WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature.

PubWeight™: 3.44‹?› | Rank: Top 1%

🔗 View Article (PMC 4259146)

Published in Nature on September 15, 2005

Authors

Ivan B Lobov1, Sujata Rao, Thomas J Carroll, Jefferson E Vallance, Masataka Ito, Jennifer K Ondr, Savita Kurup, Donald A Glass, Millan S Patel, Weiguo Shu, Edward E Morrisey, Andrew P McMahon, Gerard Karsenty, Richard A Lang

Author Affiliations

1: Division of Developmental Biology, The Children's Hospital Research Foundation and Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio 45229, USA.

Articles citing this

(truncated to the top 100)

Macrophage diversity enhances tumor progression and metastasis. Cell (2010) 13.41

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93

Trophic macrophages in development and disease. Nat Rev Immunol (2009) 5.37

Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity (2010) 3.49

Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87

Origin and functions of tissue macrophages. Immunity (2014) 2.63

The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci (2010) 2.61

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development (2009) 2.55

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med (2009) 2.29

Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med (2006) 2.18

A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature (2013) 1.98

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature (2011) 1.91

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90

Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages. Mol Oncol (2007) 1.88

Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone. J Bone Miner Res (2009) 1.85

Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice. J Clin Invest (2007) 1.72

Dynamic endothelial cell rearrangements drive developmental vessel regression. PLoS Biol (2015) 1.65

Haemodynamics-driven developmental pruning of brain vasculature in zebrafish. PLoS Biol (2012) 1.65

Ocular neovascularization. J Mol Med (Berl) (2013) 1.65

Gene expression analysis of macrophages that facilitate tumor invasion supports a role for Wnt-signaling in mediating their activity in primary mammary tumors. J Immunol (2009) 1.64

Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J (2011) 1.47

Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development (2007) 1.47

Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Dev Biol (2007) 1.40

IP-10 induces dissociation of newly formed blood vessels. J Cell Sci (2009) 1.38

The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38

Notch and wingless signaling cooperate in regulation of dendritic cell differentiation. Immunity (2009) 1.37

Secreted frizzled related protein 2 protects cells from apoptosis by blocking the effect of canonical Wnt3a. J Mol Cell Cardiol (2008) 1.35

Discovery and characterization of a small molecule inhibitor of the PDZ domain of dishevelled. J Biol Chem (2009) 1.34

Metchnikoff's policemen: macrophages in development, homeostasis and regeneration. Trends Mol Med (2011) 1.34

The regulation of valvular and vascular sclerosis by osteogenic morphogens. Circ Res (2011) 1.29

Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nat Med (2016) 1.26

Role of innate and adaptive immune mechanisms in cardiac injury and repair. Nat Rev Immunol (2015) 1.22

Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development (2010) 1.22

High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation. Diabetes (2011) 1.22

Wnt signaling in eye organogenesis. Organogenesis (2008) 1.21

Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation (2011) 1.18

Automated discovery of functional generality of human gene expression programs. PLoS Comput Biol (2007) 1.18

betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development. Mol Cell Neurosci (2007) 1.18

Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mech Dev (2009) 1.17

Vascular development in the zebrafish. Cold Spring Harb Perspect Med (2012) 1.16

Differentiation of the brain vasculature: the answer came blowing by the Wnt. J Angiogenes Res (2010) 1.16

Notch4 normalization reduces blood vessel size in arteriovenous malformations. Sci Transl Med (2012) 1.14

Macrophages and angiogenesis: a role for Wnt signaling. Vasc Cell (2012) 1.12

Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting microenvironment. Blood (2010) 1.12

Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature. PLoS One (2010) 1.11

Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer. Cancer Res (2014) 1.08

Dkk1 and MSX2-Wnt7b signaling reciprocally regulate the endothelial-mesenchymal transition in aortic endothelial cells. Arterioscler Thromb Vasc Biol (2013) 1.08

Microphthalmia, persistent hyperplastic hyaloid vasculature and lens anomalies following overexpression of VEGF-A188 from the alphaA-crystallin promoter. Mol Vis (2007) 1.08

The Flk1-myr::mCherry mouse as a useful reporter to characterize multiple aspects of ocular blood vessel development and disease. Dev Dyn (2009) 1.07

Maintaining transparency: a review of the developmental physiology and pathophysiology of two avascular tissues. Semin Cell Dev Biol (2007) 1.07

Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing. Blood (2011) 1.06

MCP-1 deficiency delays regression of pathologic retinal neovascularization in a model of ischemic retinopathy. Invest Ophthalmol Vis Sci (2008) 1.05

The two faces of serotonin in bone biology. J Cell Biol (2010) 1.05

Blood-vessel formation: Bridges that guide and unite. Nature (2010) 1.02

Blood flow changes coincide with cellular rearrangements during blood vessel pruning in zebrafish embryos. PLoS One (2013) 1.02

Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis. Vasc Cell (2012) 1.01

Seeing through VEGF: innate and adaptive immunity in pathological angiogenesis in the eye. Trends Mol Med (2014) 1.00

Angiogenesis in eye disease: immunity gained or immunity lost? Semin Immunopathol (2008) 1.00

Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes. J Immunol (2011) 1.00

Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes (2008) 0.99

von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development (2010) 0.99

High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res (2014) 0.98

Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A (2014) 0.97

Microvascular rarefaction: the decline and fall of blood vessels. Organogenesis (2010) 0.96

IL-34 and CSF-1: similarities and differences. J Bone Miner Metab (2013) 0.96

Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Mol Cell Biol (2010) 0.96

Endothelial cell self-fusion during vascular pruning. PLoS Biol (2015) 0.96

Wnt signaling in angiogenesis. Curr Drug Targets (2008) 0.95

A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Res (2013) 0.94

The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells. J Clin Invest (2011) 0.93

Wnt your brain be inflamed? Yes, it Wnt! Trends Mol Med (2013) 0.93

NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation. BMC Genomics (2007) 0.93

Overexpression of angiopoietin-2 impairs myocardial angiogenesis and exacerbates cardiac fibrosis in the diabetic db/db mouse model. Am J Physiol Heart Circ Physiol (2011) 0.93

Role of WNT7B-induced noncanonical pathway in advanced prostate cancer. Mol Cancer Res (2013) 0.93

Induction of vascular atrophy as a novel approach to treating restenosis. A review. J Vasc Surg (2007) 0.92

Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol (2013) 0.92

A nonautonomous role for retinal frizzled-5 in regulating hyaloid vitreous vasculature development. Invest Ophthalmol Vis Sci (2008) 0.91

Macrophages: gatekeepers of tissue integrity. Cancer Immunol Res (2013) 0.91

Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis. Microcirculation (2016) 0.91

Wnt pathway in pulmonary fibrosis in the bleomycin mouse model. J Environ Pathol Toxicol Oncol (2009) 0.91

Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. PLoS One (2012) 0.90

Rogue proliferation versus restorative protection: where do we draw the line for Wnt and forkhead signaling? Expert Opin Ther Targets (2008) 0.90

Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword. Lab Invest (2015) 0.90

Macrophages and CSF-1: implications for development and beyond. Organogenesis (2013) 0.90

pitx2 Deficiency results in abnormal ocular and craniofacial development in zebrafish. PLoS One (2012) 0.89

Role of CX3CR1 receptor in monocyte/macrophage driven neovascularization. PLoS One (2013) 0.89

Recurrent turnover of senescent cells during regeneration of a complex structure. Elife (2015) 0.89

The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding. Prog Retin Eye Res (2014) 0.89

Crim1 maintains retinal vascular stability during development by regulating endothelial cell Vegfa autocrine signaling. Development (2013) 0.89

Understanding endothelial cell apoptosis: what can the transcriptome, glycome and proteome reveal? Philos Trans R Soc Lond B Biol Sci (2007) 0.89

Graft microvascular disease in solid organ transplantation. J Mol Med (Berl) (2014) 0.88

Computer simulations reveal complex distribution of haemodynamic forces in a mouse retina model of angiogenesis. J R Soc Interface (2014) 0.88

Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential. Nat Commun (2015) 0.88

Migration of CD11b+ accessory cells during murine lung regeneration. Stem Cell Res (2013) 0.88

Regulation of blood vessel sprouting. Semin Cell Dev Biol (2011) 0.87

Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT. Blood Cancer J (2014) 0.87

Macrophages contribute to the cyclic activation of adult hair follicle stem cells. PLoS Biol (2014) 0.86

Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels. Am J Pathol (2010) 0.86

Functional analysis LRP6 novel mutations in patients with coronary artery disease. PLoS One (2014) 0.86

A developmental defect in astrocytes inhibits programmed regression of the hyaloid vasculature in the mammalian eye. Eur J Cell Biol (2011) 0.86

