Published in J Biol Chem on August 15, 1992
High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT. J Cell Biol (2001) 2.35
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Mol Cell Biol (1993) 2.25
The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors. Proc Natl Acad Sci U S A (1994) 2.05
Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem J (1997) 1.60
Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts. J Cell Biol (2005) 1.58
Compartment-specific regulation of phosphoinositide 3-kinase by platelet-derived growth factor and insulin in 3T3-L1 adipocytes. Biochem J (1996) 1.49
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Mol Cell Biol (1995) 1.42
Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J (1993) 1.42
Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity. Proc Natl Acad Sci U S A (2005) 1.34
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts. J Cell Sci (2009) 1.22
Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase. Mol Biol Cell (1996) 1.18
Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase. J Cell Sci (1996) 1.18
Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta. Mol Cell Biol (1994) 1.17
PI3K: from the bench to the clinic and back. Curr Top Microbiol Immunol (2010) 1.16
Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: II. Parameter estimates for individual cells from experiments. Biophys J (2004) 1.13
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras. Mol Cell Biol (1998) 1.10
Rapid turnover of phosphatidylinositol 3-phosphate in the green alga Chlamydomonas eugametos: signs of a phosphatidylinositide 3-kinase signalling pathway in lower plants? Biochem J (1994) 1.08
Quantitative model of Ras-phosphoinositide 3-kinase signalling cross-talk based on co-operative molecular assembly. Biochem J (2006) 1.04
In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling. Biophys J (2011) 0.99
Deterministic model of dermal wound invasion incorporating receptor-mediated signal transduction and spatial gradient sensing. Biophys J (2006) 0.98
Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K- and Ras-dependent ERK activation. Biochem J (2012) 0.92
Phorbol esters stimulate phosphatidylinositol 3,4,5-trisphosphate production in 3T3-L1 adipocytes: implications for stimulation of glucose transport. Biochem J (1996) 0.86
Impaired activation of phosphoinositide 3-kinase by insulin in fibroblasts from patients with severe insulin resistance and pseudoacromegaly. A disorder characterized by selective postreceptor insulin resistance. J Clin Invest (1998) 0.86
Receptor regulation of phosphoinositide 3-hydroxykinase in the NG115-401L-C3 neuronal cell line: stimulation by insulin-like growth factor-I. Biochem J (1993) 0.79
The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts. Biochem J (1995) 0.79
Pathogenicity of Salmonella: SopE-mediated membrane ruffling is independent of inositol phosphate signals. FEBS Lett (2006) 0.77
Participation of protein kinases in staurosporine-induced interleukin-6 production by rat peritoneal macrophages. Br J Pharmacol (1999) 0.77
Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28. Biochem J (1997) 0.75
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science (1997) 8.17
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell (2000) 5.23
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones. Biochem J (1983) 4.11
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim Biophys Acta (1993) 3.77
Infectious thromboembolic meningoencephalitis in cattle: a review. J Am Vet Med Assoc (1981) 3.75
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell (2000) 3.68
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell (1994) 3.50
Signalling through Class I PI3Ks in mammalian cells. Biochem Soc Trans (2006) 3.37
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. Biochem J (1986) 3.04
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell (1997) 3.03
Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol (1998) 2.69
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Mol Cell (2001) 2.47
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39
L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells. Biochem J (1988) 2.10
Platelet-derived growth factor stimulates synthesis of PtdIns(3,4,5)P3 by activating a PtdIns(4,5)P2 3-OH kinase. Nature (1992) 2.09
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s). J Biol Chem (1993) 2.09
Prevalence and distribution of Haemophilus somnus in the male bovine reproductive tract. Am J Vet Res (1982) 1.97
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature (2000) 1.93
Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. Biochem J (1988) 1.88
Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases. Proc Natl Acad Sci U S A (1997) 1.85
Morphological, biochemical, antigenic, and cytochemical relationships among Haemophilus somnus, Haemophilus agni, Haemophilus haemoglobinophilus, Histophilus ovis, and Actinobacillus seminis. J Clin Microbiol (1983) 1.82
Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. Biochem J (1988) 1.81
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol Cell (2002) 1.69
Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate. Biochem J (1987) 1.68
Humoral immunity in experimental thromboembolic meningoencephalitis in cattle caused by Haemophilus somnus. Am J Vet Res (1981) 1.67
Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate. Biochem J (1989) 1.62
Occurrence of "Haemophilus somnus" in bovine semen and in the prepuce of bulls and steers. Can J Comp Med (1982) 1.57
myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate. Biochem J (1991) 1.57
Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells. Curr Biol (1994) 1.55
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci (2001) 1.52
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol (2001) 1.49
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase. Biochem J (1988) 1.44
Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J (1993) 1.42
Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway. J Biol Chem (1998) 1.40
Analysis of inositol metabolites produced by Saccharomyces cerevisiae in response to glucose stimulation. J Biol Chem (1993) 1.34
The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes. Biochem J (1986) 1.31
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. J Biol Chem (1987) 1.23
An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes. Biochem J (1989) 1.22
Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase. J Cell Sci (1996) 1.18
Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands. Biochem J (1987) 1.18
Changes in the levels of inositol lipids and phosphates during the differentiation of HL60 promyelocytic cells towards neutrophils or monocytes. Proc Biol Sci (1991) 1.16
Ultrastructure of Haemophilus somnus, causative agent of bovine infectious thromboembolic meningoencephalitis. Am J Vet Res (1981) 1.13
Vaccination of cattle against experimentally induced thromboembolic meningoencephalitis with a Haemophilus somnus bacterin. Am J Vet Res (1982) 1.12
Adherence of Tritrichomonas foetus to bovine vaginal epithelial cells. Infect Immun (1989) 1.11
A simple assay method for determination of the specific radioactivity of the gamma-phosphate group of 32P-labelled ATP. Biochem J (1983) 1.10
Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen. J Virol (1990) 1.10
Phosphatidylinositol 4,5-bisphosphate hydrolysis in turkey erythrocytes is regulated by P2y purinoceptors. Mol Pharmacol (1989) 1.08
Isolation of Haemophilus somnus antigens and their use as vaccines for prevention of bovine thromboembolic meningoencephalitis. Am J Vet Res (1984) 1.03
Characterization of metal ion-induced [3H]inositol hexakisphosphate binding to rat cerebellar membranes. J Biol Chem (1993) 1.02
Inositol polyphosphate metabolism and inositol lipids in a green alga, Chlamydomonas eugametos. Biochem J (1992) 1.02
Selective medium for isolation of Haemophilus somnus from cattle and sheep. Vet Rec (1985) 1.02
Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins. J Biol Chem (1993) 0.99
Investigation of purulent vaginal discharge in cows, with particular reference to Haemophilus somnus. Aust Vet J (1986) 0.99
Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits. J Biol Chem (1999) 0.97
Activation of phosphatidylinositol 4,5-bisphosphate supply by agonists and non-hydrolysable GTP analogues. Biochem J (1993) 0.96
Antigenic heterogeneity of Haemophilus somnus. Aust Vet J (1987) 0.95
A heterotrimeric GTPase-regulated isoform of PI3K and the regulation of its potential effectors. Philos Trans R Soc Lond B Biol Sci (1996) 0.92
DAPP1 undergoes a PI 3-kinase-dependent cycle of plasma-membrane recruitment and endocytosis upon cell stimulation. Curr Biol (2000) 0.90
Production of inositol trisphosphates and inositol tetrakisphosphate in stimulated pancreatic islets. Biochim Biophys Acta (1987) 0.88
The metabolism and functions of inositol pentakisphosphate and inositol hexakisphosphate. Biochem Soc Trans (1989) 0.88
Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42. Biochem J (1999) 0.85
Priming of human neutrophil superoxide generation by tumour necrosis factor-alpha is signalled by enhanced phosphatidylinositol 3,4,5-trisphosphate but not inositol 1,4,5-trisphosphate accumulation. FEBS Lett (1998) 0.81
Arginine-vasopressin stimulates inositol phospholipid metabolism in rat hippocampus. J Neurochem (1986) 0.81
Metabolism of myo-inositol pentakisphosphates in mammalian brain. Biochem Soc Trans (1992) 0.80
Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase. Biochem J (2000) 0.79
Receptor regulation of phosphoinositide 3-hydroxykinase in the NG115-401L-C3 neuronal cell line: stimulation by insulin-like growth factor-I. Biochem J (1993) 0.79
Determination of the steady-state turnover rates of the metabolically active pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in human erythrocytes. Biochem J (1989) 0.79
Diagnosis by ELISA of bovine abortion due to Campylobacter fetus. Aust Vet J (1991) 0.79
Changes in inositol lipids and phosphates after stimulation of the MAS-transfected NG115-401L-C3 cell line by mitogenic and non-mitogenic stimuli. Biochem J (1990) 0.78
An inositol 1,4,5-trisphosphate-6-kinase activity in pea roots. Planta (1992) 0.78
Receptor and G-protein-dependent regulation of turkey erythrocyte phosphoinositidase C. Philos Trans R Soc Lond B Biol Sci (1988) 0.78
Cell biology. Moving in mysterious ways. Nature (2000) 0.78
Inositol lipids and phosphates in erythrocytes and HL60 cells. Soc Gen Physiol Ser (1988) 0.77
Src family kinases mediate receptor-stimulated, phosphoinositide 3-kinase-dependent, tyrosine phosphorylation of dual adaptor for phosphotyrosine and 3-phosphoinositides-1 in endothelial and B cell lines. J Biol Chem (2001) 0.77
Experimental induction of vaginitis in heifers by infection with Haemophilus somnus. Aust Vet J (1986) 0.77
Relationships between days post partum, observed estrus and uterine microflora in commercial dairy cows. Theriogenology (1988) 0.76
Knowledge about medical instruments and reported anxiety in pediatric surgery patients. Child Health Care (1986) 0.76
Inositol phospholipids and phosphates for investigation of intact cell phospholipase C substrates and products. Methods Enzymol (1991) 0.75