Published in Annu Rev Biochem on January 01, 2006
Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44
The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J (2010) 3.76
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Adv Nutr (2012) 2.27
Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase. J Clin Invest (2007) 2.05
Asparagine synthetase: regulation by cell stress and involvement in tumor biology. Am J Physiol Endocrinol Metab (2013) 1.26
Mitochondria as biosynthetic factories for cancer proliferation. Cancer Metab (2015) 1.17
Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges. Cancer Res Treat (2013) 1.13
Tumour-specific proline vulnerability uncovered by differential ribosome codon reading. Nature (2016) 1.10
Integrative molecular profiling reveals asparagine synthetase is a target in castration-resistant prostate cancer. Am J Pathol (2012) 1.06
Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. Neuron (2013) 1.06
How do tumours adapt to nutrient stress? EMBO J (2010) 1.05
Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism. Br J Cancer (2009) 1.04
ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia. Blood (2011) 1.01
Metabolomics of the tumor microenvironment in pediatric acute lymphoblastic leukemia. PLoS One (2013) 1.01
The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment. Am J Physiol Endocrinol Metab (2013) 0.90
Integrative mixture of experts to combine clinical factors and gene markers. Bioinformatics (2010) 0.90
Glutaminase activity determines cytotoxicity of L-asparaginases on most leukemia cell lines. Leuk Res (2015) 0.90
Asparagine synthetase is an independent predictor of surgical survival and a potential therapeutic target in hepatocellular carcinoma. Br J Cancer (2013) 0.88
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase. Biochemistry (2009) 0.88
An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line. Chem Biol (2006) 0.87
Free glycine accelerates the autoproteolytic activation of human asparaginase. Chem Biol (2013) 0.86
Role of glutamine and interlinked asparagine metabolism in vessel formation. EMBO J (2017) 0.86
Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. Mol Cancer Res (2014) 0.85
An artifact in LC-MS/MS measurement of glutamine and glutamic acid: in-source cyclization to pyroglutamic acid. Anal Chem (2014) 0.85
Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. J Biol Chem (2010) 0.83
Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy. Semin Cancer Biol (2015) 0.82
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma. Elife (2015) 0.80
Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase. Invest New Drugs (2014) 0.79
The kinase activity of the Helicobacter pylori Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase is sensitive to distal mutations in its putative ammonia tunnel. Biochemistry (2011) 0.79
Asparagine requirement in Plasmodium berghei as a target to prevent malaria transmission and liver infections. Nat Commun (2015) 0.79
GFP reporter screens for the engineering of amino acid degrading enzymes from libraries expressed in bacteria. Methods Mol Biol (2013) 0.78
L-asparaginase-induced pancreatic injury is associated with an imbalance in plasma amino acid levels. Drugs R D (2012) 0.78
General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol (2016) 0.78
Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines. Sci Rep (2015) 0.78
Identification and functional characterization of a novel bacterial type asparagine synthetase A: a tRNA synthetase paralog from Leishmania donovani. J Biol Chem (2014) 0.76
Enhanced oxidative stress resistance through activation of a zinc deficiency transcription factor in Brachypodium distachyon. Plant Physiol (2014) 0.75
Optimized CGenFF force-field parameters for acylphosphate and N-phosphonosulfonimidoyl functional groups. J Mol Model (2013) 0.75
Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase. Neoplasia (2016) 0.75
A conserved glutamate controls the commitment to acyl-adenylate formation in asparagine synthetase. Biochemistry (2010) 0.75
KMT2E-ASNS: a novel relapse-specific fusion gene in early T-cell precursor acute lymphoblastic leukemia. Blood (2017) 0.75
Expression, purification and crystallization of Helicobacter pylori L-asparaginase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.75
Monitoring amino acid deficiencies in cancer. Cell Cycle (2016) 0.75
Loss of asparagine synthetase suppresses the growth of human lung cancer cells by arresting cell cycle at G0/G1 phase. Cancer Gene Ther (2016) 0.75
