Bag-1M accelerates nucleotide release for human Hsc70 and Hsp70 and can act concentration-dependent as positive and negative cofactor.

PubWeight™: 1.52‹?› | Rank: Top 4%

🔗 View Article (PMID 11441021)

Published in J Biol Chem on July 05, 2001

Authors

C S Gassler1, T Wiederkehr, D Brehmer, B Bukau, M P Mayer

Author Affiliations

1: Institut für Biochemie und Molekularbiologie, Universität Freiburg, 79104 Freiburg, Germany.

Articles citing this

Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci (2005) 9.75

The HSP70 chaperone machinery: J proteins as drivers of functional specificity. Nat Rev Mol Cell Biol (2010) 5.37

Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58

Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor. EMBO J (2006) 2.45

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation. EMBO J (2012) 1.62

Nucleotide exchange factor for the yeast Hsp70 molecular chaperone Ssa1p. Mol Cell Biol (2002) 1.62

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell (2005) 1.52

The chloroplastic GrpE homolog of Chlamydomonas: two isoforms generated by differential splicing. Plant Cell (2001) 1.32

Scanning mutagenesis identifies amino acid residues essential for the in vivo activity of the Escherichia coli DnaJ (Hsp40) J-domain. Genetics (2002) 1.30

BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions. Cell Stress Chaperones (2003) 1.27

Mechanisms of the Hsp70 chaperone system. Biochem Cell Biol (2010) 1.23

Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo. Nucleic Acids Res (2003) 1.19

Functional divergence between co-chaperones of Hsc70. J Biol Chem (2008) 1.17

The activities and function of molecular chaperones in the endoplasmic reticulum. Semin Cell Dev Biol (2007) 1.16

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease. Circulation (2010) 1.13

Functional analysis of Hsp70 inhibitors. PLoS One (2013) 1.13

Chemical rescue of deltaF508-CFTR mimics genetic repair in cystic fibrosis bronchial epithelial cells. Mol Cell Proteomics (2008) 1.09

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2. Nat Struct Mol Biol (2008) 1.08

Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system. Nucleic Acids Res (2007) 1.05

The chaperone network connected to human ribosome-associated complex. Mol Cell Biol (2011) 1.02

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem (2013) 1.01

Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity. Mol Cell Biol (2005) 0.95

Hsp70 chaperones are non-equilibrium machines that achieve ultra-affinity by energy consumption. Elife (2014) 0.95

Biological activities of HAP46/BAG-1. The HAP46/BAG-1 protein: regulator of HSP70 chaperones, DNA-binding protein and stimulator of transcription. EMBO Rep (2004) 0.90

The nucleotide exchange factors of Hsp70 molecular chaperones. Front Mol Biosci (2015) 0.89

Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci (2011) 0.87

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle. Nat Struct Mol Biol (2013) 0.86

Drosophila starvin encodes a tissue-specific BAG-domain protein required for larval food uptake. Genetics (2005) 0.85

A role for an Hsp70 nucleotide exchange factor in the regulation of synaptic vesicle endocytosis. J Neurosci (2013) 0.85

Multiple, but concerted cellular activities of the human protein Hap46/BAG-1M and isoforms. Int J Mol Sci (2009) 0.82

The lid domain of Caenorhabditis elegans Hsc70 influences ATP turnover, cofactor binding and protein folding activity. PLoS One (2012) 0.80

Transcriptional stimulation by the DNA binding protein Hap46/BAG-1M involves hsp70/hsc70 molecular chaperones. Nucleic Acids Res (2003) 0.79

Hsp70 cochaperones HspBP1 and BAG-1M differentially regulate steroid hormone receptor function. PLoS One (2014) 0.79

The BAG homology domain of Snl1 cures yeast prion [URE3] through regulation of Hsp70 chaperones. G3 (Bethesda) (2014) 0.78

The BAG-1 isoform BAG-1M regulates keratin-associated Hsp70 chaperoning of aPKC in intestinal cells during activation of inflammatory signaling. J Cell Sci (2014) 0.77

Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. J Med Chem (2016) 0.77

In silico study on Arabidopsis BAG gene expression in response to environmental stresses. Protoplasma (2016) 0.76

Targeting HSP70 and GRP78 in canine osteosarcoma cells in combination with doxorubicin chemotherapy. Cell Stress Chaperones (2016) 0.75

Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70. Sci Rep (2016) 0.75

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis. Cell Discov (2016) 0.75

Articles by these authors

Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci (2005) 9.75

DnaK, DnaJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage. EMBO J (1993) 4.32

Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J (1997) 4.28

Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins. Mol Microbiol (1997) 3.51

Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor sigma 32. Cell (1992) 3.46

The ATP hydrolysis-dependent reaction cycle of the Escherichia coli Hsp70 system DnaK, DnaJ, and GrpE. Proc Natl Acad Sci U S A (1994) 3.33

Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network. Proc Natl Acad Sci U S A (1999) 3.33

Mechanism of regulation of hsp70 chaperones by DnaJ cochaperones. Proc Natl Acad Sci U S A (1999) 3.30

Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB. EMBO J (1999) 3.20

Escherichia coli FtsH is a membrane-bound, ATP-dependent protease which degrades the heat-shock transcription factor sigma 32. EMBO J (1995) 3.18

The role of ATP in the functional cycle of the DnaK chaperone system. J Mol Biol (1995) 3.00

Trigger factor and DnaK cooperate in folding of newly synthesized proteins. Nature (1999) 2.95

A cycle of binding and release of the DnaK, DnaJ and GrpE chaperones regulates activity of the Escherichia coli heat shock transcription factor sigma32. EMBO J (1996) 2.55

Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol. Mol Microbiol (2001) 2.54

Nucleotide-induced conformational changes in the ATPase and substrate binding domains of the DnaK chaperone provide evidence for interdomain communication. J Biol Chem (1995) 2.53

Multistep mechanism of substrate binding determines chaperone activity of Hsp70. Nat Struct Biol (2000) 2.37

The major yeast poly(A)-binding protein is associated with cleavage factor IA and functions in premessenger RNA 3'-end formation. Proc Natl Acad Sci U S A (1997) 2.26

Interaction of Hsp70 chaperones with substrates. Nat Struct Biol (1997) 2.26

Mutations in the DnaK chaperone affecting interaction with the DnaJ cochaperone. Proc Natl Acad Sci U S A (1998) 2.10

ClpS is an essential component of the N-end rule pathway in Escherichia coli. Nature (2006) 2.09

Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein. Science (1990) 2.04

The heat shock response of Escherichia coli. Int J Food Microbiol (2000) 2.02

The second step of ATP binding to DnaK induces peptide release. J Mol Biol (1996) 1.96

Relationship between conversion of localized juvenile periodontitis-susceptible children from health to disease and Actinobacillus actinomycetemcomitans leukotoxin promoter structure. J Periodontol (1998) 1.95

Its substrate specificity characterizes the DnaJ co-chaperone as a scanning factor for the DnaK chaperone. EMBO J (2001) 1.94

Regulatory region C of the E. coli heat shock transcription factor, sigma32, constitutes a DnaK binding site and is conserved among eubacteria. J Mol Biol (1996) 1.85

Osmoregulation of the maltose regulon in Escherichia coli. J Bacteriol (1986) 1.85

The chaperone function of DnaK requires the coupling of ATPase activity with substrate binding through residue E171. EMBO J (1994) 1.71

Escherichia coli trigger factor is a prolyl isomerase that associates with nascent polypeptide chains. Proc Natl Acad Sci U S A (1996) 1.69

Investigation of the interaction between DnaK and DnaJ by surface plasmon resonance spectroscopy. J Mol Biol (1999) 1.69

Levels of DnaK and DnaJ provide tight control of heat shock gene expression and protein repair in Escherichia coli. Mol Microbiol (1998) 1.68

Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation. Hum Reprod (1990) 1.67

Hsp70 chaperone machines. Adv Protein Chem (2001) 1.67

Size-dependent disaggregation of stable protein aggregates by the DnaK chaperone machinery. J Biol Chem (2000) 1.65

A conserved loop in the ATPase domain of the DnaK chaperone is essential for stable binding of GrpE. Nat Struct Biol (1994) 1.64

Proteolysis of the phage lambda CII regulatory protein by FtsH (HflB) of Escherichia coli. Mol Microbiol (1997) 1.62

Tuning of chaperone activity of Hsp70 proteins by modulation of nucleotide exchange. Nat Struct Biol (2001) 1.61

A module of the DnaJ heat shock proteins found in malaria parasites. Trends Biochem Sci (1992) 1.60

Protein folding and degradation in bacteria: to degrade or not to degrade? That is the question. Cell Mol Life Sci (2002) 1.58

Hsp70 chaperone systems: diversity of cellular functions and mechanism of action. Biol Chem (1998) 1.51

Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem (1999) 1.50

Heat shock regulation in the ftsH null mutant of Escherichia coli: dissection of stability and activity control mechanisms of sigma32 in vivo. Mol Microbiol (1998) 1.48

GrpE accelerates nucleotide exchange of the molecular chaperone DnaK with an associative displacement mechanism. Biochemistry (1997) 1.48

Binding specificity of Escherichia coli trigger factor. Proc Natl Acad Sci U S A (2001) 1.45

Molecular chaperones: the busy life of Hsp90. Curr Biol (1999) 1.42

Reconstitution of maltose transport in Escherichia coli: conditions affecting import of maltose-binding protein into the periplasm of calcium-treated cells. J Bacteriol (1983) 1.40

The DnaK chaperone system of Escherichia coli: quaternary structures and interactions of the DnaK and GrpE components. J Biol Chem (1995) 1.39

Substrate shuttling between the DnaK and GroEL systems indicates a chaperone network promoting protein folding. J Mol Biol (1996) 1.28

The human DnaJ homologue dj2 facilitates mitochondrial protein import and luciferase refolding. J Cell Biol (1997) 1.28

Molecular basis for interactions of the DnaK chaperone with substrates. Biol Chem (2001) 1.28

Water-insoluble glucan synthesis by mutans streptococcal strains correlates with caries incidence in 12- to 30-month-old children. J Dent Res (2000) 1.26

Low temperature or GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor and DnaK. FEBS Lett (2004) 1.23

Conserved ATPase and luciferase refolding activities between bacteria and yeast Hsp70 chaperones and modulators. FEBS Lett (1995) 1.21

The amino-terminal 118 amino acids of Escherichia coli trigger factor constitute a domain that is necessary and sufficient for binding to ribosomes. J Biol Chem (1997) 1.20

Identification of the prolyl isomerase domain of Escherichia coli trigger factor. FEBS Lett (1996) 1.17

Contrasting mechanisms of envZ control of mal and pho regulon genes in Escherichia coli. J Bacteriol (1986) 1.16

Substrate specificity of the SecB chaperone. J Biol Chem (1999) 1.11

Modulation of substrate specificity of the DnaK chaperone by alteration of a hydrophobic arch. J Mol Biol (2000) 1.11

Association between caries prevalence and clinical, microbiological and dietary variables in 1.0 to 2.5-year-old Brazilian children. Caries Res (1998) 1.10

Role of the DnaK and HscA homologs of Hsp70 chaperones in protein folding in E.coli. EMBO J (1998) 1.09

Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains. J Bacteriol (2004) 1.07

Mutans streptococci oral colonization in 12-30-month-old Brazilian children over a one-year follow-up period. J Public Health Dent (2001) 1.07

Mechanism of substrate recognition by Hsp70 chaperones. Biochem Soc Trans (2004) 1.05

