Published in Nat Neurosci on August 01, 2001
GSK3 signalling in neural development. Nat Rev Neurosci (2010) 3.29
Establishment of axon-dendrite polarity in developing neurons. Annu Rev Neurosci (2009) 2.73
Microtubule stabilization specifies initial neuronal polarization. J Cell Biol (2008) 2.60
AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity. J Cell Biol (2008) 2.59
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation. Nat Neurosci (2006) 2.42
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex. Nat Med (2011) 2.11
GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J Biol Chem (2004) 1.91
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol (2005) 1.64
Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol (2005) 1.56
An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels. J Biol Chem (2009) 1.51
Semaphorin3A regulates neuronal polarization by suppressing axon formation and promoting dendrite growth. Neuron (2011) 1.50
The CRMP family of proteins and their role in Sema3A signaling. Adv Exp Med Biol (2007) 1.43
Neuronal polarity. Cold Spring Harb Perspect Biol (2009) 1.42
Retracted Ubiquitination of the GTPase Rap1B by the ubiquitin ligase Smurf2 is required for the establishment of neuronal polarity. EMBO J (2007) 1.42
Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell (2006) 1.40
Transport of PIP3 by GAKIN, a kinesin-3 family protein, regulates neuronal cell polarity. J Cell Biol (2006) 1.40
The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth. Dev Cell (2005) 1.39
ROCK and Rho: biochemistry and neuronal functions of Rho-associated protein kinases. Neuroscientist (2007) 1.38
Shootin1: A protein involved in the organization of an asymmetric signal for neuronal polarization. J Cell Biol (2006) 1.36
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biol Chem (2006) 1.33
Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. EMBO J (2002) 1.32
Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. EMBO J (2003) 1.29
Growth cone-like waves transport actin and promote axonogenesis and neurite branching. Dev Neurobiol (2009) 1.28
New insights into the molecular mechanisms specifying neuronal polarity in vivo. Curr Opin Neurobiol (2008) 1.25
UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting. Nat Neurosci (2011) 1.25
Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization. Semin Cell Dev Biol (2008) 1.24
Initiating and growing an axon. Cold Spring Harb Perspect Biol (2010) 1.24
Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway. J Biol Chem (2009) 1.23
Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain. Free Radic Biol Med (2012) 1.18
MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity. Mol Biol Cell (2010) 1.17
Regulation of N-type voltage-gated calcium channels (Cav2.2) and transmitter release by collapsin response mediator protein-2 (CRMP-2) in sensory neurons. J Cell Sci (2009) 1.17
Localized activation of p21-activated kinase controls neuronal polarity and morphology. J Neurosci (2007) 1.15
Collapsin response mediator protein-1: a novel invasion-suppressor gene. Clin Exp Metastasis (2003) 1.12
Shootin1 interacts with actin retrograde flow and L1-CAM to promote axon outgrowth. J Cell Biol (2008) 1.11
Critical role of collapsin response mediator protein-associated molecule CRAM for filopodia and growth cone development in neurons. Mol Biol Cell (2004) 1.09
Semaphorins as signals for cell repulsion and invasion. J Clin Invest (2002) 1.07
Proteome analysis of human substantia nigra in Parkinson's disease. Proteome Sci (2008) 1.06
Organization and maintenance of molecular domains in myelinated axons. J Neurosci Res (2013) 1.06
4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies. Antioxid Redox Signal (2012) 1.01
Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model. Lab Anim Res (2013) 1.00
Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem (2010) 0.99
Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization. Neuroscience (2012) 0.98
In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation. J Biol Chem (2010) 0.98
Axon growth inhibition by RhoA/ROCK in the central nervous system. Front Neurosci (2014) 0.97
Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis. Dev Biol (2006) 0.96
Developmentally regulated impediments to skin reinnervation by injured peripheral sensory axon terminals. Curr Biol (2009) 0.96
Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2. Neurobiol Dis (2012) 0.96
Proteomic analysis of hypoxia/ischemia-induced alteration of cortical development and dopamine neurotransmission in neonatal rat. J Proteome Res (2006) 0.96
A diffusion-based neurite length-sensing mechanism involved in neuronal symmetry breaking. Mol Syst Biol (2010) 0.96
Dendrites differ from axons in patterns of microtubule stability and polymerization during development. Neural Dev (2009) 0.96
Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. Future Neurol (2012) 0.95
The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels. Genes Dev (2008) 0.95
CRMP3 is required for hippocampal CA1 dendritic organization and plasticity. FASEB J (2007) 0.94
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. J Biol Chem (2009) 0.93
Interactions of the proteins of neuronal ceroid lipofuscinosis: clues to function. Cell Mol Life Sci (2010) 0.93
Regulation of microtubule stability and organization by mammalian Par3 in specifying neuronal polarity. Dev Cell (2012) 0.92
Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. J Biol Chem (2008) 0.91
The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem (2010) 0.89
