In vitro generation and transplantation of precursor-derived human dopamine neurons.

PubWeight™: 1.09‹?› | Rank: Top 10%

🔗 View Article (PMID 11494363)

Published in J Neurosci Res on August 15, 2001

Authors

R Sánchez-Pernaute1, L Studer, K S Bankiewicz, E O Major, R D McKay

Author Affiliations

1: Laboratory of Molecular Medicine and Neuroscience, NINDS, NIH, Bethesda, Maryland, USA.

Articles citing this

Stem cells in human neurodegenerative disorders--time for clinical translation? J Clin Invest (2010) 3.62

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol (2007) 2.54

Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation. Stem Cells (2005) 1.56

Cell therapeutics in Parkinson's disease. Neurotherapeutics (2011) 1.32

Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice. J Clin Invest (2008) 1.29

Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease. Stem Cells (2006) 1.16

Parthenogenetic dopamine neurons from primate embryonic stem cells restore function in experimental Parkinson's disease. Brain (2008) 1.06

Achieving stable human stem cell engraftment and survival in the CNS: is the future of regenerative medicine immunodeficient? Regen Med (2011) 1.03

Cell-based therapies for Parkinson disease—past insights and future potential. Nat Rev Neurol (2015) 0.97

Generation of functional human serotonergic neurons from fibroblasts. Mol Psychiatry (2015) 0.96

Moving stem cells to the clinic: potential and limitations for brain repair. Neuron (2015) 0.94

Stem cells in drug screening for neurodegenerative disease. Korean J Physiol Pharmacol (2012) 0.85

Cell-based therapies for Parkinson's disease: past, present, and future. Antioxid Redox Signal (2009) 0.85

The promise of stem cells in Parkinson disease. J Clin Invest (2005) 0.84

Preclinical assessment of stem cell therapies for neurological diseases. ILAR J (2009) 0.81

Clonal human fetal ventral mesencephalic dopaminergic neuron precursors for cell therapy research. PLoS One (2012) 0.80

Adult human neural stem cell therapeutics: Current developmental status and prospect. World J Stem Cells (2015) 0.78

Neurological disorders and neural regeneration, with special reference to Parkinson's disease and cerebral ischemia. J Artif Organs (2009) 0.77

A Compendium of Preparation and Application of Stem Cells in Parkinson's Disease: Current Status and Future Prospects. Front Aging Neurosci (2016) 0.75

Proceedings: cell therapies for Parkinson's disease from discovery to clinic. Stem Cells Transl Med (2014) 0.75

Stem cell therapy for Parkinson's disease. Dialogues Clin Neurosci (2004) 0.75

Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/β-catenin/ROS signaling dependent manner. J Biomed Sci (2017) 0.75

Articles by these authors

CNS stem cells express a new class of intermediate filament protein. Cell (1990) 11.96

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol (2000) 6.21

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol (2001) 6.08

Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science (1999) 5.13

Binding of a simian virus 40 T antigen-related protein to DNA. J Mol Biol (1981) 4.76

Immune reconstitution inflammatory syndrome in natalizumab-associated PML. Neurology (2011) 4.63

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev (1996) 4.61

Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech Dev (1996) 3.45

Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science (2001) 3.44

Establishment of a line of human fetal glial cells that supports JC virus multiplication. Proc Natl Acad Sci U S A (1985) 2.93

Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci U S A (1998) 2.89

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alpha. Oncogene (2009) 2.86

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease. Neurology (2008) 2.80

JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency. J Virol (1996) 2.60

Identification of major cell classes in the developing mammalian nervous system. J Neurosci (1985) 2.50

Restoring production of hippocampal neurons in old age. Nat Neurosci (1999) 2.49

Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nat Neurosci (1998) 2.49

Detection of JC virus DNA in human tonsil tissue: evidence for site of initial viral infection. J Virol (1998) 2.43