Transcriptomics of liver and muscle in Holstein cows genetically divergent for fertility highlight differences in nutrient partitioning and inflammation processes. BMC Genomics (2016) 0.75
Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival. Nat Immunol (2017) 0.75
Targeting metabolic reprogramming in KRAS-driven cancers. Int J Clin Oncol (2017) 0.75
Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell (2000) 17.44
The mammalian unfolded protein response. Annu Rev Biochem (2005) 16.31
The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem (1999) 8.97
Docking and scoring in virtual screening for drug discovery: methods and applications. Nat Rev Drug Discov (2004) 8.10
Acute lymphoblastic leukemia. N Engl J Med (2004) 7.83
Aminoacyl-tRNA synthesis. Annu Rev Biochem (2000) 7.68
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci U S A (2004) 7.03
Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol Cell Biol (2001) 6.05
The behavior and significance of slow-binding enzyme inhibitors. Adv Enzymol Relat Areas Mol Biol (1988) 5.84
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. J Cell Biol (2004) 5.44
Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosome. J Biol Chem (1997) 5.37
Enzyme-catalyzed phosphoryl transfer reactions. Annu Rev Biochem (1980) 4.32
Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies. Annu Rev Biochem (2001) 4.17
Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med (2004) 4.16
Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system. Anal Biochem (1983) 4.09
Catalytic promiscuity and the evolution of new enzymatic activities. Chem Biol (1999) 3.54
Navigating chemical space for biology and medicine. Nature (2004) 3.44
Molecular recognition and docking algorithms. Annu Rev Biophys Biomol Struct (2003) 3.40
A protein catalytic framework with an N-terminal nucleophile is capable of self-activation. Nature (1995) 3.30
The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol (2002) 3.22
The Design of Leadlike Combinatorial Libraries. Angew Chem Int Ed Engl (1999) 2.83
A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics (2000) 2.73
Integration of virtual and high-throughput screening. Nat Rev Drug Discov (2002) 2.61
The art and practice of structure-based drug design: a molecular modeling perspective. Med Res Rev (1996) 2.46
The asparagine synthetase of Escherhic coli. I. Biosynthetic role of the enzyme, purification, and characterization of the reaction products. J Biol Chem (1969) 2.30
Structural and functional considerations of the aminoacylation reaction. Trends Biochem Sci (1997) 2.22
Channeling of substrates and intermediates in enzyme-catalyzed reactions. Annu Rev Biochem (2001) 2.21
Penicillin acylase has a single-amino-acid catalytic centre. Nature (1995) 2.18
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat Struct Biol (1996) 2.11
The amidotransferases. Adv Enzymol Relat Areas Mol Biol (1993) 2.07
Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. Am J Physiol (1997) 2.05
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2002) 2.04
Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci U S A (2004) 1.98
Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr (2005) 1.97
Proteomics by FTICR mass spectrometry: top down and bottom up. Mass Spectrom Rev (2005) 1.91
Computer-based de novo design of drug-like molecules. Nat Rev Drug Discov (2005) 1.83
Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase. Biochemistry (1969) 1.82
Studies on glutamine synthetase from Escherichia coli. Formation of pyrrolidone carboxylate and inhibition by methionine sulfoximine. J Biol Chem (1973) 1.76
Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site. Biochemistry (1997) 1.70
Use of L-asparaginase in childhood ALL. Crit Rev Oncol Hematol (1998) 1.69
Enzymes utilizing glutamine as an amide donor. Adv Enzymol Relat Areas Mol Biol (1998) 1.67
Synthesis and Applications of Small Molecule Libraries. Chem Rev (1996) 1.67
Upregulation of asparagine synthetase fails to avert cell cycle arrest induced by L-asparaginase in TEL/AML1-positive leukaemic cells. Leukemia (2004) 1.66
Structural basis for the recognition of isoleucyl-adenylate and an antibiotic, mupirocin, by isoleucyl-tRNA synthetase. J Biol Chem (2001) 1.59
Three-dimensional structure of human lysosomal aspartylglucosaminidase. Nat Struct Biol (1995) 1.56
Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry (1999) 1.56
Structural comparison of Ntn-hydrolases. Protein Sci (2000) 1.55
Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein. Mol Cell Biol (1999) 1.53
