Published in J Cell Biol on February 09, 1998
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73
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Leukocyte polarization in cell migration and immune interactions. EMBO J (1999) 3.08
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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. Biochem J (2009) 2.33
Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia. Proc Natl Acad Sci U S A (2004) 2.31
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Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. J Clin Invest (2001) 2.26
Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A (1999) 2.21
Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol (1999) 2.17
Entry of the two infectious forms of vaccinia virus at the plasma membane is signaling-dependent for the IMV but not the EEV. Mol Biol Cell (2000) 2.16
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Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes. EMBO J (2000) 1.85
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Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation. Mol Biol Cell (2003) 1.67
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Differential regulation of phagosome maturation in macrophages and dendritic cells mediated by Rho GTPases and ezrin-radixin-moesin (ERM) proteins. Proc Natl Acad Sci U S A (2006) 1.64
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Rho kinase in the regulation of cell death and survival. Arch Immunol Ther Exp (Warsz) (2007) 1.60
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Emerging role for ERM proteins in cell adhesion and migration. Cell Adh Migr (2011) 1.58
Characterization of human palladin, a microfilament-associated protein. Mol Biol Cell (2001) 1.56
Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes. EMBO J (2000) 1.47
RhoA-binding kinase alpha translocation is facilitated by the collapse of the vimentin intermediate filament network. Mol Cell Biol (1998) 1.46
Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium. J Cell Biol (1999) 1.46
Ezrin and moesin function together to promote T cell activation. J Immunol (2009) 1.44
Phospholipase C-mediated hydrolysis of PIP2 releases ERM proteins from lymphocyte membrane. J Cell Biol (2009) 1.41
LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc Natl Acad Sci U S A (2009) 1.39
Activated radixin is essential for GABAA receptor alpha5 subunit anchoring at the actin cytoskeleton. EMBO J (2006) 1.39
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Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth. Genes Dev (2004) 1.38
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G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton. Mol Biol Cell (2005) 1.36
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EPI64 regulates microvillar subdomains and structure. J Cell Biol (2006) 1.30
The actin cytoskeleton in store-mediated calcium entry. J Physiol (2000) 1.29
Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS One (2006) 1.28
A method for measuring Rho kinase activity in tissues and cells. Methods Enzymol (2008) 1.27
Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. J Cell Biol (2001) 1.26
Structural basis for CD44 recognition by ERM proteins. J Biol Chem (2008) 1.26
Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region. Mol Cell Biol (2000) 1.26
ROCKs as therapeutic targets in cardiovascular diseases. Expert Rev Cardiovasc Ther (2005) 1.25
Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil. J Cardiovasc Pharmacol (2013) 1.24
Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium. Mol Biol Cell (2004) 1.24
Janus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transduction. Mol Med (1998) 1.24
Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. J Biol Chem (2004) 1.22
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Role of Rho and Rho kinase in the activation of volume-regulated anion channels in bovine endothelial cells. J Physiol (1999) 1.21
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Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins. Mol Cell Biol (2000) 1.16
Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. J Cell Biol (2010) 1.16
The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association. Biochem J (2001) 1.15
Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B. J Gen Physiol (2004) 1.15
Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells. Oncogene (2011) 1.14
Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion. PLoS One (2008) 1.14
Atypical protein kinase C (iota) activates ezrin in the apical domain of intestinal epithelial cells. J Cell Sci (2008) 1.13
Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells. Mol Biol Cell (2007) 1.12
Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Proc Natl Acad Sci U S A (2011) 1.12
Rho kinase phosphorylation promotes ezrin-mediated metastasis in hepatocellular carcinoma. Cancer Res (2011) 1.11
Local ERM activation and dynamic growth cones at Schwann cell tips implicated in efficient formation of nodes of Ranvier. J Cell Biol (2003) 1.10
Net1 and Myeov: computationally identified mediators of gastric cancer. Br J Cancer (2006) 1.09
Ezrin mediates growth and survival in Ewing's sarcoma through the AKT/mTOR, but not the MAPK, signaling pathway. Clin Exp Metastasis (2006) 1.08
Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase. J Cell Biol (2006) 1.07
Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. J Biol Chem (2010) 1.07
Enteropathogenic Escherichia coli activates ezrin, which participates in disruption of tight junction barrier function. Infect Immun (2001) 1.06
NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer. Br J Cancer (2008) 1.06
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Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22. Mol Biol Cell (1999) 1.05
RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response. Cardiovasc Diabetol (2012) 1.04
Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway. Mol Biol Cell (2007) 1.04
Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells. BMC Cancer (2011) 1.04
Regulation of cell survival by Na+/H+ exchanger-1. Am J Physiol Renal Physiol (2008) 1.04
Local phosphocycling mediated by LOK/SLK restricts ezrin function to the apical aspect of epithelial cells. J Cell Biol (2012) 1.03
TTC7A mutations disrupt intestinal epithelial apicobasal polarity. J Clin Invest (2014) 1.02
Ezrin induces long-range interdomain allostery in the scaffolding protein NHERF1. J Mol Biol (2009) 1.02
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