Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells.

PubWeight™: 4.07‹?› | Rank: Top 1%

🔗 View Article (PMC 35429)

Published in Proc Natl Acad Sci U S A on June 26, 2001

Authors

D C Colter1, I Sekiya, D J Prockop

Author Affiliations

1: Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue SL-99, New Orleans, LA 70112, USA.

Articles citing this

(truncated to the top 100)

Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell (2009) 7.62

Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther (2007) 3.97

Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem (2006) 3.11

One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues. Proc Natl Acad Sci U S A (2003) 2.65

The elusive nature and function of mesenchymal stem cells. Nat Rev Mol Cell Biol (2011) 2.31

Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis. Proc Natl Acad Sci U S A (2004) 2.09

Phenotypic and functional characterization of adult brain neuropoiesis. Proc Natl Acad Sci U S A (2005) 2.08

Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis. Arthritis Res Ther (2010) 1.95

Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1. Haematologica (2008) 1.80

The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A (2008) 1.77

The CD34-like protein PODXL and alpha6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice. Blood (2008) 1.75

Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population. J Cell Biol (2006) 1.74

Mesenchymal stem cells use integrin beta1 not CXC chemokine receptor 4 for myocardial migration and engraftment. Mol Biol Cell (2007) 1.72

Hydrodynamic mechanisms of cell and particle trapping in microfluidics. Biomicrofluidics (2013) 1.67

Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-γ licensing. Cytotherapy (2011) 1.65

Bone marrow mesenchymal stem cells: historical overview and concepts. Hum Gene Ther (2010) 1.63

Continuing differentiation of human mesenchymal stem cells and induced chondrogenic and osteogenic lineages in electrospun PLGA nanofiber scaffold. Biomaterials (2006) 1.41

Researching into the cellular shape, volume and elasticity of mesenchymal stem cells, osteoblasts and osteosarcoma cells by atomic force microscopy. J Cell Mol Med (2008) 1.40

Effects of plating density and culture time on bone marrow stromal cell characteristics. Exp Hematol (2008) 1.36

Bone marrow stem cell derived paracrine factors for regenerative medicine: current perspectives and therapeutic potential. Bone Marrow Res (2010) 1.34

Introducing a single-cell-derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer. J Cell Mol Med (2008) 1.31

Neural differentiation potential of human bone marrow-derived mesenchymal stromal cells: misleading marker gene expression. BMC Neurosci (2009) 1.31

Mesenchymal stem cell mechanics from the attached to the suspended state. Biophys J (2010) 1.31

Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol (2009) 1.30

Labeling of mesenchymal stem cells by bioconjugated quantum dots. Nano Lett (2007) 1.28

Clonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potency. Biotechnol Bioeng (2011) 1.24

Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing. J Anat (2009) 1.24

Identification of subpopulations in mesenchymal stem cell-like cultures from human umbilical cord. Cell Commun Signal (2009) 1.23

2010 Nicolas Andry Award: Multipotent adult stem cells from adipose tissue for musculoskeletal tissue engineering. Clin Orthop Relat Res (2010) 1.21

TSG-6 as a biomarker to predict efficacy of human mesenchymal stem/progenitor cells (hMSCs) in modulating sterile inflammation in vivo. Proc Natl Acad Sci U S A (2014) 1.19

Inducible expression of chimeric EWS/ETS proteins confers Ewing's family tumor-like phenotypes to human mesenchymal progenitor cells. Mol Cell Biol (2008) 1.18

Radiation rescue: mesenchymal stromal cells protect from lethal irradiation. PLoS One (2011) 1.17

Multilayer tendon slices seeded with bone marrow stromal cells: a novel composite for tendon engineering. J Orthop Res (2009) 1.16

Epidermal growth factor (EGF) treatment on multipotential stromal cells (MSCs). Possible enhancement of therapeutic potential of MSC. J Biomed Biotechnol (2010) 1.16

Differentiation of bone marrow mesenchymal stem cells into the smooth muscle lineage by blocking ERK/MAPK signaling pathway. Stem Cells Dev (2008) 1.15

Monolayer cell expansion conditions affect the chondrogenic potential of adipose-derived stem cells. Biotechnol Bioeng (2008) 1.14

Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow. PLoS One (2007) 1.14

Functional investigations on human mesenchymal stem cells exposed to magnetic fields and labeled with clinically approved iron nanoparticles. BMC Cell Biol (2010) 1.13

