Published in Science on February 05, 1988
N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J (1996) 4.31
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells. Mol Cell Biol (1989) 2.78
Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C. Proc Natl Acad Sci U S A (1989) 2.75
Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex. Mol Cell Biol (1990) 2.71
Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors. Mol Biol Cell (1998) 2.07
Phosphatidylinositol 4,5-bisphosphate regulates two steps of homotypic vacuole fusion. Mol Biol Cell (2000) 1.80
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells. Mol Cell Biol (1992) 1.80
Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. Proc Natl Acad Sci U S A (1988) 1.48
Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF. EMBO J (1993) 1.29
Phosphoinositides regulate membrane-dependent actin assembly by latex bead phagosomes. Mol Biol Cell (2002) 1.25
Reducing inositol lipid hydrolysis, Ins(1,4,5)P3 receptor availability, or Ca2+ gradients lengthens the duration of the cell cycle in Xenopus laevis blastomeres. J Cell Biol (1992) 1.11
PDGF and intracellular signaling in the timing of oligodendrocyte differentiation. J Cell Biol (1989) 1.10
S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C. Proc Natl Acad Sci U S A (1989) 1.07
Modulation of mitogenic stimuli by angiogenin correlates with in vitro phosphatidylinositol bisphosphate synthesis. Proc Natl Acad Sci U S A (1989) 1.05
Bombesin and platelet-derived growth factor stimulate formation of inositol phosphates and Ca2+ mobilization in Swiss 3T3 cells by different mechanisms. Biochem J (1989) 1.02
Constitutive inositol phosphate formation in cytomegalovirus-infected human fibroblasts is due to expression of the chemokine receptor homologue pUS28. J Virol (2003) 1.01
Neuropeptide stimulation of calcium flux in human lung cancer cells: delineation of alternative pathways. Proc Natl Acad Sci U S A (1990) 0.99
Mitogenic signaling pathways of growth factors can be distinguished by the involvement of pertussis toxin-sensitive guanosine triphosphate-binding protein and of protein kinase C. Cell Regul (1990) 0.84
Modified kinetics of platelet-derived growth factor-induced Ca2+ increases in NIH-3T3 cells overexpressing phospholipase C gamma 1. Biochem J (1992) 0.84
Phosphoinositide-binding interface proteins involved in shaping cell membranes. Proc Jpn Acad Ser B Phys Biol Sci (2010) 0.84
Oscillations of cytosolic free calcium concentration in the presence of intracellular antibodies to phosphatidylinositol 4,5-bisphosphate in voltage-clamped guinea-pig hepatocytes. Biochem J (1992) 0.82
Effects of fluorinated inositols on the proliferation of Swiss 3T3 fibroblasts. Biochem J (1993) 0.75
Preparation and characterization of a D-myo-inositol 1,4,5-trisphosphate-specific antibody. Biochem J (1995) 0.75
New procedure for DNA transfection with polycation and dimethyl sulfoxide. Mol Cell Biol (1984) 8.63
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell (1999) 8.07
The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutant. Virology (1971) 7.83
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Nature (1998) 4.95
Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants. J Exp Med (1977) 4.79
WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J (1998) 4.46
N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J (1996) 4.31
Genetic recombination with avian tumor virus. Virology (1972) 4.23
The erbB gene of avian erythroblastosis virus is a member of the src gene family. Cell (1983) 3.82
Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 3.73
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Science (2001) 3.67
Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity. Proc Natl Acad Sci U S A (1980) 3.58
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature (2000) 3.56
GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J Cell Biol (2000) 3.46
Isolation of defective mutant of avian sarcoma virus. Proc Natl Acad Sci U S A (1973) 3.38
ATP-dependent inositide phosphorylation required for Ca(2+)-activated secretion. Nature (1995) 3.30
A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci U S A (1999) 3.26
Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. Biochem Biophys Res Commun (1999) 3.03
