Published in Biochem J on July 01, 2001
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest (2007) 2.05
Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr (2005) 1.97
Asparagine synthetase chemotherapy. Annu Rev Biochem (2006) 1.82
The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cells. Blood (2014) 1.76
Polymorphisms of asparaginase pathway and asparaginase-related complications in children with acute lymphoblastic leukemia. Clin Cancer Res (2014) 1.51
Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion. Mol Cell (2014) 1.36
Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization. J Biol Chem (2005) 1.28
The transcription factor network associated with the amino acid response in mammalian cells. Adv Nutr (2012) 1.27
Asparagine synthetase: regulation by cell stress and involvement in tumor biology. Am J Physiol Endocrinol Metab (2013) 1.26
Cancer-stromal interactions: role in cell survival, metabolism and drug sensitivity. Cancer Biol Ther (2011) 1.20
Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood (2007) 1.19
Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter. Biochem J (2003) 1.08
A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity. Leukemia (2010) 1.03
Comparison of native E. coli and PEG asparaginase pharmacokinetics and pharmacodynamics in pediatric acute lymphoblastic leukemia. Clin Pharmacol Ther (2009) 1.01
ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia. Blood (2011) 1.01
Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence. Biochem J (2005) 1.00
Auto-activation of c-JUN gene by amino acid deprivation of hepatocellular carcinoma cells reveals a novel c-JUN-mediated signaling pathway. J Biol Chem (2011) 0.93
Filamentation of Metabolic Enzymes in Saccharomyces cerevisiae. J Genet Genomics (2016) 0.93
AsnB is involved in natural resistance of Mycobacterium smegmatis to multiple drugs. Antimicrob Agents Chemother (2006) 0.92
Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma. Br J Cancer (2013) 0.88
An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line. Chem Biol (2006) 0.87
Role of glutamine and interlinked asparagine metabolism in vessel formation. EMBO J (2017) 0.86
Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. Mol Cancer Res (2014) 0.85
Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase. Invest New Drugs (2014) 0.79
Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity. Sci Rep (2016) 0.79
Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines. Sci Rep (2015) 0.78
Establishment of real-time polymerase chain reaction method for quantitative analysis of asparagine synthetase expression. J Mol Diagn (2004) 0.77
A nuclear-directed human pancreatic ribonuclease (PE5) targets the metabolic phenotype of cancer cells. Oncotarget (2016) 0.76
Optimized CGenFF force-field parameters for acylphosphate and N-phosphonosulfonimidoyl functional groups. J Mol Model (2013) 0.75
Safety, efficacy, and clinical utility of asparaginase in the treatment of adult patients with acute lymphoblastic leukemia. Onco Targets Ther (2017) 0.75
Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase. Neoplasia (2016) 0.75
KMT2E-ASNS: a novel relapse-specific fusion gene in early T-cell precursor acute lymphoblastic leukemia. Blood (2017) 0.75
A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase. Biochemistry (2010) 0.75
Drug-induced amino acid deprivation as strategy for cancer therapy. J Hematol Oncol (2017) 0.75
A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal Biochem (1978) 38.54
A five-drug remission induction regimen with intensive consolidation for adults with acute lymphoblastic leukemia: cancer and leukemia group B study 8811. Blood (1995) 2.43
Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity (1998) 2.11
Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. Am J Physiol (1997) 2.05
Prednisolone resistance in childhood acute lymphoblastic leukemia: vitro-vivo correlations and cross-resistance to other drugs. Blood (1998) 1.69
In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase. Cancer Res (1989) 1.37
E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children. Cancer (1970) 1.31
In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia. Blood (1997) 1.28
l-asparaginase resistance in human leukemia--asparagine synthetase. Biochem Pharmacol (1969) 1.23
Regulation of asparagine synthetase gene expression by amino acid starvation. Mol Cell Biol (1991) 1.22
Characterization of apoptotic phenomena induced by treatment with L-asparaginase in NIH3T3 cells. Exp Cell Res (1995) 1.22
Cis- and trans-acting elements involved in amino acid regulation of asparagine synthetase gene expression. Mol Cell Biol (1993) 1.22
Efficient retroviral-mediated gene transfer into human B lymphoblastoid cells expressing mouse ecotropic viral receptor. Nucleic Acids Res (1992) 1.16
Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content. Biochem J (1994) 1.14
L-asparaginase kills lymphoma cells by apoptosis. Cancer Chemother Pharmacol (1993) 1.12
Asparagine synthetase in asparaginase resistant and susceptible mouse lymphomas. Biochem Biophys Res Commun (1968) 1.10
L-Asparaginase inhibits the rapamycin-targeted signaling pathway. Biochem Biophys Res Commun (1999) 1.06
L-asparaginase in the treatment of neoplastic diseases in children. Cancer Res (1971) 0.97
DNA methylation patterns associated with asparagine synthetase expression in asparagine-overproducing and -auxotrophic cells. Mol Cell Biol (1989) 0.95
Everything you always wanted to know about cellular drug resistance in childhood acute lymphoblastic leukemia. Crit Rev Oncol Hematol (1997) 0.95
Acute lymphoblastic leukemia. A comprehensive review with emphasis on biology and therapy. Cancer (1995) 0.93
Biochemical characterization of U937 cells resistant to L-asparaginase: the role of asparagine synthetase. Leukemia (1989) 0.91
L-asparaginase therapy in children with advanced leukemia. The Southwest Cancer Chemotherapy Study Group. Cancer (1971) 0.90
Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin. Somat Cell Mol Genet (1990) 0.86
Management of adult acute lymphocytic leukemia: present issues and key challenges. J Clin Oncol (1994) 0.84
Methotrexate plus L-asparaginase. An active combination for children with acute nonlymphocytic leukemia. Cancer (1990) 0.83
Hypomethylation and reactivation of the asparagine synthetase gene induced by L-asparaginase and ethyl methanesulfonate. Cancer Res (1991) 0.82
Role of asparaginase synthetase and asparagyl-transfer RNA synthetase in the cell-killing activity of asparaginase in Chinese hamster ovary cell mutants. Cancer Res (1981) 0.81
Human monocytic leukemia expresses low levels of asparagine synthase and is potentially sensitive to L-asparaginase. Leukemia (1995) 0.81
TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem (1991) 5.62
Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs. J Biol Chem (1980) 2.32
The regulation of neutral amino acid transport in mammalian cells. Biochim Biophys Acta (1983) 2.17
Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. Am J Physiol (1997) 2.05
A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric-oxide synthase may explain the "arginine paradox". J Biol Chem (1997) 1.97
Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ (2010) 1.52
Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. J Biol Chem (2000) 1.51
Amino acid transport in isolated rat hepatocytes. J Membr Biol (1982) 1.48
v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element. Mol Cell Biol (1994) 1.42
Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells. J Biol Chem (1993) 1.41
Characteristics and hormonal regulation of amino acid transport system A in isolated rat hepatocytes. Curr Top Cell Regul (1985) 1.29
Characteristics of system ASC for transport of neutral amino acids in the isolated rat hepatocyte. J Biol Chem (1981) 1.25
Specificity of amino acid regulated gene expression: analysis of genes subjected to either complete or single amino acid deprivation. Amino Acids (2008) 1.23
CCAAT/enhancer-binding protein-beta is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2001) 1.22
Effect of low-protein diet-induced intrauterine growth retardation on rat placental amino acid transport. Am J Physiol (1996) 1.20
Molecular biology of mammalian amino acid transporters. Annu Rev Biochem (1996) 1.20
Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters. J Biol Chem (1993) 1.16
Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia. Proc Natl Acad Sci U S A (2001) 1.16
Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content. Biochem J (1994) 1.14
Amino acid-dependent increase in hepatic system N activity is linked to cell swelling. J Biol Chem (1991) 1.13
Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability. Biochem J (1999) 1.13
Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression. J Biol Chem (1999) 1.12
Storage and release of a sex pheromone by the Queensland fruit fly, Dacus tryoni (Diptera: Trypetidae). Nature (1968) 1.12
Evidence for two Na+-independent neutral amino acid transport systems in primary cultures of rat hepatocytes. Time-dependent changes in activity. J Biol Chem (1982) 1.11
Amino acid transport systems. Nature (1984) 1.08
Induction and decay of amino acid transport in the liver. Turnover of transport activity in isolated hepatocytes after stimulation by diabetes or glucagon. J Biol Chem (1984) 1.03
Neutral amino acid transport systems in Chinese hamster ovary cells. J Biol Chem (1981) 1.03
Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor. J Clin Invest (1995) 1.03
