Published in J Biol Chem on July 10, 2001
Cancer drug resistance: an evolving paradigm. Nat Rev Cancer (2013) 6.77
Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol (2002) 1.54
Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem (2012) 1.53
Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. J Biol Chem (2011) 1.49
MAP-1 is a mitochondrial effector of Bax. Proc Natl Acad Sci U S A (2005) 1.30
Death pathways activated in CaCo-2 cells by Clostridium perfringens enterotoxin. Infect Immun (2003) 1.14
Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta (2012) 1.11
Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cereb Cortex (2008) 1.08
Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. J Exp Med (2001) 1.07
A Bax-mediated mechanism for obatoclax-induced apoptosis of cholangiocarcinoma cells. Cancer Res (2010) 1.02
Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin. Mol Biol Cell (2007) 1.02
Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Mol Cancer Ther (2008) 1.00
Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum. J Cell Biol (2005) 0.99
Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells. EMBO Mol Med (2012) 0.96
Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line. Neoplasia (2005) 0.92
Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation. Biochem Pharmacol (2009) 0.86
Apoptosis-inducing factor (AIF) is targeted in IFN-α2a-induced Bid-mediated apoptosis through Bak activation in ovarian cancer cells. Biochim Biophys Acta (2012) 0.85
The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. Bioorg Med Chem Lett (2014) 0.82
Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer (2015) 0.82
Altered mitochondrial apoptotic pathway in placentas from undernourished rat gestations. Am J Physiol Regul Integr Comp Physiol (2011) 0.81
BAK overexpression mediates p53-independent apoptosis inducing effects on human gastric cancer cells. BMC Cancer (2004) 0.80
Bak is a key molecule in apoptosis induced by methanol extracts of Codonopsis lanceolata and Tricholoma matsutake in HSC-2 human oral cancer cells. Oncol Lett (2012) 0.80
Cisplatin inhibits hippocampal cell proliferation and alters the expression of apoptotic genes. Neurotox Res (2013) 0.79
Apoptotic effect of cordycepin combined with cisplatin and/or paclitaxel on MA-10 mouse Leydig tumor cells. Onco Targets Ther (2015) 0.79
The Effect of Growth Hormone Administration on the Regulation of Mitochondrial Apoptosis in-Vivo. Int J Mol Sci (2015) 0.78
A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells. J Biol Chem (2015) 0.78
A RNA nanotechnology platform for a simultaneous two-in-one siRNA delivery and its application in synergistic RNAi therapy. Sci Rep (2016) 0.75
Pyoluteorin derivatives induce Mcl-1 degradation and apoptosis in hematological cancer cells. Cancer Biol Ther (2014) 0.75
Targeting proteomics to investigate metastasis-associated mitochondrial proteins. J Bioenerg Biomembr (2012) 0.75
Celecoxib Enhances the Chemotherapeutic Response of Cisplatin and TNF-α in SiHa Cells through Reactive Oxygen Species-Mediated Mitochondrial Pathway. Int J Biomed Sci (2007) 0.75
Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell (1993) 10.83
BID: a novel BH3 domain-only death agonist. Genes Dev (1996) 5.90
Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem (1999) 4.56
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med (2000) 4.40
Structure and function of the interferon-beta enhanceosome. Cold Spring Harb Symp Quant Biol (1998) 3.81
Immunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporine A. Transplant Proc (1987) 3.73
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A (1997) 3.66
In Vitro Immunosuppressive Effects of FK506 in Combination With Other Drugs. Transplant Proc (1988) 3.15
IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol (2009) 2.65
Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route. J Biol Chem (2000) 2.62
Distribution of ADH2 and ALDH2 genotypes in different populations. Hum Genet (1992) 2.55
Functional and ontogenetic analysis of murine CD45Rhi and CD45Rlo CD4+ T cells. J Immunol (1990) 2.41
