Published in Cancer Res on July 01, 2001
CD44 in cancer progression: adhesion, migration and growth regulation. J Mol Histol (2004) 2.71
Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis. J Clin Invest (2005) 1.93
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression. Semin Cancer Biol (2008) 1.91
Association of survival and disease progression with chromosomal instability: a genomic exploration of colorectal cancer. Proc Natl Acad Sci U S A (2009) 1.72
Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1. Leuk Lymphoma (2011) 1.68
Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance. Drug Resist Updat (2008) 1.49
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood (2005) 1.45
CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway. PLoS One (2011) 1.44
CD44 variant isoforms in head and neck squamous cell carcinoma progression. Laryngoscope (2009) 1.37
Evaluation of cancer stem cell markers CD133, CD44, CD24: association with AKT isoforms and radiation resistance in colon cancer cells. PLoS One (2014) 1.29
Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis. Blood (2005) 1.11
Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal (2012) 1.11
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer. Front Immunol (2015) 1.06
Whole-genome approach implicates CD44 in cellular resistance to carboplatin. Hum Genomics (2009) 1.04
Targeting Lyn inhibits tumor growth and metastasis in Ewing's sarcoma. Mol Cancer Ther (2008) 1.02
Identification of stem-like cells and clinical significance of candidate stem cell markers in gastric cancer. Oncotarget (2016) 1.02
Caught in the Akt: regulation of Wnt signaling in the intestine. Gastroenterology (2010) 0.99
Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling. Arch Otolaryngol Head Neck Surg (2010) 0.99
Breast cancer patients' clinical outcome measures are associated with Src kinase family member expression. Br J Cancer (2010) 0.98
ARK5 expression in colorectal cancer and its implications for tumor progression. Am J Pathol (2004) 0.95
Prognostic significance of CD44s expression in resected non-small cell lung cancer. BMC Cancer (2011) 0.94
Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem (2008) 0.94
Alteration of cellular behavior and response to PI3K pathway inhibition by culture in 3D collagen gels. PLoS One (2012) 0.92
Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways. PLoS One (2014) 0.91
Fra-1 governs cell migration via modulation of CD44 expression in human mesotheliomas. Mol Cancer (2007) 0.90
Targeting dendritic cells with CD44 monoclonal antibodies selectively inhibits the proliferation of naive CD4+ T-helper cells by induction of FAS-independent T-cell apoptosis. Immunology (2003) 0.89
New Insights into the Crossroads between EMT and Stemness in the Context of Cancer. J Clin Med (2016) 0.88
Exon-level transcriptome profiling in murine breast cancer reveals splicing changes specific to tumors with different metastatic abilities. PLoS One (2010) 0.87
Expression and prognostic significance of Src family members in renal clear cell carcinoma. Br J Cancer (2012) 0.86
Therapeutic potential of stem cells expressing suicide genes that selectively target human breast cancer cells: evidence that they exert tumoricidal effects via tumor tropism (review). Int J Oncol (2012) 0.86
ADAM17-mediated CD44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC. Cancer Med (2013) 0.84
Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy. PLoS One (2013) 0.84
Suppression of human breast tumors in NOD/SCID mice by CD44 shRNA gene therapy combined with doxorubicin treatment. Onco Targets Ther (2012) 0.84
Inhibition of glycogen synthase kinase-3 increases the cytotoxicity of enzastaurin. J Invest Dermatol (2011) 0.82
Exemestane blocks mesothelioma growth through downregulation of cAMP, pCREB and CD44 implicating new treatment option in patients affected by this disease. Mol Cancer (2014) 0.80
Regulation of SRC kinases by microRNA-3607 located in a frequently deleted locus in prostate cancer. Mol Cancer Ther (2014) 0.78
Radotinib Induces Apoptosis of CD11b+ Cells Differentiated from Acute Myeloid Leukemia Cells. PLoS One (2015) 0.78