Evidence for high translational potential of mesenchymal stromal cell therapy to improve recovery from ischemic stroke. J Cereb Blood Flow Metab (2013) 1.13

Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition. J Cell Biochem (2011) 1.12

Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure. Bone (2008) 1.11

Mesenchymal stem cells for regenerative therapy: optimization of cell preparation protocols. Biomed Res Int (2014) 1.10

Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes. Am J Pathol (2007) 1.10

Human mesenchymal stem cells at the single-cell level: simultaneous seven-colour immunofluorescence. J Anat (2007) 1.10

Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies. Exp Hematol (2008) 1.10

Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review. Stem Cell Res Ther (2013) 1.10

Mesenchymal stem cell labeling and in vitro MR characterization at 1.5 T of new SPIO contrast agent: Molday ION Rhodamine-B™. Contrast Media Mol Imaging (2010) 1.09

Multipotent properties of myofibroblast cells derived from human placenta. Cell Tissue Res (2008) 1.08

Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age. PLoS One (2011) 1.08

Bone marrow stem cells for urologic tissue engineering. World J Urol (2008) 1.08

Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles. Mol Ther (2012) 1.07

The use of four-colour immunofluorescence techniques to identify mesenchymal stem cells. J Anat (2004) 1.07

Differentiation of human bone marrow stem cells into cells with a neural phenotype: diverse effects of two specific treatments. BMC Neurosci (2006) 1.05

Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"? J Biomed Sci (2011) 1.04

Morphological characterization of GFP stably transfected adult mesenchymal bone marrow stem cells. J Anat (2006) 1.04

Clonal analysis and hierarchy of human bone marrow mesenchymal stem and progenitor cells. Exp Hematol (2010) 1.03

Sox11 is expressed in early progenitor human multipotent stromal cells and decreases with extensive expansion of the cells. Tissue Eng Part A (2010) 1.03

Derivation of neural stem cells from mesenchymal stemcells: evidence for a bipotential stem cell population. Stem Cells Dev (2008) 1.02

Bone marrow-derived human mesenchymal stem cells express cardiomyogenic proteins but do not exhibit functional cardiomyogenic differentiation potential. Stem Cells Dev (2012) 1.02

Quantitative approaches to detect donor and passage differences in adipogenic potential and clonogenicity in human bone marrow-derived mesenchymal stem cells. Tissue Eng Part C Methods (2012) 1.01

Multipotent mesenchymal stromal stem cell expansion by plating whole bone marrow at a low cellular density: a more advantageous method for clinical use. Stem Cells Int (2011) 1.01

Multivariate biophysical markers predictive of mesenchymal stromal cell multipotency. Proc Natl Acad Sci U S A (2014) 1.01

Human periosteum is a source of cells for orthopaedic tissue engineering: a pilot study. Clin Orthop Relat Res (2011) 1.00

Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression. Br J Haematol (2009) 1.00

Isolation and enrichment of rat mesenchymal stem cells (MSCs) and separation of single-colony derived MSCs. J Vis Exp (2010) 0.99

Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma. Sarcoma (2010) 0.99

Deterministic and stochastic approaches in the clinical application of mesenchymal stromal cells (MSCs). Front Cell Dev Biol (2014) 0.98

Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-β/SMAD2 and PI3K/Akt pathways. Int J Mol Sci (2014) 0.97

Housekeeping gene stability influences the quantification of osteogenic markers during stem cell differentiation to the osteogenic lineage. Cytotechnology (2010) 0.97

Reprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT-SSX2. Oncogene (2011) 0.96

Cell therapy for autoimmune diseases. Arthritis Res Ther (2007) 0.95

Identification and purification of mesodermal progenitor cells from human adult bone marrow. Stem Cells Dev (2009) 0.94

Engineered tendon with decellularized xenotendon slices and bone marrow stromal cells: an in vivo animal study. J Tissue Eng Regen Med (2011) 0.93

Osteoblastic/cementoblastic and neural differentiation of dental stem cells and their applications to tissue engineering and regenerative medicine. Tissue Eng Part B Rev (2012) 0.93

In vitro and in vivo properties of distinct populations of amniotic fluid mesenchymal progenitor cells. J Cell Mol Med (2011) 0.93

Comparative study of mesenchymal stem cells from C57BL/10 and mdx mice. BMC Cell Biol (2008) 0.92

Synthesis of embryonic tendon-like tissue by human marrow stromal/mesenchymal stem cells requires a three-dimensional environment and transforming growth factor β3. Matrix Biol (2010) 0.92