Second neoplasms after acute lymphoblastic leukemia in childhood. N Engl J Med (1991) 2.27
Lumbosacral transitional vertebrae and their relationship with lumbar extradural defects. Spine (Phila Pa 1976) (1984) 2.21
Dendritic cells acquire antigens from live cells for cross-presentation to CTL. J Immunol (2001) 2.12
Features of myocardial injury in severe organophosphate poisoning. Clin Toxicol (Phila) (2014) 2.09
PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. Genes Dev (1999) 2.09
Homing receptors and vascular addressins: cell adhesion molecules that direct lymphocyte traffic. Immunol Rev (1989) 2.06
Prognostic factors and recurrence pattern in node-negative advanced gastric cancer. Eur J Surg Oncol (2012) 2.05
Successful bone-marrow transplantation for infantile malignant osteopetrosis. N Engl J Med (1980) 1.95
Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene. Cancer Res (2001) 1.91
Memory B and T cells. Annu Rev Immunol (1991) 1.79
Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]. Ann Surg Oncol (1998) 1.78
Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression. Cancer Res (1999) 1.78
Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature. Neuroepidemiology (2013) 1.76
In vivo hepatic gene therapy: complete albeit transient correction of factor IX deficiency in hemophilia B dogs. Proc Natl Acad Sci U S A (1994) 1.70
Long-term preservation and storage of mycobacteria. Appl Microbiol (1972) 1.69
Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population. Diabetologia (2008) 1.67
Emergent excitations in a geometrically frustrated magnet. Nature (2002) 1.66
Stenting from the vertebral artery to the posterior inferior cerebellar artery. AJNR Am J Neuroradiol (2011) 1.64
Preservation of mycobacteria: 100 percent viability of suspensions stored at -70 C. Appl Microbiol (1973) 1.54
Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro. Proc Natl Acad Sci U S A (1998) 1.54
Angiotensin-converting enzyme gene polymorphism and vascular manifestations in Korean patients with SLE. Lupus (2002) 1.53
Two new acute lymphoblastic leukemia cell lines with early B-cell phenotypes. Blood (1982) 1.52
Large airway inflammation in heart-lung transplant recipients--its significance and prognostic implications. Transplantation (1990) 1.51
Cross-cultural adaptation and validation of Korean Western Ontario and McMaster Universities (WOMAC) and Lequesne osteoarthritis indices for clinical research. Osteoarthritis Cartilage (2001) 1.49
Growth factor signal transduction immediately after two-thirds partial hepatectomy in the rat. Cancer Res (1999) 1.48
Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease. J Biol Chem (1997) 1.48
Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma. Clin Cancer Res (1996) 1.46
Coexistence of ankylosing spondylitis and mixed connective tissue disease in a single patient. Clin Exp Rheumatol (1999) 1.46
Chemotherapy for induction of remission of childhood acute myeloid leukemia followed by marrow transplantation or multiagent chemotherapy: a report from the Childrens Cancer Group. J Clin Oncol (1994) 1.45
Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax. J Biol Chem (2000) 1.45
Fas ligand is expressed on human squamous cell carcinomas of the head and neck, and it promotes apoptosis of T lymphocytes. Cancer Res (1999) 1.44
T-category reflects the histopathologic characteristics of gallbladder cancer. Eur J Surg Oncol (2012) 1.41
Quality of marital life in Korean patients with spondyloarthropathy. Clin Rheumatol (2003) 1.40
Autologous bone marrow transplantation in non-Hodgkin's lymphoma: monoclonal antibodies plus complement for ex vivo marrow treatment. Am J Med (1988) 1.39
Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas. Oncogene (2011) 1.39
Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers. Cancer Res (2000) 1.37
Human intestinal Vdelta1+ lymphocytes recognize tumor cells of epithelial origin. J Exp Med (1996) 1.36
Subgenus classification of Acanthamoeba by riboprinting. Korean J Parasitol (1998) 1.35
Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury. J Biol Chem (2001) 1.31