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol (1990) 2.40

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology (2009) 2.37

Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. N Engl J Med (1988) 2.32

Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab Invest (1992) 2.30

JC virus DNA is present in the mucosa of the human colon and in colorectal cancers. Proc Natl Acad Sci U S A (1999) 2.08

Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy. Ann Neurol (1992) 2.07

Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons. Neuron (1995) 2.06

Proliferation and differentiation of rat neuroepithelial precursor cells in vivo. J Neurosci (1988) 2.02

Malignant transformation of BHK21 clone 13 cells by BK virus--a human papovavirus. Proc Natl Acad Sci U S A (1973) 2.01

Multiple routes to astrocytic differentiation in the CNS. J Neurosci (1998) 1.97

Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons. J Neurosci (1998) 1.95

Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats. Nat Biotechnol (1998) 1.95

Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion. J Neurosurg (1995) 1.94

Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon. J Biol Chem (1999) 1.90

HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology (1994) 1.86

Sequential actions of BMP receptors control neural precursor cell production and fate. Genes Dev (2001) 1.84

Management and outcome of CSF-JC virus PCR-negative PML in a natalizumab-treated patient with MS. Neurology (2011) 1.83

Persistent human immunodeficiency virus type 1 infection in human fetal glial cells reactivated by T-cell factor(s) or by the cytokines tumor necrosis factor alpha and interleukin-1 beta. J Virol (1991) 1.81

Progressive multifocal leukoencephalopathy. Semin Neurol (1999) 1.75

In vitro-generated neural precursors participate in mammalian brain development. Proc Natl Acad Sci U S A (1997) 1.73

A classification scheme for human polyomavirus JCV variants based on the nucleotide sequence of the noncoding regulatory region. J Neurovirol (2001) 1.72

Characterization of the human nestin gene reveals a close evolutionary relationship to neurofilaments. J Cell Sci (1992) 1.65

HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes. J Immunol (1999) 1.63

Association of cellular 56,000- and 32,000-molecular-weight protein with BK virus and polyoma virus t-antigens. J Virol (1981) 1.63

Comparison of antibody titers determined by hemagglutination inhibition and enzyme immunoassay for JC virus and BK virus. J Clin Microbiol (2000) 1.63

Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain. Cell (1991) 1.58

Regulation of neurogenesis by growth factors and neurotransmitters. J Neurobiol (1998) 1.55

Progression of progressive multifocal leukoencephalopathy despite treatment with beta-interferon. Neurology (2006) 1.47

Coexpression of nestin in neural and glial cells in the developing human CNS defined by a human-specific anti-nestin antibody. Exp Neurol (2000) 1.45

Interaction of the human polyomavirus, JCV, with human B-lymphocytes. Virology (1992) 1.44

Extension of JC virus host range to monkey cells by insertion of a simian virus 40 enhancer into the JC virus regulatory region. Virology (1989) 1.41

BK-related polyomavirus vasculopathy in a renal-transplant recipient. N Engl J Med (2001) 1.41

Hemiparkinsonism in monkeys after unilateral internal carotid artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Life Sci (1986) 1.39

Interaction of a nuclear factor-1-like protein with the regulatory region of the human polyomavirus JC virus. J Biol Chem (1989) 1.36

Human microglia convert l-tryptophan into the neurotoxin quinolinic acid. Biochem J (1996) 1.32

Host-guided migration allows targeted introduction of neurons into the embryonic brain. Neuron (1995) 1.32

Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes. J Neurovirol (1996) 1.32

Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats. Mol Ther (2001) 1.31

Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin. Exp Neurol (2001) 1.30

Re-expression of the intermediate filament nestin in reactive astrocytes. Neurobiol Dis (1995) 1.29

Axonal transport of adeno-associated viral vectors is serotype-dependent. Gene Ther (2012) 1.29

Cell contact regulates fate choice by cortical stem cells. J Neurosci (2000) 1.29

