Multiple compartments with different metabolic characteristics are involved in biosynthesis of intracellular and released glutamine and citrate in astrocytes.

PubWeight™: 0.90‹?›

🔗 View Article (PMID 11494415)

Published in Glia on September 01, 2001

Authors

H S Waagepetersen1, U Sonnewald, O M Larsson, A Schousboe

Author Affiliations

1: Department of Pharmacology, NeuroScience PharmaBiotec Research Center, Royal Danish School of Pharmacy, Copenhagen, Denmark.

Articles citing this

Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas. Int J Cancer (2010) 1.11

An enquiry into metabolite domains. Biophys J (2007) 0.98

Expression of mitochondrial branched-chain aminotransferase and α-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism. Front Neuroanat (2012) 0.93

A comprehensive metabolic profile of cultured astrocytes using isotopic transient metabolic flux analysis and C-labeled glucose. Front Neuroenergetics (2011) 0.90

Metabolic aspects of neuron-oligodendrocyte-astrocyte interactions. Front Endocrinol (Lausanne) (2013) 0.90

Characterization of glucose-related metabolic pathways in differentiated rat oligodendrocyte lineage cells. Glia (2015) 0.90

Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation. ASN Neuro (2012) 0.89

Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain. Neurochem Res (2012) 0.88

A simple method for measuring intracellular activities of glutamine synthetase and glutaminase in glial cells. Am J Physiol Cell Physiol (2011) 0.85

Metabolic Flux and Compartmentation Analysis in the Brain In vivo. Front Endocrinol (Lausanne) (2013) 0.85

Proposed cycles for functional glutamate trafficking in synaptic neurotransmission. Neurochem Int (2007) 0.84

Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity? Neurochem Int (2011) 0.81

Pyruvate carboxylation in different model systems studied by (13)C MRS. Neurochem Res (2010) 0.80

Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6-(13)C2]Glucose Metabolism in Anesthetized Rats. Neurochem Res (2016) 0.75

Articles by these authors

Both developmental and metabolic signals activate the promoter of a class I patatin gene. EMBO J (1989) 4.15

Inhibition of the ADP-glucose pyrophosphorylase in transgenic potatoes leads to sugar-storing tubers and influences tuber formation and expression of tuber storage protein genes. EMBO J (1992) 3.55

Expression of a yeast-derived invertase in the cell wall of tobacco and Arabidopsis plants leads to accumulation of carbohydrate and inhibition of photosynthesis and strongly influences growth and phenotype of transgenic tobacco plants. EMBO J (1990) 3.43

Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem (1984) 3.39

Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase. J Neurosci (2000) 3.10

Evidence of the crucial role of sucrose synthase for sink strength using transgenic potato plants (Solanum tuberosum L.). Plant J (1995) 3.08

One of two different ADP-glucose pyrophosphorylase genes from potato responds strongly to elevated levels of sucrose. Mol Gen Genet (1990) 2.79

The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48

An ethanol inducible gene switch for plants used to manipulate carbon metabolism. Nat Biotechnol (1998) 2.12

Inorganic pyrophosphate content and metabolites in potato and tobacco plants expressing E. coli pyrophosphatase in their cytosol. Planta (1992) 1.86

A small decrease of plastid transketolase activity in antisense tobacco transformants has dramatic effects on photosynthesis and phenylpropanoid metabolism. Plant Cell (2001) 1.79

Apoplastic expression of yeast-derived invertase in potato : effects on photosynthesis, leaf solute composition, water relations, and tuber composition. Plant Physiol (1992) 1.74

High affinity glutamate transporters: regulation of expression and activity. Mol Pharmacol (1997) 1.73

Astrocytes: glutamate producers for neurons. J Neurosci Res (1999) 1.62

Combined expression of glucokinase and invertase in potato tubers leads to a dramatic reduction in starch accumulation and a stimulation of glycolysis. Plant J (1998) 1.56

A moderate decrease of plastid aldolase activity inhibits photosynthesis, alters the levels of sugars and starch, and inhibits growth of potato plants. Plant J (1998) 1.55

Cloning and expression analysis of a potato cDNA that encodes branching enzyme: evidence for co-expression of starch biosynthetic genes. Mol Gen Genet (1991) 1.51

Clinical 1H magnetic resonance spectroscopy of brain metastases at 1.5T and 3T. Acta Radiol (2006) 1.43

