Published in Biochem J on April 01, 1989
TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast. Mol Biol Cell (1994) 3.23
Phosphoinositides: tiny lipids with giant impact on cell regulation. Physiol Rev (2013) 3.21
PI3K signalling: the path to discovery and understanding. Nat Rev Mol Cell Biol (2012) 3.11
Endosomal phosphoinositides and human diseases. Traffic (2008) 1.64
A phosphatidylinositol (PI) kinase gene family in Dictyostelium discoideum: biological roles of putative mammalian p110 and yeast Vps34p PI 3-kinase homologs during growth and development. Mol Cell Biol (1995) 1.64
Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking. Mol Biol Cell (2008) 1.48
Determination of mass changes in phosphatidylinositol 4,5-bisphosphate and evidence for agonist-stimulated metabolism of inositol 1,4,5-trisphosphate in airway smooth muscle. Biochem J (1991) 1.28
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen. J Virol (1990) 1.25
An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes. Biochem J (1989) 1.22
3- and 4-phosphorylated phosphatidylinositols in the aquatic plant Spirodela polyrhiza L. Biochem J (1992) 1.20
Inositol phosphates in barley (Hordeum vulgare L.) aleurone tissue are stereochemically similar to the products of breakdown of InsP6 in vitro by wheat-bran phytase. Biochem J (1996) 1.20
Pathway of synthesis of 3,4- and 4,5-phosphorylated phosphatidylinositols in the duckweed Spirodela polyrhiza L. Biochem J (1993) 1.19
Phosphoinositides and vesicular membrane traffic. Biochim Biophys Acta (2012) 1.14
Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen. J Virol (1990) 1.10
D-3 phosphoinositide metabolism in cells treated with platelet-derived growth factor. Biochem J (1996) 1.06
The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells. Biochem J (1994) 1.05
The inositol phosphates in WRK1 rat mammary tumour cells. Biochem J (1992) 1.05
Quantification of PtdIns(3,4,5)P(3) dynamics in EGF-stimulated carcinoma cells: a comparison of PH-domain-mediated methods with immunological methods. Biochem J (2008) 0.99
Measurement of picomole amounts of any inositol phosphate isomer separable by h.p.l.c. by means of a bioluminescence assay. Biochem J (1991) 0.95
A myo-inositol D-3 hydroxykinase activity in Dictyostelium. Biochem J (1990) 0.93
Purification and characterization of human erythrocyte phosphatidylinositol 4-kinase. Phosphatidylinositol 4-kinase and phosphatidylinositol 3-monophosphate 4-kinase are distinct enzymes. Biochem J (1992) 0.92
Identification of a phosphatidylinositol 3-hydroxy kinase in plant cells: association with the cytoskeleton. Biochem J (1994) 0.91
The characteristics, capacity and receptor regulation of inositol uptake in 1321N1 astrocytoma cells. Biochem J (1993) 0.91
Effects of inositol starvation on the levels of inositol phosphates and inositol lipids in Neurospora crassa. Biochem J (1993) 0.89
Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets. Biochem J (1994) 0.86
Evidence for substrate-cycling of 3-, 3,4-, 4-, and 4,5-phosphorylated phosphatidylinositols in plants. Biochem J (1995) 0.86
Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells. Biochem J (1993) 0.84
Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets. Proc Natl Acad Sci U S A (1990) 0.81
Changes in inositol lipids and phosphates after stimulation of the MAS-transfected NG115-401L-C3 cell line by mitogenic and non-mitogenic stimuli. Biochem J (1990) 0.78
Granulocyte/macrophage colony-stimulating factor affects myo-inositol metabolism in a novel manner. Implications for its priming action on human neutrophils. Biochem J (1992) 0.75
Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (1984) 25.71
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature (1985) 7.10
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature (1988) 5.88
Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices. Biochem J (1985) 5.79
Myo-inositol phosphates obtained by alkaline hydrolysis of beef brain phosphoinositide. J Biol Chem (1961) 4.80
Alkaline O leads to N-transacylation. A new method for the quantitative deacylation of phospholipids. Biochem J (1981) 4.72
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. Biochem J (1986) 3.04
Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation. Biochem J (1987) 2.84
Phosphatidylinositol metabolism and polyoma-mediated transformation. Proc Natl Acad Sci U S A (1986) 2.62
Complete characterization of the myo-inositol polyphosphates from beef brain phosphoinositide. J Biol Chem (1961) 2.56
The structure of triphosphoinositide from beef brain. Biochim Biophys Acta (1966) 2.41
An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature (1988) 2.07
Inositol tetrakis- and pentakisphosphates in GH4 cells. J Exp Biol (1985) 2.02
Metabolism of D-myo-inositol 1,3,4,5-tetrakisphosphate by rat liver, including the synthesis of a novel isomer of myo-inositol tetrakisphosphate. Biochem J (1987) 1.86
Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. Biochem J (1988) 1.81
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase. Biochem J (1988) 1.44
THE CHROMATOGRAPHIC SEPARATION OF POLYPHOSPHOINOSITIDES AND STUDIES ON THEIR TURNOVER IN VARIOUS TISSUES. Biochim Biophys Acta (1964) 1.43
Muscarinic cholinergic receptor-mediated activation of phosphodiesterase. Mol Pharmacol (1982) 1.36
The metabolism of inositol 1,3,4-trisphosphate to inositol 1,3-bisphosphate. J Biol Chem (1987) 1.32
Regulation of inositol trisphosphate accumulation by muscarinic cholinergic and H1-histamine receptors on human astrocytoma cells. Differential induction of desensitization by agonists. Biochem J (1987) 1.28
Novel aspects of gonadotropin-releasing hormone action on inositol polyphosphate metabolism in cultured pituitary gonadotrophs. J Biol Chem (1987) 1.22
Characterization of the hormone-sensitive phosphatidylinositol pool in WRK-1 cells. J Biol Chem (1983) 1.22
On the metabolism of the brain phosphoinositide complex. J Biol Chem (1962) 1.17
Stimulation of hydrolysis of phosphatidic acid by cholinergic agents in guinea pig synaptosomes. J Biol Chem (1974) 0.97
Analogue computer analysis of tracer flow patterns through the glycolytic and related pathway in erythrocytes and other intact metabolic systems. Eur J Biochem (1968) 0.90
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol (1997) 15.32
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J (1983) 10.35
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science (1997) 8.17
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J (1982) 8.16
The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A (1998) 6.98
The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane. Biochem J (1982) 6.82
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science (1998) 6.79
The polyphosphoinositide phosphodiesterase of erythrocyte membranes. Biochem J (1981) 6.16
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature (1988) 5.88
The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions. Philos Trans R Soc Lond B Biol Sci (1981) 5.30
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol Cell (2000) 5.23
Metabolism of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in rat parotid glands. Biochem J (1985) 4.19
Neural and developmental actions of lithium: a unifying hypothesis. Cell (1989) 4.13
Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones. Biochem J (1983) 4.11
Inositol trisphosphates in carbachol-stimulated rat parotid glands. Biochem J (1984) 4.05
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate: a new intracellular signalling system? Biochim Biophys Acta (1993) 3.77
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma. Cell (2000) 3.68
Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J (2000) 3.53
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits. Cell (1994) 3.50
Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation. Biochem J (1996) 3.13
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2. Curr Biol (1999) 3.05
Inositol 1,3,4,5-tetrakisphosphate and not phosphatidylinositol 3,4-bisphosphate is the probable precursor of inositol 1,3,4-trisphosphate in agonist-stimulated parotid gland. Biochem J (1986) 3.04
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101. Cell (1997) 3.03
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J (1999) 3.03
Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function. Biochem Soc Trans (1981) 2.73
Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B. Curr Biol (1998) 2.69
The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate. Mol Cell (2001) 2.47
Breakdown of polyphosphoinositides and not phosphatidylinositol accounts for muscarinic agonist-stimulated inositol phospholipid metabolism in rat parotid glands. Biochem J (1983) 2.47
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39
Kinetics of activation of phospholipase C by P2Y purinergic receptor agonists and guanine nucleotides. J Biol Chem (1989) 2.23
L-myo-inositol 1,4,5,6-tetrakisphosphate is present in both mammalian and avian cells. Biochem J (1988) 2.10
The detection, purification, structural characterization, and metabolism of diphosphoinositol pentakisphosphate(s) and bisdiphosphoinositol tetrakisphosphate(s). J Biol Chem (1993) 2.09
Understanding PTEN regulation: PIP2, polarity and protein stability. Oncogene (2008) 2.07
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature (2000) 1.93
Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes. Biochem J (1988) 1.88
Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases. Proc Natl Acad Sci U S A (1997) 1.85
Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN. Curr Biol (2001) 1.83
Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. Biochem J (1988) 1.81
Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett (1997) 1.71
DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. Biochem J (1999) 1.69