Epigenetic reprogramming of IGF1 and leptin genes by serum deprivation in multipotential mesenchymal stromal cells. Stem Cells (2009) 0.92

Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density. PLoS One (2014) 0.92

Caffeine inhibits the viability and osteogenic differentiation of rat bone marrow-derived mesenchymal stromal cells. Br J Pharmacol (2010) 0.91

Are MSCs angiogenic cells? New insights on human nestin-positive bone marrow-derived multipotent cells. Front Cell Dev Biol (2014) 0.91

Cell-surface expression of neuron-glial antigen 2 (NG2) and melanoma cell adhesion molecule (CD146) in heterogeneous cultures of marrow-derived mesenchymal stem cells. Tissue Eng Part A (2013) 0.91

Establishing criteria for human mesenchymal stem cell potency. Stem Cells (2015) 0.91

Hypoxia-inducible factor 1-α-AA-modified bone marrow stem cells protect PC12 cells from hypoxia-induced apoptosis, partially through VEGF/PI3K/Akt/FoxO1 pathway. Stem Cells Dev (2012) 0.90

Mesenchymal Progenitor Cells: Tissue Origin, Isolation and Culture. Transfus Med Hemother (2008) 0.90

Influence of different commercial scaffolds on the in vitro differentiation of human mesenchymal stem cells to nucleus pulposus-like cells. Eur Spine J (2011) 0.90

Mesodermal progenitor cells (MPCs) differentiate into mesenchymal stromal cells (MSCs) by activation of Wnt5/calmodulin signalling pathway. PLoS One (2011) 0.89

Expression of blood group genes by mesenchymal stem cells. Br J Haematol (2011) 0.89

Development of methods for studying the differentiation of human mesenchymal stem cells under cyclic compressive strain. Tissue Eng Part C Methods (2011) 0.88

Migration and proliferation of human mesenchymal stem cells is stimulated by different regions of the mechano-growth factor prohormone. J Mol Cell Cardiol (2010) 0.88

Stem cell therapy to treat diabetes mellitus. Rev Diabet Stud (2009) 0.88

Differential expression of surface markers in mouse bone marrow mesenchymal stromal cell subpopulations with distinct lineage commitment. PLoS One (2012) 0.86

Human bone marrow-derived mesenchymal stem cell gene expression patterns vary with culture conditions. Blood Res (2013) 0.86

Comparison of phenotypic markers and neural differentiation potential of multipotent adult progenitor cells and mesenchymal stem cells. World J Stem Cells (2013) 0.86

Concise review: guidance in developing commercializable autologous/patient-specific cell therapy manufacturing. Stem Cells Transl Med (2013) 0.85

Bone Marrow - Home of Versatile Stem Cells. Transfus Med Hemother (2008) 0.85

Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state. Exp Mol Med (2013) 0.85

Characteristics and neural-like differentiation of mesenchymal stem cells derived from foetal porcine bone marrow. Biosci Rep (2013) 0.85

Lactate modulates gene expression in human mesenchymal stem cells. Langenbecks Arch Surg (2008) 0.85

Should publications on mesenchymal stem/progenitor cells include in-process data on the preparation of the cells? Stem Cells Transl Med (2014) 0.85

Articles cited by this

Multilineage potential of adult human mesenchymal stem cells. Science (1999) 66.19

Mesenchymal stem cells. J Orthop Res (1991) 10.98

Muscle regeneration by bone marrow-derived myogenic progenitors. Science (1998) 10.66

Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med (1999) 9.73

In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res (1998) 8.24

Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res (2000) 7.87

The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet (1970) 7.16

Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species. Nat Med (1997) 6.13

Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A (1999) 5.20

Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci U S A (2000) 4.72

Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem (1997) 4.68

Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci U S A (1999) 4.48

Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci U S A (1995) 4.47

Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts. Proc Natl Acad Sci U S A (1998) 4.13

Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol (1999) 4.08

Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine. Muscle Nerve (1995) 3.84

Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci (1992) 3.69

Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res (1997) 3.54

Characterization of human bone marrow fibroblast colony-forming cells (CFU-F) and their progeny. Blood (1980) 3.51

Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A (1998) 3.17

Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport (2000) 2.49

Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete developmental stages in primary cultures of human bone cells. J Bone Miner Res (1999) 1.73

Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. Proc Natl Acad Sci U S A (1999) 1.53

Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J Exp Med (1999) 1.51

Factors required for bone marrow stromal fibroblast colony formation in vitro. Br J Haematol (1997) 1.45

Biology of bone marrow stroma. Ann N Y Acad Sci (1995) 1.41

In vitro aging of human bone marrow derived stromal cells. Mech Ageing Dev (1981) 1.30

Characterization of fibroblastic stromal cells from murine bone marrow. Exp Hematol (1985) 1.27

Expression of the developmental markers STRO-1 and alkaline phosphatase in cultures of human marrow stromal cells: regulation by fibroblast growth factor (FGF)-2 and relationship to the expression of FGF receptors 1-4. Bone (2000) 1.12

Articles by these authors

Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med (1999) 9.73

Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res (2000) 7.87

Modifications of a specific assay for hydroxyproline in urine. Anal Biochem (1967) 5.48

Conformation-sensitive gel electrophoresis for rapid detection of single-base differences in double-stranded PCR products and DNA fragments: evidence for solvent-induced bends in DNA heteroduplexes. Proc Natl Acad Sci U S A (1993) 5.47

Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains. Proc Natl Acad Sci U S A (1999) 5.20

Modified procedure for the assay of H-3-or C-14-labeled hydroxyproline. Anal Biochem (1966) 5.08

Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci U S A (2000) 4.72

Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice. Proc Natl Acad Sci U S A (1995) 4.47

Heritable diseases of collagen. N Engl J Med (1984) 4.39

Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats--similarities to astrocyte grafts. Proc Natl Acad Sci U S A (1998) 4.13

Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol (1999) 4.08

The biosynthesis of collagen and its disorders (first of two parts). N Engl J Med (1979) 3.87

Two improved methods for preparing ferritin-protein conjugates for electron microscopy. J Cell Biol (1975) 3.81

Plastic adherent stromal cells from the bone marrow of commonly used strains of inbred mice: variations in yield, growth, and differentiation. J Cell Biochem (1999) 3.75

Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A (1998) 3.17

Cloning a cDNA for the pro-alpha 2 chain of human type I collagen. Proc Natl Acad Sci U S A (1981) 2.97

Mutations in collagen genes: causes of rare and some common diseases in humans. FASEB J (1991) 2.86

Structure of cDNA clones coding for the entire prepro alpha 1 (III) chain of human type III procollagen. Differences in protein structure from type I procollagen and conservation of codon preferences. Biochem J (1989) 2.84

Single base mutation in the type II procollagen gene (COL2A1) as a cause of primary osteoarthritis associated with a mild chondrodysplasia. Proc Natl Acad Sci U S A (1990) 2.79

The biosynthesis of collagen and its disorders (second of two parts). N Engl J Med (1979) 2.76

Internal deletion in a collagen gene in a perinatal lethal form of osteogenesis imperfecta. Nature (1983) 2.73

The thermal transition of a non-hydroxylated form of collagen. Evidence for a role for hydroxyproline in stabilizing the triple-helix of collagen. Biochem Biophys Res Commun (1973) 2.66

Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. Blood (2001) 2.65

Radial packing, order, and disorder in collagen fibrils. Biophys J (1995) 2.60

Restriction fragment length polymorphism associated with the pro alpha 2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta. J Clin Invest (1983) 2.50

Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution. Biochemistry (1983) 2.42

Structure of a cDNA for the pro alpha 2 chain of human type I procollagen. Comparison with chick cDNA for pro alpha 2(I) identifies structurally conserved features of the protein and the gene. Biochemistry (1983) 2.41

The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper. Annu Rev Biophys Biophys Chem (1991) 2.33

Structure of a full-length cDNA clone for the prepro alpha 2(I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation. Biochem J (1988) 2.30

cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain. J Biol Chem (1985) 2.30

Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels. Hum Mutat (1997) 2.27

Osteogenesis imperfecta: cloning of a pro-alpha 2(I) collagen gene with a frameshift mutation. J Biol Chem (1984) 2.25

Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy). Proc Natl Acad Sci U S A (1991) 2.24

Proteolytic enzymes as probes for the triple-helical conformation of procollagen. Anal Biochem (1981) 2.19

In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem Biophys Res Commun (2001) 2.17

Donor variation in the growth properties and osteogenic potential of human marrow stromal cells. J Cell Biochem (1999) 2.17