The isotope trapping method: desorption rates of productive E.S complexes. Methods Enzymol (1980) 1.53
Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. J Biol Chem (2000) 1.51
The amidotransferases. Adv Enzymol Relat Areas Mol Biol (1973) 1.51
Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells. Biochem J (2001) 1.49
Asparagine synthetase activity of mouse leukemias. Science (1968) 1.49
A P-loop-like motif in a widespread ATP pyrophosphatase domain: implications for the evolution of sequence motifs and enzyme activity. Proteins (1994) 1.48
Enzymatic transition states and transition state analog design. Annu Rev Biochem (1998) 1.48
The mechanism of glutamine-dependent amidotransferases. Cell Mol Life Sci (1998) 1.44
Drug discovery by dynamic combinatorial libraries. Nat Rev Drug Discov (2002) 1.41
beta-Lactam synthetase: a new biosynthetic enzyme. Proc Natl Acad Sci U S A (1998) 1.39
Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL. Blood (2002) 1.36
Relationship of protein structure of isoleucyl-tRNA synthetase with pseudomonic acid resistance of Escherichia coli. A proposed mode of action of pseudomonic acid as an inhibitor of isoleucyl-tRNA synthetase. J Biol Chem (1994) 1.35
Enzymes with molecular tunnels. Acc Chem Res (2003) 1.35
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry (2004) 1.35
L-asparaginase and L-asparagine metabolism. Annu Rev Pharmacol (1970) 1.31
E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 children. Cancer (1970) 1.31
Molecular cloning of a gene that is necessary for G1 progression in mammalian cells. Proc Natl Acad Sci U S A (1987) 1.29
The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications. Proc Natl Acad Sci U S A (1999) 1.26
Transfer of monoclonal antibodies into mammalian cells by electroporation. J Biol Chem (1989) 1.25
A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia. Cancer Res (2005) 1.24
Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev (2003) 1.24
Regulation of asparagine synthetase gene expression by amino acid starvation. Mol Cell Biol (1991) 1.22
CCAAT/enhancer-binding protein-beta is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2001) 1.22
Structural model for the reaction mechanism of glutamine synthetase, based on five crystal structures of enzyme-substrate complexes. Biochemistry (1994) 1.22
Cis- and trans-acting elements involved in amino acid regulation of asparagine synthetase gene expression. Mol Cell Biol (1993) 1.22
L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. Ann Intern Med (1971) 1.21
Channeling of ammonia in glucosamine-6-phosphate synthase. J Mol Biol (2001) 1.21
Mechanistic issues in asparagine synthetase catalysis. Adv Enzymol Relat Areas Mol Biol (1998) 1.21
Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase. Nat Struct Biol (1998) 1.18
Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase. J Biol Chem (2002) 1.16
Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics. Appl Microbiol Biotechnol (2003) 1.16
Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nat Struct Biol (2001) 1.15
Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content. Biochem J (1994) 1.14
A relationship between asparagine synthetase A and aspartyl tRNA synthetase. J Biol Chem (1992) 1.13
Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability. Biochem J (1999) 1.13
Sulfamates and their therapeutic potential. Med Res Rev (2005) 1.12
Chemistry and biosynthesis of clavulanic acid and other clavams. Nat Prod Rep (1997) 1.11
Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia. Blood (2005) 1.11
Crystal structure of Escherichia coli cytidine triphosphate synthetase, a nucleotide-regulated glutamine amidotransferase/ATP-dependent amidoligase fusion protein and homologue of anticancer and antiparasitic drug targets. Biochemistry (2004) 1.11
Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase. Mol Cell Biol (1989) 1.11
TEL/AML1 gene fusion is related to in vitro drug sensitivity for L-asparaginase in childhood acute lymphoblastic leukemia. Blood (2000) 1.10
Asparagine synthetase in asparaginase resistant and susceptible mouse lymphomas. Biochem Biophys Res Commun (1968) 1.10
Structural studies on the synchronization of catalytic centers in glutamate synthase. J Biol Chem (2002) 1.08
Glutamine-dependent nitrogen transfer in Escherichia coli asparagine synthetase B. Searching for the catalytic triad. J Biol Chem (1994) 1.08
Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter. Biochem J (2003) 1.08
Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis. Protein Sci (1999) 1.08
Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase. Biochemistry (2003) 1.07