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Mol Cell (2002) 1.69
Multiple metabolic pools of phosphoinositides and phosphatidate in human erythrocytes incubated in a medium that permits rapid transmembrane exchange of phosphate. Biochem J (1987) 1.68
The role of PI 3-kinase in insulin action. Biochim Biophys Acta (1998) 1.65
TPIP: a novel phosphoinositide 3-phosphatase. Biochem J (2001) 1.60
Receptor coupled events in bradykinin action: rapid production of inositol phosphates and regulation of cytosolic free Ca2+ in a neural cell line. EMBO J (1987) 1.59
Histamine stimulation of inositol 1-phosphate accumulation in lithium-treated slices from regions of guinea pig brain. J Neurochem (1984) 1.59
A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets. J Biol Chem (1998) 1.58
myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate. Biochem J (1991) 1.57
Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells. Curr Biol (1994) 1.55
Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain. FEBS Lett (1999) 1.53
FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci (2001) 1.52
Multiple roles of phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells. Endocrinology (1995) 1.50
Distinct phosphatidylinositol 3-kinase lipid products accumulate upon oxidative and osmotic stress and lead to different cellular responses. J Biol Chem (1999) 1.49
Phosphatidylinositol 3-phosphate is generated in phagosomal membranes. Curr Biol (2001) 1.49
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia (2001) 1.45
L-myo-inositol 1,4,5,6-tetrakisphosphate (3-hydroxy)kinase. Biochem J (1988) 1.44
The control by Ca2+ of the polyphosphoinositide phosphodiesterase and the Ca2+-pump ATPase in human erythrocytes. Biochem J (1982) 1.44
Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells. EMBO J (1993) 1.42
Receptor specificity of growth factor-stimulated synthesis of 3-phosphorylated inositol lipids in Swiss 3T3 cells. J Biol Chem (1992) 1.40
Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway. J Biol Chem (1998) 1.40
Ca2+/calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation. J Biol Chem (1999) 1.38
Essential role of phosphoinositide 3-kinase in leptin-induced K(ATP) channel activation in the rat CRI-G1 insulinoma cell line. J Biol Chem (2000) 1.35
Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1. J Biol Chem (1998) 1.32
Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells. J Biol Chem (1992) 1.31
The labelling of polyphosphoinositides with [32P]Pi and the accumulation of inositol phosphates in vasopressin-stimulated hepatocytes. Biochem J (1986) 1.31
Substance P induced hydrolysis of inositol phospholipids in guinea-pig ileum and rat hypothalamus. Eur J Pharmacol (1983) 1.31
Lithium-induced reduction in intracellular inositol supply in cholinergically stimulated parotid gland. Biochem J (1986) 1.30
Muscarinic receptors and hydrolysis of inositol phospholipids in rat cerebral cortex and parotid gland. J Neurochem (1985) 1.29
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions. Biochem J (2001) 1.29
Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN. Oncogene (2009) 1.27
Turkey erythrocytes possess a membrane-associated inositol 1,4,5-trisphosphate 3-kinase that is activated by Ca2+ in the presence of calmodulin. Biochem J (1987) 1.26
Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem J (2000) 1.26
Turkey erythrocyte membranes as a model for regulation of phospholipase C by guanine nucleotides. J Biol Chem (1987) 1.23
Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 1.23
An analysis of myo-[3H]inositol trisphosphates found in myo-[3H]inositol prelabelled avian erythrocytes. Biochem J (1989) 1.22
A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. J Biol Chem (1994) 1.21
Initiation and maintenance of NGF-stimulated neurite outgrowth requires activation of a phosphoinositide 3-kinase. J Cell Sci (1996) 1.18
Inositol 1,2-cyclic 4,5-trisphosphate is not a product of muscarinic receptor-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis in rat parotid glands. Biochem J (1987) 1.18
The role of dynamin and its binding partners in coated pit invagination and scission. J Cell Biol (2001) 1.17
Interleukin 3 stimulates proliferation via protein kinase C activation without increasing inositol lipid turnover. Proc Natl Acad Sci U S A (1988) 1.16
Phosphatidylinositol synthase and phosphatidylinositol/inositol exchange reactions in turkey erythrocyte membranes. Biochem J (1991) 1.13
A simple assay method for determination of the specific radioactivity of the gamma-phosphate group of 32P-labelled ATP. Biochem J (1983) 1.10
Phosphatidylinositol metabolism in cells transformed by polyomavirus middle T antigen. J Virol (1990) 1.10
Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Nature (1984) 1.09
Modification of AlF-4- and receptor-stimulated phospholipase C activity by G-protein beta gamma subunits. J Biol Chem (1989) 1.09