Histone modifications: Targeting head and neck cancer stem cells. World J Stem Cells (2014) 0.78
Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer. J Cancer Res Clin Oncol (2004) 0.77
Macrophage migration inhibitory factor down-regulates the RANKL-RANK signaling pathway by activating Lyn tyrosine kinase in mouse models. Arthritis Rheumatol (2014) 0.77
GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation. Cell Signal (2015) 0.75
Chicken sarcoma to human cancers: a lesson in molecular therapeutics. Ochsner J (2007) 0.75
Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation. Sci Rep (2017) 0.75
Shifting to first-line regimen after previous failure of irinotecan and oxaliplatin containing chemotherapies in unresectable metastatic colorectal cancer: a retrospective study of case analysis. Int J Colorectal Dis (2008) 0.75
p53 status and the efficacy of cancer therapy in vivo. Science (1994) 6.72
MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature (1998) 3.53
microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. Genes Dev (1994) 3.44
c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev (2000) 3.13
Small nuclear ribonucleoprotein particle assembly in vivo: demonstration of a 6S RNA-free core precursor and posttranslational modification. Cell (1985) 2.36
Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment. J Virol (1995) 2.20
Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes. J Cell Biol (1998) 2.20
Idiotype-like molecules on cells of a human T cell leukemia. J Exp Med (1983) 2.19
Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol Cell Biol (1998) 2.11
Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms. Proc Natl Acad Sci U S A (1988) 2.08
Stimulation of proliferation, differentiation, and function of human cells by primate interleukin 3. Proc Natl Acad Sci U S A (1987) 1.89
Coxsackievirus A21 binds to decay-accelerating factor but requires intercellular adhesion molecule 1 for cell entry. J Virol (1997) 1.88
Percutaneous central venous catheterization. Three years' experience in a neonatal intensive care unit. Am J Dis Child (1990) 1.85
atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet (1997) 1.85
Linking osteopetrosis and pycnodysostosis: regulation of cathepsin K expression by the microphthalmia transcription factor family. Proc Natl Acad Sci U S A (2001) 1.81
Microphthalmia transcription factor. A sensitive and specific melanocyte marker for MelanomaDiagnosis. Am J Pathol (1999) 1.80
Selective intrapartum chemoprophylaxis of neonatal group B streptococcal early-onset disease. I. Epidemiologic rationale. J Infect Dis (1983) 1.78
Pre-bending of a promoter sequence enhances affinity for the TATA-binding factor. Nature (1995) 1.74
Monoclonal antibody OKT-9 recognizes the receptor for transferrin on human acute lymphocytic leukemia cells. J Immunol (1981) 1.70
Synthesis and assembly of human small nuclear ribonucleoproteins generated by cell-free translation. Proc Natl Acad Sci U S A (1983) 1.68
Two monoclonal anti-human T lymphocyte antibodies have similar biologic effects and recognize the same cell surface antigen. J Immunol (1982) 1.68
Corticosteroid-induced avascular necrosis. A clinical study of seventy-seven patients. J Bone Joint Surg Am (1971) 1.64
GMP-140 binding to neutrophils is inhibited by sulfated glycans. J Biol Chem (1991) 1.62
Apoptosis induced by inhibition of intercellular contact. J Cell Biol (1994) 1.49
Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. J Biol Chem (1998) 1.47
Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice. Mol Cell (2001) 1.45
Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance. Hum Mol Genet (2000) 1.44
The IIb-IIIa glycoprotein complex that mediates platelet aggregation is directly implicated in leukocyte adhesion. Cell (1986) 1.40
Activated killer cell lymphoma: an erythrophagocytic syndrome simulating histiocytic medullary histiocytosis. Pathology (1988) 1.39
Loss of matrix adhesion triggers rapid transformation-selective apoptosis in fibroblasts. J Cell Biol (1997) 1.38
Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulate alpha v integrin expression on cultured human macrophages. Proc Natl Acad Sci U S A (1993) 1.37
Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits. J Biol Chem (1990) 1.36
Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. J Exp Med (1998) 1.35
Histologic demonstration of fat emboli in aseptic necrosis associated with hypercortisonism. Mayo Clin Proc (1969) 1.34
alpha-Melanocyte-stimulating hormone signaling regulates expression of microphthalmia, a gene deficient in Waardenburg syndrome. J Biol Chem (1998) 1.34
Isolation of mouse stromal cells associated with a human tumor using differential diphtheria toxin sensitivity. Am J Pathol (1999) 1.33
Discrimination of B, T and null lymphocytes by esterase cytochemistry. Scand J Haematol (1977) 1.32
Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation. J Invest Dermatol (2002) 1.25
Spheroids and cell survival. Crit Rev Oncol Hematol (2001) 1.25
Mouse cells expressing human intercellular adhesion molecule-1 are susceptible to infection by coxsackievirus A21. J Virol (1997) 1.23
Apoptosis and cancer drug targeting. J Clin Invest (1999) 1.22
FAT, E-cadherin, beta catenin, HER 2/neu, Ki67 immuno-expression, and histological grade in intrahepatic cholangiocarcinoma. J Clin Pathol (2005) 1.19
Biochemical isolation of a membrane microdomain from resting platelets highly enriched in the plasma membrane glycoprotein CD36. Biochem J (1996) 1.17
The integrins alpha3beta1 and alpha6beta1 physically and functionally associate with CD36 in human melanoma cells. Requirement for the extracellular domain OF CD36. J Biol Chem (2000) 1.14
TLiSA1, a human T lineage-specific activation antigen involved in the differentiation of cytotoxic T lymphocytes and anomalous killer cells from their precursors. J Exp Med (1985) 1.11
New evidence relating to the nature and origin of the hairy cell of leukaemic reticuloendotheliosis. Br J Haematol (1977) 1.11
Psoriasis and Raynaud's phenomenon associated with autoantibodies to U1 and U2 small nuclear ribonucleoproteins. N Engl J Med (1986) 1.10
Microphthalmia transcription factor expression in cutaneous benign, malignant melanocytic, and nonmelanocytic tumors. Am J Surg Pathol (2001) 1.10
The role of fat embolism in the etiology of corticosteroid-induced avascular necrosis: clinical and experimental results. Clin Orthop Relat Res (1978) 1.09
The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. Leukemia (2011) 1.08
Regulation of expression of a human intercellular adhesion molecule (ICAM-1) during lymphohematopoietic differentiation. Blood (1989) 1.08
The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms. Am J Pathol (2001) 1.08
A chronic lymphoproliferative disorder with distinctive features: a distinct variant of hairy-cell leukaemia. Leuk Res (1980) 1.08
Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. J Biol Chem (2000) 1.07
Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints. Cancer Res (1997) 1.07
Involvement of integrins in cell survival. Cancer Metastasis Rev (1995) 1.05
Interferon: a cytotoxic T lymphocyte differentiation signal. Eur J Immunol (1986) 1.04
The semidominant Mi(b) mutation identifies a role for the HLH domain in DNA binding in addition to its role in protein dimerization. EMBO J (1996) 1.04
CD36 is a ditopic glycoprotein with the N-terminal domain implicated in intracellular transport. Biochem Biophys Res Commun (2000) 1.04
Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies. Proc Natl Acad Sci U S A (1984) 1.04
Characterization of a novel membrane glycoprotein involved in platelet activation. J Biol Chem (1989) 1.03
Individual embryonic fibroblasts express multiple beta chains in association with the alpha v integrin subunit. Loss of beta 3 expression with cell confluence. J Biol Chem (1991) 1.02
Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates f Met-Leu-Phe receptors on human neutrophils. Immunology (1988) 1.02
Surface marker and other characteristics of Gaucher's cells. J Clin Pathol (1977) 1.01
Sensorineural deafness and pigmentation genes: melanocytes and the Mitf transcriptional network. Neuron (2001) 1.00