Conformation sensitive gel electrophoresis for simple and accurate detection of mutations: comparison with denaturing gradient gel electrophoresis and nucleotide sequencing. Proc Natl Acad Sci U S A (1998) 2.14

Synovial fluid-derived mesenchymal stem cells increase after intra-articular ligament injury in humans. Rheumatology (Oxford) (2008) 2.11

Synthesis of a shortened pro-alpha 2(I) chain and decreased synthesis of pro-alpha 2(I) chains in a proband with osteogenesis imperfecta. J Biol Chem (1983) 2.03

Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene. Am J Hum Genet (1999) 1.98

Assignment of the human pro alpha 2(I) collagen structural gene (COLIA2) to chromosome 7 by molecular hybridization. Am J Hum Genet (1982) 1.98

Folding mechanism of the triple helix in type-III collagen and type-III pN-collagen. Role of disulfide bridges and peptide bond isomerization. Eur J Biochem (1980) 1.96

Intra-articular injection of human mesenchymal stem cells (MSCs) promote rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen. Osteoarthritis Cartilage (2012) 1.96

Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasia. N Engl J Med (1990) 1.93

Splicing mutations of 54-bp exons in the COL11A1 gene cause Marshall syndrome, but other mutations cause overlapping Marshall/Stickler phenotypes. Am J Hum Genet (1999) 1.88

Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone. Genes Dev (1995) 1.86

Assembly of collagen fibrils de novo by cleavage of the type I pC-collagen with procollagen C-proteinase. Assay of critical concentration demonstrates that collagen self-assembly is a classical example of an entropy-driven process. J Biol Chem (1987) 1.86

An allele of COL9A2 associated with intervertebral disc disease. Science (1999) 1.85

Rat marrow stromal cells are more sensitive to plating density and expand more rapidly from single-cell-derived colonies than human marrow stromal cells. Stem Cells (2001) 1.84

Mutations in COL11A2 cause non-syndromic hearing loss (DFNA13). Nat Genet (1999) 1.82

BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun (2001) 1.80

A transport form of collagen from embryonic tendon: electron microscopic demonstration of an NH 2 -terminal extension and evidence suggesting the presence of cystine in the molecule (chick embryo-tropocollagen-gel filtration). Proc Natl Acad Sci U S A (1972) 1.79

Analysis of the COL1A1 and COL1A2 genes by PCR amplification and scanning by conformation-sensitive gel electrophoresis identifies only COL1A1 mutations in 15 patients with osteogenesis imperfecta type I: identification of common sequences of null-allele mutations. Am J Hum Genet (1998) 1.79

Human type I procollagen genes are located on different chromosomes. Proc Natl Acad Sci U S A (1982) 1.78

Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization. J Biol Chem (1985) 1.71

Synthesis and processing of a type I procollagen containing shortened pro-alpha 1(I) chains by fibroblasts from a patient with osteogenesis imperfecta. J Biol Chem (1983) 1.71

Evidence for a structural mutation of procollagen type I in a patient with the Ehlers-Danlos syndrome type VII. J Biol Chem (1980) 1.69

Collagen fibrils in vitro grow from pointed tips in the C- to N-terminal direction. Biochem J (1990) 1.66

Stem cell properties of human periodontal ligament cells. J Periodontal Res (2006) 1.64

Molecular heterogeneity in the mild autosomal dominant forms of osteogenesis imperfecta. Am J Hum Genet (1984) 1.62

Enzymatic hydroxylation of proline and lysine in protocollagen. Proc Natl Acad Sci U S A (1967) 1.61

The biosynthesis of collagen. 1. N Engl J Med (1972) 1.61

Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine. Biochim Biophys Acta (1972) 1.60

Affinity column purification of protocollagen proline hydroxylase from chick embryos and further characterization of the enzyme. J Biol Chem (1973) 1.58

A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms. J Clin Invest (1990) 1.57

The clinical features of homozygous alpha 2(I) collagen deficient osteogenesis imperfecta. J Med Genet (1984) 1.56

Isolation and characterization of rapidly self-renewing stem cells from cultures of human marrow stromal cells. Cytotherapy (2001) 1.55

Hydroxylation of proline and the intracellular accumulation of a polypeptide precursor of collagen. Science (1966) 1.54

Single base mutation in the type III procollagen gene that converts the codon for glycine 883 to aspartate in a mild variant of Ehlers-Danlos syndrome IV. J Biol Chem (1989) 1.53