Impaired photoassimilate partitioning caused by phloem-specific removal of pyrophosphate can be complemented by a phloem-specific cytosolic yeast-derived invertase in transgenic plants. Plant Cell (1995) 1.42

Analysis of the expression of potato uridinediphosphate-glucose pyrophosphorylase and its inhibition by antisense RNA. Planta (1993) 1.41

Overexpression of pyrophosphatase leads to increased sucrose degradation and starch synthesis, increased activities of enzymes for sucrose-starch interconversions, and increased levels of nucleotides in growing potato tubers. Planta (1998) 1.40

Soluble acid invertase determines the hexose-to-sucrose ratio in cold-stored potato tubers. Planta (1996) 1.38

Spinach hexokinase I is located in the outer envelope membrane of plastids. FEBS Lett (1999) 1.37

Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. J Neurochem (1983) 1.31

Ectopic expression of a tobacco invertase inhibitor homolog prevents cold-induced sweetening of potato tubers. Nat Biotechnol (1999) 1.31

Regulation of carbohydrate partitioning during the interaction of potato virus Y with tobacco. Mol Plant Pathol (2000) 1.29

Trafficking of amino acids between neurons and glia in vivo. Effects of inhibition of glial metabolism by fluoroacetate. J Cereb Blood Flow Metab (1997) 1.29

Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons. Neurochem Int (1993) 1.28

Dantrolene prevents glutamate cytotoxicity and Ca2+ release from intracellular stores in cultured cerebral cortical neurons. J Neurochem (1991) 1.27

Salicylic acid-independent induction of pathogenesis-related protein transcripts by sugars is dependent on leaf developmental stage. FEBS Lett (1996) 1.26

A truncated version of an ADP-glucose pyrophosphorylase promoter from potato specifies guard cell-selective expression in transgenic plants. Plant Cell (1994) 1.23

The first immunoglobulin-like neural cell adhesion molecule (NCAM) domain is involved in double-reciprocal interaction with the second immunoglobulin-like NCAM domain and in heparin binding. J Biol Chem (1997) 1.22

Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J Neurochem (1996) 1.21

Neuronal soluble factors differentially regulate the expression of the GLT1 and GLAST glutamate transporters in cultured astroglia. J Neurochem (1997) 1.19

Glial-neuronal interactions as studied by cerebral metabolism of [2-13C]acetate and [1-13C]glucose: an ex vivo 13C NMR spectroscopic study. J Neurochem (1995) 1.16

Experimental studies of the influence of vigabatrin on the GABA system. Br J Clin Pharmacol (1989) 1.15

Reconstitution of an active lactose carrier in vivo by simultaneous synthesis of two complementary protein fragments. J Bacteriol (1990) 1.14

The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms. Neurochem Int (2000) 1.13

Regional cerebral glucose phosphorylation and blood flow after insertion of a microdialysis fiber through the dorsal hippocampus in the rat. J Neurochem (1987) 1.13

Reduction of the cytosolic fructose-1,6-bisphosphatase in transgenic potato plants limits photosynthetic sucrose biosynthesis with no impact on plant growth and tuber yield. Plant J (1996) 1.12

A simplified procedure for the subtractive cDNA cloning of photoassimilate-responding genes: isolation of cDNAs encoding a new class of pathogenesis-related proteins. Plant Mol Biol (1995) 1.12

Glutamate transport and metabolism in astrocytes. Glia (1997) 1.11

Molecular determinants of sink strength. Curr Opin Plant Biol (1998) 1.11

Metabolic fate of 14C-labeled glutamate in astrocytes in primary cultures. J Neurochem (1982) 1.11

Trafficking between glia and neurons of TCA cycle intermediates and related metabolites. Glia (1997) 1.11

The GABA paradox: multiple roles as metabolite, neurotransmitter, and neurodifferentiative agent. J Neurochem (1999) 1.11

Transport and metabolism of glutamate and GABA in neurons are glial cells. Int Rev Neurobiol (1981) 1.11

Evidence for expression level-dependent modulation of carbohydrate status and viral resistance by the potato leafroll virus movement protein in transgenic tobacco plants. Plant J (2001) 1.08

Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro. J Neurochem (1985) 1.07

(13)C MR spectroscopy study of lactate as substrate for rat brain. Dev Neurosci (2001) 1.06