Inhibition of Escherichia coli glutamine synthetase by alpha- and gamma-substituted phosphinothricins. Biochemistry (1990) 1.03
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat Cell Biol (2013) 3.84
ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem (2002) 2.04
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem (2008) 1.51
Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation. Biochem J (2007) 1.34
Differences in the molecular mechanisms involved in the transcriptional activation of the CHOP and asparagine synthetase genes in response to amino acid deprivation or activation of the unfolded protein response. J Biol Chem (2002) 1.31
Interaction of RNA-binding proteins HuR and AUF1 with the human ATF3 mRNA 3'-untranslated region regulates its amino acid limitation-induced stabilization. J Biol Chem (2005) 1.28
Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J Biol Chem (2003) 1.27
Asparagine synthetase: regulation by cell stress and involvement in tumor biology. Am J Physiol Endocrinol Metab (2013) 1.26
Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene. Biochem J (2006) 1.25
MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. J Biol Chem (2008) 1.23
Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines. Pediatr Blood Cancer (2008) 1.23
Deprivation of protein or amino acid induces C/EBPbeta synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription. Biochem J (2008) 1.18
Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization. Biochem J (2004) 1.17
Human CCAAT/enhancer-binding protein beta gene expression is activated by endoplasmic reticulum stress through an unfolded protein response element downstream of the protein coding sequence. J Biol Chem (2004) 1.15
Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells. Physiol Genomics (2010) 1.15
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Mol Biol Cell (2013) 1.13
Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter. Biochem J (2003) 1.08
Haem oxygenase 1 gene induction by glucose deprivation is mediated by reactive oxygen species via the mitochondrial electron-transport chain. Biochem J (2003) 1.07
Despite increased ATF4 binding at the C/EBP-ATF composite site following activation of the unfolded protein response, system A transporter 2 (SNAT2) transcription activity is repressed in HepG2 cells. J Biol Chem (2008) 1.06
Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements. J Biol Chem (2009) 1.04
Amino-acid limitation induces transcription from the human C/EBPbeta gene via an enhancer activity located downstream of the protein coding sequence. Biochem J (2005) 1.00
Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway. Biochem J (2009) 0.99
Role of Sp1 and Sp3 in the nutrient-regulated expression of the human asparagine synthetase gene. J Biol Chem (2002) 0.96
Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway. Hepatology (2009) 0.95
The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase. J Nutr (2002) 0.94
Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response. J Biol Chem (2001) 0.94
Auto-activation of c-JUN gene by amino acid deprivation of hepatocellular carcinoma cells reveals a novel c-JUN-mediated signaling pathway. J Biol Chem (2011) 0.93
ATF4-dependent regulation of the JMJD3 gene during amino acid deprivation can be rescued in Atf4-deficient cells by inhibition of deacetylation. J Biol Chem (2012) 0.91
Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients. J Proteomics (2007) 0.88
An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line. Chem Biol (2006) 0.87
Elevated cJUN expression and an ATF/CRE site within the ATF3 promoter contribute to activation of ATF3 transcription by the amino acid response. Physiol Genomics (2012) 0.85
Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex. Nucleic Acids Res (2008) 0.84
Biosynthesis, intracellular targeting, and degradation of the EAAC1 glutamate/aspartate transporter in C6 glioma cells. J Biol Chem (2002) 0.83
Metabolic regulation of manganese superoxide dismutase expression via essential amino acid deprivation. J Biol Chem (2008) 0.81
Ontogeny of the neutral amino acid transporter SAT1/ATA1 in rat brain. Brain Res Dev Brain Res (2003) 0.79
Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells. Ann N Y Acad Sci (2003) 0.79
Activation of the amino acid response modulates lineage specification during differentiation of murine embryonic stem cells. Am J Physiol Endocrinol Metab (2013) 0.77
Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation. Biochem J (2013) 0.76