A PEPTIDE UNCOUPLING CRMP-2 FROM THE PRESYNAPTIC Ca(2+) CHANNEL COMPLEX DEMONSTRATES EFFICACY IN ANIMAL MODELS OF MIGRAINE AND AIDS THERAPY-INDUCED NEUROPATHY. Transl Neurosci (2012) 0.89
Vertebrate-specific glutaredoxin is essential for brain development. Proc Natl Acad Sci U S A (2011) 0.89
Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2. J Neurosci Res (2009) 0.87
The role of microRNAs in regulating neuronal connectivity. Front Cell Neurosci (2014) 0.86
The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons. BMC Dev Biol (2007) 0.86
A dominant mutation in mec-7/β-tubulin affects axon development and regeneration in Caenorhabditis elegans neurons. Mol Biol Cell (2012) 0.85
Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines. Front Neuroanat (2014) 0.85
PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain. Int J Mol Sci (2014) 0.85
CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation. Neural Plast (2015) 0.85
Collapsin response mediator protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton. J Biol Chem (2014) 0.84
Altered brain protein expression profiles are associated with molecular neurological dysfunction in the PKU mouse model. J Neurochem (2014) 0.84
Hepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neurons. J Biol Chem (2009) 0.84
The cytoskeleton and neurite initiation. Bioarchitecture (2014) 0.83
CRMP2 protein SUMOylation modulates NaV1.7 channel trafficking. J Biol Chem (2013) 0.83
CRMPs: critical molecules for neurite morphogenesis and neuropsychiatric diseases. Mol Psychiatry (2015) 0.83
SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons. Channels (Austin) (2013) 0.82
The Beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton. Int J Alzheimers Dis (2013) 0.82
CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization. Dev Neurobiol (2013) 0.81
Functional variants in DPYSL2 sequence increase risk of schizophrenia and suggest a link to mTOR signaling. G3 (Bethesda) (2014) 0.81
Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation. Elife (2016) 0.81
Identification of a dithiol-disulfide switch in collapsin response mediator protein 2 (CRMP2) that is toggled in a model of neuronal differentiation. J Biol Chem (2013) 0.81
Collapsin response mediator protein 3 deacetylates histone H4 to mediate nuclear condensation and neuronal death. Sci Rep (2013) 0.81
Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. Front Pharmacol (2015) 0.80
Targeting of CRMP-2 to the primary cilium is modulated by GSK-3β. PLoS One (2012) 0.80
Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem (2011) 0.80
Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development. Int Rev Cell Mol Biol (2016) 0.80
Estrogen regulation of proteins in the rat ventromedial nucleus of the hypothalamus. J Proteome Res (2008) 0.80
Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. PLoS One (2012) 0.80
Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation. J Biol Chem (2011) 0.80
Insight into the role of CRMP2 (collapsin response mediator protein 2) in T lymphocyte migration: the particular context of virus infection. Cell Adh Migr (2012) 0.79
PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol Chem (2012) 0.79
Flexible search for single-axon morphology during neuronal spontaneous polarization. PLoS One (2011) 0.78
Expressed sequence tag analysis of adult human optic nerve for NEIBank: identification of cell type and tissue markers. BMC Neurosci (2009) 0.78
Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer's Disease: Comparison and Contrast with Microtubule-Associated Protein Tau. J Alzheimers Dis (2016) 0.77
New proteins found interacting with brain metallothionein-3 are linked to secretion. Int J Alzheimers Dis (2010) 0.77
Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons. Cell Rep (2015) 0.77
Emerging roles of Axin in cerebral cortical development. Front Cell Neurosci (2015) 0.77
Docosahexaenoic Acid Promotes Axon Outgrowth by Translational Regulation of Tau and Collapsin Response Mediator Protein 2 Expression. J Biol Chem (2016) 0.77
A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases. Mol Cell Proteomics (2011) 0.77
Anti-obesity sodium tungstate treatment triggers axonal and glial plasticity in hypothalamic feeding centers. PLoS One (2012) 0.77
Effects of hypothyroidism on expression of CRMP2B and ARPC5 during development of the rat frontal cortex. Int J Biol Sci (2013) 0.76
Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. PLoS Genet (2016) 0.76
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem (1996) 10.51
Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science (1987) 10.25
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase. Science (1997) 5.80
Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol (1998) 5.15
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem (1994) 4.90
Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells. Annu Rev Biochem (1999) 4.53
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction. Cell (1987) 4.50
Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation. J Biol Chem (1983) 3.69
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion. Science (1998) 3.39
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci (2001) 3.32
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem (1997) 3.12
Regulation and functions of Rho-associated kinase. Exp Cell Res (2000) 3.11
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science (1996) 3.09
Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model. Gene Ther (2004) 2.97
Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J Biol Chem (1992) 2.90
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins. Oncogene (1990) 2.89
Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nat Rev Mol Cell Biol (2001) 2.68
The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells. Immunity (1997) 2.66
Alveolar fluid clearance in the resected human lung. Am J Respir Crit Care Med (1994) 2.63
Rab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins. J Biol Chem (1993) 2.62
Feeder vessel photocoagulation of subfoveal choroidal neovascularization secondary to age-related macular degeneration. Ophthalmology (1998) 2.58
Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc Natl Acad Sci U S A (1988) 2.54
Ultrasound-guided infraclavicular brachial plexus block: an alternative technique to anatomical landmark-guided approaches. Reg Anesth Pain Med (2001) 2.53
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Mol Cell Biol (1993) 2.48
Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences. Genes Dev (1990) 2.46
Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res (2000) 2.45
Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J Cell Sci (2001) 2.38
Uveal effusion syndrome: clinical features, surgical treatment, histologic examination of the sclera, and pathophysiology. Ophthalmology (2000) 2.36
Cloning and nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene from the PCB-degrading strain of Pseudomonas paucimobilis Q1. Biochemistry (1988) 2.34
The COOH terminus of Rho-kinase negatively regulates rho-kinase activity. J Biol Chem (1999) 2.32
Failure of parturition in mice lacking the prostaglandin F receptor. Science (1997) 2.27
A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc Natl Acad Sci U S A (1991) 2.22
Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem (1996) 2.22
Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403). Br J Cancer (2008) 2.19
Small GTP-binding proteins. Int Rev Cytol (1992) 2.19
Elevated expression of messenger RNA for peripheral myelin protein 22 in biopsied peripheral nerves of patients with Charcot-Marie-Tooth disease type 1A. Ann Neurol (1994) 2.18
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol (1999) 2.17
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity (2001) 2.17
Continuous Fick cardiac output measurement during exercise by monitoring of mixed venous oxygen saturation and oxygen uptake. Chest (1993) 2.13
Prions prevent neuronal cell-line death. Nature (1999) 2.13
Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol Cell Biol (1995) 2.10
The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junctions in epithelial cells. J Cell Biol (1997) 2.10
Rho-associated kinase of chicken gizzard smooth muscle. J Biol Chem (1999) 2.10
Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures. J Biol Chem (1998) 2.09
Validity of 18F-fluorodeoxyglucose imaging with a dual-head coincidence gamma camera for detection of myocardial viability. J Nucl Med (1999) 2.06
Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16. J Med Genet (2007) 2.06
p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J Biol Chem (1998) 2.05
Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis. J Biol Chem (1998) 2.04
Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun (1998) 2.04
Synergistic functions of phorbol ester and calcium in serotonin release from human platelets. Biochem Biophys Res Commun (1983) 2.03
Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells. J Biol Chem (1998) 2.02
Metabolism of iodine-123-BMIPP in perfused rat hearts. J Nucl Med (1995) 2.02
Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Mol Biol Cell (2000) 2.00
Continuous ambulatory radionuclide monitoring of left ventricular function: effect of body position during ergometer exercise. J Nucl Med (1997) 1.99
Nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene of Pseudomonas pseudoalcaligenes. J Bacteriol (1987) 1.99
Continuous determination of cardiac output using a flow-directed Doppler pulmonary artery catheter. J Cardiothorac Vasc Anesth (1991) 1.97
Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems. Proc Natl Acad Sci U S A (1999) 1.93
Post-translational modifications of the C-terminal region of the rho protein are important for its interaction with membranes and the stimulatory and inhibitory GDP/GTP exchange proteins. Oncogene (1991) 1.93
Rho-kinase--mediated contraction of isolated stress fibers. J Cell Biol (2001) 1.92
Proton chemical shift imaging in normal pressure hydrocephalus. AJNR Am J Neuroradiol (2001) 1.89
Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue. J Biol Chem (1998) 1.86
Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphatase. J Cell Biol (1998) 1.85
Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J Cell Biol (2001) 1.85
Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts. Am J Physiol Cell Physiol (2001) 1.81
Acute retinal necrosis as a novel complication of chickenpox in adults. Br J Ophthalmol (1990) 1.81
Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase. J Biol Chem (1998) 1.81
A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells. Nat Genet (1993) 1.81
Hepatocellular carcinoma presenting as intrabile duct tumor growth: a clinicopathologic study of 24 cases. Cancer (1982) 1.80
Expression of a kinase-defective Eph-like receptor in the normal human brain. Biochem Biophys Res Commun (1997) 1.79
Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler Thromb Vasc Biol (2000) 1.79
alpha-galactosylceramide induces early B-cell activation through IL-4 production by NKT cells. Cell Immunol (2000) 1.77
Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis. Mucosal Immunol (2011) 1.76
Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse. J Biol Chem (2000) 1.73