Human ESC-derived neural rosettes and neural stem cell progression. Cold Spring Harb Symp Quant Biol (2009) 1.28

POU transcription factors control expression of CNS stem cell-specific genes. Development (1998) 1.28

Mechanisms of leukocyte trafficking into the CNS. J Neurovirol (2000) 1.28

Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes. J Virol (1996) 1.27

A glia-derived signal regulating neuronal differentiation. J Neurosci (2000) 1.26

Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain. Neuroreport (2001) 1.26

Adjacent nuclear factor-1 and activator protein binding sites in the enhancer of the neurotropic JC virus. A common characteristic of many brain-specific genes. J Biol Chem (1992) 1.24

Transplanted CNS stem cells form functional synapses in vivo. Eur J Neurosci (2000) 1.24

Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types. Biochem J (1997) 1.24

Evolution of a human Y chromosome-specific repeated sequence. Cell (1978) 1.23

Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy. Ann Neurol (1999) 1.22

Distribution of AAV-TK following intracranial convection-enhanced delivery into rats. Cell Transplant (2000) 1.21

Progressive multifocal leukoencephalopathy: JC virus induced demyelination in the immune compromised host. J Neurovirol (2000) 1.21

Progressive multifocal leukoencephalopathy: molecular biology, pathogenesis and clinical impact. Intervirology (1997) 1.20

Hypothesis: "Rogue cell"-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncopenesis. Proc Natl Acad Sci U S A (1996) 1.17

Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy. Ann Neurol (1992) 1.17

Downregulation of CDC2 upon terminal differentiation of neurons. New Biol (1991) 1.16

Human embryonic kidney cells: stable transformation with an origin-defective simian virus 40 DNA and use as hosts for human papovavirus replication. Mol Cell Biol (1984) 1.16

Progressive multifocal leukoencephalopathy: investigation of three cases using in situ hybridization with JC virus biotinylated DNA probe. Ann Neurol (1985) 1.15

6-[18F]fluoro-L-m-tyrosine: metabolism, positron emission tomography kinetics, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesions in primates. Brain Res (1997) 1.15

Changes in neurotrophin responsiveness during the development of cerebellar granule neurons. Neuron (1992) 1.13

Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells. J Neurovirol (1995) 1.12

An embryonic origin for medulloblastoma. New Biol (1991) 1.11

The efficacy of nucleoside analogs against JC virus multiplication in a persistently infected human fetal brain cell line. J Neurovirol (1998) 1.11

Progressive multifocal leukoencephalopathy: JC virus detection by in situ hybridization compared with immunohistochemistry. Neurology (1986) 1.10

A rod end deletion in the intermediate filament protein nestin alters its subcellular localization in neuroepithelial cells of transgenic mice. J Cell Sci (1998) 1.10

A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate. Brain (1993) 1.10

AIDS- and non-AIDS-related PML association with distinct p53 polymorphism. Neurology (2000) 1.08

JC virus-induced owl monkey glioblastoma cells in culture: biological properties associated with the viral early gene product. Virology (1984) 1.08

Cellular targets and trophic functions of neurotrophin-3 in the developing rat hippocampus. Neuron (1992) 1.07

Neuronal progenitors as tools for cell replacement in the nervous system. Curr Opin Neurobiol (1996) 1.05

The neuroepithelial stem cell concept: implications for neuro-oncology. J Neurooncol (1995) 1.05

Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential. EMBO J (1993) 1.04

Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor. J Neurosci (1998) 1.04

Early cortical precursors do not undergo LIF-mediated astrocytic differentiation. J Neurosci Res (2000) 1.04

Comparison of the serology, transforming ability, and polypeptide composition of human papovaviruses isolated from urine. J Virol (1976) 1.04

Factors and their influence on regional cerebral blood flow during nonpulsatile cardiopulmonary bypass. Ann Thorac Surg (1984) 1.03