Adaptive regulation of the cationic amino acid transporter-1 (Cat-1) in Fao cells. J Biol Chem (1997) 1.02
Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells. Biochem J (2001) 1.02
Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene. Proc Natl Acad Sci U S A (1994) 1.01
Characterization of neutral and cationic amino acid transport in Xenopus oocytes. J Cell Physiol (1989) 1.00
Induction of amino acid transport system A in rat hepatocytes is blocked by tunicamycin. J Biol Chem (1983) 0.99
Measurement of amino acid transport by hepatocytes in suspension or monolayer culture. Methods Enzymol (1989) 0.98
Cysteine as a system-specific substrate for transport system ASC in rat hepatocytes. Biochem Biophys Res Commun (1979) 0.97
Solubilization and reconstitution of hepatic System A-mediated amino acid transport. Preparation of proteoliposomes containing glucagon-stimulated transport activity. Biochim Biophys Acta (1987) 0.96
Characterization and distribution of the neuronal glutamate transporter EAAC1 in rat brain. Am J Physiol (1996) 0.96
Maintenance of glucagon-stimulated system A amino acid transport activity in rat liver plasma membrane vesicles. Biochim Biophys Acta (1986) 0.95
Electron-transferring enzymes in the plasma membrane of the Ehrlich ascites tumor cell. Biochemistry (1979) 0.95
Expression of the mammalian system A neutral amino acid transporter in Xenopus oocytes. J Biol Chem (1990) 0.94
Adaptive regulation of neutral amino acid transport System A in rat H4 hepatoma cells. J Cell Physiol (1985) 0.94
Evidence for inherent differences in the system A carrier from normal and transformed liver tissue. Differential inactivation and substrate protection in membrane vesicles and reconstituted proteoliposomes. J Biol Chem (1987) 0.93
Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25. J Biol Chem (1994) 0.92
Incomplete correspondence between repressive and substrate action by amino acids on transport systems A and N in monolayered rat hepatocytes. J Biol Chem (1982) 0.91
Cis-inhibition, trans-inhibition, and repression of hepatic amino acid transport mediated by System A. Substrate specificity and other properties. J Biol Chem (1986) 0.89
Identification of a system N-like Na(+)-dependent glutamine transport activity in rat brain neurons. J Neurochem (1997) 0.89
Solubilization and reconstitution characteristics of hepatic system A-mediated amino acid transport. J Biol Chem (1989) 0.89
Glutamine transport by basolateral plasma-membrane vesicles prepared from rabbit intestine. Biochem J (1991) 0.88
Indoleamine 2,3-dioxygenase attenuates inhibitor development in gene-therapy-treated hemophilia A mice. Gene Ther (2009) 0.86
Eukaryotic gene expression: metabolite control by amino acids. Prog Nucleic Acid Res Mol Biol (1996) 0.86
Amino acid activation of amino acid transport System N early in primary cultures of rat hepatocytes. J Cell Physiol (1984) 0.86
Sodium-dependent neutral amino acid transport by human liver plasma membrane vesicles. J Biol Chem (1990) 0.86
Seasonal phenology of Bactrocera minax (Diptera: Tephritidae) in western Bhutan. Bull Entomol Res (2006) 0.85
Energization of amino acid transport in energy-depleted Ehrlich cells and plasma membrane vesicles. Biochim Biophys Acta (1980) 0.85
Expressed human hippocampal ASCT1 amino acid transporter exhibits a pH-dependent change in substrate specificity. Biochim Biophys Acta (1996) 0.84
Placental anionic and cationic amino acid transporter expression in growth hormone overexpressing and null IGF-II or null IGF-I receptor mice. Placenta (1999) 0.84
Heterogeneity of Na+-independent 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid and L-leucine transport in isolated rat hepatocytes in primary culture. Biochem Biophys Res Commun (1982) 0.83
Plasma membrane clustering of system y+ (CAT-1) amino acid transporter as detected by immunohistochemistry. Am J Physiol (1994) 0.83
Neutral amino acid transport in hepatocytes isolated from streptozotocin-induced diabetic rats. J Biol Chem (1982) 0.83
Transport system a is not responsive to hormonal stimulation in primary cultures of fetal rat hepatocytes. Biochem Biophys Res Commun (1982) 0.83
An expression system for mammalian amino acid transporters using a stably maintained episomal vector. Anal Biochem (1997) 0.83
Functional reconstitution of the hepatic system N amino acid transport activity. Biochem J (1991) 0.83
System A transport activity in normal rat hepatocytes and transformed liver cells: substrate protection from inactivation by sulfhydryl-modifying reagents. J Cell Physiol (1986) 0.82
Substrate-dependent adaptive regulation and trans-inhibition of System A-mediated amino acid transport. Studies using rat hepatoma plasma membrane vesicles. Biochim Biophys Acta (1990) 0.82
