Published in J Biol Chem on June 29, 2001
Hierarchical regulation of WASP/WAVE proteins. Mol Cell (2008) 2.86
Physical mechanisms of signal integration by WASP family proteins. Annu Rev Biochem (2010) 2.18
The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1. J Clin Invest (2011) 1.44
Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J (2004) 1.20
Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles. J Biol Chem (2009) 1.19
Haematopoietic lineage cell-specific protein 1 (HS1) promotes actin-related protein (Arp) 2/3 complex-mediated actin polymerization. Biochem J (2003) 1.11
Motility determinants in WASP family proteins. Mol Biol Cell (2002) 1.08
Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2. Mol Cell Biol (2009) 1.08
Interaction of HSP90 to N-WASP leads to activation and protection from proteasome-dependent degradation. EMBO J (2005) 0.98
VCA nanobodies target N-WASp to reduce invadopodium formation and functioning. PLoS One (2017) 0.75
The transcriptional landscape of the mammalian genome. Science (2005) 37.63
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell (1999) 8.07
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell (1999) 7.56
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature (1998) 4.95
WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J (1998) 4.46
N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J (1996) 4.31
WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J Cell Sci (2001) 3.74
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Science (2001) 3.67
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature (2000) 3.56
ATP-dependent inositide phosphorylation required for Ca(2+)-activated secretion. Nature (1995) 3.30
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes (2000) 3.01
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem (2001) 2.69
Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function. Nature (1992) 2.62
C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc Natl Acad Sci U S A (1994) 2.57
The essential role of profilin in the assembly of actin for microspike formation. EMBO J (1998) 2.28
WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol (2001) 2.18
Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri. EMBO J (1998) 2.09
Fractal analysis of cerebral blood flow distribution in Alzheimer's disease. J Nucl Med (2001) 2.08
A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. J Biol Chem (1989) 2.06
Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. Biochem Biophys Res Commun (1999) 2.01
Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form. J Biol Chem (1991) 2.00
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest (2001) 1.97
In vitro and in vivo antifungal activities of ER-30346, a novel oral triazole with a broad antifungal spectrum. Antimicrob Agents Chemother (1996) 1.97
Preservation of the bone mineral density of the femur after surface replacement of the hip. J Bone Joint Surg Br (2004) 1.88
Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. Proc Natl Acad Sci U S A (1992) 1.79
Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization. Biochem Biophys Res Commun (1998) 1.76
Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line. Am J Physiol Lung Cell Mol Physiol (2001) 1.71
Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments. Mol Cell Biol (1997) 1.65
Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. J Biol Chem (1994) 1.57
A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. J Cell Biol (2001) 1.56
Measurement of cerebral hemodynamics with perfusion-weighted MR imaging: comparison with pre- and post-acetazolamide 133Xe-SPECT in occlusive carotid disease. AJNR Am J Neuroradiol (2001) 1.54
alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase. J Biol Chem (1994) 1.54
Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates. Oncogene (2009) 1.54
Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity. Proc Natl Acad Sci U S A (1994) 1.51
Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. Proc Natl Acad Sci U S A (1988) 1.48
Failed hip prostheses in hemodialysis patients. Amyloid deposition at the bone-implant interface in 4 cases. Acta Orthop Scand (1998) 1.45
Intracranial vascular stenosis and occlusion: diagnostic accuracy of three-dimensional, Fourier transform, time-of-flight MR angiography. Radiology (1994) 1.44
Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2. Science (1988) 1.43
Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology (2001) 1.41
Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. J Biol Chem (1994) 1.38
Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. Proc Natl Acad Sci U S A (2000) 1.37
Purification of phosphatidylinositol-specific phospholipase C from rat liver. J Biol Chem (1981) 1.37
Efficacy of ER-30346, a novel oral triazole antifungal agent, in experimental models of aspergillosis, candidiasis, and cryptococcosis. Antimicrob Agents Chemother (1996) 1.35
Solitary pulmonary nodule: preliminary study of evaluation with incremental dynamic CT. Radiology (1995) 1.35
Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1996) 1.35
