Published in Nature on July 05, 2001
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Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism. Genetics (2005) 0.99
Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling. Cell Signal (2013) 0.99
Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential. J Physiol (2012) 0.98
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling. PLoS One (2008) 0.96
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Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis. PLoS One (2012) 0.95
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Functionally important segments in proteins dissected using Gene Ontology and geometric clustering of peptide fragments. Genome Biol (2008) 0.92
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Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. BMC Cancer (2013) 0.91
Comprehensive genomic analysis of a BRCA2 deficient human pancreatic cancer. PLoS One (2011) 0.91
Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors. Anal Biochem (2010) 0.91
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Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling. Nat Commun (2013) 0.89
Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment. J Biol Chem (2013) 0.89
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Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer. Br J Cancer (2009) 0.88
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The Netrin-related domain of Sfrp1 interacts with Wnt ligands and antagonizes their activity in the anterior neural plate. Neural Dev (2008) 0.87
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Corin mutations K317E and S472G from preeclamptic patients alter zymogen activation and cell surface targeting. [Corrected]. J Biol Chem (2014) 0.85
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Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8. PLoS One (2012) 0.82
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Expression of Wnt5a and its receptor Fzd2 is changed in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice. Int J Clin Exp Pathol (2013) 0.82
Molecular model of the Wnt protein binding site on the surface of dimeric CRD domain of the hFzd8 receptor. Dokl Biochem Biophys (2008) 0.81
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Structural mechanisms of the agrin-LRP4-MuSK signaling pathway in neuromuscular junction differentiation. Cell Mol Life Sci (2012) 0.81
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Capsosiphon fulvescens glycoprotein inhibits AGS gastric cancer cell proliferation by downregulating Wnt-1 signaling. Int J Oncol (2013) 0.80
Wnt acylation and its functional implication in Wnt signalling regulation. Biochem Soc Trans (2015) 0.80
Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases. J Biol Chem (2012) 0.80
Citrobacter Infection and Wnt signaling. Curr Colorectal Cancer Rep (2012) 0.79
Binding of sFRP-3 to EGF in the extra-cellular space affects proliferation, differentiation and morphogenetic events regulated by the two molecules. PLoS One (2008) 0.79
Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers. Biol Open (2014) 0.79
Large-scale production and protein engineering of G protein-coupled receptors for structural studies. Front Pharmacol (2015) 0.79
Distinct roles of N-glycosylation at different sites of corin in cell membrane targeting and ectodomain shedding. J Biol Chem (2014) 0.79
The role of WNT signaling in adult ovarian folliculogenesis. Reproduction (2015) 0.78
Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. J Biol Chem (2015) 0.78
Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer. Cancers (Basel) (2016) 0.78
Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding. Proc Natl Acad Sci U S A (2017) 0.78
Pharmacological folding chaperones act as allosteric ligands of Frizzled4. Nat Chem Biol (2015) 0.77
Wnt-5a/Frizzled9 Receptor Signaling through the Gαo-Gβγ Complex Regulates Dendritic Spine Formation. J Biol Chem (2016) 0.76
Prediction of structure of human WNT-CRD (FZD) complex for computational drug repurposing. PLoS One (2013) 0.76
Binding of the Extracellular Eight-Cysteine Motif of Opy2 to the Putative Osmosensor Msb2 Is Essential for Activation of the Yeast High-Osmolarity Glycerol Pathway. Mol Cell Biol (2015) 0.76
Mechanisms of immunomodulation by mammalian and viral decoy receptors: insights from structures. Nat Rev Immunol (2016) 0.76
Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation. J Biol Chem (2016) 0.76
Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells. Mediators Inflamm (2017) 0.75
Novel mutations in FZD4 and phenotype-genotype correlation in Chinese patients with familial exudative vitreoretinopathy. Mol Vis (2016) 0.75
Expression of signaling components in embryonic eyelid epithelium. PLoS One (2014) 0.75
Induction of CXC chemokines in human mesenchymal stem cells by stimulation with secreted frizzled-related proteins through non-canonical Wnt signaling. World J Stem Cells (2015) 0.75
Planar cell polarity (PCP) proteins and spermatogenesis. Semin Cell Dev Biol (2016) 0.75
Cardiac hormones are potent inhibitors of secreted frizzled-related protein-3 in human cancer cells. Exp Ther Med (2012) 0.75
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