Characterization of uptake and release processes for D- and L-aspartate in primary cultures of astrocytes and cerebellar granule cells. Neurochem Res (1983) 1.05

High CO2-mediated down-regulation of photosynthetic gene transcripts is caused by accelerated leaf senescence rather than sugar accumulation. FEBS Lett (2000) 1.05

Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission. Neurochem Int (2004) 1.05

Cloning and characterization of the gene cluster for palatinose metabolism from the phytopathogenic bacterium Erwinia rhapontici. J Bacteriol (2001) 1.05

Effects of GABA analogues of restricted conformation on GABA transport in astrocytes and brain cortex slices and on GABA receptor binding. J Neurochem (1979) 1.05

Truncated forms of Escherichia coli lactose permease: models for study of biosynthesis and membrane insertion. J Bacteriol (1988) 1.04

A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons. J Neurochem (2000) 1.04

Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents. Neuroscience (2008) 1.03

Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures. Neurochem Res (1988) 1.03

Metabolic trafficking between neurons and astrocytes: the glutamate/glutamine cycle revisited. Dev Neurosci (1995) 1.02

Cellular distribution and kinetic properties of high-affinity glutamate transporters. Brain Res Bull (1998) 1.01

Impact of elevated cytosolic and apoplastic invertase activity on carbon metabolism during potato tuber development. J Exp Bot (2000) 1.01

Mitochondrial heterogeneity in the brain at the cellular level. J Cereb Blood Flow Metab (1998) 1.00

Acetoacetate and glucose as lipid precursors and energy substrates in primary cultures of astrocytes and neurons from mouse cerebral cortex. J Neurochem (1986) 1.00

In vivo injection of [1-13C]glucose and [1,2-13C]acetate combined with ex vivo 13C nuclear magnetic resonance spectroscopy: a novel approach to the study of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab (1998) 1.00

Glutamate and glutamine metabolism and compartmentation in astrocytes. Dev Neurosci (1993) 1.00

Glutamate decreases pyruvate carboxylase activity and spares glucose as energy substrate in cultured cerebellar astrocytes. J Neurosci Res (2001) 1.00

Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. Eur J Pharmacol (1991) 0.99

Purification and characterization of the 4-aminobutyrate--2,ketoglutarate transaminase from mouse brain. Biochemistry (1973) 0.99

Cloning and expression analysis of sucrose-phosphate synthase from sugar beet (Beta vulgaris L.). Mol Gen Genet (1995) 0.99

Characterization of L-glutamate uptake into and release from astrocytes and neurons cultured from different brain regions. Exp Brain Res (1982) 0.98

Development of excitatory amino acid induced cytotoxicity in cultured neurons. Int J Dev Neurosci (1990) 0.97

Direct evidence that excitotoxicity in cultured neurons is mediated via N-methyl-D-aspartate (NMDA) as well as non-NMDA receptors. J Neurochem (1989) 0.96

Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival. J Cereb Blood Flow Metab (2001) 0.96

Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling. J Neurochem (1996) 0.96

Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons. J Neurochem (2000) 0.96

Transport and metabolism of gamma-aminobutyric acid in neurons and glia: implications for epilepsy. Epilepsia (1983) 0.96

Phosphate activated glutaminase activity and glutamine uptake in primary cultures of astrocytes. J Neurochem (1979) 0.95

Comparison of lactate and glucose metabolism in cultured neocortical neurons and astrocytes using 13C-NMR spectroscopy. Dev Neurosci (1998) 0.95

Ionic mechanisms in glutamate-induced astrocyte swelling: role of K+ influx. J Neurosci Res (1998) 0.95

Utilization of glutamine and of TCA cycle constituents as precursors for transmitter glutamate and GABA. Dev Neurosci (1993) 0.95

Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA. Prog Brain Res (1992) 0.95

Uptake and metabolism of glutamate in astrocytes cultured from dissociated mouse brain hemispheres. J Neurochem (1977) 0.95

GABA uptake inhibitors: relevance to antiepileptic drug research. Epilepsy Res (1987) 0.95

Excitatory amino acid-induced release of 3H-GABA from cultured mouse cerebral cortex interneurons. J Neurosci (1987) 0.95

Volume regulation in astrocytes: a role for taurine as an osmoeffector. J Neurosci Res (1988) 0.94