In vitro generation of human activated lymphocyte killer cells: separate precursors and modes of generation of NK-like cells and "anomalous" killer cells. J Immunol (1984) 1.00
Temporal shifts from Sm to ribonucleoprotein reactivity in systemic lupus erythematosus. Arthritis Rheum (1985) 0.99
Synovial fluid neutrophils of patients with rheumatoid arthritis have membrane antigen changes that reflect activation. Ann Rheum Dis (1988) 0.99
Autoimmune sera reactive with Sm antigen contain high levels of RNP-like antibodies. J Clin Invest (1985) 0.99
Hemangioendothelioma of the leg following metallic fixation of the tibia. Cancer (1972) 0.98
Epitope diversity of monoclonal antibodies revealed by cross-species reactivity. Mol Immunol (1984) 0.98
p53 in life and death. Clin Cancer Res (1996) 0.98
T cell antiidiotypic antibodies reveal differences between two human leukemias. J Exp Med (1984) 0.97
Multiple heavy chain isotypes on the surface of the cells of hairy cell leukemia. Blood (1978) 0.97
Hairy-cell leukemia with T-cell features. Blood (1978) 0.97
Cytochemistry of human T-cell subpopulations. Scand J Immunol (1980) 0.96
Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein. J Biol Chem (1998) 0.95
Identification of the hairy cells of leukaemic reticuloendotheliosis by an esterase method. Br J Haematol (1978) 0.95
Terminal B cell development as seen in different human myelomas and related disorders. Clin Exp Immunol (1979) 0.95
Stimulation of platelet activation and aggregation by a carboxyl-terminal peptide from thrombospondin binding to the integrin-associated protein receptor. J Biol Chem (1997) 0.94
Surface antigen changes occurring in short-term cultures of activated human T lymphocytes: analysis by flow cytometry. Cell Immunol (1982) 0.94
Adhesion to thrombospondin by human embryonic fibroblasts is mediated by multiple receptors and includes a role for glycoprotein 88 (CD36). Exp Cell Res (1992) 0.94
The identification of lymphoid cell subpopulations in sections of human lymphoid tissue and gingivitis in children using monoclonal antibodies. J Periodontal Res (1982) 0.94
Chronic myelomonocytic leukemia with paraproteinemia but no detectable plasmacytosis: a detailed cytological and immunological study. Cancer (1979) 0.93
Oncogene-dependent regulation of caspase activation by p53 protein in a cell-free system. J Biol Chem (1998) 0.93
Mechanisms of apoptotic cell death. Leukemia (1997) 0.93
Mechanisms of p53-mediated apoptosis. Crit Rev Oncog (1998) 0.92
The leucine zipper may induce electrophoretic mobility anomalies without DNA bending. Proc Natl Acad Sci U S A (1996) 0.91
TGF beta down-regulates TLiSA1 expression and inhibits the differentiation of precursor lymphocytes into CTL and LAK cells. Immunology (1989) 0.91
Extensive apoptosis in ductal carcinoma in situ of the breast. Cancer (1996) 0.91
In vitro growth of B lymphocytes infiltrating human melanoma tissue by transformation with EBV: evidence for secretion of anti-melanoma antibodies by some transformed cells. J Immunol (1983) 0.91
Apoptosis in tumorigenesis and cancer therapy. Front Biosci (1997) 0.91
Experimental gingivitis in humans. A histochemical and immunological characterization of the lymphoid cell subpopulations. J Periodontal Res (1983) 0.90
p53 and cancer therapy: a double-edged sword. J Clin Invest (1999) 0.90
Improved oxygenation with prone positioning in neonates: stability of increased transcutaneous PO2. J Perinatol (1991) 0.90
Evidence for the presence of a receptor for IgM on the pathological cells of Sézary's syndrome. Clin Exp Immunol (1978) 0.90
Corticosteroid-induced aseptic necrosis. II. Experimental study. Clin Orthop Relat Res (1972) 0.89
Membrane receptors of human leukaemic myeloid cells: sequential expression of the gamma Fc receptor. Br J Haematol (1979) 0.89
A novel antigenic cell surface protein associated with T200 is involved in the post-activation stage of human NK cell-mediated lysis. J Immunol (1984) 0.89
Arg-Gly-Asp-containing peptides expose novel collagen receptors on fibroblasts: implications for wound healing. Cell Regul (1991) 0.89