The molecular defect in a nonlethal variant of osteogenesis imperfecta. Synthesis of pro-alpha 2(I) chains which are not incorporated into trimers of type I procollagen. J Biol Chem (1983) 1.52

The biosynthesis of collagen. 3. N Engl J Med (1972) 1.52

A substitution of cysteine for glycine 748 of the alpha 1 chain produces a kink at this site in the procollagen I molecule and an altered N-proteinase cleavage site over 225 nm away. J Biol Chem (1988) 1.51

Proline analogue removes fibroblasts from cultured mixed cell populations. Nature (1977) 1.44

The biosynthesis of basement membrane collagen in embryonic chick lens. I. Delay between the synthesis of polypeptide chains and the secretion of collagen by matrix-free cells. J Biol Chem (1972) 1.44

Genetic linkage analysis of hereditary arthro-ophthalmopathy (Stickler syndrome) and the type II procollagen gene. Am J Hum Genet (1989) 1.44

Formation of collagen fibrils in vitro by cleavage of procollagen with procollagen proteinases. J Biol Chem (1982) 1.44

A rapid and simple PCR-based method for isolation of cDNAs from differentially expressed genes. Nucleic Acids Res (1994) 1.43

Two-bundle reconstruction of the anterior cruciate ligament using semitendinosus tendon with endobuttons: operative technique and preliminary results. Arthroscopy (1999) 1.43

Ferritin-conjugated antibodies used for labeling of organelles involved in the cellular synthesis and transport of procollagen. Proc Natl Acad Sci U S A (1974) 1.42

Collagen synthesis: localization of prolyl hydroxylase in tendon cells detected with ferritin-labeled antibodies. Science (1973) 1.41

A point mutation in a type I procollagen gene converts glycine 748 of the alpha 1 chain to cysteine and destabilizes the triple helix in a lethal variant of osteogenesis imperfecta. J Biol Chem (1987) 1.41

The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified as bone morphogenic protein-1. Proc Natl Acad Sci U S A (1996) 1.41

Partial isodisomy for maternal chromosome 7 and short stature in an individual with a mutation at the COL1A2 locus. Am J Hum Genet (1992) 1.40

cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components. Proc Natl Acad Sci U S A (1997) 1.39

A single base mutation that substitutes serine for glycine 790 of the alpha 1 (III) chain of type III procollagen exposes an arginine and causes Ehlers-Danlos syndrome IV. J Biol Chem (1989) 1.39

Synthesis of an altered type III procollagen in a patient with type IV Ehlers-Danlos syndrome. A structural change in the alpha 1(III) chain which makes the protein more susceptible to proteinases. J Biol Chem (1985) 1.39

A heterozygous defect for structurally altered pro-alpha 2 chain of type I procollagen in a mild variant of osteogenesis imperfecta. The altered structure decreases the thermal stability of procollagen and makes it resistant to procollagen N-proteinase. J Biol Chem (1984) 1.38

Assembly of type I collagen fibrils de novo. Between 37 and 41 degrees C the process is limited by micro-unfolding of monomers. J Biol Chem (1988) 1.38

Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia. Proc Natl Acad Sci U S A (1991) 1.38

Synthesis of (Pro-Hyp-Gly) n of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline. Biochim Biophys Acta (1973) 1.37

A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide. Proc Natl Acad Sci U S A (1980) 1.36

Thermal stability of type I and type III procollagens from normal human fibroblasts and from a patient with osteogenesis imperfecta. Proc Natl Acad Sci U S A (1980) 1.36

The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region. J Biol Chem (1988) 1.35

Formation of interchain disulfide bonds and helical structure during biosynthesis of procollagen by embryonic tendon cells. Biochemistry (1974) 1.33

Growing tips of type I collagen fibrils formed in vitro are near-paraboloidal in shape, implying a reciprocal relationship between accretion and diameter. Proc Natl Acad Sci U S A (1992) 1.33

Kinetics for the secretion of procollagen by freshly isolated tendon cells. J Biol Chem (1977) 1.32

First-stage autosomal genome screen in extended pedigrees suggests genes predisposing to low bone mineral density on chromosomes 1p, 2p and 4q. Eur J Hum Genet (1998) 1.32

Structure of cDNA clones coding for human type II procollagen. The alpha 1(II) chain is more similar to the alpha 1(I) chain than two other alpha chains of fibrillar collagens. Biochem J (1989) 1.31

Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta. Proc Natl Acad Sci U S A (1991) 1.31