Molecular cloning of bovine actin-like protein, actin2. Biochem Biophys Res Commun (1992) 1.35
Rectus sheath hematoma in an elderly woman under anti-coagulant therapy. J Med Invest (2001) 1.34
CDP-diglyceride:inositol transferase from rat liver. Purification and properties. J Biol Chem (1977) 1.34
Role of Ca2+ in phosphatidylinositol response and arachidonic acid release in formylated tripeptide- or Ca2+ ionophore A23187-stimulated guinea pig neutrophils. J Immunol (1983) 1.33
Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF. EMBO J (1993) 1.29
High intraocular pressure-induced ischemia and reperfusion injury in the optic nerve and retina in rats. Graefes Arch Clin Exp Ophthalmol (1996) 1.29
A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals. J Biol Chem (1998) 1.28
Positive regulation of mu-calpain action by polyphosphoinositides. J Biol Chem (1992) 1.28
Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal. J Biol Chem (1992) 1.26
Inhibitory effect of prostaglandin E2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils. J Biol Chem (1986) 1.26
Essential role for phosphatidylinositol 4,5-bisphosphate in yeast cell proliferation. Nature (1988) 1.24
Identification of a phosphatidylinositol 4,5-bisphosphate-binding site in chicken skeletal muscle alpha-actinin. J Biol Chem (1996) 1.24
A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs. Biochem Biophys Res Commun (1997) 1.23
Identification of kinesin neck region as a stable alpha-helical coiled coil and its thermodynamic characterization. Biochemistry (1997) 1.22
Phosphatidylinositol 4-phosphate 5-kinase type I is regulated through phosphorylation response by extracellular stimuli. J Biol Chem (2000) 1.22
Birth of offspring following transplantation of cryopreserved immature testicular pieces and in-vitro microinsemination. Hum Reprod (2002) 1.22
Profilin enhances Cdc42-induced nucleation of actin polymerization. J Cell Biol (2000) 1.21
Mid-term results of cementless total hip replacement using a ceramic-on-ceramic bearing with and without computer navigation. J Bone Joint Surg Br (2007) 1.21
Molecular cloning of the human glucose-regulated protein ERp57/GRP58, a thiol-dependent reductase. Identification of its secretory form and inducible expression by the oncogenic transformation. Eur J Biochem (1995) 1.20
Phase transformation of a zirconia ceramic head after total hip arthroplasty. J Bone Joint Surg Br (2001) 1.18
Profilin is required for sustaining efficient intra- and intercellular spreading of Shigella flexneri. J Biol Chem (2000) 1.17
Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling. J Biol Chem (1999) 1.16
Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells. J Biol Chem (2000) 1.15
Phosphatidylinositol 4-phosphate 5-kinase Its3 and calcineurin Ppb1 coordinately regulate cytokinesis in fission yeast. J Biol Chem (2000) 1.14
N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia. J Cell Sci (2001) 1.14
Solubilization of the enzyme catalyzing CDP-diglyceride-independent incorporation of myo-inositol into phosphatidyl inositol and its comparison to CDP-diglyceride:inositol transferase. Arch Biochem Biophys (1977) 1.13
Requirement of phospholipase Cdelta4 for the zona pellucida-induced acrosome reaction. Science (2001) 1.13
Identification and characterization of a new phospholipase C-like protein, PLC-L(2). Biochem Biophys Res Commun (1999) 1.13
Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma. Int J Cancer (1999) 1.10
K-ras activation in premalignant and malignant epithelial lesions of the human uterus. Cancer Res (1991) 1.10
Regulation of endocytosis by phosphatidylinositol 4,5-bisphosphate and ENTH proteins. Curr Top Microbiol Immunol (2004) 1.10
Sentinel lymph node biopsy in patients with papillary thyroid carcinoma. Cancer (2001) 1.09
Role of phosphatidylinositol 4,5-bisphosphate in Ras/Rac-induced disruption of the cortactin-actomyosin II complex and malignant transformation. Mol Cell Biol (1998) 1.09
Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. J Biol Chem (2001) 1.08
Effects of a thiolate axial ligand on the pi-->pi* electronic states of oxoferryl porphyrins: a study of the optical and resonance Raman spectra of compounds I and II of chloroperoxidase. J Biol Inorg Chem (2001) 1.08
Sonographic findings in muscle strain injury: clinical and MR imaging correlation. J Ultrasound Med (1995) 1.08
Phospholipase C-gamma 1 associates with viral and cellular src kinases. J Biol Chem (1993) 1.08
Inhibitory effect of src homology (SH) 2/SH3 fragments of phospholipase C-gamma on the catalytic activity of phospholipase C isoforms. Identification of a novel phospholipase C inhibitor region. J Biol Chem (1992) 1.08
Asymmetric distribution of phosphoinositides and phosphatidic acid in the human erythrocyte membrane. Biochim Biophys Acta (1991) 1.07
Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. J Biol Chem (1996) 1.07
The alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor. J Biol Chem (1993) 1.06
Identification and characterization of a novel inositol polyphosphate 5-phosphatase. J Biol Chem (2000) 1.06