Optical coherence tomography evaluation of zotarolimus-eluting stents at 9-month follow-up: comparison with sirolimus-eluting stents. Heart (2009) 1.31
Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer. Cancer Res (1998) 1.29
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes (1999) 1.29
Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8. Hepatology (2000) 1.29
Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family. Biochim Biophys Acta (1995) 1.26
Functional analysis of mononuclear cells infiltrating into tumors: lysis of autologous human tumor cells by cultured infiltrating lymphocytes. Cancer Res (1987) 1.23
Minimally invasive localization of oncolytic herpes simplex viral therapy of metastatic pleural cancer. Cancer Gene Ther (2006) 1.23
Lymphocyte apoptosis induced by Fas ligand- expressing ovarian carcinoma cells. Implications for altered expression of T cell receptor in tumor-associated lymphocytes. J Clin Invest (1998) 1.22
Aerosol-delivered programmed cell death 4 enhanced apoptosis, controlled cell cycle and suppressed AP-1 activity in the lungs of AP-1 luciferase reporter mice. Gene Ther (2007) 1.22
Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release. J Biol Chem (1998) 1.20
Intestinal bacterial metabolism of flavonoids and its relation to some biological activities. Arch Pharm Res (1998) 1.20
Arabidopsis eIF3e (INT-6) associates with both eIF3c and the COP9 signalosome subunit CSN7. J Biol Chem (2001) 1.19
Spinal cord compression in malignant lymphoma. Treatment and results. Cancer (1976) 1.19
Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol (1999) 1.19
The incidence of second neoplasms following megavoltage radiation for pediatric tumors. Cancer (1985) 1.19
Hepatic cavernous hemangioma: sonographic patterns and speed of contrast enhancement on multiphase dynamic MR imaging. AJR Am J Roentgenol (1998) 1.18
A randomized study of the prevention of acute graft-versus-host disease. N Engl J Med (1982) 1.18
Human adenovirus type 35: nucleotide sequence and vector development. Gene Ther (2003) 1.18
Formation of phalanges and small joints by tissue-engineering. J Bone Joint Surg Am (1999) 1.15
Esophageal perforations: a 15 year experience. Am J Surg (1982) 1.15
Cytomegalovirus serologic status and postoperative infection correlated with risk of developing chronic rejection after pulmonary transplantation. Transplantation (1991) 1.13
Induction of apoptosis and G2/M cell cycle arrest by DCC. Oncogene (1999) 1.12
An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53. Gene Ther (2002) 1.11
Phylogenetic relationships among Acanthamoeba spp. based on PCR-RFLP analyses of mitochondrial small subunit rRNA gene. Korean J Parasitol (1999) 1.09
Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18). Gene Ther (1999) 1.08
Improved treatment satisfaction and weight-related quality of life with exenatide once weekly or twice daily. Diabet Med (2009) 1.08
Purification and characterization of a secretory serine proteinase of Acanthamoeba healyi isolated from GAE. J Parasitol (2000) 1.07
Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells. J Exp Med (2001) 1.07
Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. J Neurosci (2001) 1.05
Caspase-mediated degradation of T-cell receptor zeta-chain. Cancer Res (1999) 1.05
Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. Cancer Res (1996) 1.05
A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax. Gene Ther (2000) 1.05
Mechanisms responsible for signaling and functional defects. J Immunother (1998) 1.04
Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth. Cancer Res (1999) 1.04
Adenoviral Bak overexpression mediates caspase-dependent tumor killing. Cancer Res (2000) 1.04
Factors limiting adenovirus-mediated gene transfer into human lung and pancreatic cancer cell lines. Clin Cancer Res (1999) 1.04
Sonography of inflammatory bowel disease: findings and value in differential diagnosis. AJR Am J Roentgenol (1994) 1.03
Inhibitor of apoptosis protein hILP undergoes caspase-mediated cleavage during T lymphocyte apoptosis. Cancer Res (2000) 1.03