Partial dissection of the zona pellucida of frozen-thawed human embryos may enhance blastocyst hatching, implantation, and pregnancy rates. Am J Obstet Gynecol (1991) 1.04

Functional dissection of trigger factor and DnaK: interactions with nascent polypeptides and thermally denatured proteins. Biol Chem (2001) 1.01

Role of region C in regulation of the heat shock gene-specific sigma factor of Escherichia coli, sigma32. J Bacteriol (1999) 1.01

The Escherichia coli trigger factor. FEBS Lett (1996) 1.01

Protein turnover: a CHIP programmed for proteolysis. Curr Biol (2002) 0.99

Ca2+-induced permeabilization of the Escherichia coli outer membrane: comparison of transformation and reconstitution of binding-protein-dependent transport. J Bacteriol (1985) 0.97

The C terminus of sigma(32) is not essential for degradation by FtsH. J Bacteriol (2001) 0.96

Pseudo-T-even bacteriophage RB49 encodes CocO, a cochaperonin for GroEL, which can substitute for Escherichia coli's GroES and bacteriophage T4's Gp31. J Biol Chem (2000) 0.93

Long-term effect of two preventive programs on the incidence of plaque and gingivitis in adolescents. J Periodontol (1994) 0.92

[Incidence of endomycoses in the autopsy material of the Berlin Charité Hospital]. Mycoses (1998) 0.90

Immunosuppression supports implantation of zona pellucida dissected human embryos. Fertil Steril (1990) 0.88

[Schwannoma of the tongue]. Laryngorhinootologie (2001) 0.88

Subgingival occurrence and antimicrobial susceptibility of enteric rods and pseudomonads from Brazilian periodontitis patients. Oral Microbiol Immunol (2001) 0.87

[Oncocytic adenocarcinoma of the submandibular gland]. HNO (2002) 0.87

Functional defects of the DnaK756 mutant chaperone of Escherichia coli indicate distinct roles for amino- and carboxyl-terminal residues in substrate and co-chaperone interaction and interdomain communication. J Biol Chem (1999) 0.85

Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis. Exp Cell Res (2001) 0.85

Effect of two preventive programs on oral health knowledge and habits among Brazilian schoolchildren. Community Dent Oral Epidemiol (1994) 0.84

Practical evolution and application of direct intracytoplasmic sperm injection for male factor and idiopathic fertilization failure infertilities. Fertil Steril (1995) 0.83

Oral manifestations in Rett syndrome: a study of 17 cases. Pediatr Dent (1997) 0.82

Construction and analysis of hybrid Escherichia coli-Bacillus subtilis dnaK genes. J Bacteriol (1999) 0.82

Effects of subinhibitory concentrations of chemical agents on hydrophobicity and in vitro adherence of Streptococcus mutans and Streptococcus sanguis. Caries Res (1994) 0.80

[Drug costs in patients with chronic complex tinnitus]. HNO (1999) 0.79

[Distraction and relaxation training in acute tinnitus : effects of a complement to otorhinolaryngological treatment]. HNO (2010) 0.78

Compensatory levels of salivary IgM anti-Streptococcus mutans antibodies in IgA-deficient patients. J Investig Allergol Clin Immunol (1995) 0.78

Low temperature of GroEL/ES overproduction permits growth of Escherichia coli cells lacking trigger factor DnaK. FEBS Lett (2005) 0.78

Effect of cyclosporin A on carbohydrate metabolism in the rat. Transpl Int (1989) 0.77

Salivary Streptococcus mutans and caries prevalence in Brazilian schoolchildren. Community Dent Oral Epidemiol (1989) 0.76

[Value of informed consent in tympanoplasty and FESS procedures]. Laryngorhinootologie (2009) 0.75

Anti-Streptococcus mutans antibodies in saliva of children with different degrees of dental caries. Pediatr Allergy Immunol (1999) 0.75

[Reactive hysterical vertigo. An important component in recurrent Menière episodes]. HNO (1999) 0.75