Characterization of a Rous sarcoma virus mutant defective in packaging its own genomic RNA: biochemical properties of mutant TK15 and mutant-induced transformants. J Virol (1984) 2.95
Requirement of phosphatidylinositol 4,5-bisphosphate for alpha-actinin function. Nature (1992) 2.62
C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. Proc Natl Acad Sci U S A (1994) 2.57
Unifected avian cells contain structurally unrelated progenitors of viral sarcoma genes. Nature (1980) 2.50
Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length. J Virol (1977) 2.43
RNA of replication-defective strains of Rous sarcoma virus. Proc Natl Acad Sci U S A (1975) 2.37
Isolation of different kinds of non-virus producing chick cells transformed by Schmidt-Ruppin strain (subgroup A) of Rous sarcoma virus. Jpn J Exp Med (1970) 2.35
The essential role of profilin in the assembly of actin for microspike formation. EMBO J (1998) 2.28
v-maf, a viral oncogene that encodes a "leucine zipper" motif. Proc Natl Acad Sci U S A (1989) 2.24
Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res (1993) 2.22
WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol (2001) 2.18
Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus. Virology (1981) 2.16
Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam. J Clin Microbiol (1996) 2.12
Long-term safety and efficacy of tocilizumab, an anti-IL-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis (the STREAM study): evidence of safety and efficacy in a 5-year extension study. Ann Rheum Dis (2008) 2.11
Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri. EMBO J (1998) 2.09
A second type of rat phosphoinositide-specific phospholipase C containing a src-related sequence not essential for phosphoinositide-hydrolyzing activity. J Biol Chem (1989) 2.06
Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex. Biochem Biophys Res Commun (1999) 2.01
Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form. J Biol Chem (1991) 2.00
Free vascularized thin corticoperiosteal graft. Plast Reconstr Surg (1991) 1.98
A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erythroblastosis and sarcomas. Cell (1983) 1.95
Plaque assay for some strains of avian leukosis virus. Virology (1972) 1.87
A cellular protein is immunologically crossreactive with and functionally homologous to the Fujinami sarcoma virus transforming protein. Cell (1982) 1.86
Genome structure of avian sarcoma virus Y73 and unique sequence coding for polyprotein p90. J Virol (1981) 1.85
Serum lipoprotein(a) and apolipoprotein(a) phenotypes in patients with rheumatoid arthritis. Arthritis Rheum (1999) 1.85
Molecular cloning and nucleotide sequence of DNA complementary to rat ribosomal protein S26 messenger RNA. J Biochem (1985) 1.83
Characterization of a Rous sarcoma virus mutant defective in packaging its own genomic RNA: biological properties of mutant TK15 and mutant-induced transformants. J Virol (1984) 1.83
Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries. Proc Natl Acad Sci U S A (1992) 1.79
Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization. Biochem Biophys Res Commun (1998) 1.76
Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci (2001) 1.74
Inhibition of transforming activity of tyrosine kinase oncogenes by herbimycin A. Virology (1988) 1.70
Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts. J Biol Chem (1994) 1.70
Phosphatidylinositol 4,5-bisphosphate phosphatase regulates the rearrangement of actin filaments. Mol Cell Biol (1997) 1.65
Detection of a raf-related and two other transforming DNA sequences in human tumors maintained in nude mice. Proc Natl Acad Sci U S A (1985) 1.61
Transformation of rat cells by fusion-infection with Rous sarcoma virus. J Virol (1980) 1.60
Association of Ash/Grb-2 with dynamin through the Src homology 3 domain. J Biol Chem (1994) 1.57
A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42. J Cell Biol (2001) 1.56
The effect of current direction induced by transcranial magnetic stimulation on the corticospinal excitability in human brain. Electroencephalogr Clin Neurophysiol (1996) 1.56
Successful treatment of a hepatic abscess that formed secondary to fish bone penetration by percutaneous transhepatic removal of the foreign body: report of a case. Surg Today (1999) 1.54
alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase. J Biol Chem (1994) 1.54
Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates. Oncogene (2009) 1.54
Presence of antigen common to avian tumor viral envelope antigen in normal chick embryo cells. Virology (1973) 1.54
A bacterial enzyme degrading the model lignin compound beta-etherase is a member of the glutathione-S-transferase superfamily. FEBS Lett (1993) 1.52
Epidermal growth factor-receptor mutant lacking the autophosphorylation sites induces phosphorylation of Shc protein and Shc-Grb2/ASH association and retains mitogenic activity. Proc Natl Acad Sci U S A (1994) 1.51
Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis. Proc Natl Acad Sci U S A (1988) 1.48
Cushing's syndrome due to primary adrenocortical nodular dysplasia, cardiac myxomas, and spotty pigmentation, complicated by sarcoidosis. Intern Med (1992) 1.46
Arrhythmogenic right ventricular cardiomyopathy with an initial manifestation of severe left ventricular impairment and normal contraction of the right ventricle. Jpn Circ J (2000) 1.46
Cloning and sequencing of the gene for a Pseudomonas paucimobilis enzyme that cleaves beta-aryl ether. J Bacteriol (1991) 1.44
Structure-function analysis of the maf oncogene product, a member of the b-Zip protein family. J Virol (1993) 1.43
Clinical application of the perineal scan: prepartum screening for cord presentation. Am J Obstet Gynecol (1986) 1.42
Contributions and co-ordination of individual fingers in multiple finger prehension. Ergonomics (1995) 1.41
18 years mitotane therapy for intractable Cushing's disease. Lancet (1999) 1.39
Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. J Biol Chem (1994) 1.38
Evidence for facilitation of motor evoked potentials (MEPs) induced by motor imagery. Brain Res (1997) 1.38
Molecular cloning and nucleotide sequences of cDNAs specific for rat liver ribosomal proteins S17 and L30. Gene (1985) 1.37
Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. Proc Natl Acad Sci U S A (2000) 1.37
Genetic control of expression of endogenous virus genes in chicken cells. Virology (1974) 1.37
Purification of phosphatidylinositol-specific phospholipase C from rat liver. J Biol Chem (1981) 1.37
Potent antitumor activity of MS-247, a novel DNA minor groove binder, evaluated by an in vitro and in vivo human cancer cell line panel. Cancer Res (1999) 1.37
Separation and determination of mugineic acid and its analogues by high-performance liquid chromatography. J Chromatogr (1987) 1.36
Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A (1996) 1.35
Molecular cloning of bovine actin-like protein, actin2. Biochem Biophys Res Commun (1992) 1.35
Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation. Bone (2001) 1.35
CDP-diglyceride:inositol transferase from rat liver. Purification and properties. J Biol Chem (1977) 1.34
Complementation of functions required for cell transformation by double infection with RSV mutants. Virology (1972) 1.34
Role of Ca2+ in phosphatidylinositol response and arachidonic acid release in formylated tripeptide- or Ca2+ ionophore A23187-stimulated guinea pig neutrophils. J Immunol (1983) 1.33
Bone disease in infants and children with hepatobiliary disease. Arch Dis Child (1974) 1.32
Unusual features of the leader sequence of Rous sarcoma virus packaging mutant TK15. J Virol (1985) 1.32
Alkaline detergent enzymes from alkaliphiles: enzymatic properties, genetics, and structures. Extremophiles (1998) 1.31
An avian transforming retrovirus isolated from a nephroblastoma that carries the fos gene as the oncogene. J Virol (1987) 1.31
Selective recruitment of CCR6-expressing cells by increased production of MIP-3 alpha in rheumatoid arthritis. Clin Exp Immunol (2001) 1.30
Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF. EMBO J (1993) 1.29
Diabetic nephropathy: where hemodynamics meets metabolism. Exp Clin Endocrinol Diabetes (2007) 1.29
A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals. J Biol Chem (1998) 1.28
Positive regulation of mu-calpain action by polyphosphoinositides. J Biol Chem (1992) 1.28
Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal. J Biol Chem (1992) 1.26