PubRank

P T Hawkins

Author PubWeight™ 106.84‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 1997 8.17
2 Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 1998 6.79
3 Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell 2000 5.23
4 Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones. Biochem J 1983 4.11
5 Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim Biophys Acta 1993 3.77
6 Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell 2000 3.68
7 A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell 1994 3.50
8 Rapid formation of inositol 1,3,4,5-tetrakisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands may both result indirectly from receptor-stimulated release of inositol 1,4,5-trisphosphate from phosphatidylinositol 4,5-bisphosphate. Biochem J 1986 3.41
9 Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. Biochem J 1986 3.04
10 The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell 1997 3.03
11 Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol 1998 2.69
12 The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Mol Cell 2001 2.47
13 PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol 2001 2.39
14 L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells. Biochem J 1988 2.10
15 The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s). J Biol Chem 1993 2.09
16 Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature 2000 1.93
17 Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. Biochem J 1988 1.88
18 Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases. Proc Natl Acad Sci U S A 1997 1.85
19 Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. Biochem J 1988 1.81
20 Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol Cell 2002 1.69
21 Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate. Biochem J 1987 1.68
22 Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate. Biochem J 1989 1.62
23 Analysis of the metabolic turnover of the individual phosphate groups of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate. Validation of novel analytical techniques by using 32P-labelled lipids from erythrocytes. Biochem J 1984 1.61
24 myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate. Biochem J 1991 1.57
25 Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells. Curr Biol 1994 1.55
26 FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci 2001 1.52
27 Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol 2001 1.49
28 L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase. Biochem J 1988 1.44
29 Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J 1993 1.42
30 Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway. J Biol Chem 1998 1.40
31 Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells. J Biol Chem 1992 1.40
32 The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes. Biochem J 1986 1.31
33 Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J 1993 1.29
34 Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. J Biol Chem 1987 1.23
35 An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes. Biochem J 1989 1.22
36 Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase. J Cell Sci 1996 1.18
37 Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands. Biochem J 1987 1.18
38 Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen. J Virol 1990 1.10
39 A simple assay method for determination of the specific radioactivity of the gamma-phosphate group of 32P-labelled ATP. Biochem J 1983 1.10
40 Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors. Mol Pharmacol 1989 1.08
41 Characterization of metal ion-induced [3H]inositol hexakisphosphate binding to rat cerebellar membranes. J Biol Chem 1993 1.02
42 Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. J Biol Chem 1993 0.99
43 Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. J Biol Chem 1999 0.97
44 Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues. Biochem J 1993 0.96
45 A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors. Philos Trans R Soc Lond B Biol Sci 1996 0.92
46 DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation. Curr Biol 2000 0.90
47 Production of inositol trisphosphates and inositol tetrakisphosphate in stimulated pancreatic islets. Biochim Biophys Acta 1987 0.88
48 The metabolism and functions of inositol pentakisphosphate and inositol hexakisphosphate. Biochem Soc Trans 1989 0.88
49 Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42. Biochem J 1999 0.85
50 Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation. FEBS Lett 1998 0.81
51 Metabolism of myo-inositol pentakisphosphates in mammalian brain. Biochem Soc Trans 1992 0.80
52 Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase. Biochem J 2000 0.79
53 Determination of the steady-state turnover rates of the metabolically active pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in human erythrocytes. Biochem J 1989 0.79
54 Receptor regulation of phosphoinositide 3-hydroxykinase in the NG115-401L-C3 neuronal cell line: stimulation by insulin-like growth factor-I. Biochem J 1993 0.79
55 Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C. Philos Trans R Soc Lond B Biol Sci 1988 0.78
56 Cell biology. Moving in mysterious ways. Nature 2000 0.78
57 Changes in inositol lipids and phosphates after stimulation of the MAS-transfected NG115-401L-C3 cell line by mitogenic and non-mitogenic stimuli. Biochem J 1990 0.78
58 Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines. J Biol Chem 2001 0.77
59 Structural analysis of a novel isoform of phosphoinositide 3OH-kinase. Biochem Soc Trans 1997 0.75
60 Metabolic pooling of inositol lipids in mature erythrocytes and in hormone-stimulated mammalian cells. Prog Clin Biol Res 1987 0.75
61 Inositol hexakisphosphate biosynthesis in mammalian brain: identification of a novel inositol pentakisphosphate kinase. Biochem Soc Trans 1990 0.75
62 Stimulation of phosphatidylinositol-3-kinase by insulin-like growth factor 1 and other agonists. Biochem Soc Trans 1992 0.75
63 Is vasopressin-stimulated inositol lipid breakdown intrinsic to the mechanism of Ca2+-mobilization at V1 vasopressin receptors? Prog Brain Res 1983 0.75
64 Inositol phospholipids and phosphates for investigation of intact cell phospholipase C substrates and products. Methods Enzymol 1991 0.75