Articles cited by this

Functional interaction of beta-catenin with the transcription factor LEF-1. Nature (1996) 15.88

Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer (2004) 14.55

Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature (2003) 12.54

LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99

Linking colorectal cancer to Wnt signaling. Cell (2000) 11.58

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development (1999) 9.82

A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol (2002) 8.79

Intrinsic tumour suppression. Nature (2004) 8.73

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58

LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way. Development (2004) 6.21

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev (1994) 6.07

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J (1996) 5.17

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell (2004) 5.04

New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev (2001) 3.63

Phagocytosis promotes programmed cell death in C. elegans. Nature (2001) 3.12

Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development (2002) 2.88

Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature (2001) 2.67

Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature (2001) 2.64

Macrophages are required for cell death and tissue remodeling in the developing mouse eye. Cell (1993) 2.39

Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development (2001) 2.19

Regression of the hyaloid vessels and pupillary membrane of the mouse. Anat Embryol (Berl) (1999) 2.06

Macrophages induce apoptosis in normal cells in vivo. Development (1997) 1.94

WNT targets. Repression and activation. Trends Genet (1999) 1.91

Wnt signaling in the vasculature. Angiogenesis (2002) 1.62

Microglia-derived nerve growth factor causes cell death in the developing retina. Neuron (1998) 1.47

Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression. Development (1999) 1.40

Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer. Br J Cancer (1999) 1.19

Serpentine proteins slither into the wingless and hedgehog fields. Cell (1996) 1.18

Articles by these authors

In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity (2002) 14.57

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87

Endocrine regulation of energy metabolism by the skeleton. Cell (2007) 10.41

p53 mutant mice that display early ageing-associated phenotypes. Nature (2002) 10.05

Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34

Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development (2006) 7.08

Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01

Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54

Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature (2005) 6.43

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20

Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell (2011) 6.11

Leptin regulates bone formation via the sympathetic nervous system. Cell (2002) 5.95

Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell (2008) 5.93

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature (2010) 5.81

Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell (2004) 5.80

Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48

A twist code determines the onset of osteoblast differentiation. Dev Cell (2004) 5.40

ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell (2004) 5.27

Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03

Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell (2005) 4.91

Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci U S A (2008) 4.77

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68

Containing HIV/AIDS in India: the unfinished agenda. Lancet Infect Dis (2006) 4.58

Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55

The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci (2006) 4.49

NCCN Clinical Practice Guidelines in Oncology: colon cancer. J Natl Compr Canc Netw (2009) 4.41

Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development (2002) 4.18

A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development (2002) 4.13

SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell (2006) 4.01

The molecular clock mediates leptin-regulated bone formation. Cell (2005) 3.88

A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One (2009) 3.86

Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science (2008) 3.86

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron (2003) 3.76

The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66

Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development (2007) 3.56

Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev (2002) 3.49

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone. Genes Dev (2005) 3.38

beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem (2003) 3.37

A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet (2008) 3.37

NCCN Clinical Practice Guidelines in Oncology: rectal cancer. J Natl Compr Canc Netw (2009) 3.37

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development (2008) 3.30

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell (2009) 3.28

Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc Natl Acad Sci U S A (2002) 3.25

Endocrine regulation of male fertility by the skeleton. Cell (2011) 3.20

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A (2008) 3.10

Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest (2013) 3.03

Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain. J Comp Neurol (2003) 3.01

Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development (2005) 2.98

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell (2005) 2.95

Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development (2007) 2.92

Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins. J Cell Biol (2004) 2.90

Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development (2002) 2.88

Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87

Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. Anesthesiology (2009) 2.87

FoxP2 expression in avian vocal learners and non-learners. J Neurosci (2004) 2.87

The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet (2007) 2.85

Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet (2009) 2.84

Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol (2004) 2.77

Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74

Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73

Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72

Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell (2009) 2.72

22q11.2 distal deletion: a recurrent genomic disorder distinct from DiGeorge syndrome and velocardiofacial syndrome. Am J Hum Genet (2008) 2.71

Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev (2008) 2.66

The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell (2006) 2.62

Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development (2007) 2.60

ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development (2009) 2.55

Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50

Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation. J Immunol (2005) 2.50

Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol (2004) 2.48

Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal. Development (2008) 2.46

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest (2009) 2.46

Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron (2008) 2.44

Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell (2008) 2.44

Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development (2007) 2.44