Association of hepatic system A amino acid transporter with the membrane-cytoskeletal proteins ankyrin and fodrin. Biochim Biophys Acta (1996) 0.82
Plasma membrane domain localization and transcytosis of the glucagon-induced hepatic system A carrier. Am J Physiol (1992) 0.81
TIS10, a mitogen-inducible glucocorticoid-inhibited gene that encodes a second prostaglandin synthase/cyclooxygenase enzyme. J Lipid Mediat (1993) 0.81
The relation between membrane potential and the transport activity of system A and L in plasma membrane vesicles of the Ehrlich cell. Membr Biochem (1980) 0.81
Demonstration of system y+L activity on the basal plasma membrane surface of rat placenta and developmentally regulated expression of 4F2HC mRNA. Placenta (1997) 0.81
Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-induced) in rat hepatoma cells. J Biol Chem (1990) 0.80
Growth-dependent regulation of system A in SV40-transformed fetal rat hepatocytes. Am J Physiol (1988) 0.80
Inhibition of endothelial cell amino acid transport System y+ by arginine analogs that inhibit nitric oxide synthase. Biochim Biophys Acta (1997) 0.80
Production of monospecific antibodies to a low-abundance hepatic membrane protein using nitrocellulose immobilized protein as antigen. Anal Biochem (1987) 0.80
Hormone-induced system A amino acid transport activity in rat liver plasma membrane and Golgi vesicles. Evidence for a differential sensitivity to inactivation by N-ethylmaleimide during carrier maturation. J Biol Chem (1990) 0.79
Identification of an amino acid-regulated mRNA from rat liver as the mammalian equivalent of bacterial ribosomal protein L22. J Biol Chem (1991) 0.79
Inactivation of amino acid transport in rat hepatocytes and hepatoma cells by PCMBS. Am J Physiol (1988) 0.79
Hormonal regulation of hepatic amino acid transport. J Supramol Struct (1977) 0.79
Characteristics and regulation of hepatic glutamine transport. JPEN J Parenter Enteral Nutr (1990) 0.78
Ontogeny and localization of the neutral amino acid transporter ASCT1 in rat brain. Brain Res Dev Brain Res (2001) 0.78
The tis genes, primary response genes induced by growth factors and tumor promoters in 3T3 cells. Prog Nucleic Acid Res Mol Biol (1994) 0.78
Plasma membrane transport of 2-ketoisocaproate by rat hepatocytes in primary culture. J Biol Chem (1983) 0.78
Enhanced mRNA content in response to amino acid starvation for a 73 kDa protein of the inner mitochondrial membrane. Biochem Biophys Res Commun (1993) 0.78
Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta. Am J Physiol (1998) 0.78
An example of nutrient control of gene expression: amino acid-dependent regulation of asparagine synthetase. Clin Nutr (1996) 0.77
Molecular alterations resulting from frameshift mutations in peripheral myelin protein 22: implications for neuropathy severity. J Neurosci Res (2005) 0.77
Chromosomal organization of the inducible and constitutive prostaglandin synthase/cyclooxygenase genes in mouse. Genomics (1993) 0.77
Ontogeny of cationic amino acid transport systems in rat placenta. Am J Physiol (1994) 0.77
Glucocorticoid regulation of splanchnic glutamine, alanine, glutamate, ammonia, and glutathione fluxes. Am J Physiol (1993) 0.77
Ontogeny and plasma-membrane domain localization of amino acid transport system L in rat liver. Biochem J (1994) 0.77
Identification of the protein responsible for hepatic system N amino acid transport activity. J Biol Chem (1992) 0.77
Rat placental amino acid transport after protein-deprivation-induced intrauterine growth retardation. Biochem Soc Trans (1996) 0.76
Substrate regulation of hepatic system A transport activity after induction by substrate starvation or glucagon. Fed Proc (1986) 0.76
Preferential binding of vasoactive intestinal peptide to hepatic nonparenchymal cells. Am J Physiol (1985) 0.75
Amino acid-dependent inactivation of glucagon-induced System A transport activity in cultured rat hepatocytes. Mol Cell Endocrinol (1985) 0.75
Protein modification of glutamine transporters in SV40-transformed hepatocytes and immunodetection of proteins associated with hepatic system N transport activity. J Nutr (1994) 0.75
Transport of branched-chain amino acids and their corresponding 2-keto acids by mammalian cells. Methods Enzymol (1988) 0.75
Response of placental amino acid transport to gestational age and intrauterine growth retardation. Proc Nutr Soc (1998) 0.75
Accumulation of alpha-aminoisobutyric acid by rat tissues after whole-body gamma-irradiation. Radiat Res (1975) 0.75
Hormonal control of amino acid transport in the liver of rats exposed to whole-body gamma irradiation. Radiat Res (1978) 0.75
Regulation of neutral amino acid transport in hepatocytes isolated from adrenalectomized rats. J Cell Physiol (1983) 0.75