial of exercise for low back pain: clinical outcomes, costs, and preferences. BMJ (1999) 2.94

gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science (2000) 2.90

Occurrence of hemophilia in the United States. The Hemophilia Surveillance System Project Investigators. Am J Hematol (1998) 2.78

Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine. J Cereb Blood Flow Metab (1996) 2.78

Population screening for congenital hypothyroidism. Br Med J (1980) 2.71

Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates. Development (2001) 2.71

Spontaneous modulation of granulomatous hypersensitivity in schistosomiasis mansoni. J Immunol (1975) 2.59

Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development (1996) 2.54

Potassium current suppression by quinidine reveals additional calcium currents in neuroblastoma cells. Proc Natl Acad Sci U S A (1981) 2.45

Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proc Natl Acad Sci U S A (1972) 2.41

A radiation hybrid map of the zebrafish genome. Nat Genet (1999) 2.31

Childhood lead poisoning. A controlled trial of the effect of dust-control measures on blood lead levels. N Engl J Med (1983) 2.30

Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development (1996) 2.29

Antigenic variation during infection with Neisseria gonorrhoeae: detection of antibodies to surface proteins in sera of patients with gonorrhea. J Infect Dis (1984) 2.28

Hematopoietic mutations in the zebrafish. Development (1996) 2.25

Stapled haemorrhoidopexy compared to Milligan-Morgan and Ferguson haemorrhoidectomy: a systematic review. Int J Colorectal Dis (2008) 2.25

The inhibition of granuloma formation around Schistosoma mansoni eggs. II. Thymectomy. Am J Pathol (1967) 2.23

UACUAAC is the preferred branch site for mammalian mRNA splicing. Proc Natl Acad Sci U S A (1989) 2.22

A role for the eosinophil in acquired resistance to Schistosoma mansoni infection as determined by antieosinophil serum. J Exp Med (1975) 2.19

Endogenous desensitization: changing host granulomatou response to schistosome eggs at different stages of infection with schistosoma mansoni. Am J Pathol (1968) 2.18

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. Proc Natl Acad Sci U S A (1995) 2.17

Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. The Transfusion Safety Study Group. J Virol (1995) 2.15

Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70. J Biol Chem (1997) 2.14

Zebrafish pigmentation mutations and the processes of neural crest development. Development (1996) 2.14

Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (1996) 2.13

Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development (1996) 2.12

Developmental roles of platelet-derived growth factors. Bioessays (2001) 2.12

Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells. Proc Natl Acad Sci U S A (1973) 2.11

Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo. Nature (1994) 2.10

Fibrinolytic activity and coronary-artery disease. Lancet (1968) 2.10

Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development (1998) 2.08

A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene. Proc Natl Acad Sci U S A (1984) 2.07

A simple oral test of growth-hormone secretion in children. Lancet (1968) 2.07

Identification of human immunodeficiency virus type 1 envelope genes recombinant between subtypes B and F in two epidemiologically linked individuals from Brazil. J Virol (1994) 2.05

The pathogenesis of "clay-pipe stem cirrhosis" in mice with chronic schistosomiasis mansoni, with a note on the longevity of the schistosomes. Am J Pathol (1966) 2.03

Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J Cereb Blood Flow Metab (1996) 2.01

Prediction of response to iron sucrose in inflammatory bowel disease-associated anemia. Am J Gastroenterol (2001) 2.00

Vessel patterning in the embryo of the zebrafish: guidance by notochord. Dev Biol (1997) 1.99

Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development (1996) 1.97

The fasciated ear2 gene encodes a leucine-rich repeat receptor-like protein that regulates shoot meristem proliferation in maize. Genes Dev (2001) 1.97

Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule. Biochemistry (1988) 1.94

The immunopathogenesis of schistosomiasis: a multidisciplinary approach. Trans R Soc Trop Med Hyg (1972) 1.91

Wnt5 is required for tail formation in the zebrafish embryo. Cold Spring Harb Symp Quant Biol (1997) 1.91

Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Exp Med (1997) 1.89

Follow-up study of twenty-four families with Li-Fraumeni syndrome. Cancer Res (1991) 1.89

Interferon treatment of mice: enhanced expression of histocompatibility antigens on lymphoid cells. Proc Natl Acad Sci U S A (1976) 1.88

Association of serotypes of Streptococcus pneumoniae with disease severity and outcome in adults: an international study. Clin Infect Dis (2007) 1.87

Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation. Development (1993) 1.85

Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development (1997) 1.84

Jaw and branchial arch mutants in zebrafish I: branchial arches. Development (1996) 1.84

Classification of non-bacterial osteitis: retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (Oxford) (2006) 1.84