Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR.

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Published in Cancer Res on July 15, 2001

Authors

R B Luwor1, T G Johns, C Murone, H J Huang, W K Cavenee, G Ritter, L J Old, A W Burgess, A M Scott

Author Affiliations

1: Ludwig Institute for Cancer Research, Melbourne Branch, Tumour Targeting Program, Austin and Repatriation Medical Centre, Heidelberg 3084, Victoria, Australia.

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Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature (1983) 11.57

IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature (2001) 11.03

Tumor necrosis factor (TNF). Science (1985) 8.80

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat Genet (2000) 8.58

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci U S A (1999) 7.70

Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci (1968) 7.51

Expression of T-cell differentiation antigens on effector cells in cell-mediated cytotoxicity in vitro. Evidence for functional heterogeneity related to the surface phenotype of T cells. J Exp Med (1975) 7.20

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci U S A (1979) 6.93

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Antigens of leukemias induced by naturally occurring murine leukemia virus: their relation to the antigens of gross virus and other murine leukemia viruses. J Exp Med (1966) 6.45

The G (Gross) leukemia antigen. Cancer Res (1965) 6.07

The G-IX system. A cell surface allo-antigen associated with murine leukemia virus; implications regarding chromosomal integration of the viral genome. J Exp Med (1971) 6.06

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci U S A (1994) 5.44

Surface alloantigens of plasma cells. J Exp Med (1970) 5.19

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Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies. Proc Natl Acad Sci U S A (1980) 4.66

Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med (1998) 4.65

Antigenic modulation. Loss of TL antigen from cells exposed to TL antibody. Study of the phenomenon in vitro. J Exp Med (1968) 4.63

Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice. Proc Natl Acad Sci U S A (1976) 4.52

Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature (1984) 4.46

Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera. Proc Natl Acad Sci U S A (1979) 4.14

Characterization of tumor necrosis factor-deficient mice. Proc Natl Acad Sci U S A (1997) 4.10

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Cell surface antigens of chemically induced sarcomas of the mouse. I. Murine leukemia virus-related antigens and alloantigens on cultured fibroblasts and sarcoma cells: description of a unique antigen on BALB/c Meth A sarcoma. J Exp Med (1977) 3.93

Computer-assisted follow-up register for the north-east of Scotland. Br Med J (1970) 3.92

Current enigmas in cancer research. Harvey Lect (1973) 3.91

Human tumor necrosis factor produced by human B-cell lines: synergistic cytotoxic interaction with human interferon. Proc Natl Acad Sci U S A (1983) 3.83

G-estimation of the effect of prophylaxis therapy for Pneumocystis carinii pneumonia on the survival of AIDS patients. Epidemiology (1992) 3.79

Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. J Biol Chem (1977) 3.74

p53 transformation-related protein: detection by monoclonal antibody in mouse and human cells. Proc Natl Acad Sci U S A (1981) 3.72

Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture. Cancer Res (1981) 3.62

Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells. Proc Natl Acad Sci U S A (1982) 3.58

Antigenic structure of cell surfaces. An immunoferritin study of the occurrence and topography of H-2' theta, and TL alloantigens on mouse cells. J Exp Med (1969) 3.53

Immunoglobulin and other surface antigens of cells of the immune system. J Exp Med (1971) 3.50

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Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour. Nature (1984) 3.37

Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse. Transplantation (1972) 3.34

Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets. J Exp Med (1982) 3.27

Modification of the antigenic structure of the cell membrane by thymus-leukemia (TL) antibody. Proc Natl Acad Sci U S A (1967) 3.26

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Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad Sci U S A (1986) 2.94

The nature and action of granulocyte-macrophage colony stimulating factors. Blood (1980) 2.94

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers. Proc Natl Acad Sci U S A (1990) 2.91

Mouse isoantigens: separation of soluble TL (thymus-leukemia) antigen from soluble H-2 histocompatibility antigen by column chromatography. J Exp Med (1967) 2.86

Shared viral antigen of mammalian leukaemia viruses. Nature (1970) 2.84

Eradication of established tumors by CD8+ T cell adoptive immunotherapy. Immunity (2000) 2.81

Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses. Proc Natl Acad Sci U S A (2000) 2.79

Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. Genomics (1998) 2.79

G (Gross) and H-2 cell-surface antigens: location on Gross leukemia cells by electron microscopy with visually labeled antibody. Proc Natl Acad Sci U S A (1970) 2.77

GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody. J Exp Med (1982) 2.74

Immunogenetics of cell surface antigens of mouse leukemia. Annu Rev Genet (1977) 2.69

Use of hybrid antibody with anti-gamma-G and anti-ferritin specificities in locating cell surface antigens by electron microscopy. J Exp Med (1968) 2.62

Detection of antibody to autologous human leukemia cells by immune adherence assays. Proc Natl Acad Sci U S A (1977) 2.59

Occurrence of natural antibody to the G (gross) leukemia antigen in mice. Cancer Res (1966) 2.57

Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5. Am J Hum Genet (1989) 2.56

T-cell-mediated cytotoxicity against autologous malignant melanoma: analysis with interleukin 2-dependent T-cell cultures. Proc Natl Acad Sci U S A (1984) 2.54

Thymus cells of radiation-chimeras: TL phenotype, sensitivity to guinea-pig serum, and origin from donor cells. Nature (1965) 2.54

Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens. J Exp Med (1981) 2.53

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality. Proc Natl Acad Sci U S A (1999) 2.53

Leukemia-associated transplantation antigens related to murine leukemia virus. The X.1 system: immune response controlled by a locus linked to H-2. J Exp Med (1973) 2.52

Assessment of some problems associated with prediction of the three-dimensional structure of a protein from its amino-acid sequence. Proc Natl Acad Sci U S A (1975) 2.49

Serologically demonstrable alloantigens of mouse epidermal cells. J Exp Med (1972) 2.48

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. Nat Med (1995) 2.47

Effect of tumour necrosis factor on cultured human melanoma cells. Nature (1975) 2.46

Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition. Proc Natl Acad Sci U S A (1985) 2.44

Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc Natl Acad Sci U S A (1994) 2.44

Partial purification of a serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A (1976) 2.42

Clonal genomic alterations in glioma malignancy stages. Cancer Res (1988) 2.39

Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism. Cell (1985) 2.36

Horizontal transmission of feline leukaemia virus. Nature (1973) 2.34

Amitriptyline and cardiac disease. Risk of sudden death identified by monitoring system. Lancet (1970) 2.31

A computer assisted follow-up register. Methods Inf Med (1969) 2.29

Group-specific viral antigens in the milk and tissues of mice naturally infected with mammary tumor virus or Gross leukemia virus. Virology (1968) 2.26

Humoral immune responses of cancer patients against "Cancer-Testis" antigen NY-ESO-1: correlation with clinical events. Int J Cancer (1999) 2.26

Rape trauma syndrome. Am J Psychiatry (1974) 2.23

Genetic origin of mutations predisposing to retinoblastoma. Science (1985) 2.22

Common properties of the oncogenic RNA viruses (oncornaviruses). Virology (1970) 2.20